Alteration in the voltage dependence of NMDA receptor channels in rat dorsal horn neurones following peripheral inflammation

Journal of Physiology

Volumn 537, Issue 1, 2001, Pages 115-123

  Guo, Hua ^a   Huang, L Y M ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISINDOLYLMALEIMIDE; CHELERYTHRINE; FREUND ADJUVANT; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HINDLIMB; HYPERALGESIA; HYPERPOLARIZATION; INFLAMMATION; NONHUMAN; PAIN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SENSORY STIMULATION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; TISSUE INJURY; ADULT; ANIMAL MODEL; ELECTRIC POTENTIAL; HIND PAW; MEMBRANE TRANSPORT; NEGATIVE FEEDBACK; PATCH CLAMP TECHNIQUE; PROTEIN FUNCTION; UPREGULATION;

ANIMALS; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; FREUND'S ADJUVANT; HINDLIMB; HYPERALGESIA; HYPERESTHESIA; INFLAMMATION; ION CHANNELS; MAGNESIUM; NEURONS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD;

EID: 0035890288     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2001.0115k.x     Document Type: Article

References (52)

1. Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: Correlation with restricted localisation of NR2B subunit in dorsal horn
2. 2+ block of NMDA-receptor channels as a mechanism of modulation
3. Contribution of protein kinase C to central sensitization and persistent pain following tissue injury
4. The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury
5. NMDA receptor subunits: Diversity, development and disease
6. The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord
7. The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli
8. Activity-dependent neuronal plasticity following tissue injury and inflammation
9. Subunit composition of N-methyl-d-aspartate receptors in the central nervous system that contain the NR2D subunit
10. Regulated subcellular distribution of the NR1 subunit of the NMDA receptor
11. Slow excitatory postsynaptic currents mediated by N-methyl-d-aspartate receptors on cultured mouse central neurones
12. Multiple effects of phorbol esters in the rat spinal dorsal horn
13. - Channels by protein kinase C and cAMP-dependent protein kinase in the rat
14. Peripheral inflammation modulates NMDA receptor-mediated responses in rat spinal dorsal horn neurons
15. Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat
16. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
17. Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies
18. N-methyl-d-aspartate (NMDA) and non-NMDA glutamate receptor antagonists differentially suppress dorsal horn neuron responses to mechanical stimuli in rats with peripheral nerve injury
19. The postsynaptic density protein PSD-95 differentially regulates insulin- and Src-mediated current modulation of mouse NMDA receptors expressed in Xenopus oocytes
20. Evidence for direct protein kinase-C mediated modulation of N-methyl-d-aspartate receptor current
21. G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors
22. Alternatively spliced isoforms of the N-methyl-d-aspartate receptor subunit 1 are differentially distributed within the rat spinal cord
23. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
24. Modulation of NMDA receptors
25. Preserved acute pain and reduced neuropathic pain in mice lacking PKCγ
26. Inflammation-induced up-regulation of protein kinase Cγ immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing
27. Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions
28. Permeation and block of N-methyl-d-aspartic acid receptor channels by divalent cations in mouse cultured central neurones
29. Identification of subunits contributing to synaptic and extrasynaptic NMDA receptors in Golgi cells of the rat cerebellum
30. Distinct synaptic and extrasynaptic NMDA receptors identified in dorsal horn neurones of the adult rat spinal cord
31. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
32. Developmental change in voltage dependency of NMDA receptor-mediated response in nucleus tractus solitarii neurons
33. Cellular mechanisms of hyperalgesia and spontaneous pain in a spinalized rat model of peripheral neuropathy: Changes in myelinated afferent inputs implicated
34. N-methyl-d-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies
35. Distinct synaptic and extrasynaptic NMDA receptors in developing cerebellar granule neurons
36. Ligand-gated ion channel interactions with cytoskeletal and signaling proteins
37. The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin
38. Microtube disorientation and axonal swelling in unmyelinated sensory axons during vincristine-induced painful neuropathy in rat
39. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-d-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies
40. The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray
41. Electrophysiological studies on the role of the NMDA receptor in nociception in the developing rat spinal cord
42. 2+-sensitivity of cloned NMDA receptors
43. Protein kinase C potentiation of currents from mouse ξ1/ε2 NMDA receptors expressed in Xenopus oocytes depends on f-actin/g-actin cycling
44. Transcriptional and posttranslational plasticity and the generation of inflammatory pain
45. The induction and maintenance of central sensitization is dependent on N-methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states
46. Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes
47. NMDA receptor channel regulation by endogenous modulator present in isolated PSDs: A patch clamp study
48. Regulation of N-methyl-d-aspartate receptor function by constitutively active protein kinase C
49. Modulation of the channel activity of the ε2/ξ1-subtype N-methyl-d-aspartate receptor by PSD-95
50. Localization of glutamate receptors in dorsal horn of rat spinal cord
51. 2+ blockade of NMDA current in mechanically injured neurons
52. 2+ influx amplifies protein kinase C potentiation of recombinant NMDA receptors