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Volumn 987, Issue , 2003, Pages 38-50

Activation of rheumatoid factor (RF) B cells and somatic hypermutation outside of germinal centers in autoimmune-prone MRL/lpr mice

Author keywords

Autoantibody; Autoimmunity; Immunoglobulin V gene; Rheumatoid factor; Somatic hypermutation; Systemic lupus erythematosus

Indexed keywords

AUTOANTIGEN; IMMUNOGLOBULIN G2A; RHEUMATOID FACTOR;

EID: 0038579720     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb06031.x     Document Type: Conference Paper
Times cited : (19)

References (70)
  • 1
    • 0032769336 scopus 로고    scopus 로고
    • The central and multiple roles of B cells in lupus pathogenesis
    • CHAN, O.T.M., M.P. MADAIO & M.J. SHLOMCHIK. 1999. The central and multiple roles of B cells in lupus pathogenesis. Immunol. Rev. 169: 107-121.
    • (1999) Immunol. Rev. , vol.169 , pp. 107-121
    • Chan, O.T.M.1    Madaio, M.P.2    Shlomchik, M.J.3
  • 2
    • 0035525528 scopus 로고    scopus 로고
    • From T to B and back again: Positive feedback in systemic autoimmune disease
    • SHLOMCHIK, M.J., J. CRAFT & M.J. MAMULA. 2001. From T to B and back again: positive feedback in systemic autoimmune disease. Nature Rev. Immunol. 1: 147-153.
    • (2001) Nature Rev. Immunol. , vol.1 , pp. 147-153
    • Shlomchik, M.J.1    Craft, J.2    Mamula, M.J.3
  • 3
    • 0026041119 scopus 로고
    • Peripheral deletion of self-reactive B cells
    • RUSSELL, D.M., Z. DEMBIC, G. MORAHAN, et al. 1991. Peripheral deletion of self-reactive B cells. Nature 354: 308-311.
    • (1991) Nature , vol.354 , pp. 308-311
    • Russell, D.M.1    Dembic, Z.2    Morahan, G.3
  • 4
    • 0027478391 scopus 로고
    • Receptor editing in self-reactive bone marrow B cells
    • TIEGS, S.L., D.M. RUSSELL & D. NEMAZEE. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177: 1009-1020.
    • (1993) J. Exp. Med. , vol.177 , pp. 1009-1020
    • Tiegs, S.L.1    Russell, D.M.2    Nemazee, D.3
  • 5
    • 0024529870 scopus 로고
    • Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class-I antibody genes
    • NEMAZEE, D.A. & K. BURKI. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class-I antibody genes. Nature 337: 562-566.
    • (1989) Nature , vol.337 , pp. 562-566
    • Nemazee, D.A.1    Burki, K.2
  • 6
    • 0023729241 scopus 로고
    • Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
    • GOODNOW, C.C., J. CROSBIE, S. ADELSTEIN, et al. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334: 676-682.
    • (1988) Nature , vol.334 , pp. 676-682
    • Goodnow, C.C.1    Crosbie, J.2    Adelstein, S.3
  • 7
    • 0025812171 scopus 로고
    • Breakdown of self-tolerance in anergic B lymphocytes
    • GOODNOW, C.C., R.A. BRINK & A.E. ADAMS. 1991. Breakdown of self-tolerance in anergic B lymphocytes. Nature 352: 532-536.
    • (1991) Nature , vol.352 , pp. 532-536
    • Goodnow, C.C.1    Brink, R.A.2    Adams, A.E.3
  • 8
    • 0025923303 scopus 로고
    • Self tolerance in the B-cell repertoire
    • BASTEN, A., R. BRINK, E. ADAMS, et al. 1991. Self tolerance in the B-cell repertoire. Immunol. Rev. 122: 5-19.
    • (1991) Immunol. Rev. , vol.122 , pp. 5-19
    • Basten, A.1    Brink, R.2    Adams, E.3
  • 9
    • 0029076561 scopus 로고
    • CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells
    • RATHMELL, J.C., M.P. COOKE, W.Y. HO, et al. 1995. CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature 376: 181-184.
    • (1995) Nature , vol.376 , pp. 181-184
    • Rathmell, J.C.1    Cooke, M.P.2    Ho, W.Y.3
  • 10
    • 0029994303 scopus 로고    scopus 로고
    • Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice beating autoantibody transgenes
    • RUBIO, C.F., J. KENCH, D.M. RUSSELL, et al. 1996. Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice beating autoantibody transgenes. J. Immunol. 157: 65-71.
    • (1996) J. Immunol. , vol.157 , pp. 65-71
    • Rubio, C.F.1    Kench, J.2    Russell, D.M.3
  • 11
    • 0023918934 scopus 로고
    • Somatic mutations in B lymphocytes: New perspectives in tolerance research
    • NOSSAL, G.J.V. 1988. Somatic mutations in B lymphocytes: new perspectives in tolerance research. Immunol. Cell Biol. 66:105-110.
    • (1988) Immunol. Cell Biol. , vol.66 , pp. 105-110
    • Nossal, G.J.V.1
  • 12
    • 0025368647 scopus 로고
    • The need for central and peripheral tolerance in the B cell repertoire
    • GOODNOW, C.C., S. ADELSTEIN & A. BASTEN. 1990. The need for central and peripheral tolerance in the B cell repertoire. Science 248: 1373-1379.
    • (1990) Science , vol.248 , pp. 1373-1379
    • Goodnow, C.C.1    Adelstein, S.2    Basten, A.3
  • 13
    • 0028151819 scopus 로고
    • Negative selection of lymphocytes
    • NOSSAL, G.J.V. 1994. Negative selection of lymphocytes. Cell 76: 229-239.
    • (1994) Cell , vol.76 , pp. 229-239
    • Nossal, G.J.V.1
  • 14
    • 0029059370 scopus 로고
    • Soluble antigen can cause enhanced apoptosis of germinal-centre B cells
    • PULENDRAN, B., G. KANNOURAKIS, S. NOURI, et al. 1995. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. Nature 375:331-334.
    • (1995) Nature , vol.375 , pp. 331-334
    • Pulendran, B.1    Kannourakis, G.2    Nouri, S.3
  • 15
    • 0029014435 scopus 로고
    • Antigen-induced B-cell death and elimination during germinal-centre immune responses
    • SHOKAT, K.M. & C.C. GOODNOW. 1995. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature 375: 334-338.
    • (1995) Nature , vol.375 , pp. 334-338
    • Shokat, K.M.1    Goodnow, C.C.2
  • 16
    • 0024518559 scopus 로고
    • Antinuclear antibodies: Diagnostic markers for autoimmune diseases and probes for cell biology
    • TAN, E.M. 1989. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. 44: 93-151.
    • (1989) Adv. Immunol. , vol.44 , pp. 93-151
    • Tan, E.M.1
  • 17
    • 0020066608 scopus 로고
    • Anti-DNA, anti-deoxyribonucleoprotein and rheumatoid factor measured by ELISA in patients with systemic lupus erythematosus, Sjogren's syndrome and rheumatoid arthritis
    • KARSH, J., S.P. HALBERT, M. ANKEN, et al. 1982. Anti-DNA, anti-deoxyribonucleoprotein and rheumatoid factor measured by ELISA in patients with systemic lupus erythematosus, Sjogren's syndrome and rheumatoid arthritis. Int. Arch. Allergy Appl. Immunol. 68: 60-69.
    • (1982) Int. Arch. Allergy Appl. Immunol. , vol.68 , pp. 60-69
    • Karsh, J.1    Halbert, S.P.2    Anken, M.3
  • 18
    • 0028923130 scopus 로고
    • Novel packages of viral and self-antigens are generated during apoptosis
    • ROSEN, A., R.L. CASCIOLA & J. AHEARN. 1995. Novel packages of viral and self-antigens are generated during apoptosis. J. Exp. Med. 181: 1557-1561.
    • (1995) J. Exp. Med. , vol.181 , pp. 1557-1561
    • Rosen, A.1    Casciola, R.L.2    Ahearn, J.3
  • 19
    • 0033588955 scopus 로고    scopus 로고
    • Cleavage by granzyme B is strongly predictive of autoantigen status: Implications for initiation of autoimmunity
    • CASCIOLA-ROSEN, L., F. ANDRADE, D. ULANET, et al. 1999. Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J. Exp. Med. 190: 815-826.
    • (1999) J. Exp. Med. , vol.190 , pp. 815-826
    • Casciola-Rosen, L.1    Andrade, F.2    Ulanet, D.3
  • 20
    • 0025980973 scopus 로고
    • Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice
    • ERIKSON, J., M.Z. RADIC, S.A. CAMPER, et al. 1991. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 349: 331-334.
    • (1991) Nature , vol.349 , pp. 331-334
    • Erikson, J.1    Radic, M.Z.2    Camper, S.A.3
  • 21
    • 0027499537 scopus 로고
    • Receptor editing: An approach by autoreactive B cells to escape tolerance
    • GAY, D., T. SAUNDERS, S. CAMPER & M. WEIGERT. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177: 999-1008.
    • (1993) J. Exp. Med. , vol.177 , pp. 999-1008
    • Gay, D.1    Saunders, T.2    Camper, S.3    Weigert, M.4
  • 22
    • 0028215530 scopus 로고
    • Deletion and editing of B cells that express antibodies to DNA
    • CHEN, C., M.Z. RADIC, J. ERIKSON, et al. 1994. Deletion and editing of B cells that express antibodies to DNA. J. Immunol. 152: 1970-1982.
    • (1994) J. Immunol. , vol.152 , pp. 1970-1982
    • Chen, C.1    Radic, M.Z.2    Erikson, J.3
  • 23
    • 0028850944 scopus 로고
    • The site and stage of anti-DNA B-cell deletion
    • CHEN, C., Z. NAGY, M.Z. RADIC, et al. 1995. The site and stage of anti-DNA B-cell deletion. Nature 373: 252-255.
    • (1995) Nature , vol.373 , pp. 252-255
    • Chen, C.1    Nagy, Z.2    Radic, M.Z.3
  • 24
    • 0032212186 scopus 로고    scopus 로고
    • B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain
    • PEWZNER-JUNG, Y., D. FRIEDMANN, E. SONODA, et al. 1998. B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain. J. Immunol. 161: 4634-4645.
    • (1998) J. Immunol. , vol.161 , pp. 4634-4645
    • Pewzner-Jung, Y.1    Friedmann, D.2    Sonoda, E.3
  • 25
    • 0032006227 scopus 로고    scopus 로고
    • Autoreactive B cell regulation: Peripheral induction of developmental arrest by lupus-associated autoantigens
    • SANTULLI-MAROTTO, S., M.W. RETTER, R. GEE, et al. 1998. Autoreactive B cell regulation: peripheral induction of developmental arrest by lupus-associated autoantigens. Immunity 8: 209-219.
    • (1998) Immunity , vol.8 , pp. 209-219
    • Santulli-Marotto, S.1    Retter, M.W.2    Gee, R.3
  • 26
    • 0027505015 scopus 로고
    • A rheumatoid factor transgenic mouse model of autoantibody regulation
    • SHLOMCHIK, M.J., D. ZHARHARY, S. CAMPER, et al. 1993. A rheumatoid factor transgenic mouse model of autoantibody regulation. Int. Immunol. 5: 1329-1341.
    • (1993) Int. Immunol. , vol.5 , pp. 1329-1341
    • Shlomchik, M.J.1    Zharhary, D.2    Camper, S.3
  • 27
    • 0029854905 scopus 로고    scopus 로고
    • A disease-related RF autoantibody is not tolerized in a normal mouse: Implications for the origins of autoantibodies in autoimmune disease
    • HANNUM, L.G., D. NI, A.M. HABERMAN, et al. 1996. A disease-related RF autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease. J. Exp. Med. 184: 1269-1278.
    • (1996) J. Exp. Med. , vol.184 , pp. 1269-1278
    • Hannum, L.G.1    Ni, D.2    Haberman, A.M.3
  • 28
    • 0031205293 scopus 로고    scopus 로고
    • High affinity rheumatoid factor transgenic B cells are eliminated in normal mice
    • WANG, H. & M.J. SHLOMCHIK. 1997. High affinity rheumatoid factor transgenic B cells are eliminated in normal mice. J. Immunol. 159: 1125-1134.
    • (1997) J. Immunol. , vol.159 , pp. 1125-1134
    • Wang, H.1    Shlomchik, M.J.2
  • 29
    • 0032031497 scopus 로고    scopus 로고
    • Maternal Ig mediates neonatal tolerance in rheumatoid factor transgenic mice but tolerance breaks down in adult mice
    • WANG, H.W. & M.J. SHLOMCHIK. 1998. Maternal Ig mediates neonatal tolerance in rheumatoid factor transgenic mice but tolerance breaks down in adult mice. J. Immunol. 160: 2263-2271.
    • (1998) J. Immunol. , vol.160 , pp. 2263-2271
    • Wang, H.W.1    Shlomchik, M.J.2
  • 30
    • 0032841840 scopus 로고    scopus 로고
    • Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice
    • WANG, H. & M.J. SHLOMCHIK. 1999. Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice. J. Exp. Med. 190: 639-649.
    • (1999) J. Exp. Med. , vol.190 , pp. 639-649
    • Wang, H.1    Shlomchik, M.J.2
  • 31
    • 0025729604 scopus 로고
    • An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity
    • SOBEL, E.S., T. KATAGIRI, K. KATAGIRI, et al. 1991. An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity. J. Exp. Med. 173: 1441-1449.
    • (1991) J. Exp. Med. , vol.173 , pp. 1441-1449
    • Sobel, E.S.1    Katagiri, T.2    Katagiri, K.3
  • 32
    • 0026441378 scopus 로고
    • Influence of the Ig H chain locus on autoantibody production in autoimmune mice
    • HALPERN, M.D., C.L. FISHER, P.L. COHEN & R.A. EISENBERG. 1992. Influence of the Ig H chain locus on autoantibody production in autoimmune mice. J. Immunol. 149: 3735-3740.
    • (1992) J. Immunol. , vol.149 , pp. 3735-3740
    • Halpern, M.D.1    Fisher, C.L.2    Cohen, P.L.3    Eisenberg, R.A.4
  • 34
    • 0021341140 scopus 로고
    • Specificity analysis of monoclonal anti-DNA antibodies from B6-lpr/lpr mice
    • WARREN, R.W., D.M. SAILSTAD, S.A. CASTER & D.S. PISETSKY. 1984. Specificity analysis of monoclonal anti-DNA antibodies from B6-lpr/lpr mice. Arthritis Rheum. 27: 545-551.
    • (1984) Arthritis Rheum. , vol.27 , pp. 545-551
    • Warren, R.W.1    Sailstad, D.M.2    Caster, S.A.3    Pisetsky, D.S.4
  • 35
    • 0037144519 scopus 로고    scopus 로고
    • Somatic hypermutation outside of GCs in autoantibody responses
    • WILLIAM, J., C. EULER, S. CHRISTENSEN & M.J. SHLOMCHIK. 2002. Somatic hypermutation outside of GCs in autoantibody responses. Science 297: 2066-2070.
    • (2002) Science , vol.297 , pp. 2066-2070
    • William, J.1    Euler, C.2    Christensen, S.3    Shlomchik, M.J.4
  • 36
    • 0023251534 scopus 로고
    • The role of clonal selection and somatic mutation in autoimmunity
    • SHLOMCHIK, M.J., A. MARSHAK-ROTHSTEIN, C.B. WOLFOWICZ, et al. 1987. The role of clonal selection and somatic mutation in autoimmunity. Nature 328: 805.
    • (1987) Nature , vol.328 , pp. 805
    • Shlomchik, M.J.1    Marshak-Rothstein, A.2    Wolfowicz, C.B.3
  • 37
    • 0023462643 scopus 로고
    • Structure and function of anti-DNA antibodies derived from a single autoimmune mouse
    • SHLOMCHIK, M.J., A.H. AUCOIN, D.S. PISETSKY & M.G. WEIGERT. 1987. Structure and function of anti-DNA antibodies derived from a single autoimmune mouse. Proc. Natl. Acad. Sci. USA 84: 9150-9154.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 9150-9154
    • Shlomchik, M.J.1    Aucoin, A.H.2    Pisetsky, D.S.3    Weigert, M.G.4
  • 38
    • 0025017688 scopus 로고
    • Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
    • SHLOMCHIK, M.J., M.A. MASCELLI, H. SHAN, et al. 1990. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J. Exp. Med. 171: 265.
    • (1990) J. Exp. Med. , vol.171 , pp. 265
    • Shlomchik, M.J.1    Mascelli, M.A.2    Shan, H.3
  • 40
    • 0026761402 scopus 로고
    • Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice
    • TILLMAN, D.M., N.T. JOU, R.J. HILL & T.N. MARION. 1992. Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice. J. Exp. Med. 176: 761-779.
    • (1992) J. Exp. Med. , vol.176 , pp. 761-779
    • Tillman, D.M.1    Jou, N.T.2    Hill, R.J.3    Marion, T.N.4
  • 41
    • 0026564699 scopus 로고
    • Monoclonal autoantibodies to subnucleosomes from a MRL/Mp-+/+ mouse: Oligoclonality of the antibody response and recognition of a determinant composed for histones H2A, H2B, and DNA
    • LOSMAN, M.J., T.M. FASY, K.E. NOVICK & M. MONESTIER 1992. Monoclonal autoantibodies to subnucleosomes from a MRL/Mp-+/+ mouse: oligoclonality of the antibody response and recognition of a determinant composed for histones H2A, H2B, and DNA. J. Immunol. 148: 1561-1569.
    • (1992) J. Immunol. , vol.148 , pp. 1561-1569
    • Losman, M.J.1    Fasy, T.M.2    Novick, K.E.3    Monestier, M.4
  • 42
    • 0025733837 scopus 로고
    • Variable region genes of anti-histone autoantibodies from a MRL/Mp-lpr/lpr mouse
    • MONESTIER, M. 1991. Variable region genes of anti-histone autoantibodies from a MRL/Mp-lpr/lpr mouse. Eur. J. Immunol. 21: 1725-1731.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1725-1731
    • Monestier, M.1
  • 43
    • 0026740330 scopus 로고
    • Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas
    • WINKLER, T.H., H. FEHR & J.R. KALDEN. 1992. Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur. J. Immunol. 22: 1719-1728.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1719-1728
    • Winkler, T.H.1    Fehr, H.2    Kalden, J.R.3
  • 44
    • 0026523224 scopus 로고
    • Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue
    • RANDEN, I., D. BROWN, K.M. THOMPSON, et al. 1992. Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue. J. Immunol. 148: 3296-3301.
    • (1992) J. Immunol. , vol.148 , pp. 3296-3301
    • Randen, I.1    Brown, D.2    Thompson, K.M.3
  • 45
    • 0029555719 scopus 로고    scopus 로고
    • V-gene repertoire and hypermutation of rheumatoid factors produced in rheumatoid synovial inflammation and immunized healthy donors
    • THOMPSON, K.M., M. BORRETZEN, I. RANDEN, et al. 1996. V-gene repertoire and hypermutation of rheumatoid factors produced in rheumatoid synovial inflammation and immunized healthy donors. Ann. N.Y. Acad. Sci. 764: 440-449.
    • (1996) Ann. N.Y. Acad. Sci. , vol.764 , pp. 440-449
    • Thompson, K.M.1    Borretzen, M.2    Randen, I.3
  • 46
    • 0021162469 scopus 로고
    • Prospective study of early rheumatoid arthritis. II. Association of rheumatoid factor isotypes with fluctuations in disease activity
    • WITHRINGTON, R.H., I. TEITSSON, H. VALDIMARSSON & M.H. SEIFERT. 1984. Prospective study of early rheumatoid arthritis. II. Association of rheumatoid factor isotypes with fluctuations in disease activity. Ann. Rheum. Dis. 43: 679-685.
    • (1984) Ann. Rheum. Dis. , vol.43 , pp. 679-685
    • Withrington, R.H.1    Teitsson, I.2    Valdimarsson, H.3    Seifert, M.H.4
  • 47
    • 0019825309 scopus 로고
    • Serum IgG and IgM rheumatoid factors by solid phase radioimmunoassay
    • WERNICK, R., J.J. LOSPALLUTO, C.W. FINK & M. ZIFF. 1981. Serum IgG and IgM rheumatoid factors by solid phase radioimmunoassay. Arthritis Rheum. 24: 1501-1511.
    • (1981) Arthritis Rheum. , vol.24 , pp. 1501-1511
    • Wernick, R.1    LoSpalluto, J.J.2    Fink, C.W.3    Ziff, M.4
  • 48
    • 0021693755 scopus 로고
    • IgG rheumatoid factors and cryoglobulins in mice bearing the mutant gene lpr (lymphroliferation)
    • IZUI, S., M. ABDELMOULA, Y. GYOTOKU, et al. 1984. IgG rheumatoid factors and cryoglobulins in mice bearing the mutant gene lpr (lymphroliferation). Rheumatol. Int. 4(Suppl): 45-48.
    • (1984) Rheumatol. Int. , vol.4 , Issue.SUPPL. , pp. 45-48
    • Izui, S.1    Abdelmoula, M.2    Gyotoku, Y.3
  • 49
    • 0022273898 scopus 로고
    • Murine models of systemic lupus erthematosus
    • THEOFILOPOULOS, A.N. & F.J. DIXON. 1985. Murine models of systemic lupus erthematosus. Adv. Immunol. 37: 269-390.
    • (1985) Adv. Immunol. , vol.37 , pp. 269-390
    • Theofilopoulos, A.N.1    Dixon, F.J.2
  • 50
    • 0019964811 scopus 로고
    • A spontaneous rheumatoid arthritis-like disease in MRL/l mice
    • HANG, L., A.N. THEOFILOPOULOS & F.J. DIXON. 1982. A spontaneous rheumatoid arthritis-like disease in MRL/l mice. J. Exp. Med. 155: 1690-1701.
    • (1982) J. Exp. Med. , vol.155 , pp. 1690-1701
    • Hang, L.1    Theofilopoulos, A.N.2    Dixon, F.J.3
  • 51
    • 0021744805 scopus 로고
    • Specificity of plasma cells in the rheumatoid synovium
    • YOUINOU, P.Y., J.W. MORROW, A.W.F. LETTIN, et al. 1984. Specificity of plasma cells in the rheumatoid synovium. Scand. J. Immunol. 20: 307-315.
    • (1984) Scand. J. Immunol. , vol.20 , pp. 307-315
    • Youinou, P.Y.1    Morrow, J.W.2    Lettin, A.W.F.3
  • 52
    • 0025827340 scopus 로고
    • Rheumatoid factor, cryoglobulinemia, anti-DNA, and renal disease in patients with systemic lupus erythematosus
    • HOWARD, T.W., M.J. IANNINI, J.J. BURGE & J.T. DAVIS. 1991. Rheumatoid factor, cryoglobulinemia, anti-DNA, and renal disease in patients with systemic lupus erythematosus. J. Rheumatol. 18: 826-830.
    • (1991) J. Rheumatol. , vol.18 , pp. 826-830
    • Howard, T.W.1    Iannini, M.J.2    Burge, J.J.3    Davis, J.T.4
  • 53
    • 0021084609 scopus 로고
    • Rheumatoid factors and secondary immune responses in the mouse. I. Frequent occurrence of hybridomas secreting IgM anti-IgG1 autoantibodies after immunization with protein antigens
    • VAN SNICK, J. & P. COULIE. 1983. Rheumatoid factors and secondary immune responses in the mouse. I. Frequent occurrence of hybridomas secreting IgM anti-IgG1 autoantibodies after immunization with protein antigens. Eur. J. Immunol. 13: 890-894.
    • (1983) Eur. J. Immunol. , vol.13 , pp. 890-894
    • Van Snick, J.1    Coulie, P.2
  • 54
    • 0020573342 scopus 로고
    • Induction of rheumatoid factors in the mouse. Regulated production of autoantibody in secondary humoral response
    • NEMAZEE, D. & V. SATO. 1983. Induction of rheumatoid factors in the mouse. Regulated production of autoantibody in secondary humoral response. J. Exp. Med. 158: 529-545.
    • (1983) J. Exp. Med. , vol.158 , pp. 529-545
    • Nemazee, D.1    Sato, V.2
  • 55
    • 0020691845 scopus 로고
    • Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid
    • WELCH, M.J., S. FONG, J. VAUGHAN & D. CARSON. 1983. Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid. Clin. Exp. Immunol. 51: 299-304.
    • (1983) Clin. Exp. Immunol. , vol.51 , pp. 299-304
    • Welch, M.J.1    Fong, S.2    Vaughan, J.3    Carson, D.4
  • 56
    • 0029819961 scopus 로고    scopus 로고
    • Comparison of rheumatoid factors of rheumatoid arthritis patients, of individuals with mycobacterial infections and of normal controls: Evidence for maturation in the absence of an autoimmune response
    • DJAVAD, N., S. BAS, X. Sin, et al. 1996. Comparison of rheumatoid factors of rheumatoid arthritis patients, of individuals with mycobacterial infections and of normal controls: evidence for maturation in the absence of an autoimmune response. Eur. J. Immunol. 26: 2480-2486.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2480-2486
    • Djavad, N.1    Bas, S.2    Sin, X.3
  • 57
    • 0025726702 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell population
    • JACOB, J., R. KASSIR & G. KELSOE. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell population. J. Exp. Med. 173: 1165-1175.
    • (1991) J. Exp. Med. , vol.173 , pp. 1165-1175
    • Jacob, J.1    Kassir, R.2    Kelsoe, G.3
  • 58
    • 0025951891 scopus 로고
    • Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens
    • LIU, Y.J., J. ZHANG, P.J. LANE, et al. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21: 2951-2962.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2951-2962
    • Liu, Y.J.1    Zhang, J.2    Lane, P.J.3
  • 59
    • 0006379753 scopus 로고    scopus 로고
    • Affinity maturation without germinal centres in lymphotoxin-α-deficient mice
    • MATSUMOTO, M., S.F. LO, C.J.L. CARRUTHERS, et al. 1996. Affinity maturation without germinal centres in lymphotoxin-α-deficient mice. Nature 382: 462-466.
    • (1996) Nature , vol.382 , pp. 462-466
    • Matsumoto, M.1    Lo, S.F.2    Carruthers, C.J.L.3
  • 60
    • 0030902491 scopus 로고    scopus 로고
    • Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node
    • FU, Y.-X., G. HUANG, M. MATSUMOTO, et al. 1997. Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node. Proc. Natl. Acad. Sci. USA 94: 5739-5743.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5739-5743
    • Fu, Y.-X.1    Huang, G.2    Matsumoto, M.3
  • 61
    • 0030917003 scopus 로고    scopus 로고
    • Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice
    • KONI, P.A., R. SACCA, P. LAWTON, et al. 1997. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity 6: 491-500.
    • (1997) Immunity , vol.6 , pp. 491-500
    • Koni, P.A.1    Sacca, R.2    Lawton, P.3
  • 62
    • 0033838426 scopus 로고    scopus 로고
    • Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin
    • WANG, Y., G. HUANG, J. WANG, et al. 2000. Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin. Eur. J. Immunol. 30: 2226-2234.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 2226-2234
    • Wang, Y.1    Huang, G.2    Wang, J.3
  • 63
    • 0035970105 scopus 로고    scopus 로고
    • CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans
    • WELLER, S., A. FAILI, C. GARCIA, et al. 2001. CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. Proc. Natl. Acad. Sci. USA 98: 1166-1170.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1166-1170
    • Weller, S.1    Faili, A.2    Garcia, C.3
  • 64
    • 0029589915 scopus 로고
    • Fas is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen
    • SMITH, K.G., G.J. NOSSAL & D.M. TARLINTON. 1995. Fas is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen. Proc. Natl. Acad. Sci. USA 92: 11628-11632.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11628-11632
    • Smith, K.G.1    Nossal, G.J.2    Tarlinton, D.M.3
  • 65
    • 0035099037 scopus 로고    scopus 로고
    • Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire
    • TAKAHASHI, Y., H. OHTA & T. TAKEMORI. 2001. Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire. Immunity 14: 181-192.
    • (2001) Immunity , vol.14 , pp. 181-192
    • Takahashi, Y.1    Ohta, H.2    Takemori, T.3
  • 66
    • 0029879794 scopus 로고    scopus 로고
    • Somatic mutation of immunoglobulin V genes in vitro
    • KALLBERG, E., S. JAINANDUNSING, D. GRAY & T. LEANDERSON. 1996. Somatic mutation of immunoglobulin V genes in vitro. Science 271: 1285-1289.
    • (1996) Science , vol.271 , pp. 1285-1289
    • Kallberg, E.1    Jainandunsing, S.2    Gray, D.3    Leanderson, T.4
  • 67
    • 0026670190 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers
    • JACOB, J. & G. KELSOE. 1992. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176: 679-687.
    • (1992) J. Exp. Med. , vol.176 , pp. 679-687
    • Jacob, J.1    Kelsoe, G.2
  • 69
    • 0037061453 scopus 로고    scopus 로고
    • Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    • LEADBETTER, E.A., A.M. HOHLBAUM, I.R. RIFKIN, et al. 2002. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416: 603-607.
    • (2002) Nature , vol.416 , pp. 603-607
    • Leadbetter, E.A.1    Hohlbaum, A.M.2    Rifkin, I.R.3
  • 70
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • HEMMI, H., O. TAKEUCHI, T. KAWAI, et al. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745.
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.