Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils

British Journal of Pharmacology

Volumn 138, Issue 7, 2003, Pages 1244-1250

  Idzko, Marco ^a   Panther, Elisabeth ^a   Bremer, Hinrich C ^a   Sorichter, Stephan ^a   Luttmann, Werner ^a   Virchow Jr , Christian J ^b   Di Virgilio, Francesco ^c   Herouy, Yared ^a   Norgauer, Johannes ^a   Ferrari, Davide ^c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

ECP; Extracellular ATP; Human eosinophils; IL 8; P2 receptors

Indexed keywords

CYTOSKELETON PROTEIN; EOSINOPHIL CATIONIC PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 8; PERTUSSIS TOXIN; PURINE P2 RECEPTOR;

ARTICLE; CELL DIFFERENTIATION; CELL STIMULATION; CYTOKINE RELEASE; EFFECTOR CELL; ENZYME ACTIVITY; EOSINOPHIL; EXTRACELLULAR MATRIX; GLYCOSYLATION; HUMAN; HUMAN CELL; MEDIATOR RELEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN TRANSPORT; RECEPTOR UPREGULATION; TISSUE INJURY;

BLOOD PROTEINS; CELLS, CULTURED; EOSINOPHIL GRANULE PROTEINS; EOSINOPHILS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-8; MUTATION; NUCLEOTIDES; RECEPTORS, PURINERGIC P2; RIBONUCLEASES;

EID: 0038415901     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705145     Document Type: Article

References (49)

1. ALLAM, M. & RENZI, P.M. (2001). Inhibition of GM-CSF/IL-3/IL-5 signaling by antisense oligodeoxynucleotides targeting the common beta chain of their receptors. Antisense Nucl. Acid Drug Dev., 11, 289-300.
2. BAGGIOLINI, M. (2001). Chemokines in pathology and medicine. J. Intern. Med., 250, 91-104.
3. BLANCHARD, D.K., HOFFMAN, S.L. & DJEU, J.Y. (1995). Inhibition of extracellular ATP-mediated lysis of human macrophages by calmodulin antagonists. J. Cell Biochem., 57, 452-464.
4. BOUSQUET, J., CHANEZ, P., LACOSTE, J.Y., BARNEON, G., GHAVANIAN, N., ENANDER, I., VENGE, P., AHLSTEDT, S., SIMONY-LAFONTAINE, J., GODARD, P., (1990). Eosimophilic inflammation in asthma. N. Engl. J. Med., 323, 1033-1039.
5. BURGERS, J.A., SCHWEIZER, R.C., KOENDERMAN, L., BRUIJNZEEL, P.L. & AKKERMAN, J.W. (1993). Human platelets secrete chemotactic activity for eosinophils. Blood, 81, 49-55.
6. BUTTERWORTH, A.E., STURROCK, R.F., HOUBA, V.A., MAHMOUD, A., SHER, A. & REES, P.H. (1975). Eosinophils as mediators of antibody-dependent damage to schistosomula. Nature, 256, 727-729.
7. CAMPBELL, J.J., QIN, S., UNUTMAZ, D., SOLER, D., MURPHY, K.E., HODGE, M.R., WU, L. & BUTCHER, E.C. (2001). Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J. Immunol., 167, 6477-6482.
8. COOK, S.P. & MCCLESKEY, E.W. (2002). Cell damage excites nociceptors through release of cytosolic ATP. Pain, 95, 41-47.
9. DICHMANN, S., IDZKO, M., ZIMPFER, U., HOFMANN, C., FERRARI, D., LUTTMANN, W., VIRCHOW, C., DI VIRGILIO, F. & NORGAUER, J. (2000). Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca(+ +) mobilization and actin reorganization in human eosinophils. Blood, 95, 973-988.
10. DI VIRGILIO, F., CHIOZZI, P., FERRARI, D., FALZONI, S., SANZ, J.M., MORELLI, A., TORBOLI, M., BOLOGNESI, G. & BARICORDI, O.R. (2001). Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood, 97, 587-600.
11. DUBUCQUOI, S., DESREUMAUX, P., JANIN, A., KLEIN, O., GOLDMAN, M., TAVERNIER, J., CAPRON, A. & CAPRON, M. (1994). Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion. J. Exp. Med., 179, 703-708.
12. DUBYAK, G.R. & EL-MOATASSIM C. (1993). Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides. Am. J. Physiol., 265, C577-C606.
13. EDGERTON, M. & KOSHLUKOVA, S.E. (2000). Salivary histatin 5 and its similarities to the other antimicrobial proteins in human saliva. Adv. Dent. Res., 14, 16-21.
14. ESNAULT, S. & MALTER, J.S. (2002). GM-CSF regulation in eosinophils. Arch. Immunol. Ther. Exp. (Warsz), 50, 121-130.
15. FERRARI, D., CHIOZZI, P., FALZONI, S., HANAU, S. & DI VIRGILIO, F. (1997). Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. J. Exp. Med., 185, 579-582.
16. FERRARI, D., IDZKO, M., DICHMANN, S., PURLIS, D., VIRCHOW, C., NORGAUER, J., CHIOZZI, P., DI VIRGILIO, F. & LUTTMANN, W. (2000). P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production. FEBS Lett., 486, 217-224.
17. GARGETT, C.E. & WILEY, J.S. (1997). The isoquinoline derivate KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br. J. Pharmacol., 120, 1483-1490.
18. GLEICH, G.-J. (1990). The eosinophil and bronchial asthma: current understanding. J. Allergy Clin. Immunol., 85, 422-436.
19. GU, B.J., ZHANG, W.Y., BENDALL, L.J., CHESSELL, I.P., BUELL, G.N. & WILEY, J.S. (2000). Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for non-functional P2X(7) receptors. Am. J. Physiol. Cell Physiol., 279, C1189-C1197.
20. HOONTRAKOON, R., CHU, H.W., GARDAI, S.J., WENZEL, S.E., McDONALD, P., FADOK, V.A., HENSON, P.M. & BRATTON, D.L. (2002). Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation. Am. J. Respir. Cell Mol. Biol., 26, 404-412.
21. IDZKO, M., DICHMANN, S., PANTHER, E., FERRARI, D., HEROUY, Y., VIRCHOW Jr., C., LUTTMANN, W., DI VIRGILIO, F. & NORGAUER, J. (2001). Functional characterization of P2Y and P2X receptors in human eosinophils. J. Cell Physiol., 188, 329-336.
22. JO, Y.H. & ROLE, L.W. (2002). Coordinate release of ATP and GABA at in vitro synapses of lateral hypothalamic neurons. J. Neurosci., 22, 4794-4804.
23. KITA, H., ABU-GHAZALEH, R.I., SUR, S. & GLEICH, G.J. (1995). Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils. J. Immunol., 154, 4749-4758.
24. KITA, H., OHNISHI, T., OKUBO, Y., WEILER, D., ABRAMS, J.S. & GLEICH, G.J. (1991). Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils. J. Exp. Med., 174, 745-748.
25. LEUNG, D.Y. (1999). Pathogenesis of atopic dermatitis. J. Allergy Clin. Immunol., 104, S99-S108.
26. LIM, K.G., WAN, H.C., BOZZA, P.T., RESNICK, M.B., WONG, D.T., CRUIKSHANK, W.W., KORNFELD, H., CENTER, D.M. & WELLER, P.F. (1996). Human eosinophils elaborate the lymphocyte chemoattractants. IL-16 (lymphocyte chemoattractant factor) and RANTES. J. Immunol., 156, 2566-2570.
27. MAEDA, T., KITAZO, E.M., TADA, H., DE LLORENS, R., SALOMON, D.S., UEDA, M., YAMADA, H. & SENO, M. (2002). Growth inhibition of mammalian cells by eosinophil cationic protein. Eur. J. Biochem., 269, 307-316.
28. MARGUET, C., DEAN, T.P., BASUYAU, J.P. & WARNER, J.O. (2001). Eosinophil cationic protein and interleukin-8 levels in bronchial lavage fluid from children with asthma and infantile wheeze. Pediatr. Allergy Immunol., 12, 27-33.
29. MERTENS, A.V., DE CLERCK, L.S., MOENS, M.M., BRIDTS, C.H. & STEVENS, W.J. (1993). Study of eosinophil - endothelial adhesion, production of oxygen radicals and release of eosinophil cationic protein by peripheral blood eosinophils of patients with rheumatoid arthritis. Clin. Exp. Allergy, 23, 868-873.
30. MIZUMOTO, N., KUMAMOTO, T., ROBSON, S.C., SEVIGNY, J., MATSUE, H., ENJYOJI, K. & TAKASHIMA, A. (2002). CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nat. Med., 8, 358-365.
31. 2+ in human eosinophils: activation of purinergic P2Y receptors. J. Allergy Clin. Immunol., 107, 849-855.
32. MUKAIDA, N. (2000). Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation. Int. J. Hematol., 72, 391-398.
33. NORTH, R.A. & SURPRENANT, A. (2000). Pharmacology of cloned P2X receptors. Annu. Rev. Pharmacol. Toxicol., 40, 563-580.
34. OLSSON, I. & VENGE, P. (1972). Cationic proteins of human granulocytes. I. Isolation of the cationic proteins from the granules of leukaemic myeloid cells. Scand. J. Haematol., 9, 204-214.
35. OLSSON, I., VENGE, P., SPITZNAGEL, J.K. & LEHRER, R.I. (1977). Arginine-rich cationic proteins of human eosinophil granules: comparison of the constituents of eosinophilic and neutrophilic leukocytes. Lab. Invest., 36, 493-500.
36. PERREGAUX, D.G., MCNIFF, P., LALIBERTE, R., CONKLYN, M. & GABEL, C.A. (2000). ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood. J. Immunol., 165, 4615-4623.
37. PRONK-ADMIRAAL, C.J. & BARTELS, P.C. (2001). Total amount of ECP per eosinophil as indicator for the activity state of eosinophils. Scand J. Clin. Lab. Invest., 61, 453-457.
38. RALEVIC, V. & BURNSTOCK, G. (1998). Receptors for purines and pyrimidines. Pharmacol. Rev., 50, 413-492.
39. SHIGEMOTO-MOGAMI, Y., KOIZUMI, S., TSUDA, M., OHSAWA, K., KOHSAKA, S. & INOUE, K. (2001). Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J. Neurochem., 78, 1339-1349.
40. SIMON, H.U., YOUSEFI, S., WEBER, M., SIMON, D., HOLZER, C., HARTUNG, K. & BLASER, K. (1995). Human peripheral blood eosinophils express and release interleukin-8. Int. Arch. Allergy Immunol., 107, 124-126.
41. SUGIHARA, R., KUMAMOTO, T., ITO, T., UEYAMA, H., TOYOSHIMA, I. & TSUDA, T. (2001). Human muscle protein degradation in vitro by eosinophil cationic protein (ECP). Muscle Nerve, 24, 1627-1634.
42. TERAN, L.M., CARROLL, M.P., FREW, A.J., REDINGTON, A.E., DAVIES, D.E., LINDLEY, I., HOWARTH, P.H., CHURCH, M.K. & HOLGATE, S.T. (1996). Leukocyte recruitment after local endobronchial allergen challenge in asthma. Relationship to procedure and to airway interleukin-8 release. Am. J. Respir. Crit. Care Med., 154, 469-476.
43. VENGE, P., BYSTROM, J., CARLSON, M., HAKANSSON, L., KARAWACJZYK, M., PETERSON, C., SEVEUS, L. & TRULSON, A. (1999). Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease. Clin. Exp. Allergy, 29, 1172-1186.
44. VONEND, O., OBERHAUSER, V., VON KUGELGEN, I., APEL, T.W., AMANN, K., RITZ, E. & RUMP, L.C. (2002). ATP release in human kidney cortex and its mitogenic effects in visceral glomerular epithelial cells. Kidney Int., 61, 1617-1626.
45. VON KUEGELGEN, I. & WETTER, A. (2000). Molecular pharmacology of P2Y-receptors. Naunyn Schmiedebergs Arch. Pharmacol., 362, 310-323.
46. WARNY, M., ABOUDOLA, S., ROBSON, S.C., SEVIGNY, J., COMMUNI, D., SOLTOFF, S.P. & KELLY, C.P. (2001). P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide. J. Biol. Chem., 276, 26051-26056.
47. WELLER, P.F., RAND, T.H., BARRETT, T., ELOVIC, A., WONG, D.T. & FINBERG, R.W. (1993). Accessory cell function of human eosinophils. HLA-DR-dependent, MHC-restricted antigen-presentation and IL-1 alpha expression. J. Immunol., 150, 2554-2562.
48. YOUSEFI, S., HEMMANN, S., WEBER, M., HOLZER, C., HARTUNG, K., BLASER, K. & SIMON, H.U. (1995). IL-8 is expressed by human peripheral blood eosinophils. Evidence for increased secretion in asthma. J. Immunol., 154, 5481-5490.
49. ZIMMERMANN, H. (1992). 5′-Nucleotidase: molecular structure and functional aspects. Biochem. J., 285, 345-365.