Efficiencies of transgene expression in nociceptive neurons through different routes of delivery of adeno-associated viral vectors

Human Gene Therapy

Volumn 14, Issue 9, 2003, Pages 897-906

  Xu, Ya ^a   Gu, Yanping ^a,b   Wu, Ping ^a,b   Li, Guang Wen ^a   Huang, Li Yen Mae ^a,c  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; NEURON SPECIFIC ENOLASE; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DRUG EFFICACY; GENE; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; GREEN FLUORESCENT PROTEIN GENE; MALE; MU OPIOID RECEPTOR GENE; NOCICEPTION; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; RAT; SCIATIC NERVE; SPINAL GANGLION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT;

ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; CELLS, CULTURED; DEPENDOVIRUS; GANGLIA, SPINAL; GENE EXPRESSION; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; INJECTIONS, SPINAL; INJECTIONS, SUBCUTANEOUS; LUMINESCENT PROTEINS; MORPHINE; NOCICEPTORS; POSTERIOR HORN CELLS; RATS; RECEPTORS, OPIOID, MU; SCIATIC NERVE; SUBARACHNOID SPACE; TRANSDUCTION, GENETIC; TRANSGENES;

ADENO-ASSOCIATED VIRUS; ANIMALIA;

EID: 0038618928     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303403765701187     Document Type: Article

References (30)

1. BARTLETT, J.S., SAMULSKI, R.J., and MCCOWN, T.J. (1998). Selective and rapid uptake of adeno-associated virus type 2 in brain. Hum. Gene Ther. 9, 1181-1186.
2. BERNS, K.I., and ADLER, S. (1972). Separation of two types of adeno-associated virus particles containing complementary polynucleotide chains. J. Virol. 9, 394-396.
3. BOULIS, N.M., NOORDMANS, A.J., FELDMAN, E.L., and IMPERIALE, M.J. (2000). Adeno-associated viral gene expression in the adult rat spinal cord following remote vector delivery [abstract 1]. Mol. Ther. 1, 5110-5111.
4. BRAZ, J., BEAUFOUR, C., COUTAUX, A., EPSTEIN, A.L., CESSELIN, F., HAMON, M., and POHL, M. (2001). Therapeutic efficacy in experimental polyarthritis of viral-driven enkephalin overproduction in sensory neurons. J. Neurosci. 21, 7881-7888.
5. CHAMBERLIN, N.L., DU, B., DE LACALLE, S., and SAPER, C.B. (1998). Recombinant adeno-associated virus vector: Use for transgene expression and anterograde tract tracing in the CNS. Brain Res. 793, 169-175.
6. CLARK, K.R., LIU, X., MCGRATH, J.P., and JOHNSON, P.R. (1999). Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses. Hum. Gene Ther. 10, 1031-1039.
7. COGGESHALL, R.E. (1992). A consideration of neural counting methods. Trends Neurosci. 15, 9-13.
8. DHILLON, H., MINTER, R.M., TOPPING, D., PRIMA, V., MOLDAWER, L.L., and MUZYCZKA, N. (1999). Long-term correction of obesity using centrally delivered rAAV encoding anorexigenic cytokines [abstract 2]. Am. Soc. Gene Ther. 2, 45a.
9. FERRARI, F.K., XIAO, X., MCCARTY, D., and SAMULSKI, R.J. (1997). New developments in the generation of Ad-free, high-titer rAAV gene therapy vectors. Nat. Med. 3, 1295-1297.
10. FLEMING, J., GINN, S.L., WEINBERGER, R.P., TRAHAIR, T.N., SMYTHE, J.A., and ALEXANDER, I.E. (2001). Adeno-associated virus and lentivirus vectors mediate efficient and sustained transduction of cultured mouse and human dorsal root ganglia sensory neurons. Hum. Gene Ther. 12, 77-86.
11. GLATZEL, M., FLECHSIG, E., NAVARRO, B., KLEIN, M.A., PATERNA, J.C., BUELER, H., and AGUZZI, A. (2000). Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system. Proc. Natl. Acad. Sci. U.S.A. 97, 442-447.
12. GUO, H., and HUANG, L.Y. (2001). Alteration in the voltage dependence of NMDA receptor channels in rat dorsal horn neurones following peripheral inflammation. J. Physiol. 537, 115-123.
13. HARGREAVES, K., DUBNER, R., BROWN, F., FLORES, C., and JORIS, J. (1988). A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32, 77-88.
14. HERMENS, W.T., and VERHAAGEN, J. (1998). Viral vectors, tools for gene transfer in the nervous system. Prog. Neurobiol. 55, 399-432.
15. JOOSS, K., YANG, Y., FISHER, K.J., and WILSON, J.M. (1998). Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers. J. Virol. 72, 4212-4223.
16. KAPLITT, M.G., LEONE, P., SAMULSKI, R.J., XIAO, X., PFAFF, D.W., O'MALLEY, K.L., and DURING, M.J. (1994). Long-term gone expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat. Genet. 8, 148-154.
17. KLEIN, R.L., MEYER, E.M., PEEL, A.L., ZOLOTUKHIN, S., MEYERS, C., MUZYCZKA, N., and KING, M.A. (1998). Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors. Exp. Neurol. 150, 183-194.
18. MCCOWN, T.J., XIAO, X., LI, J., BREESE, G.R., and SAMULSKI, R.J. (1996). Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res. 713, 99-107.
19. MULLIGAN, R.C. (1993). The basic science of gene therapy. Science 260, 926-932.
20. PEEL, A.L., and KLEIN, R.L. (2000). Adeno-associated virus vectors: Activity and applications in the CNS. J. Neurosci. Methods 98, 95-104.
21. PEEL, A.L., ZOLOTUKHIN, S., SCHRIMSHER, G.W., MUZYCZKA, N., and REIER, P.J. (1997). Efficient transdnction of green fluorescent protein in spinal cord neurons using adeno-associated virus vectors containing cell type-specific promoters. Gene Ther. 4, 16-24.
22. SAMULSKI, R.J., CHANG, L.S., and SHENK, T. (1989). Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gone expression. J. Virol. 63, 3822-3828.
23. THOMPSON, R.C., MANSOUR, A., AKIL, H., and WATSON, S.J. (1993). Cloning and pharmacological characterization of a rat υ opiold receptor. Neuron 11, 903-913.
24. WILSON, S.P., and YEOMANS, D.C. (2000). Genetic therapy for pain management. Curr. Rev. Pain 4, 445-450.
25. WILSON, S.P., YEOMANS, D.C., BENDER, M.A., LU, Y., GOINS, W.F., and GLORIOSO, J.C. (1999). Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus. Proc. Natl. Acad. Sci. U.S.A. 96, 3211-3216.
26. WU, P., YE, Y., and SVENDSEN, C.N. (2002). Transduction of human neural progenitor cells using recombinant adeno-associated viral vectors. Gone Ther. 9, 245-255.
27. XIAO, X., LI, J., and SAMULSKI, R.J. (1998). Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J. Virol. 72, 2224-2232.
28. XU, Y., GU, Y., XU, G.Y., WU, P., LI, G.-W., and HUANG, L.-Y.M. (2003). Adeno-associated viral transfer of opioid receptor gone to primary sensory neurons: A novel strategy to increase opioid antinociception. Proc. Natl. Acad. Sci. U.S.A. (in press).
29. YAKSH, T.L. (2000). Analgesics, pain and tolerance: the St. John's discussion. Pain Res. Manag. 5, 19-22.
30. ZOLOTUKHIN, S., BYRNE, B.J., MASON, E., ZOLOTUKHIN, I., POTTER, M., CHESNUT, K., SUMMERFORD, C., SAMULSKI, R.J., and MUZYCZKA, N. (1999). Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gone Ther. 6, 973-985.