Crystal structure of imidazole glycerol phosphate synthase: A tunnel through a (β/α)8 barrel joins two active sites

Structure

Volumn 9, Issue 10, 2001, Pages 987-997

  Chaudhuri, Barnali N ^a,c   Lange, Stephanie C ^a,d   Myers, Rebecca S ^b   Chittur, Sridar V ^b   Davisson, V Jo ^b   Smith, Janet L ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ammonia tunnel; Glutamine amidotransferase; Histidine biosynthesis; Intermediate channeling

Indexed keywords

AMMONIA; GLUTAMINASE; IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; YEAST;

AMINOHYDROLASES; AMMONIA; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; GLUTAMINASE; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PHOSPHORUS-OXYGEN LYASES; PROTEIN STRUCTURE, SECONDARY; SACCHAROMYCES CEREVISIAE; TRANSFERASES;

MAMMALIA;

EID: 0034793603     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00661-X     Document Type: Article

References (44)

1. Enzymes utilizing glutamine as an amide donor
2. Structure of carbamoyl phosphate synthetase: A journey of 96 Å from substrate to product
3. Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site
4. Crosstalk and ammonia channeling between active centers in the unexpected domain arrangement of glutamate synthase
5. Three-dimensional structure of Escherichia coli asparagine synthetase B: A short journey from substrate to product
6. The molecular basis of substrate channeling
7. Imidazole glycerol phosphate synthase: The glutamine amidotransferase in histidine biosynthesis
8. Subunit interactions and glutamine utilization by Escherichia coli imidazole glycerol phosphate synthase
9. Cloning, primary structure, and regulation of the HIS7 gene encoding a bifunctional glutamine amidotransferase:cyclase from Saccharomyces cerevisiae
10. Expression and purification of imidazole glycerol phosphate synthase from Saccharomyces cerevisiae
11. The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families
12. The crystal structure of anthranilate synthase from Sulfolobus solfataricus: Functional implications
13. Mechanism for acivicin inactivation of triad glutamine amidotransferases
14. Imidazole glycerol phosphate synthase from Thermotoga maritima: Quaternary structure, steady-state kinetics and reaction mechanism of the bi-enzyme complex
15. Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion
16. Paralogous histidine biosynthetic genes: Evolutionary analysis of the Saccharomyces cerevisiae his6 and his7 genes
17. The α/β hydrolase fold
18. Carbamoyl phosphate synthetase: Caught in the act of glutamine hydrolysis
19. The small subunit of carbamoyl phosphate synthetase: Snapshots along the reaction pathway
20. Model bias in macromolecular crystal structures
21. Structural basis for the function of pyridoxine 5′-phosphate synthase
22. 2.0 Å structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: Possible determinants of protein stability
23. The TIM barrel - The most frequently occurring folding motif in proteins
24. Structural conservation in parallel beta/alpha-barrel enzymes that catalyze three sequential reactions in the pathway of tryptophan biosynthesis
25. Divergent evolution of a beta/alpha-barrel subclass: Detection of numerous phosphate-binding sites by motif search
26. 12 radicals are generated: The crystal structure of methylmalonyl-coenzyme A mutase at 2 Å resolution
27. 8-barrel enzyme into two folded halves
28. Processing of X-ray diffraction data collected in oscillatin mode
29. Automated structure solution for MIR and MAD
30. The CCP4 suite: Programs for protein crystallography
31. Improved methods for binding protein models in electron density maps and the location of errors in these models
32. Crystallography and NMR system (CNS): A new software system for macromolecular structure determination
33. The crystal and molecular structure of [N, N′-di(2-aminoethyl)malondiamidato]nickel (II) trihydrate
34. Model-building and refinement practice
35. PROCHECK: A program to check the stereochemical quality of protein structures
36. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
37. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
38. Detection, delineation, measurement and display of cavities in macromolecular structures
39. Quality control of protein models: Directional atomic contact analysis
40. Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
41. Molscript. A program to produce both detailed and schematic plots of protein structures
42. Further additions to MolScript version 1.4, including reading and contouring of electron-density maps
43. Raster3D: Photorealistic molecular graphics