Structure of imidazole glycerol phosphate synthase from Thermus thermophilus HB8: Open-closed conformational change and ammonia tunneling

Journal of Biochemistry

Volumn 132, Issue 5, 2002, Pages 759-765

  Omi, Rie ^a,b   Mizuguchi, Hiroyuki ^c   Goto, Masaru ^a,b   Miyahara, Ikuko ^a,b   Hayashi, Hideyuki ^c   Kagamiyama, Hiroyuki ^c   Hirotsu, Ken ^a,b  

^a Osaka Prefecture University   (Japan)

^b RIKEN   (Japan)

^c OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Ammonia tunnel; Conformational change; Glutamine amidotransferase; Imidazole glycerol phosphate synthase; Three dimensional structure; X ray crystallography

Indexed keywords

AMMONIA; BACTERIAL ENZYME; GLUTAMINE; IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE; UNCLASSIFIED DRUG; GLUTAMINASE; HYDROLASE;

ARTICLE; BIOSYNTHESIS; CONFORMATIONAL TRANSITION; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBUNIT; NONHUMAN; PROTEIN BINDING; STRUCTURE ANALYSIS; THERMUS THERMOPHILUS; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ENZYMOLOGY; METABOLISM; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; THERMOTOGA MARITIMA; THERMUS THERMOPHILUS;

AMINOHYDROLASES; AMMONIA; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GLUTAMINASE; GLUTAMINE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; THERMUS THERMOPHILUS;

EID: 0038325358     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a003284     Document Type: Article

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