Editing of an immunodominant epitope of glutamate decarboxylase by HLA-DM

Journal of Immunology

Volumn 171, Issue 2, 2003, Pages 853-859

  Lich, John D ^a,c   Jayne, Jennifer A ^a,d   Zhou, Delu ^a   Elliott, John F ^b   Blum, Janice S ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d SOUTHERN UTAH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; EPITOPE; GLUTAMATE DECARBOXYLASE; HLA DM ANTIGEN; HLA DR4 ANTIGEN; SYNTHETIC PEPTIDE;

ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL ORGANELLE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0038445901     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.2.853     Document Type: Article

References (62)

1. Zhong, G., P. Romagnoli, and R. N. Germain. 1997. Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein. J. Exp. Med. 185:429.
2. Watts, C. 1997. Capture and processing of exogenous antigens for presentation on MHC molecules. In Annual Review of Immunology, Vol. 15. W. E. Paul, C. G. Fathman, and H. Metzger, eds. Annual Reviews, Palo Alto, p. 821.
3. Roche, P., and P. Cresswell. 1990. Invariant chain association with HLA-DR molecules inhibits immunogenic pepfide binding. Nature 345:615.
4. Blum, J. S., and P. Cresswell. 1988. Role for intracellular proteases in the processing and transport of class II HLA antigens. Proc. Natl. Acad. Sci., USA 85:3975.
5. Mizuochi, T., S.-T. Yee, M. Kasai, D. Muno, and E. Kominami. 1994. Both cathepsin B and cathepsin D are necessary for the processing of ovalbumin as well as for the degradation of class II MHC invariant chain. Immunol. Lett. 43:189.
6. Nakagawa, T., and A. Rudenski. 1999. The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentation. Immunol. Rev. 172:121.
7. Kropshofer, H., G. Hammerling, and A. Vogt. 1997. How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest? Immunol. Today 18:77.
8. Avva, R., and P. Cresswell. 1994. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides. Immunity 1:763.
9. Riberdy, J., J. Newcomb, M. Surman, J. Barbosa, and P. Cresswell. 1992. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature 360:474.
10. Kropshofer, H., A. Vogt, L. Stern, and G. Hammerling. 1995. Self release of CLIP in peptide loading of HLA-DR molecules. Science 270:1357.
11. Mellins, E., L. Smith, B. Arp, T. Cotner, E. Celis, and D. Pious. 1990. Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. Nature 343:71.
12. Denzin, L., and P. Cresswell. 1995. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 82:155.
13. Martin, W. D., G. G. Hicks, S. K. Mendiratta, H. I. Leva, H. E. Ruley, and L. Van Kaer. 1996. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84:543.
14. Nanda, N. K., and A. J. Sant. 2000. DM determines the cryptic and immunodominant fate of T cell epitopes. J. Exp. Med. 192:781.
15. Kovats, S., C. Grubin, S. Eastman, P. deRoos, A. Dongre, L. V. Kaer, and A. Rudensky. 1998. Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J. Exp. Med. 187:245.
16. Ramachandra, L., S. Kovats, S. Eastman, and A. Rudensky. 1996. Variations in HLA-DM expression influences conversion of MHC class II αβ:class II-associated invariant chain peptide complexes to mature peptide-bound class II αβ dimers in a normal B cell line. J. Immunol. 156:2196.
17. Muczynski, K. A., S. K. Anderson, and D. Pious. 1998. Discoordinate surface expression of IFN-γ-induced HLA class II proteins in nonprofessional antigen-presenting cells with absence of DM and class II localization. J. Immunol. 160:3207.
18. Cucchi-Mouillot, P., S. Lai, C. Carcassi, P. Sorba, M. Stuart-Simoni, J. P. Amoros, B. Genetet, D. Haras, and L. Contu. 1998. Implication of HLA-DMA alleles in corsican IDDM. Dis. Markers 14:135.
19. Siegmund, T., H. Donner, J. Braun, K. H. Usadel, and K. Badenhoop. 1999. HLA-DMA and HLA-DMB alleles in German patients with type I diabetes mellitus. Tissue Antigens 54:291.
20. Louis-Plence, P., S. Kerlan-Candon, J. Morel, B. Combe, J. Clot, V. Pinet, and J. F. Eliaou. 2000. The down-regulation of HLA-DM gene expression in rheumatoid arthritis is not related to their promoter polymorphism. J. Immunol. 165:4861.
21. Pinet, V., B. Combe, O. Avinens, S. Caillat-Zucman, J. Sany, J. Clot, and J. F. Eliaou. 1998. Polymorphisms of the HLA-DMA and DMB genes in rheumatoid arthritis. Arthritis Rheumatol. 41:946.
22. Toussirot, E., C. Sauvageot, J. Chabod, C. Ferrand, P. Tiberghien, and D. Wendling. 2000. The association of HLA-DM genes with rheumatoid arthritis in eastern France. Hum. Immunol. 61:303.
23. Perdriger, A., P. Guggenbuhl, G. Chales, J. Yaouanq, E. Quelvennec, M. N. Bonnard, Y. Pawlotsky, and G. Semana. 1999. Positive association of the HLA DMB1*0101-0101 genotype with rheumatoid arthritis. Rheumatology 38:448.
24. Singal, D. P., and M. Ye. 1998. HLA-DM polymorphisms in patients with rheumatoid arthritis. J. Rheumatol. 25:1295.
25. Vejbaesya, S., P. Luangtrakool, K. Luangtrakool, C. Sermduangprateep, and L. Parivisutt. 2000. Analysis of TAP and HLA-DM polymorphism in Thai rheumatoid arthritis. Hum. Immunol. 61:309.
26. Moxley, G., and J. Han. 2001. HLA DMA and DMB show no association with rheumatoid arthritis in US Caucasians. Eur. J. Immunogenet. 28:539.
27. Geluk, A., K. E. v. Meijgaarden, N. C. Schloot, J. W. Drijfhout, T. Ottenhoff, and B. O. Roep. 1998. HLA-DR binding analysis of peptides from islet antigens in IDDM. Diabetes 47:1594.
28. Abraham, R., and C. David. 2000. Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice. Curr. Opim. Immunol. 12:122.
29. Reijonen, H., J. F. Elliott, P. v. Endert, and G. Nepom. 1999. Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals. J. Immunol. 163:1674.
30. Wicker, L. S., S.-L. Chen, G. T. Nepom, J. F. Elliott, D. C. Freed, A. Bansai, S. Zhen, A. Herman, A. Lemmark, D. M. Zaller, et al. 1996. Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type I diabetes-associated human MHC class II allele. DRB1*0401. J. Clin. Invest. 98:2597.
31. Lich, J. D., J. F. Elliott, and J. S. Blum. 2000. Cytoplasmic processing is a prerequisite for presentation of an endogeneous antigen by major histocompatibility complex class II proteins. J. Exp. Med. 191:1513.
32. Denzin, L., N. Robbins, C. Carboy-Newcomb, and P. Cresswell. 1994. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. Immunity 1:595.
33. Kovats, S., P. E. Whiteley, P. Concannon, A. Y. Rudensky, and J. S. Blum. 1997. Presentation of abundant endogenous class II DR-restricted antigens by DM-negative B cell lines. Eur. J. Immunol. 27:1014.
34. Pathak, S. S., J. D. Lich, and J. S. Blum. 2001. Cutting edge: editing of recycling class II:peptide complexes by HLA-DM. J. Immunol. 167:632.
35. Haque, M. A., P. Li, S. K. Jackson, H. M. Zarour, J. W. Hawes, U. T. Phan, M. Maric, P. Cresswell, and J. S. Blum. 2002. Absence of γ-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes. J. Exp. Med. 195:1267.
36. Elliott, J. F., H.-y. Qin, S. Bhatti, D. K. Smith, R. K. Singh, T. Dillon, J. Lauzon, and B. Singh. 1994. Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice. Diabetes 43:1494.
37. Christgau, S., H.-J. Aanstoot, H. Schierbeck, K. Begley, S. Tullin, K. Hejnaes, and S. Baekkeskov. 1992. Membrane anchoring of the autoantigen GA65 to microvesicles in pancreatic β-cells by palmitoylation in the N-terminal domain. J. Cell Biol. 118:309.
38. Vogt, A. B., H. Kropshofer, G. Moldenhauer, and G. J. Hammerling. 1996. Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM. Proc. Natl. Acad. Sci. 93:9724.
39. Patel, S. D., A. P. Cope, M. Congia, T. T. Chen, E. Kim, L. Fugger, D. Wherrett, and G. Sonderstrup-McDevitt. 1997. Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR (A1*0101, B1*0401) transgenic mice. Proc. Natl. Acad. Sci. 94:8082.
40. Monji, T., A. McCormack, J. Yates, and D. Pious. 1994. Invariant-cognant peptide exchange restores class II dimer stability in HLA-DM mutants. J. Immunol. 153:4468.
41. Alfonso, C., and L. Karlsson. 2000. Nonclassical MHC class II molecules. Annu. Rev. Immunol. 18:113.
42. Ma, C., P. Whiteley, P. Cameron, D. Freed, A. Pressey, S. Chen, B. Gami-Wagner, C. Fang, D. Zaller, L. Wicker, et al. 1999. Role of APC in the selection of immunodominant T cell epitopes. J. Immunol. 163:6413.
43. Bonifaz, L. C., S. Arzate, and J. Moreno. 1999. Endogenous and exogenous forms of the same antigen are processed from different pools to bind MHC class II molecules in endocytic compartments. Eur. J. Immunol. 29:119.
44. Nuchtern, J. G., W. E. Biddison, and R. D. Klausner. 1990. Class II MHC molecules can use the endogenous pathway of antigen presentation. Nature 343:74.
45. Ma, C., and J. S. Blum. 1997. Receptor-mediated endocytosis of antigens overcomes the requirement for HLA-DM in class II-restricted antigen presentation. J. Immunol. 158:1.
46. Fremont, D., F. Crawford, P. Marrack, W. Hendrickson, and J. Kappler. 1998. Crystal structure of mouse H2-M. Immunity 9:385.
47. Mosyak, L., D. Zaller, and D. Wiley. 1998. The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation. Immunity 9:377.
48. Kropshofer, H., A. B. Vogt, and G. J. Hammerling. 1995. Structural features of the invariant chain fragment CLIP controlling rapid release from HLA-DR molecules and inhibition of peptide binding. Proc. Natl. Acad. Sci. USA 92:8313.
49. Kropshofer, H., S. Arndt, G. Mouldenhauer, G. Hammerling, and A. Vogt. 1997. HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH. Immunity 6:293.
50. Rabinowitz, J. D., M. Vrljic, P. M. Kasson, M. N. Liang, R. Busch, J. J. Boniface, M. M. Davis, and H. M. McConnell. 1998. Formation of a highly peptide-receptive state of class II MHC. Immunity 9:699.
51. Sherman, M., D. Weber, and P. Jensen. 1995. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptides. Immunity 3:197.
52. Drover, S., S. Kovats, S. Masewicz, J. Blum, and G. Nepom. 1998. Modulation of peptide-dependent allospecific epitopes on HLA-DR4 molecules by HLA-DM. Hum. Immunol. 59:77.
53. Roucard, C., C. Thomas, M.-A. Pasquier, J. Trowsdale, J.-J. Sotto, J. Neefjes, and M. van Ham. 2001. In vivo and in vitro modulation of HLA-DM and HLA-DO is induced by B lymphocyte activation. J. Immunol. 167:6849.
54. Koh, L. D., G. Napolitano, D. S. Singer, M. Molteni, R. Scorza, N. Shimojo, Y. Kohno, E. Mozes, M. Nakazato, L. Ulianich, et al. 2000. Graves' disease: a host defense mechanism gone awry. Int. Rev. Immunol. 19:633.
55. Amdt, S. O., A. B. Vogt, S. Markovik-Plese, R. Martin, G. Moldenhauer, A. Wolpl, Y. Sun, D. Schadendorf, G. J. Hammerling, and H. Kropshofer. 2000. Functional HLA-DM on the surface of B cells and immature dendritic cells. EMBO J. 19:1241.
56. Zhu, X., Y. Zhang, Q. Wang, and F. Wang. 2000. Polymorphisms of TAP, LMP, and HLA-DM genes in the Chinese. Chinese Med. J. 113:372.
57. Liljeddahl, M., T. Kuwana, W.-P. Fung-Leung, M. Jackson, P. Peterson, and L. Karlsson. 1996. HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. EMBO 15:4817.
58. Liljedahl, M., O. Winqvist, C. Surh, P. Wong, K. Ngo, L. Teyton, P. Peterson, A. Brunmark, A. Rudensky, W. Fung-Leung, et al. 1998. Altered antigen presentation in mice lacking H2-O. Immunity 8:233.
59. Jaraquemada, D., M. Marti, and E. O. Long. 1990. An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells. J. Exp. Med. 172:947.
60. Rudensky, A. Y., M. Maric, S. Eastman, L. Shoemaker, P. C. DeRoos, and J. S. Blum. 1994. Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity 1:585.
61. Fernandez-Borja, M., D. Verwoerd, F. Sanderson, H. Aerts, J. Trowsdale, A. Tulp, and J. Neefjes. 1996. HLA-DM and MHC class II molecules co-distribute with peptidase-containing lysosomal subcompartments. Int. Immunol. 8:625.
62. Harding, C. V. 1996. Class II antigen processing: analysis of compartments and functions. Crit. Rev. Immunol. 16:13.