Variation in HLA-DM expression influences conversion of MHC class II αβ:Class II-associated invariant chain peptide complexes to mature peptide-bound class II αβ dimers in a normal B cell line

Journal of Immunology

Volumn 156, Issue 6, 1996, Pages 2196-2204

  Ramachandra, Lakshmi ^a   Kovats, Susan ^c   Eastman, Susan ^b   Rudensky, Alexander Y ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; HLA D ANTIGEN; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELL MATURATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LYMPHOBLASTOID CELL LINE; NORTHERN BLOTTING; PRIORITY JOURNAL; TRANSGENE;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; CELL LINE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; HLA-DR5 ANTIGEN; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; TRANSFECTION;

EID: 0029921609     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Cresswell, P. 1994 Assembly, transport, and function of MHC class II molecules. Annu. Rev Immunol 12 259.
2. Marks, M. S., J S. Blum, and P Cresswell. 1990. Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens. J. Cell Biol 111:839.
3. Roche, P A , M S Marks, and P. Cresswell. 1993. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain Nature 354:392
4. Bakke, O , and B Dobberstein. 1990. MHC class II-associaced invariant chain contains a sorting signal for endosomal compartments. Cell 63.707
5. Lotteau, V., L. Teyton, A Peleraux, T. Nilsson, L Karlsson, S L. Schmid, V Quaranta, and P. A. Peterson. 1990. Intracellular transport of class II molecules directed by the invariant chain. Nature 348:600.
6. Blum, J S., and P Cresswell. 1988 Role for intracellular proteases in the processing and transport of class II HLA antigens. Proc Natl. Acad Sci. USA 85 3975
7. Avva, R. R., and P. Cresswell. 1994. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides Immunity 1:763.
8. Eastman, S., M. Deftos, P. C. DeRoos, D.-H. Hsu, L. Teyton, N. S. Braunstein, C. J. Hackett, and A. Y. Rudensky. 1996. A study of invariant chain peptide CLIP:MHC class II complexes using new complex-specific monoclonal antibody. Eur. J. Immunol. In press
9. Germain, R. N., and L. R. Hendrix. 1991. MHC class II structure, occupancy and surface expression determined by postendoplasmic reticulum antigen binding. Nature 353:134.
10. Amigorena, S , J. R. Drake, P Webster, and I. Melman 1994. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes. Nature 369:113.
11. Qui, Y., X Xu, A Wandinger-Ness, D. P. Dalke, and S. K. Pierce. 1994 Separation of subcellular compartments containing distinct functional forms of MHC class II. J. Cell Biol. 124:595.
12. Tulp, A., D. Verwoed, B. Dobberetein, H. L. Ploegh, and J Pieters. 1994. Isolation and characterization of the intracellular MHC class II compartment. Nature 369:120.
13. West, M. A., J. M. Lucocq, and C. Watts. 1994 Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells Nature 369 147.
14. Rudensky, A. Y., M. Maric, S. Eastman, L. Shoemaker, P. C. DeRoos, and J. S. Blum. 1994. Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity 1:585.
15. Amigorena, S., P. Webster, J. Drake, J. Newcomb, P. Cresswell, and I. Mellman. 1995. Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles. J. Exp. Med. 181:1729.
16. Mellins, E., L. Smith, B. Arp, T. Cotner, E. Celis, and D. Pious. 1990 Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. Nature 343:71.
17. Fling, S. P., B. Arp, and D Pious. 1994. HLA-DMA and DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells. Nature 368:554.
18. Riberdy, J. M , and P. Cresswell. 1992. The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen processing. J. Immunol. 148.2586.
19. Riberdy, J. M., J. R Newcomb, M. J. Surman, J. A Barbosa, and P. Cresswell. 1992. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature 360:474.
20. Mellins, B , S. Kempin, L. Smith, T Monji, and D. Pious. 1994. A gene for class II-restricted antigen-presentation maps to the major histocompatibility complex. J. Exp. Med. 174 1607
21. Sette, A., S. Ceman, R. T. Kubo, K. Sakaguchi, E. Appella, D. F. Hunt, T. A. Davis, H Michel, J Shabanowitz, R. Rudersdorf, H. M. Grey, and R. DeMars. 1992. Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. Science 256:1801.
22. Kelly, A P., J. J. Monaco, S. G. Cho, and J. Trowsdale. 1991. A new human HLA class II-related locus DM. Nature 353:571.
23. Morris, P., J. Shaman, M. Attaya, M. Amaya, S. Goodman, C. Bergman, J. J. Monaco, and E. Mellins. 1994. An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules. Nature 368:551.
24. Denzin, L K., N. F. Robbins, C. Carboy-Newcomb, and P. Cresswell. 1994. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing T2 cells. Immunity 1:595.
25. Ceman, S., R. A. Rudersdorf, J. M. Petersen, and R. DeMars. 1995. DMA and DMB are the only genes in the class II region of the human MHC needed for class II-associated antigen processing. J. Immunol. 154 2545
26. Sanderson, F., M J. Kleijmeer, A. Kelly, D. Verwoerd, A. Tulp, J. J. Neefjes, H. J. Geuze, and J. Trowsdale. 1994. Accumulation of HLA-DM, a regulator of antigen presentation in MHC class II compartments. Science 266.1566
27. Karlsson, L., A. Péléraux, R. Lindstedt, M. Liljedahl, and P. A. Peterson. 1994. Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells. Science 266:1569
28. Sloan, V. S., P. Cameron, G. Porter, M. Gammon, M. Amaya, E. Mellins, and D. M. Zaller. 1995. Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature 375:802.
29. Denzin, L. K., and P Cresswell. 1995. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 82:155
30. Sherman, M. A., D. A. Weber, and P. E. Jensen 1995. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide. Immunity 3:197.
31. Murphy, D. B., S. Rath, E. Pizzo, A. Y. Rudensky, A. George, J. K. Larson, and C. A. Janeway Jr. 1992. Monoclonal antibody detection of a major self peptide. MHC class II complex. J. Immunol 148:3483.
32. Rudensky, A. Y., P Preston-Hurlburt, S. C. Hong, A. Barlow, and C. A Janeway Jr. 1991. Sequence analysis of peptides bound to MHC class II molecules Nature 353:622.
33. Sette, A , S. Southwood, J. Miller, and E. Appella. 1995. Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II. J Exp. Med 181:677.
34. Radka, S. F., C. E. Machamer, and P. Cresswell. 1984. Analysis of monoclonal antibodies reactive with human class II β chains by two-dimensional electrophoresis and Western blotting. Hum. Immunol. 10:177.
35. Salter, R. D., A. J Alexander, F. Levine, D. Pious, and P. Cresswell. 1985. Evidence for two trans-acting genes regulating HLA class II antigen expression. J Immunol. 135:4235.
36. Kovats, S., S. Drover, W. H. Marshall, D. Freed, P. E. Whiteley, G. T. Nepom, and J. S. Blum 1994. Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome J. Exp. Med. 179 2017
37. Janeway, C A., Jr , P. J. Conrad, E. A. Lerner, J. Babich, P. Wettstein, and D. B. Murphy. 1984. Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells' possible role of T cell bound Ia antigens as targets of immunoregulatory T cells. J. Immunol. 132:662.
38. Lampson, L A, and R. Levy. 1980. Two populations of Ia-like molecules on a human B cell line. J. Immunol. 125:293
39. Guy, K., V. Van-Heyningen, B. B Cohen, D L. Deane, and C. M. Steel 1982. Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia α and β chains. Eur. J. Immunol 12:948.
40. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
41. Kneger, J. I., R W. Karr, H. M. Grey, W.-Y. Yu, D. O'Sullivan, L. Batovsky, Z.-L. Zheng, S. M Colon, F. C A. Gaeta, J. Sidney, M. Albertson, M.-F del Guercio, R. W. Chesnut, and A. Sette. 1991. Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition J. Immunol. 146:2331.
42. Monji, T., A. L. McCormack, J. R. Yates III, and D. Pious. 1994. Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants. J. Immunol. 153.4468.
43. Sette, A., S. Ceman, R. T. Kubo, K. Sakaguchi, E. Appella, D. F. Hunt, T A. Davis, H. Michel, J. Shabanowitz, R Rudersdorf, H. M. Grey, and R DeMars. 1992. Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant Science 258:1801.
44. Ceman, S., R. Rudersdorf, E. O. Long, and R. DeMars. 1992. MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability J. Immunol. 149:754
45. Maric, M. A., M D Taylor, and J S Blum. 1994. Endosomal aspartic proteinases are required for invariant-chain processing. Proc. Natl. Acad. Sci USA 91: 2171.
46. Morkowski, S., A. W. Goldrath, S. Eastman, L. Ramachandra, D. C Freed, P. Whiteley, and A. Y. Rudensky 1995. T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates. J. Exp. Med 182:1403.
47. Nadimi, F., J. Moreno, F. Momburg, A Heuser, S. Fuchs, L. Adorini, and G. J. Hammerling. 1991. Antigen presentation of hen egg-white lysozyme but not ribonuclease A is augmented by the major histocompatibility complex class II-associated invariant chain Eur. J Immunol. 21:1255
48. Viville, S., J. Neefjes, V. Lotteau, A Dierich, M. Lemeur, H. Ploegh, C. Benoist, and D. Mathis. 1993. Mice lacking the MHC class II-associated invariant chain Cell 72:635.
49. Pinet, V., M Vergelli, R. Martin, O. Bakke, and E. O. Long. 1995. Antigen presentation mediated by recycling of surface HLA-DR molecules. Nature 375: 603.
50. k class II molecules in human APC containing deleted or mutated HLA DM genes. J. Immunol. 153. 5382.
51. Stebbins, C. C., G. E. Loss Jr., C. G. Elias, A. Chervonsky, and A. J. Sant 1995 The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent. J. Exp. Med. 181-223