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Volumn 30, Issue 3 SUPPL. 6, 2003, Pages 39-50

Inhibition of vascular endothelial growth factor in the treatment of colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CAMPTOTHECIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUOROURACIL; FOLINIC ACID; SEMAXANIB; TAXANE DERIVATIVE; VASCULOTROPIN;

EID: 0038514919     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0093-7754(03)70024-4     Document Type: Article
Times cited : (118)

References (84)
  • 1
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, rheumatoid and other disease
    • Folkman J: Angiogenesis in cancer, rheumatoid and other disease. Nat Med 1:27-31, 1995
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 2
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman J: Angiogenic factors. Science 235:442-447, 1987
    • (1987) Science , vol.235 , pp. 442-447
    • Folkman, J.1
  • 3
    • 0002418099 scopus 로고
    • Vascular diseases
    • Garner AKG (ed). New York, NY, Dekker
    • Garner A: Vascular diseases, in Garner AKG (ed): Pathobiology of Ocular Diseases. New York, NY, Dekker, 1994, pp 1625-1710
    • (1994) Pathobiology of Ocular Diseases , pp. 1625-1710
    • Garner, A.1
  • 4
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82:4-6, 1990
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 5
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tumors in vivo: I. Vascular reactions of mice to wounds and to normal and neoplastic transplants
    • Algire G, Chalkely H, Legallais F, et al: Vascular reactions of normal and malignant tumors in vivo: I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst 6:73-85, 1945
    • (1945) J Natl Cancer Inst , vol.6 , pp. 73-85
    • Algire, G.1    Chalkely, H.2    Legallais, F.3
  • 6
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implication
    • Folkman J: Tumor angiogenesis: Therapeutic implication. N Engl J Med 285:1182-1186, 1971
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 7
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364, 1996
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 8
    • 0032852528 scopus 로고    scopus 로고
    • Molecular and biological properties of vascular endothelial growth factor
    • Ferrara N: Molecular and biological properties of vascular endothelial growth factor. J Mol Med 77:527-543, 1999
    • (1999) J Mol Med , vol.77 , pp. 527-543
    • Ferrara, N.1
  • 9
    • 0028470454 scopus 로고
    • Barriers to drug delivery in solid tumors
    • Jain R: Barriers to drug delivery in solid tumors. Sci Am 271:58-65, 1994
    • (1994) Sci Am , vol.271 , pp. 58-65
    • Jain, R.1
  • 10
    • 0025717523 scopus 로고
    • Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
    • Kerbel R: Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays 13:31-36, 1991
    • (1991) Bioessays , vol.13 , pp. 31-36
    • Kerbel, R.1
  • 11
    • 0026486664 scopus 로고
    • Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease
    • Teicher B, Sotomayor E, Huang Z, et al: Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease. Cancer Res 52:6702-6704, 1992
    • (1992) Cancer Res , vol.52 , pp. 6702-6704
    • Teicher, B.1    Sotomayor, E.2    Huang, Z.3
  • 12
    • 0032829104 scopus 로고    scopus 로고
    • Tumor angiogenesis - New drugs on the block
    • Brower V: Tumor angiogenesis - New drugs on the block. Nat Biotechnol 17:963-968, 1999
    • (1999) Nat Biotechnol , vol.17 , pp. 963-968
    • Brower, V.1
  • 13
    • 0028941001 scopus 로고
    • Vascular endothelial growth factor in human glioma cell lines: Induced secretion by EGF, PDGF-BB, bFGF
    • Tsai J, Goldman C, Gillespie G: Vascular endothelial growth factor in human glioma cell lines: Induced secretion by EGF, PDGF-BB, bFGF. J Neurosurg 82: 864-873, 1995
    • (1995) J Neurosurg , vol.82 , pp. 864-873
    • Tsai, J.1    Goldman, C.2    Gillespie, G.3
  • 14
    • 0032170035 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I
    • Akagi Y, Liu W, Zebrowski B, et al: Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res 58:4008-4014, 1998
    • (1998) Cancer Res , vol.58 , pp. 4008-4014
    • Akagi, Y.1    Liu, W.2    Zebrowski, B.3
  • 15
    • 0032987569 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression in human colon cancer by interleukin- 1 beta
    • Akagi Y, Liu W, Xie K, et al: Regulation of vascular endothelial growth factor expression in human colon cancer by interleukin-1 beta. Br J Cancer 80: 1506-1511, 1999
    • (1999) Br J Cancer , vol.80 , pp. 1506-1511
    • Akagi, Y.1    Liu, W.2    Xie, K.3
  • 16
    • 0030046481 scopus 로고    scopus 로고
    • Interleukin 6 induces the expression of vascular endothelial growth factor
    • Cohen T, Nahari D, Cerem L, et al: Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem 271:736-741, 1996
    • (1996) J Biol Chem , vol.271 , pp. 736-741
    • Cohen, T.1    Nahari, D.2    Cerem, L.3
  • 17
    • 0030066455 scopus 로고    scopus 로고
    • Platelet-derived growth factor-B/v-sis confers a tumorigenic and metastatic phenotype to human T 98G glioblastoma cells
    • Potapova O, Fakhari H, Baird S, et al: Platelet-derived growth factor-B/v-sis confers a tumorigenic and metastatic phenotype to human T98G glioblastoma cells. Cancer Res 56:280-286, 1996
    • (1996) Cancer Res , vol.56 , pp. 280-286
    • Potapova, O.1    Fakhari, H.2    Baird, S.3
  • 18
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • Levy A, Levy NC, Wegner S, et al: Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 279:13333-13340, 1995
    • (1995) J Biol Chem , vol.279 , pp. 13333-13340
    • Levy, A.1    Levy, N.C.2    Wegner, S.3
  • 19
    • 0026485002 scopus 로고
    • Vascular endothelial cell growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D, Itin A, Soffer D, et al: Vascular endothelial cell growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843-845, 1992
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3
  • 20
    • 0028870050 scopus 로고
    • Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implication for tumor angiogenesis
    • Shweiki D, Neeman M, Itin A, et al: Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implication for tumor angiogenesis. Proc Natl Acad Sci U S A 92:768-772, 1995
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 768-772
    • Shweiki, D.1    Neeman, M.2    Itin, A.3
  • 21
    • 0033590207 scopus 로고    scopus 로고
    • The role of cyclooxygenases in inflammation, cancer and development
    • Williams C, Mann M, DuBois R: The role of cyclooxygenases in inflammation, cancer and development. Oncogene 18:7908-7916, 1999
    • (1999) Oncogene , vol.18 , pp. 7908-7916
    • Williams, C.1    Mann, M.2    DuBois, R.3
  • 22
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • Tsujii M, Kawano S, Tsuiji S, et al: Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cancer 93:705-716, 1998
    • (1998) Cancer , vol.93 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsuiji, S.3
  • 23
    • 0034161878 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors
    • Masferrer J, Leahy K, Koki A, et al: Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res 60:1306-1311, 2000
    • (2000) Cancer Res , vol.60 , pp. 1306-1311
    • Masferrer, J.1    Leahy, K.2    Koki, A.3
  • 25
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara N, Henzel W: Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161:851-858, 1989
    • (1989) Biochem Biophys Res Commun , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.2
  • 26
    • 0025999033 scopus 로고
    • The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
    • Tischer E, Mitchell R, Hartman T, et al: The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266:1459-1472, 1991
    • (1991) J Biol Chem , vol.266 , pp. 1459-1472
    • Tischer, E.1    Mitchell, R.2    Hartman, T.3
  • 27
    • 0027751890 scopus 로고
    • The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
    • Park J, Keller G, Ferrara N: The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell 4:1317-1326, 1993
    • (1993) Mol Biol Cell , vol.4 , pp. 1317-1326
    • Park, J.1    Keller, G.2    Ferrara, N.3
  • 28
    • 0029937679 scopus 로고    scopus 로고
    • The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency
    • Keyt B, Berleau L, Nguyen H: The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J Biol Chem 272:7788-7795, 1996
    • (1996) J Biol Chem , vol.272 , pp. 7788-7795
    • Keyt, B.1    Berleau, L.2    Nguyen, H.3
  • 29
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung D, Cachianes G, Kuang WJ, et al: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306-1309, 1989
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.1    Cachianes, G.2    Kuang, W.J.3
  • 30
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger D, Galli S, Dvorak A, et al: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219:983-985, 1983
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.1    Galli, S.2    Dvorak, A.3
  • 31
    • 0023610220 scopus 로고
    • Fibrin containing gels induce angiogenesis. Implications for tumor stoma generation and wound healing
    • Dvorak H, Harvey V, Estrella P, et al: Fibrin containing gels induce angiogenesis. Implications for tumor stoma generation and wound healing. Lab Invest 57:673-686, 1987
    • (1987) Lab Invest , vol.57 , pp. 673-686
    • Dvorak, H.1    Harvey, V.2    Estrella, P.3
  • 32
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak H: Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315:1650-1659, 1986
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.1
  • 33
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodeling is defined by pericyte coverage of the preformed endothelial networks and is regulated by PDGF-B and VEGF
    • Benjamin L, Hemo I, Keshet E: A plasticity window for blood vessel remodeling is defined by pericyte coverage of the preformed endothelial networks and is regulated by PDGF-B and VEGF. Development 125:1591-1598, 1998
    • (1998) Development , vol.125 , pp. 1591-1598
    • Benjamin, L.1    Hemo, I.2    Keshet, E.3
  • 34
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin L, Golijanin D, Itin A, et al: Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 103:159-165, 1999
    • (1999) J Clin Invest , vol.103 , pp. 159-165
    • Benjamin, L.1    Golijanin, D.2    Itin, A.3
  • 35
    • 0032557564 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and Al in vascular endothelial cells
    • Gerber H, Dixit V, Ferrara N: Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and Al in vascular endothelial cells. J Biol Chem 273: 13313-13316, 1998
    • (1998) J Biol Chem , vol.273 , pp. 13313-13316
    • Gerber, H.1    Dixit, V.2    Ferrara, N.3
  • 36
    • 0028095127 scopus 로고
    • Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
    • Goldberg M, Schneider T: Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 269:4355-4361, 1994
    • (1994) J Biol Chem , vol.269 , pp. 4355-4361
    • Goldberg, M.1    Schneider, T.2
  • 37
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • de Vries C, Escobedo JA, Ueno H, et al: The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255:989-991, 1992
    • (1992) Science , vol.255 , pp. 989-991
    • De Vries, C.1    Escobedo, J.A.2    Ueno, H.3
  • 38
    • 0026702970 scopus 로고
    • Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
    • Terman BI, Dougher-Vermazen M, Carrion ME, et al: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 187:1579-1586, 1992
    • (1992) Biochem Biophys Res Commun , vol.187 , pp. 1579-1586
    • Terman, B.I.1    Dougher-Vermazen, M.2    Carrion, M.E.3
  • 39
    • 0033083962 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF) and its receptors in hematopoietic malignancies
    • Bellamy W, Richter L, Frutiger Y, et al: Expression of vascular endothelial growth factor (VEGF) and its receptors in hematopoietic malignancies. Cancer Res 59:728-733, 1999
    • (1999) Cancer Res , vol.59 , pp. 728-733
    • Bellamy, W.1    Richter, L.2    Frutiger, Y.3
  • 40
    • 0032838197 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor receptors in human prostate cancer
    • Ferrer F, Miller L, Lindquist R, et al: Expression of vascular endothelial growth factor receptors in human prostate cancer. Urology 54:567-572, 1999
    • (1999) Urology , vol.54 , pp. 567-572
    • Ferrer, F.1    Miller, L.2    Lindquist, R.3
  • 41
    • 0035068834 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma
    • Strizzi L, Catalano A, Vianale G, et al: Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma. J Pathol 193:468-475, 2001
    • (2001) J Pathol , vol.193 , pp. 468-475
    • Strizzi, L.1    Catalano, A.2    Vianale, G.3
  • 42
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-1 deficient mice
    • Shalaby F, Rossant J, Yamaguchi T, et al: Failure of blood-island formation and vasculogenesis in Flk-1 deficient mice. Nature 376:62-66, 1995
    • (1995) Nature , vol.376 , pp. 62-66
    • Shalaby, F.1    Rossant, J.2    Yamaguchi, T.3
  • 43
    • 0029021660 scopus 로고
    • Role of Flt- 1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong G, Rossant J, Gertsenstein M, et al: Role of Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376:66-70, 1995
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.1    Rossant, J.2    Gertsenstein, M.3
  • 44
    • 0034069028 scopus 로고    scopus 로고
    • Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors
    • Pavco P, Bouhana K, Gallegos A, et al: Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors. Clin Cancer Res 6:2094-2103, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 2094-2103
    • Pavco, P.1    Bouhana, K.2    Gallegos, A.3
  • 45
    • 0030973506 scopus 로고    scopus 로고
    • Hyperplasia of lymphatic vessels in VEGF-C transgenic mice
    • Jeltsch M, Kaipainen A, Joukov V, et al: Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 276: 1423-1425, 1997
    • (1997) Science , vol.276 , pp. 1423-1425
    • Jeltsch, M.1    Kaipainen, A.2    Joukov, V.3
  • 46
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker S, Takashima S, Miao HQ, et al: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92:735-745, 1998
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3
  • 47
    • 0032544686 scopus 로고    scopus 로고
    • Tumor induction of VEGF promoter activity in stromal cells
    • Fukumura D, Xavier R, Sugiura T, et al: Tumor induction of VEGF promoter activity in stromal cells. Cell 94:715-725, 1998
    • (1998) Cell , vol.94 , pp. 715-725
    • Fukumura, D.1    Xavier, R.2    Sugiura, T.3
  • 48
    • 0035352721 scopus 로고    scopus 로고
    • Angiogenesis: Pathological prognostic and growth-factor pathways and their link to trial design and anticancer drugs
    • Fox S, Giampietro G, Harris A: Angiogenesis: Pathological prognostic and growth-factor pathways and their link to trial design and anticancer drugs. Lancet Oncol 2:278-289, 2001
    • (2001) Lancet Oncol , vol.2 , pp. 278-289
    • Fox, S.1    Giampietro, G.2    Harris, A.3
  • 49
    • 0031032073 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor protein in nodenegative breast carcinoma
    • Gasparini G, Toi, M, Gion M, et al: Prognostic significance of vascular endothelial growth factor protein in nodenegative breast carcinoma. J Natl Cancer Inst 89:139-147, 1997
    • (1997) J Natl Cancer Inst , vol.89 , pp. 139-147
    • Gasparini, G.1    Toi, M.2    Gion, M.3
  • 50
    • 1842415455 scopus 로고    scopus 로고
    • Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer
    • Takahashi Y, Tucker S, Kitadai Y, et al: Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer. Arch Surg 132: 541-546, 1997
    • (1997) Arch Surg , vol.132 , pp. 541-546
    • Takahashi, Y.1    Tucker, S.2    Kitadai, Y.3
  • 51
    • 0031965353 scopus 로고    scopus 로고
    • Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor
    • Lin P, Sankar S, Shan S: Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. Cell Growth Differ 9:49-58, 1998
    • (1998) Cell Growth Differ , vol.9 , pp. 49-58
    • Lin, P.1    Sankar, S.2    Shan, S.3
  • 52
    • 0032559040 scopus 로고    scopus 로고
    • Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site
    • Fairbrother W, Christinger H, Cochran A: Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site. Biochem 37:17754-17764, 1998
    • (1998) Biochem , vol.37 , pp. 17754-17764
    • Fairbrother, W.1    Christinger, H.2    Cochran, A.3
  • 53
    • 12244277954 scopus 로고    scopus 로고
    • Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent
    • Mendel DB, Laird AD, Smolich BD, et al: Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Anticancer Drug Des 15:29-41, 2000
    • (2000) Anticancer Drug Des , vol.15 , pp. 29-41
    • Mendel, D.B.1    Laird, A.D.2    Smolich, B.D.3
  • 54
    • 0026708632 scopus 로고
    • The vascular endothelial growth factor proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies
    • Kim K, Li B, Houck K: The vascular endothelial growth factor proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors 7:53-64, 1992
    • (1992) Growth Factors , vol.7 , pp. 53-64
    • Kim, K.1    Li, B.2    Houck, K.3
  • 55
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presto L, Chen H, O'Connor S: Humanization of anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 57: 4593-4599, 1997
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presto, L.1    Chen, H.2    O'Connor, S.3
  • 56
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • Kim K, Li B, Winner J: Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 362:841-844, 1993
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.1    Li, B.2    Winner, J.3
  • 57
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • Warren R, Yaun H, Malti M: Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest 95:1789-1797, 1995
    • (1995) J Clin Invest , vol.95 , pp. 1789-1797
    • Warren, R.1    Yaun, H.2    Malti, M.3
  • 58
    • 0028824336 scopus 로고
    • Inhibition of tumor growth and metastasis by immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor 121
    • Asano M, Ayako Y, Matsumoto T: Inhibition of tumor growth and metastasis by immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor 121. Cancer Res 55:5296-5301, 1995
    • (1995) Cancer Res , vol.55 , pp. 5296-5301
    • Asano, M.1    Ayako, Y.2    Matsumoto, T.3
  • 59
    • 0030059075 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth
    • Melnyk O, Shuman M, Kim K: Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth. Cancer Res 56:921-924, 1996
    • (1996) Cancer Res , vol.56 , pp. 921-924
    • Melnyk, O.1    Shuman, M.2    Kim, K.3
  • 60
    • 0031898292 scopus 로고    scopus 로고
    • Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo
    • Borgstrom P, Bourdon M, Hillan K: Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo. Prostate 35:1-10, 1998
    • (1998) Prostate , vol.35 , pp. 1-10
    • Borgstrom, P.1    Bourdon, M.2    Hillan, K.3
  • 61
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T, Butterfield C, Kräling B: Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 60:1878-1886, 2000
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.2    Kräling, B.3
  • 62
    • 0026753046 scopus 로고
    • The effects of 5-fluorouracil and mitomycin C on the corneal endothelium
    • Nuyts R, Pels E, Greve E: The effects of 5-fluorouracil and mitomycin C on the corneal endothelium. Curr Eye Res 11:565-570, 1992
    • (1992) Curr Eye Res , vol.11 , pp. 565-570
    • Nuyts, R.1    Pels, E.2    Greve, E.3
  • 63
    • 0029802685 scopus 로고    scopus 로고
    • The microtubule-affecting drug paclitaxel has antiangiogenic activity
    • Belotti D, Vergani V, Drudis T, et al: The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res 2:1843-1849, 1996
    • (1996) Clin Cancer Res , vol.2 , pp. 1843-1849
    • Belotti, D.1    Vergani, V.2    Drudis, T.3
  • 64
    • 0032956544 scopus 로고    scopus 로고
    • Antiangiogenic effects of camptothecin analogues 9-amino-20(S)-camptothecin, topotecan, and CPT-11 studied in the mouse cornea model
    • O'Leary J, Shapiro R, Ren C, et al: Antiangiogenic effects of camptothecin analogues 9-amino-20(S)-camptothecin, topotecan, and CPT-11 studied in the mouse cornea model. Clin Cancer Res 5:181-187, 1999
    • (1999) Clin Cancer Res , vol.5 , pp. 181-187
    • O'Leary, J.1    Shapiro, R.2    Ren, C.3
  • 65
    • 0000748868 scopus 로고
    • The effect of antibody to vascular endothelial growth factor and cisplatin on the growth of lung tumors in nude mice. Proc Am Assoc
    • abstr 2906
    • Kabbinavar F, Wong J, Ayala R, et al: The effect of antibody to vascular endothelial growth factor and cisplatin on the growth of lung tumors in nude mice. Proc Am Assoc Cancer Res 36:488, 1995 (abstr 2906)
    • (1995) Cancer Res , vol.36 , pp. 488
    • Kabbinavar, F.1    Wong, J.2    Ayala, R.3
  • 66
    • 0032806309 scopus 로고    scopus 로고
    • Importance of VEGF for breast cancer angiogenesis in vivo: Implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin
    • Borgstom P, Gold D, Hillan K, et al: Importance of VEGF for breast cancer angiogenesis in vivo: Implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin. Anticancer Res 19:4203-4214, 1999
    • (1999) Anticancer Res , vol.19 , pp. 4203-4214
    • Borgstom, P.1    Gold, D.2    Hillan, K.3
  • 67
    • 0032962265 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor
    • Lin Y, Nguyen C, Mendoza J: Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor. J Pharmacol Exp Ther 288:371-378, 1998
    • (1998) J Pharmacol Exp Ther , vol.288 , pp. 371-378
    • Lin, Y.1    Nguyen, C.2    Mendoza, J.3
  • 68
    • 0001123178 scopus 로고    scopus 로고
    • Phase I trial of recombinant humanized monoclonal anti-vascular endothelial growth factor (anti-vegf mab) in patients with metastatic cancer
    • abstr 809
    • Gordon MS, Talpaz M, Margolin K, et al: Phase I trial of recombinant humanized monoclonal anti-vascular endothelial growth factor (anti-vegf mab) in patients with metastatic cancer. Proc Am Soc Clin Oncol 17:210a, 1998 (abstr 809)
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Gordon, M.S.1    Talpaz, M.2    Margolin, K.3
  • 69
    • 0013405842 scopus 로고    scopus 로고
    • MRI evaluation of the effects of the vascular-targeting agent ZD6126 on tumor vasculature
    • abstr 440
    • DelProposto Z, LoRusso P, Latif Z, et al: MRI evaluation of the effects of the vascular-targeting agent ZD6126 on tumor vasculature. Proc Am Soc Clin Oncol 21:111a, 2002 (abstr 440)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • DelProposto, Z.1    LoRusso, P.2    Latif, Z.3
  • 70
    • 0038599016 scopus 로고    scopus 로고
    • Clinical evaluation of the novel vascular-targeting agent, ZD6126: Assessment of toxicity and surrogate markers of vascular damage
    • abstr 439
    • Radema S, Beerepoot LV, Witteveen PO, et al: Clinical evaluation of the novel vascular-targeting agent, ZD6126: Assessment of toxicity and surrogate markers of vascular damage. Proc Am Soc Clin Oncol 21:110a, 2002 (abstr 439)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Radema, S.1    Beerepoot, L.V.2    Witteveen, P.O.3
  • 71
    • 0001410793 scopus 로고    scopus 로고
    • Clinical evaluation of ZD6474, an orally active inhibitor of VEGF signaling, in patients with solid tumors
    • abstr 325
    • Hurwitz H, Holden SN, Eckhardt SG, et al: Clinical evaluation of ZD6474, an orally active inhibitor of VEGF signaling, in patients with solid tumors. Proc Am Soc Clin Oncol 21:82a, 2002 (abstr 325)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Hurwitz, H.1    Holden, S.N.2    Eckhardt, S.G.3
  • 72
    • 0000397265 scopus 로고    scopus 로고
    • A randomized phase II trial comparing rhumab VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) plus carboplatin/paclitaxel (CP) to CP alone in patients with stage IIIB/IV NSCLC
    • abstr 1896
    • DeVore RF, Fehrenbacher L, Herbst RS, et al: A randomized phase II trial comparing rhumab VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) plus carboplatin/paclitaxel (CP) to CP alone in patients with stage IIIB/IV NSCLC. Proc Am Soc Clin Oncol 19:485a, 2000 (abstr 1896)
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • DeVore, R.F.1    Fehrenbacher, L.2    Herbst, R.S.3
  • 73
    • 0003170893 scopus 로고    scopus 로고
    • A phase II trial of single-agent rhuMab VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) in patients with relapsed metastatic breast cancer
    • abstr 5c
    • Sledge G, Miller K, Novotny W, et al: A phase II trial of single-agent rhuMab VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) in patients with relapsed metastatic breast cancer. Proc Am Soc Clin Oncol 19:3a, 2000 (abstr 5c)
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Sledge, G.1    Miller, K.2    Novotny, W.3
  • 74
    • 0001674315 scopus 로고    scopus 로고
    • A randomized double-blind placebo-controlled trial of bevacizumab (anti-VEGF antibody) demonstrating a prolongation in time to progression in patients with metastatic renal cancer
    • abstr 15
    • Yang JC, Haworth L, Steinberg SM, et al: A randomized double-blind placebo-controlled trial of bevacizumab (anti-VEGF antibody) demonstrating a prolongation in time to progression in patients with metastatic renal cancer. Proc Am Soc Clin Oncol 21:5a, 2002 (abstr 15)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Yang, J.C.1    Haworth, L.2    Steinberg, S.M.3
  • 75
    • 0003037707 scopus 로고    scopus 로고
    • A randomized phase II trial comparing rhuMAb VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) plus 5-fluorouracil/leucovorin (FU/LV) to FU/LV alone in patients with metastatic colorectal cancer
    • abstr 939
    • Bergsland EK, Hurwitz H, Fehrenbacher L, et al: A randomized phase II trial comparing rhuMAb VEGF (recombinant humanized monoclonal antibody to vascular endothelial cell growth factor) plus 5-fluorouracil/leucovorin (FU/LV) to FU/LV alone in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 19:242a, 2000 (abstr 939)
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Bergsland, E.K.1    Hurwitz, H.2    Fehrenbacher, L.3
  • 76
    • 0001496152 scopus 로고    scopus 로고
    • Bevacizumab (BV) + chemotherapy (CT) may improve survival in metastatic colorectal cancer (MCRC) subjects with unfavorable prognostic indicators
    • abstr 2247
    • Bergsland EK, Fehrenbacher L, Novotny W, et al: Bevacizumab (BV) + chemotherapy (CT) may improve survival in metastatic colorectal cancer (MCRC) subjects with unfavorable prognostic indicators. Proc Am Soc Clin Oncol 20:124b, 2001 (abstr 2247)
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Bergsland, E.K.1    Fehrenbacher, L.2    Novotny, W.3
  • 77
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
    • Saltz L, Cox J, Blanke C, et al: Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 343:905-914, 2000
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.1    Cox, J.2    Blanke, C.3
  • 78
    • 0003305378 scopus 로고    scopus 로고
    • Successful long-term therapy with bevacizumab (Avastin) in solid tumors
    • abstr 32
    • Langmuir VK, Cobleigh MA, Herbst RS, et al: Successful long-term therapy with bevacizumab (Avastin) in solid tumors. Proc Am Soc Clin Oncol 21:9a, 2002 (abstr 32)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Langmuir, V.K.1    Cobleigh, M.A.2    Herbst, R.S.3
  • 79
    • 0013152742 scopus 로고    scopus 로고
    • Patterns of tumor progression during therapy with bevacizumab (BV) and chemotherapy (CT) for metastatic colorectal cancer (MCRC) and advanced non-small cell lung cancer (NSCLC)
    • abstr 1105
    • Kabbinavar FF, Johnson D, Langmuir VK: Patterns of tumor progression during therapy with bevacizumab (BV) and chemotherapy (CT) for metastatic colorectal cancer (MCRC) and advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 20:227a, 2001 (abstr 1105)
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Kabbinavar, F.F.1    Johnson, D.2    Langmuir, V.K.3
  • 80
    • 0001410272 scopus 로고    scopus 로고
    • A phase I/II trial and pharmacokinetic (PK) study of SU5416 in combination with paclitaxel/carboplatin
    • abstr 389
    • Rosen PJ, Kabbinavar F, Figlin RA: A phase I/II trial and pharmacokinetic (PK) study of SU5416 in combination with paclitaxel/carboplatin. Proc Am Soc Clin Oncol 20:98a, 2001 (abstr 389)
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Rosen, P.J.1    Kabbinavar, F.2    Figlin, R.A.3
  • 81
    • 0030758682 scopus 로고    scopus 로고
    • Prevention of thrombotic disorders in cancer patients undergoing chemotherapy
    • Levine M: Prevention of thrombotic disorders in cancer patients undergoing chemotherapy. Thromb Haemost 78:133-136, 1997
    • (1997) Thromb Haemost , vol.78 , pp. 133-136
    • Levine, M.1
  • 82
    • 0002428162 scopus 로고
    • Biological role of nitric oxide in platelet function
    • Moncada SHE, Berrazueta JR (eds). Madrid, Edicomplet
    • Radomski M, Moncada S: Biological role of nitric oxide in platelet function, in Moncada SHE, Berrazueta JR (eds): Clinical Relevance of Nitric Oxide in the Cardiovascular System. Madrid, Edicomplet, 1991, pp 45-56
    • (1991) Clinical Relevance of Nitric Oxide in the Cardiovascular System , pp. 45-56
    • Radomski, M.1    Moncada, S.2
  • 83
    • 0003236141 scopus 로고    scopus 로고
    • Activation of the coagulation cascade and endothelial cell perturbation during treatment with cisplatin, gemcitabine, and the angiogenesis inhibitor SU5416
    • abstr 21
    • Hoekman K, Kuenen B, Levi M, et al: Activation of the coagulation cascade and endothelial cell perturbation during treatment with cisplatin, gemcitabine, and the angiogenesis inhibitor SU5416. Proc Am Soc Clin Oncol 21:6a, 2002 (abstr 21)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Hoekman, K.1    Kuenen, B.2    Levi, M.3
  • 84
    • 0003264688 scopus 로고    scopus 로고
    • Incorporating angiogenesis inhibition with bevacizumab (anti-VEGF) into frontline chemotherapy with irinotecan (CPT-11), fluorouracil and leucovorin (FU/LV) for advanced colorectal cancer (advCRC): A toxicity analysis of ECOG study E2200
    • abstr 503
    • Giantonio BJ, Levy D, Catalano PJ, et al: Incorporating angiogenesis inhibition with bevacizumab (anti-VEGF) into frontline chemotherapy with irinotecan (CPT-11), fluorouracil and leucovorin (FU/LV) for advanced colorectal cancer (advCRC): A toxicity analysis of ECOG study E2200. Proc Am Soc Clin Oncol 21:126a, 2002 (abstr 503)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Giantonio, B.J.1    Levy, D.2    Catalano, P.J.3


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