V‐GENE Repertoire and Hypermutation of Rheumatoid Factors Produced in Rheumatoid Synovial Inflammation and Immunized Healthy Donors

Annals of the New York Academy of Sciences

Volumn 764, Issue 1, 1995, Pages 440-449

  THOMPSON, KEITH M ^a   BØRRETZEN, MARIE ^a   RANDEN, INGRID ^a   FØRRE, ØYSTEIN ^a   NATVIG, JACOB B ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; RHEUMATOID FACTOR;

CELL ISOLATION; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; GENE MUTATION; GENE REARRANGEMENT; GENE SEQUENCE; GERM LINE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MARKER GENE; NUCLEOTIDE SEQUENCE; RHEUMATOID ARTHRITIS; SYNOVITIS;

EID: 0029555719     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1995.tb55861.x     Document Type: Article

References (36)

1. Lack of suppressor cell activity in rheumatoid synovial lymphocytes
2. Immunoglobulin G3 subclass production by rheumatoid synovial tissue cultures
3. The induction of a rheumatoid factor‐like substance in rabbits
4. Production of “anti‐antibodies” in rabbits. Appearance in rabbit serum of “anti‐antibodies” reacting with autogenous and isogenous antibody, following stimulation with protein antigens. Ann. Med. Exp. Biol
5. Rheumatoid factor isotypes following immunization
6. Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid
7. Immune complexes can trigger specific, T cell‐dependent, autoanti‐IgG antibody production in mice
8. + T cell
9. The T‐cell‐independent immune response to the hapten NP uses a large repertoire of heavy chain genes
10. Memory cell generation ablated by soluble protein antigen by means of effects on T‐ and B‐lymphocyte compartments
11. Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: Production and characterization
12. The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein‐Barr virus‐transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes
13. Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: Incidence of cross‐reactive idiotopes and expression of VH and V kappa subgroups. Eur. J
14. Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross‐reactive idiotypes. J. Clin
15. Nucleotide sequence analysis of rheumatoid factors and polyreactive antibodies derived from patients with rheumatoid arthritis reveals diverse use of VH and VL gene segments and extensive variability in CDR‐3. Scand. J
16. Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue
17. Human monoclonal IgG rheumatoid factors from the synovial tissue of patients with rheumatoid arthritis
18. Synovial IgG rheumatoid factors show evidence of an antigen‐driven immune response and a shift in the V‐gene repertoire compared to IgM rheumatoid factors
19. Variable region gene usage of human monoclonal rheumatoid factors derived from healthy donors following immunization
20. Control of autoantibody affinity by selection against amino acid replacements in the complementarity determining regions
21. Immunogenic and antigenic epitopes of immunoglobulins. XVII—Monoclonal antibodies reactive with common and restricted idiotopes to the heavy chain of human rheumatoid factors. Rheumatol
22. The incidence of a new human cross‐reactive idiotype linked to subgroup VHIII heavy chains
23. A conserved human germline V kappa gene directly encodes rheumatoid factor light chains
24. Rheumatoid factor V genes from patients with rheumatoid arthritis are diverse and show evidence of an antigen driven response
25. The role of clonal selection and somatic mutation in autoimmunity
26. Anti‐DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
27. The repertoire of human germline V(H) sequences reveals about 50 groups of V(H) segments with different hypervariable loops
28. The T‐cell‐independent immune response to the hapten NP uses a large repertoire of heavy chain genes
29. Efficient and selective presentation of antigen‐antibody complexes by rheumatoid factor B cells
30. Processing and presentation of immunoglobulin idiotypes to T cells
31. Mechanism of antigen‐driven selection in germinal centres
32. Somatic generation of antibody diversity
33. Restricted diversity of the variable region nucleotide sequences of the heavy and light chains of a human rheumatoid factor
34. + B) cells make somatically hypermutated high affinity IgM rheumatoid factors
35. Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated
36. Germline variable region gene segment derivation of human monoclonal anti‐Rh(D) antibodies