Acute intravesical infusion of a cobalt solution stimulates a hypoxia response, growth and angiogenesis in the rat bladder

Journal of Urology

Volumn 169, Issue 6, 2003, Pages 2402-2406

  Buttyan, Ralph ^a   Chichester, Paul ^a   Stisser, Brian ^a   Matsumoto, Seiji ^a   Ghafar, Mohamed A ^a   Levin, Robert M ^a  

^a ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

Author keywords

Anoxia; Bladder; Cobalt ion; Rats, Sprague Dawley; Vascular endothelial growth factor

Indexed keywords

BLOOD CLOTTING FACTOR 8; BROXURIDINE; COBALT; COBALT CHLORIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SODIUM CHLORIDE; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; BLADDER NECK STENOSIS; CELL LABELING; CONTROLLED STUDY; DRUG INFUSION; GENE EXPRESSION; HYPOXIA; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; RAT; RAT STRAIN; SUBMUCOSA; TISSUE GROWTH; UROTHELIUM; WESTERN BLOTTING;

EID: 0038625314     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000058406.16931.93     Document Type: Article

References (20)

1. Levin, R. M. and Wein, A. J. Experimental models of urinary bladder outlet obstruction. Neurourol Urodyn, 5: 241, 1986
2. Levin, R. M., Brading, A. F., Mills, I. W. and Longhust, P. A.: Experimental models of bladder obstruction. In: Prostatic Disease. Edited by H. Lepor. Philadelphia: W. B. Saunders Co, pp 169-196, 1999
3. Shabsigh, A., Hayek, O. H., Weiner, D., Saidi, J., Kaplan, S. A., Kiss, A. et al: Acute increase in blood flow to the rat bladder subsequent to partial bladder outlet obstruction. Neurourol Urodyn, 19: 195, 2000
4. Ghafar, M. A., Shabsigh, A., Chichester, P., Anastasiadis, A. G., Borow, A., Levin, R. M. et al: Effects of chronic partial outlet obstruction on blood flow and oxygenation of the rat bladder. J Urol, 167: 1508, 2002
5. Ghafar, M. A., Anastasiadis, A. G., Olsson, L. E., Chichester, P., Kaplan, S. A., Buttyan, R. et al: Hypoxia and an angiogenic response in the partially obstructed rat bladder. Lab Invest, 82: 903, 2002
6. Semenza, G. L.: HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol, 13: 167, 2001
7. Huang, L. E., Gu, J., Schau, M. and Bunn, H. F.: Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA, 95: 7987, 1998
8. Mole, D. R., Maxwell, P. H., Pugh, C. W. and Ratcliffe, P. J.: Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing. IUBMB Life, 52: 43, 2001
9. Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M. et al: HIF alpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science, 292: 464, 2001
10. Jaakkola, P., Mole, D. R., Tian, Y. M., Wilson, M. I., Gielbert, J., Gaskell, S. J. et al: Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292: 468, 2001
11. Yu, F., White, S. B., Zhao, Q. and Lee, F. S.: Dynamic, sitespecific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein. Cancer Res, 61: 4136, 2001
12. Yuan, Y., Beitner-Johnson, D. and Millhorn, D. E.: Hypoxiainducible factor 2alpha binds to cobalt in vitro. Biochem Biophys Res Commun, 288: 849, 2001
13. Steers, W. D.: Physiology of the urinary bladder. In: Campbell's Urology, 6th ed. Edited by P. C. Walsh, A. B. Retik, T. A. Stamey and E. D. Vaughan, Jr. Philadelphia: W. B. Saunders Co., vol. 1, chapt. 5, pp.142-176, 1992
14. Sterling, A. M., Ritter, R. C. and Zinner, N. R.: The physical basis of obstructive uropathy. In: Benign Prostatic Hypertrophy. New York: Springer-Verlag, pp. 433-442, 1983
15. Grayhack, J. T. and Kozlowski, J. M.: Benign prostatic hyperplasia. In: Adult and Pediatric Urology. Edited by J. Y. Gillenwater, J. T. Grayhack, S. S. Howards and J. W. Duckett. Chicago: Year Book Med. Pub. Inc., pp. 1062-1126, 1987
16. Levin, R. M., Levin, S. S., Zhao, Y. and Buttyan, R.: Cellular and molecular aspects of bladder hypertrophy. Eur Urol, suppl., 32: 15, 1997
17. Kato, K., Monson, F. C., Longhurst, P. A., Wein, A. J., Haugaard, N. and Levin, R. M.: The functional effects of long-term outlet obstruction on the rabbit urinary bladder. J Urol, 143: 600, 1990
18. Chen, M.-W., Buttyan, R. and Levin, R. M.: Genetic and cellular response to unilateral ischemia of the rabbit urinary bladder. J Urol, 155: 732, 1996
19. Chichester, P., Lieb, J., Levin, S. S., Buttyan, R., Horan, P. and Levin, R. M.: Vascular response of the rabbit bladder to short term partial outlet obstruction. Mol Cell Biochem, 208: 19, 2000
20. Chichester, P., Schroder, A., Horan, P. and Levin, R. M.: Vascular response of the rabbit bladder to chronic partial outlet obstruction. Mol Cell Biochem, 226: 1, 2001