EAE in the common marmoset Callithrix jacchus

International MS Journal

Volumn 10, Issue 1, 2003, Pages 6-12

  Uccelli, A ^a   Giunti, D ^a   Capello, E ^a   Roccatagliata, L ^a   Mancardi, G L ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Animal model; Experimental autoimmune encephalomyelitis; Marmose; Multiple sclerosis; Primate; Therapeutic strategies

Indexed keywords

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; AXONAL INJURY; B LYMPHOCYTE; CONTROLLED STUDY; DEMYELINATION; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; IMMUNE SYSTEM; MARMOSET; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYLOGENY; REVIEW; T LYMPHOCYTE;

ANIMALS; CALLITHRIX; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; MULTIPLE SCLEROSIS;

EID: 0038371194     PISSN: 13528963     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (26)

1. Lassmann H, Wekerle H. Experimental models of multiple sclerosis. In: McAlpine's Multiple Sclerosis (Compston DA, Ebers G, Lassmann H, MacDonald WI, Matthews WB, Weckerle H, eds). London: Churchill Livingstone, 2001; pp409-433.
2. Aharoni R, Teitelbaum D, Leitner O, Meshorer A, Sela M, Arnon R et al. Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1. Proc Natl Acad Sci U S A 2000; 97: 11472-11477.
3. Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N et al. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 1992; 356: 63-66.
4. Genain CP, Lee-Parritz D, Nguyen MH, Massacesi L, Joshi N, Ferrante R et al. In healthy primates, circulating autoreactive T cells mediate autoimmune disease. J Clin Invest 1994; 94: 1339-1345.
5. Uccelli A, Oksenberg JR, Jeong MC, Genain CP, Rombos T, Jaeger EE et al. Characterization of the TCRB chain repertoire in the New World monkey Callithrix jacchus. J Immunol 1997; 158: 1201-1207.
6. von Budingen HC, Hauser SL, Nabavi CB, Genain CP. Characterization of the expressed immunoglobulin IGHV repertoire in the New World marmoset Callithrix jacchus. Immunogenetics 2001; 53: 557-563.
7. Villinger F, Bostik P, Mayne A, King CL, Genain CP, Weiss WR et al. Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules. Immunogenetics 2001;53:315-328.
8. Antunes SG, de Groot NG, Brok H, Doxiadis G, Menezes AA, Otting N et al. The common marmoset: a new world primate species with limited Mhc class II variability. Proc Natl Acad Sci U S A 1998; 95: 11745-11750.
9. Massacesi L, Genain CP, Lee-Parritz D, Letvin NL, Canfield D, Hauser SL et al. Active and passively induced experimental autoimmune encephalomyelitis in common marmosets: a new model for multiple sclerosis. Ann Neurol 1995; 37: 519-530.
10. Brok HP, Uccelli A, Kerlero De Rosbo N, Bontrop RE, Roccatagliata L, de Groot NG et al. Myelin/oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis in common marmosets: the encephalitogenic T cell epitope pMOG24-36 is presented by a monomorphic MHC class II molecule. J Immunol 2000; 165: 1093-1101.
11. Genain CP, Nguyen MH, Letvin NL, Pearl R, Davis RL, Adelman M et al. Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate. J Clin Invest 1995; 96: 2966-2974.
12. Hart BA, Bauer J, Muller HJ, Melchers B, Nicolay K, Brok H et al. Histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis: a correlative study in the experimental autoimmune encephalomyelitis model in common marmosets (Callithrix jacchus). Am J Pathol 1998; 153: 649-663.
13. Jordan EK, McFarland HI, Lewis BK, Tresser N, Gates MA, Johnson M et al. Serial MR imaging of experimental autoimmune encephalomyelitis induced by human white matter or by chimeric myelin-basic and proteolipid protein in the common marmoset. AJNR Am J Neuroradiol 1999; 20: 965-976.
14. Mancardi G, Hart B, Roccatagliata L, Brok H, Giunti D, Bontrop R et al. Demyelination and axonal damage in a non-human primate model of multiple sclerosis. J Neurol Sci 2001; 184: 41-49.
15. Uccelli A, Giunti D, Mancardi G, Caroli F, Fiorone M, Seri M et al. Characterization of the response to myelin basic protein in a non human primate model for multiple sclerosis. Eur J Immunol 2001; 31: 474-479.
16. Ridsdale RA, Beniac DR, Tompkins TA, Moscarello MA, Harauz G. Three-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosis. J Biol Chem 1997; 272: 4269-4275.
17. Raine CS, Cannella B, Hauser SL, Genain CP. Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: a case for antigen-specific antibody mediation. Ann Neurol 1999; 46:144-160.
18. Villoslada P, Abel K, Heald N, Goertsches R, Hauser SL, Genain CP. Frequency, heterogeneity and encephalitogenicity of T cells specific for myelin oligodendrocyte glycoprotein in naive outbred primates. Eur J Immunol 2001; 31: 2942-2950.
19. McFarland HI, Lobito AA, Johnson MM, Nyswaner JT, Frank JA, Palardy GR et al. Determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis. J Immunol 1999; 162: 2384-2390.
20. Scarisbrick IA, Blaber SI, Lucchinetti CF, Genain CP, Blaber M, Rodriguez M. Activity of a newly identified serine protease in CNS demyelination. Brain 2002; 125:1283-1296.
21. Genain CP, Roberts T, Davis RL, Nguyen MH, Uccelli A, Faulds D et al. Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor. Proc Natl Acad Sci U S A 1995; 92: 3601-3605.
22. Genain CP, Gritz L, Joshi N, Panicali D, Davis RL, Whitaker JN et al. Inhibition of allergic encephalomyelitis in marmosets by vaccination with recombinant vaccinia virus encoding for myelin basic protein. J Neuroimmunol 1997; 79: 119-128.
23. Genain CP, Abel K, Belmar N, Villinger F, Rosenberg DP, Linington C et al. Late complications of immune deviation therapy in a nonhuman primate. Science 1996; 274: 2054-2057.
24. Laman JD, 't Hart BA, Brok H, Meurs M, Schellekens MM, Kasran A et al. Protection of marmoset monkeys against EAE by treatment with a murine antibody blocking CD40 (mu5D12). Eur J Immunol 2002; 32: 2218-2228.
25. Villoslada P, Hauser SL, Bartke I, Unger J, Heald N, Rosenberg D et al. Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system. J Exp Med 2000; 191: 1799-1806.
26. Poliani PL, Brok H, Furlan R, Ruffini F, Bergami A, Desina G et al. Delivery to the central nervous system of a nonreplicative herpes simplex type 1 vector engineered with the interleukin 4 gene protects rhesus monkeys from hyperacute autoimmune encephalomyelitis. Hum Gene Ther 2001; 12: 905-920.