Platelet-derived growth factor-B/v-sis confers a tumorigenic and metastatic phenotype to human T98G glioblastoma cells

Cancer Research

Volumn 56, Issue 2, 1996, Pages 280-286

  Potapova, Olga ^a   Fakhrai, Habib ^c   Baird, Stephen ^d   Mercola, Dan ^a,b  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL TRANSFORMATION; GLIOBLASTOMA; GROWTH REGULATION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; METASTASIS POTENTIAL; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, NEOPLASM; ANTIBODY SPECIFICITY; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GLIOBLASTOMA; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, NUDE; MIDDLE AGED; ONCOGENE PROTEINS V-SIS; PHENOTYPE; PLATELET-DERIVED GROWTH FACTOR; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-SIS; RETROVIRIDAE PROTEINS, ONCOGENIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030066455     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Westermark, B , and Heldin, C-H. Platelet-derived growth factor. Structure, function and implications in normal and malignant cell growth. Acta Oncol., 32: 101-105, 1993.
2. Heldin, C-H. Structural and functional studies on PDGF EMBO J., 11: 4251-4259, 1992.
3. Mercola, D. Platelet-derived growth factor, transformation and antisense: models wanted. In: R. P. Erickson and J. Izant (eds.). Gene Regulation by Antisense RNA and DNA, pp. 329-353. UCLA Symposium on Molecular Biology. Keystone, CO Raven Press, 1992.
4. Heldin, C-H., Westermark, B., and Wasteson A. Chemical and biological properties of a growth factor from human-cultured osteosarcoma cells: resemblance with platelet-derived growth factor. J. Cell. Physiol , 105: 235-246, 1980
5. Eva, A., Robbins, K. C. Andersen P. R., Srinivasan, A., Tronick, S. R., Reddy, E P., Ellmore, N W., Galen, A T., Lautenberger, J. A. Papas, T S., Westin, E. H., Wong-Staal, F., Gallo, R. C., and Aaronson, S A. Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. Nature (Lond.), 295: 116-119, 1982.
6. Nister, M., Wedell, B., Betsholtz, C., Bywater, M., Pettersson, M., Westermark, B., and Heldin, C-H A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets. Cancer Res., 47: 4953-4960, 1987.
7. Nister, A., Liberman, T., Betsholtz, C., Pettersson, L , Claesson-Welsh, L., Heldin, C-H , Schlessinger, J., and Westermark, B. Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-α and their receptors in human malignant glioma cell lines. Cancer Res., 48: 3910-3918, 1988
8. Hermansson, M , Nister, A., Betsholtz, C , Heldin, C-H., Westermark, B , and Funa, K. Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. Proc. Natl. Acad. Sci USA, 85: 7748-7752, 1988.
9. Hermanson, M., Funa, K., Hartman, M., Claesson-Welsh, L., Heldin, C-H., and Westermark, B. PDGF and its receptors in human glioma tissue: expression of mRNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res., 52: 3213-3219, 1992.
10. Vassbom, F. S., Ostman, A., Langeland, N., Holmsen, H , Westermark, B., Heldin, C-H., and Nister, M. Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line. J. Cell. Physiol., 158: 381-389, 1994
11. Hermanson, M., Funa, K., Hartman, M., Claesson-Welsh, L , Heldin, C-H., Westermark, B , and Nister, M. Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res., 52. 3213-3219, 1992.
12. Nister, M., Claesson-Welsh, L. Eriksson, A., Heldin, C-H , and Westermark, B. Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines. J. Biol Chem., 266: 16755-16763, 1991.
13. Harsh, G., R , Keating, M., T , Escobedo, J., A , and Williams, L T. Ptatelet-derived growth factor (PDGF) autocrine components in human tumor cell lines. J. Neuro-Oncol., 8: 1-12, 1990.
14. Mauro, A., Bulfone, A., Turco, E., and Schiffer, D Coexpression of platelet-derived growth factor (PDGF) B chain and PDGF B-type receptor in human gliomas. Child's Nerv. Syst , 7. 432-436, 1991.
15. Camby, I , Etievant, C., Petein, M., Dedecker, R., van Velthoven, R., Danguy, A., Pasteels, J. L., and Kiss, R. Influence of culture media on the morphological differentiation of the PC-3 and DU145 prostatic neoplastic cell lines. Prostate, 24. 187-196, 1994
16. Forsberg, K., Valyt-Nagi, I , Heldin, C-H., Herlyn, M., and Westermark, B. Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in venotransplanted human melanoma producing PDGF-BB. Proc. Natl. Acad. Sci. USA, 90: 393-397, 1992.
17. Shih, I. M , and Herlyn, M. Autocrine and paracrine roles for growth factors in melanoma. In Vivo. 8. 113-123, 1994
18. Weiner, T M., Liu, E. T., Craven, R. J., and Cance, W G. Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors. Ann. Surg. Oncol , 1: 18-27, 1994.
19. Wang, J , Coltrera, M D , and Gown, A M Cell proliferation in human soft tissue tumors correlates with platelet-derived growth factor B chain expression: an immunohistochemical and in situ hybridization study. Cancer Res , 54: 560-564, 1994
20. Ponten, F., Ren, Z., Nister, M., Westermark, B , and Ponten, J. Epithelial-stromal interactions in basal cell cancer the PDGF system J Invest. Dermatol., 102: 304-309, 1994
21. Tsai, L. H., White, L., Raines, E., Ross, R , Smith, R. G., Cushley, W , and Ozanne, B Expression of platelet-derived growth factor and its receptors by two pre-B acute lymphocytic leukemia cell lines. Blood, 83. 51-55, 1994.
22. Golub, T. R., Barker, G. F , Lovett, M., and Gilliland, D. G. Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell, 77: 307-316, 1994.
23. Drummond-Barbosa, D., Vaillancourt, R. R., Kazlauskas, A., and MiMaio, D Ligand-independent activation of the platelet-derived growth factor β receptor requirments for bovine papillomavirus E5-induced miogenic signaling. Mol Cell. Biol., 15: 2570-2581, 1995
24. Ariad, S , Seymour, L , and Bezwoda, W. R. Platelet-derived growth factor (PDGF) in plasma of breast cancer patients, correlation with stage and rate of progression. Breast Cancer Res. Treat., 20: 11-17, 1991.
25. Takanami, I., Imamura, T., Yamamoto, Y , and Kodaira, S. Usefulness of platelet-derived growth factor as a prognostic factor in pulmonary adenocarcinoma. J. Surg. Onocol., 58: 40-43, 1995
26. Betsholtz, C., and Westermark, B. Growth factor-induced proliferation of human fibroblasts in serum-free culture depends on cell density and extracellular calcium concentration. J. Cell. Physiol., 118. 203-210, 1984.
27. Stevens, C W., Brondyk, W. H., Burgess, J. A., Manoharan, T. H., Hane, B G., and Fahl, W. E. Partially transformed, anchorage-independent human diploid fibroblasts result from overexpression of the c-sis oncogene. mitogenic activity of an apparent monomeric platelet-derived growth factor 2 species. Mol. Cell. Biol., 8: 2089-2096, 1988
28. Van der Meeren, A., Seddon, M. B., Betsholtz, C. A., Lechner, J. F , and Gerwin, B. I Tumorigenic conversion of human mesothelial cells as a consequence of platelet-derived growth factor-A chain overexpression., Am. J. Respir. Cell Mol. Biol., 8: 214-221, 1993.
29. Silver, B. J. Platelet-derived growth factor in human malignancy. Biofactors, 3: 217-227, 1992.
30. Yang, D., Kohler, S. K., Maher, V. M., and McCormick, J. J. v-sis oncogene-induced transformation of human fibroblasts into cells capable of forming benign tumors Carcinogenesis (Lond.), 15. 2167-2175, 1994.
31. Assoian, R. K., Fleurdelys, B. E., Stevenson, H. C., Miller, P J., Madtes, D K , Raines, E. W., Ross, R., and Sporn, M. B. Expression and secretion of type β transforming growth factor by activated human macrophages Proc Natl. Acad. Sci USA, 84. 6020-6024, 1987.
32. Bywater, M , Rorsman, F., Bongcam-Rudloff, E., Mark, G., Hammacher, A., Heldin, C-H , Westermark, B., and Betsholtz, C. Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects. Mol. Cell. Biol., 8: 2753-2762, 1988.
33. Johnsson, A , Betsholtz, C., Heldin, C-H., and Westermark, B. The phenotypic characteristics of simian sarcoma virus-transformed human fibroblasts suggest that the v-sis gene product acts solely as a PDGF receptor agonist in cell transformation. EMBO J., 5: 1535-1541, 1986.
34. Fleming, T. P., Matsui, T., Molloy, C. J., Robbins, K. C., and Aaronson, S. A. Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors. Proc. Natl. Acad. Sci. USA, 86: 8063-8067, 1989
35. Smeal, T., Binétruy, B., Mercola, D. A., Birrer, M., and Karin, M. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on series 63 and 73. Nature (Lond.), 354: 494-496, 1991.
36. Smeal, T , Binétruy, B., Mercola, D., Bardwick-Grover, A., Heidecker, G., Rapp, U., and Kann, M. Oncoprotein mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73 Mol Cell. Biol., 12: 3507-3513, 1992.
37. 1 arrest in vitro. J. Cell Physiol , 99: 43-54, 1979.
38. Mercer, W. E., Shields, M. T., Amin, M., Sauve, G. J., Appella, E., Romano, J W., and Ullrich, S. J. Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. Proc Natl. Acad. Sci. USA, 87 6166-6170, 1990.
39. Van Meir, E G., Kikuchi, T., Tada, M., Li, H., Diserens, A. C., Wojcik, B. E., Huang, H. J., Friedmann, T., de Tribolet, N., and Cavenee, W K. Analysis of the p53 gene and its expression in human ghoblastoma cells. Cancer Res., 54. 649-652, 1994.
40. Mercola, D., Carpenter, P., Grover-Bardwick, A., and Mercola, M. Rapid, complete and reversible transformation by v-sis precedes irreversible transformation. Oncogene, 7: 1793-1803, 1992.
41. Gjerset, R., Sobol, R., Turla, S., Scalise, J , Mercola, D., and Isabella, P. Wild-type p53 gene transfer enhances sensitivitiy to chemotherapy and radiation in tumor cells with mutant p53. Mol Carcinog., in press, 1995
42. Hammacher, A , Mellström, K., Heldin, C-H , and Westermark, B. Isoform-specific induction of actin reorganization by paltelet-derived growth factor suggests that the functionally active receptor is a dimer. EMBO J., 8 2489-2495, 1989.
43. Seifert, R. A., Hart, C E., Phillips, P. E., Forstrom, J W., Ross, R., Murray, M. J , and Bowen-Pope, D. F Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. J Biol. Chem., 264: 8771-8778, 1989
44. Sitaras, N. M., Sariban, E , Bravo, M , Pantazis, P., and Antoniades, H N. Constitutive production of platelet-derived growth factor-like proteins by human prostate carcinoma cell lines. Cancer Res., 48. 1930-1935, 1988.
45. Huang, J S., Huang, S. S., and Deuel, T. F Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors. Cell, 39: 79-87, 1984.
46. Xu, Y F , Meyer, A. N., Webster, M. K., Lee, B. A , and Donoghue, D. J The v-sis protein retains biological activity as a type II membrane protein when anchored by various signal-anchor domains, including the hydrophobic domain of the bovine papilloma virus E5 oncoprotein. J. Cell Biol , 123: 549-560, 1993
47. Kim, H-R , C., Upadhyay, S , Korsmeyer, S , and Deuel, T. F. Platelet-derived growth facgor (PDGF) B and A homodimers transform murine fibroblasts depending on the genetic background of the cell J Biol Chem , 269: 30604-30608, 1994.
48. 1 arrest. Cell, 76: 1013-1023, 1994.