In vivo and in vitro modulation of HLA-DM and HLA-DO is induced by B lymphocyte activation

Journal of Immunology

Volumn 167, Issue 12, 2001, Pages 6849-6858

  Roucard, C ^a   Thomas, C ^a   Pasquier, M A ^a   Trowsdale, J ^a   Sotto, J J ^a   Neefjes, J ^a   Van Ham, M ^a  

^a INSTITUT ALBERT BONNIOT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CHAPERONE; CHLOROQUINE; HLA ANTIGEN CLASS 2; HLA DM ANTIGEN; HLA DO ANTIGEN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; PROTEIN KINASE C;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; LYSOSOME; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM;

EID: 0035892907     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.12.6849     Document Type: Article

References (70)

1. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain
2. Intracellular transport of class II MHC molecules directed by invariant chain
3. Mediation by HLA-DM of dissociation of peptides from HLA-DR
4. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading
5. Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface
6. HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport
7. The human HLA class 11 a chain gene DZa is distinct from genes in the DP, DQ and DR subregions
8. DOβ: A new β chain gene in HLA-D with a distinct regulation of expression
9. A novel class II MHC molecule with unusual tissue distribution
10. HLA-DO is an intracellular class II molecule with distinctive thymic expression
11. Altered antigen presentation in mice lacking H2-O
12. Negative regulation by HLA-DO of MHC class II-restricted antigen processing
13. HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading
14. A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules
15. Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO
16. Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes
17. Cutting edge: Signals from the B lymphocyte antigen receptor regulate MHC class II-containing late endosomes
18. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments
19. Differential expression and serologically distinct subpopulations of human la antigens detected with monoclonal antibodies to Ia α and β chains
20. Two widely used anti-DR α monoclonal antibodies bind to an intracellular C-terminal epitope
21. Subsets of human Ia-like molecules defined by monoclonal antibodies
22. Assembly and intracellular transport of HLA-DM and correction eorrection of the class II antigen-processing defect in T2 cells
23. + B lymphocytes positively selected from buffy coats by immunomagnetic separation
24. Human B-lymphocyte subpopulations. 1. Differentiation of density-separated B lymphocytes
25. Characterization of lymphoma-derived cell lines: Comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen. II. Surface markers
26. Increased expression of la antigens on resting B cells: An additional role for B-cell growth factor
27. Increased expression of I-region-associated antigen (Ia) on B cells after cross-linking of surface Ig
28. Proliferative assays for B cell function
29. HLA-DR a chain residues located on the outer loops are involved in nonpolymorphic and polymorphic antibody-binding epitopes
30. The role of class II molecules in human B cell activation: Association with phosphatidylinositol turnover, protein tyrosine phosphorylation, and proliferation
31. Early biochemical events after MHC class II-mediated signaling on human B lymphocytes
32. Activation of human B lymphocytes through CD40 and interleukin 4
33. 1 blockade induced by cell-cell contact
34. Time-dependent changes in protein kinase C distribution and disappearance in phorbol ester-treated human osteosarcoma cells
35. Bimodal effect of phorbol ester on B cell activation: Implication for the role of protein kinase C
36. Transmembrane signals generated through MHC class 11, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway
37. The role of protein kinase C signaling in activated DRA transcription
38. Protein kinase Cμ (PKCμ) associates with the B cell antigen receptor complex and regulates lymphocyte signaling
39. Lyn-mediated down-regulation of B cell antigen receptor signaling: Inhibition of protein kinase C activation by Lyn in a kinase-independent fashion
40. Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation
41. Multisite dephosphorylation and desensitization of conventional protein kinase C isotypes
42. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression
43. Identification of class II transcriptional activator-induced genes by representational difference analysis: Discoordinate regulation of the DNαDOβ heterodimer
44. Initiation and elongation of protein synthesis in growing cells: Differential inhiition by cycloheximide and emetine
45. Lysosomotropic agents
46. Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin
47. Protein kinase C isozymes and the regulation of diverse cell responses
48. Protein phosphorylation controls translation rates
49. Regulated secretion of conventional lysosomes
50. 2+-regulated exocytic vesicles in fibroblasts and epithelial cells
51. 2+-dependent exocytosis of lysosomes in fibroblasts
52. Lysosomal and cytosolic pH as regulators of exocytosis in mouse macrophages
53. Protein kinase C and intracellular pH regulate zymosan-induced lysosomal enzyme secretion in macrophages
54. Signal transduction from the B cell antigen-receptor
55. B cell activation, tolerance and antigen-presenting function
56. The complexity of signaling pathways activated by the BCR
57. Trafficking of the Igα/Igβ heterodimer with membrane Ig and bound antigen to the major histocompatibility complex crass II peptide-loading compartment
58. Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: Importance depends on the nature of the antigen-antibody interaction
59. MHC class 11 antigen processing in B cells: Accelerated intracellular targeting of antigens
60. Anti-Ig-mediated proliferation of human B cells in the absence of protein kinase C
61. B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1α chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4
62. Protein kinase C mediates activation of nuclear cAMP response dement-binding protein in B lymphocytes stimulated through surface Ig
63. B-cell receptor- and phorbol ester-induced NF-κB and c-Jun N-terminal kinase activation in B cells requires novel protein kinase C's
64. Immunodeficiency in protein kinase cβ-deficient mice
65. Expression of protein kinase C genes in hemopoietic cells is cell type- and B cell-differentiation stage specific
66. The control and facilitation of MHC class II antigen processing by the BCR
67. Presentation of ovalbumin internalized via the immunoglobulin-A Fc receptor is enhanced through Fc receptor γ-chain signaling
68. Fca receptor cross-linking causes translocation of phosphatidylinositol-dependent protein kinase I and protein kinase B α to MHC class II peptide loading-like compartments
69. Igα and Igβ are required for efficient trafficking to late endosomes and to enhance antigen presentation
70. Inflammatory stimuli induce accumulation of MHC class II complexes in dendritic cells