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Volumn 41, Issue 2, 2000, Pages 155-162

The effects of gabapentin in the rat hippocampus are mimicked by two structural analogs, but not by nimodipine

Author keywords

Dentate gyrus; Diazepam; Gabapentin; Inhibition; Nimodipine; Pregabalin

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID DERIVATIVE; ANXIOLYTIC AGENT; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; DIAZEPAM; GABAPENTIN; GABAPENTIN DERIVATIVE; NIMODIPINE; PD 167345; PREGABALIN; UNCLASSIFIED DRUG; URETHAN;

EID: 0033870712     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(00)00134-0     Document Type: Article
Times cited : (16)

References (27)
  • 2
    • 0025323968 scopus 로고
    • Suppression of epileptiform burst discharges in CA3 neurons of rat hippocampal slices by the organic calcium channel blocker, verapamil
    • Aicardi G., Schwartzkroin P.A. Suppression of epileptiform burst discharges in CA3 neurons of rat hippocampal slices by the organic calcium channel blocker, verapamil. Exp. Brain Res. 81:1990;288-296.
    • (1990) Exp. Brain Res. , vol.81 , pp. 288-296
    • Aicardi, G.1    Schwartzkroin, P.A.2
  • 5
    • 0032521582 scopus 로고    scopus 로고
    • Dose-finding study with nimodipine: A selective central nervous system calcium channel blocker on aminophylline induced seizure models in rats
    • Chakrabarti A., Saini H.L., Garg S.K. Dose-finding study with nimodipine: a selective central nervous system calcium channel blocker on aminophylline induced seizure models in rats. Brain Res. Bull. 15:1998;495-499.
    • (1998) Brain Res. Bull. , vol.15 , pp. 495-499
    • Chakrabarti, A.1    Saini, H.L.2    Garg, S.K.3
  • 6
    • 0029975930 scopus 로고    scopus 로고
    • The novel anticonvulsant drug, gabapentin (neurontin), binds to the alpha2delta subunit of a calcium channel
    • Gee N.S., Brown J.P., Dissanayake V.U., Offord J., Thurlow R., Woodruff G.N. The novel anticonvulsant drug, gabapentin (neurontin), binds to the alpha2delta subunit of a calcium channel. J. Biol. Chem. 271:1996;768-776.
    • (1996) J. Biol. Chem. , vol.271 , pp. 768-776
    • Gee, N.S.1    Brown, J.P.2    Dissanayake, V.U.3    Offord, J.4    Thurlow, R.5    Woodruff, G.N.6
  • 7
    • 0032545736 scopus 로고    scopus 로고
    • Contribution of T-type calcium channels to afterdischarge generation in rat hippocampal slices
    • Higashima M., Kinoshita H., Koshino Y. Contribution of T-type calcium channels to afterdischarge generation in rat hippocampal slices. Brain Res. 781:1998;129-136.
    • (1998) Brain Res. , vol.781 , pp. 129-136
    • Higashima, M.1    Kinoshita, H.2    Koshino, Y.3
  • 8
    • 0028907754 scopus 로고
    • Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro
    • Honmou O., Kocsis J.D., Richerson G.B. Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro. Epilepsy Res. 20:1995;193-202.
    • (1995) Epilepsy Res. , vol.20 , pp. 193-202
    • Honmou, O.1    Kocsis, J.D.2    Richerson, G.B.3
  • 9
    • 0029033256 scopus 로고
    • The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: A field potential analysis
    • Honmou O., Oyelese A.A., Kocsis D. The anticonvulsant gabapentin enhances promoted release of GABA in hippocampus: a field potential analysis. Brain Res. 692:1995;273-277.
    • (1995) Brain Res. , vol.692 , pp. 273-277
    • Honmou, O.1    Oyelese, A.A.2    Kocsis, D.3
  • 10
    • 0024574179 scopus 로고
    • Evidence that repetitive seizures in the hippocampus cause a lasting reduction of GABAergic inhibition
    • Kapur J., Stringer J.L., Lothman E.W. Evidence that repetitive seizures in the hippocampus cause a lasting reduction of GABAergic inhibition. J. Neurophysiol. 61:1989;417-426.
    • (1989) J. Neurophysiol. , vol.61 , pp. 417-426
    • Kapur, J.1    Stringer, J.L.2    Lothman, E.W.3
  • 11
    • 0030052878 scopus 로고    scopus 로고
    • The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy
    • Petroff O.A., Rothman D.L., Behar K.L., Lamoureux D., Mattson R.H. The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy. Ann. Neurol. 39:1996;95-99.
    • (1996) Ann. Neurol. , vol.39 , pp. 95-99
    • Petroff, O.A.1    Rothman, D.L.2    Behar, K.L.3    Lamoureux, D.4    Mattson, R.H.5
  • 12
    • 0028345860 scopus 로고
    • Antiepileptics from gamma-aminobutyric acid
    • Satzinger G. Antiepileptics from gamma-aminobutyric acid. Arzneimittelforschung (Drug Res.). 44:1994;261-266.
    • (1994) Arzneimittelforschung (Drug Res.) , vol.44 , pp. 261-266
    • Satzinger, G.1
  • 13
    • 0031946435 scopus 로고    scopus 로고
    • Effects of phenytoin, carbamazepine and gabapentin on calcium currents in hippocampal granule cells from patients with temporal lobe epilepsy
    • Schumacher T.B., Beck H., Steinhauser C., Schramm J., Elger C.E. Effects of phenytoin, carbamazepine and gabapentin on calcium currents in hippocampal granule cells from patients with temporal lobe epilepsy. Epilepsia. 39:1998;355-363.
    • (1998) Epilepsia , vol.39 , pp. 355-363
    • Schumacher, T.B.1    Beck, H.2    Steinhauser, C.3    Schramm, J.4    Elger, C.E.5
  • 14
    • 0011617971 scopus 로고    scopus 로고
    • Gabapentin
    • S. Shorvon, F. Dreifuss, D. Fish, & D. Thomas. Oxford, UK: Blackwell Science
    • Shorvon S.D. Gabapentin. Shorvon S., Dreifuss F., Fish D., Thomas D. The Treatment of Epilepsy. 1996;429-437 Blackwell Science, Oxford, UK.
    • (1996) The Treatment of Epilepsy , pp. 429-437
    • Shorvon, S.D.1
  • 15
    • 0031809165 scopus 로고    scopus 로고
    • Gabapentin inhibits calcium currents in isolated rat brain neurons
    • Stefani A., Spandoni F., Bernardi G. Gabapentin inhibits calcium currents in isolated rat brain neurons. Neuropharmacology. 37:1998;83-91.
    • (1998) Neuropharmacology , vol.37 , pp. 83-91
    • Stefani, A.1    Spandoni, F.2    Bernardi, G.3
  • 16
    • 0028103918 scopus 로고
    • Picrotoxin-induced epileptic activity in hippocampal and neocortical slices (guinea pig): Suppression by organic calcium channel blockers
    • Straub H., Kohling R., Speckmann E.J. Picrotoxin-induced epileptic activity in hippocampal and neocortical slices (guinea pig): suppression by organic calcium channel blockers. Brain Res. 658:1994;119-126.
    • (1994) Brain Res. , vol.658 , pp. 119-126
    • Straub, H.1    Kohling, R.2    Speckmann, E.J.3
  • 18
    • 0024448645 scopus 로고
    • Repetitive seizures cause an increase in paired-pulse inhibition in the dentate gyrus
    • Stringer J.L., Lothman E.W. Repetitive seizures cause an increase in paired-pulse inhibition in the dentate gyrus. Neurosci. Lett. 105:1989;91-95.
    • (1989) Neurosci. Lett. , vol.105 , pp. 91-95
    • Stringer, J.L.1    Lothman, E.W.2
  • 19
    • 0024340386 scopus 로고
    • Maximal dentate activation: Characteristics and alterations after repeated seizures
    • Stringer J.L., Lothman E.W. Maximal dentate activation: characteristics and alterations after repeated seizures. J. Neurophysiol. 62:1989;136-143.
    • (1989) J. Neurophysiol. , vol.62 , pp. 136-143
    • Stringer, J.L.1    Lothman, E.W.2
  • 20
    • 0025208410 scopus 로고
    • Maximal dentate activation: A tool to screen compounds for activity against limbic seizures
    • Stringer J.L., Lothman E.W. Maximal dentate activation: a tool to screen compounds for activity against limbic seizures. Epilepsy Res. 5:1990;169-176.
    • (1990) Epilepsy Res. , vol.5 , pp. 169-176
    • Stringer, J.L.1    Lothman, E.W.2
  • 21
    • 0025143801 scopus 로고
    • Use of maximal dentate activation to study the effect of drugs on kindling and kindled responses
    • Stringer J.L., Lothman E.W. Use of maximal dentate activation to study the effect of drugs on kindling and kindled responses. Epilepsy Res. 6:1990;180-186.
    • (1990) Epilepsy Res. , vol.6 , pp. 180-186
    • Stringer, J.L.1    Lothman, E.W.2
  • 22
    • 0026728535 scopus 로고
    • Reverberatory seizure discharges in hippocampal-parahippocampal circuits
    • Stringer J.L., Lothman E.W. Reverberatory seizure discharges in hippocampal-parahippocampal circuits. Neurology. 116:1992;198-203.
    • (1992) Neurology , vol.116 , pp. 198-203
    • Stringer, J.L.1    Lothman, E.W.2
  • 23
    • 0001548658 scopus 로고
    • Gabapentin: Mechanism of action
    • R.H. Levy, R.H. Mattson, & B.S. Meldrum. New York: Raven Press
    • Taylor C.P. Gabapentin: mechanism of action. Levy R.H., Mattson R.H., Meldrum B.S. Antiepileptic Drugs. fourth ed. 1995;829-842 Raven Press, New York.
    • (1995) Antiepileptic Drugs Fourth Ed. , pp. 829-842
    • Taylor, C.P.1
  • 24
    • 0032613395 scopus 로고    scopus 로고
    • Mechanisms of new antiepileptic drugs
    • A.V. Delgado-Escueta, W.A. Wilson, R.W. Olson, Porter R.J. third ed. Philadelphia: Lippincott Williams and Wilkins
    • Taylor C.P. Mechanisms of new antiepileptic drugs. Delgado-Escueta A.V., Wilson W.A., Olson R.W., Porter R.J. third ed. Jasper's Basic Mechanisms of the Epilepsies: Advances in Neurology. 79:1999;1011-1032 Lippincott Williams and Wilkins, Philadelphia.
    • (1999) Jasper's Basic Mechanisms of the Epilepsies: Advances in Neurology , vol.79 , pp. 1011-1032
    • Taylor, C.P.1
  • 25
    • 0027458479 scopus 로고
    • Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin
    • Taylor C.P., Vartanian M.G., Yuen P.W., Bigge C., Suman-Chauhan N., Hill D.R. Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin. Epilepsy Res. 14:1993;11-15.
    • (1993) Epilepsy Res. , vol.14 , pp. 11-15
    • Taylor, C.P.1    Vartanian, M.G.2    Yuen, P.W.3    Bigge, C.4    Suman-Chauhan, N.5    Hill, D.R.6
  • 27
    • 0030839307 scopus 로고    scopus 로고
    • Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus
    • Xiong Z.-Q., Stringer J.L. Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus. Epilepsy Res. 27:1997;187-194.
    • (1997) Epilepsy Res. , vol.27 , pp. 187-194
    • Xiong, Z.-Q.1    Stringer, J.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.