Carbamoyl phosphate synthetase: Caught in the act of glutamine hydrolysis

Biochemistry

Volumn 37, Issue 25, 1998, Pages 8825-8831

  Thoden, James B ^a   Miran, Sophie G ^b   Phillips, James C ^c   Howard, Andrew J ^d   Raushel, Frank M ^b   Holden, Hazel M ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c BRUKER AXS INC   (United States)

^d Illinois Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMOYL PHOSPHATE; CARBAMOYL PHOSPHATE SYNTHASE; GLUTAMINE;

AMINO ACID SYNTHESIS; ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; UREA CYCLE;

ASPARAGINE; BINDING SITES; CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING); CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ESCHERICHIA COLI; GLUTAMINE; HISTIDINE; HYDROLYSIS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED;

ESCHERICHIA COLI;

EID: 0032560616     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9807761     Document Type: Article

References (21)

1. Thoden, J. B., Holden, H. M., Wesenberg, G., Raushel, F. M., and Rayment, I. (1997) Biochemistry 36, 6305-6316.
2. Thoden, J. B., Raushel, F. M., Benning, M. M., Rayment, I., and Holden, H. M. (1998) Acta Crystallogr. D (submitted for publication).
3. Zalkin, H. (1993) Adv. Enzymol. Relat. Areas Mol. Biol. 66, 203-309.
4. Mergeay, M., Gigot, D., Beckmann, J., Glansdorff, N., and Piérard, A. (1974) Mol. Gen. Genet. 133, 299-316.
5. Piette, J., Nyunoya, H., Lusty, C. J., Cunin, R., Weyens, G., Crabeel, M., Charlier, D., Glansdorff, N., and Piérard, A. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 4134-4138.
6. Tesmer, J. J. G., Klem, T. J., Deras, M. L., Davisson, V. J., and Smith, J. L. (1996) Nat. Struct. Biol. 3, 74-86.
7. Ollis, D. L., Cheah, E., Cygler, M., Dijkstra, B., Frolow, F., Franken, S. M., Harel, M., Remington, S. J., Silman, I., Schrag, J., Sussman, J. L., Verschueren, K. H. G., and Goldman, A. (1992) Protein Eng. 5, 197-211.
8. Khedouri, E., Anderson, P. M., and Meister, A. (1966) Biochemistry 5, 3552-3557.
9. Pinkus, L. M., and Meister, A. (1972) J. Biol. Chem. 247, 6119-6127.
10. Anderson, P. M., and Carlson, J. D. (1975) Biochemistry 14, 3688-3694.
11. Rubino, S. D., Nyunoya, H., and Lusty, C. J. (1986) J. Biol. Chem. 261, 11320-11327.
12. Miran, S. G., Chang, S. H., and Raushel, F. M. (1991) Biochemistry 30, 7901-7907.
13. Lusty, C. J. (1992) FEBS Lett. 314, 135-138.
14. Thoden, J. B., Raushel, F. M., Mareya, S., Tomchick, D., and Rayment, I. (1995) Acta Crystallogr. D51, 827-829.
15. Rossmann, M. G. (1972) The Molecular Replacement Method, Gordon and Breach, New York.
16. Navaza, J. (1994) Acta Crystallogr. A50, 157-163.
17. Tronrud, D. E., Ten Eyck, L. F., and Matthews, B. W. (1987) Acta Crystallogr. A43, 489-501.
18. Bricogne, G. (1976) Acta Crystallogr. A32, 832-847.
19. Ding, X., Rasmussen, B. F., Petsko, G. A., and Ringe, D. (1994) Biochemistry 33, 9285-9293.
20. Poland, B. W., Bruns, C., Fromm, H. J., and Honzatko, R. B. (1997) J. Biol. Chem. 272, 15200-15205.
21. Roux, B., and Walsh, C. T. (1993) Biochemistry 32, 3763-3768.