Tryptophan catabolism and regulation of adaptive immunity

Journal of Immunology

Volumn 170, Issue 12, 2003, Pages 5809-5813

  Mellor, Andrew L ^a   Munn, David H ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD123 ANTIGEN; CD69 ANTIGEN; CD71 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR6; CYCLIN D3; CYCLIN DEPENDENT KINASE 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; TRYPTOPHAN; TRYPTOPHAN 2,3 DIOXYGENASE;

ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; CATABOLISM; CHRONIC INFLAMMATION; HUMAN; IMMUNITY; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOTHERAPY; INFECTION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; T LYMPHOCYTE ACTIVATION; TRYPTOPHAN METABOLISM; TUMOR IMMUNITY;

EID: 0038281451     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.12.5809     Document Type: Short Survey

References (40)

1. Steinman, R. M., and M. C. Nussenzweig. 2002. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad Sci. USA 99:351.
2. Maloy, K. J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2:816.
3. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389.
4. Lutz, M., and G. Schuler. 2002. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 23:445.
5. Munn, D. H., E. Shafizadeh, J. T. Attwood, I. Bondarev, A. Pashine, and A. L. Mellor. 1999. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J. Exp. Med. 189:1363.
6. Taylor, M. W., and G. Feng. 1991. Relationship between interferon-γ, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J. 5:2516.
7. Suzuki, S., S. Tone, O. Takikawa, T. Kubo, I. Kohno, and Y. Minatogawa. 2001. Expression of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase in early concepti. Biochem. J. 355:425.
8. + dendritic cells. Int. Immunol. 14:65.
9. Munn, D. H., M. D. Sharma, J. R. Lee, K. G. Jhaver, T. S. Johnson, D. B. Keskin, B. Marshall, P Chandler, S. J. Antonia, R. Burgess, et al. 2002. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 297:1867.
10. Mellor, A. L., and D. H. Munn. 1999. Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol. Today 20:469.
11. Hwu, P., M. X. Du, R. Lapointe, M. Do, M. W. Taylor, and H. A. Young. 2000. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J. Immunol. 164:3596.
12. Terness, P., T. M. Bauer, L. Rose, C. Dufter, A. Watzlik, H. Simon, and G. Opelz. 2002. Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J. Exp. Med. 196:447.
13. von Bubnoff, D., H. Matz, C. Frahnert, M. L. Rau, D. Hanau, H. de la Salle, and T. Bieber. 2002. FcεRI induces the tryptophan degradation pathway involved in regulating T cell responses. J. Immunol. 169:1810.
14. Grohmann, U., F. Fallarino, S. Silla, R. Bianchi, M. L. Belladonna, C. Vacca, A. Micheletti, M. C. Fioretti, and P. Puccetti. 2001. CD40 ligation ablates the tolerogenic potential of lymphoid dendritic cells. J. Immunol. 166:277.
15. + dendritic cells expressing indoleamine 2,3-dioxygenase. J. Immunol. 167:708.
16. Lee, G. K., H. J. Park, M. Macleod, P. Chandler, D. H. Munn, and A. L. Mellor. 2002. Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division. Immunology 107:1.
17. Grohmann, U., C. Orabona, F. Fallarino, C. Vacca, F. Calcinaro, A. Falorni, P. Candeloro, M. L. Belladonna, R. Bianchi, M. C. Fioretti, and P. Puccetti. 2002. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat. Immunol. 3:1097.
18. Shortman, K., and Y. J. Liu. 2002. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2:151.
19. Bodaghi, B., O. Goureau, D. Zipeto, L. Laurent, J. L. Virelizier, and S. Michelson. 1999. Role of lFN-γ-induced indoleamine 2,3 dioxygenase and inducible nitric oxide syntahse in the replication of human cytomegalovirus in retinal pigment epithelial cells. J. Immunol. 162:957.
20. Thomas, S. R., H. Salahifar, R. Mashima, N. H. Hunt, D. R. Richardson, and R. Stocker. 2001. Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-γ-activated human macrophages: posttranslational regulation by pyrrolidine dithiocarbamate. J. Immunol. 166:6332.
21. Gorczynski, R. M., S. Hadidi, G. Yu, and D. A. Clark. 2002. The same immunoregulatory molecules contribute to successful pregnancy and transplantation. Am. J. Reprod. Immunol. 48:18.
22. Finger, E. B., and J. A. Bluestone. 2002. When ligand becomes receptor - tolerance via B7 signaling on DCs. Nat. Immunol. 3:1056.
23. Fallarino, F., U. Grohmann, C. Vacca, R. Bianchi, C. Orabona, A. Spreca, M. C. Fioretti, and P. Puccetti. 2002. T cell apoptosis by tryptophan catabolism. Cell Death Differ. 9:1069.
24. Munn, D. H., J. Pressey, A. C. Beall, R. Hudes, and M. R. Alderson. 1996. Selective activation-induced apoptosis of peripheral T cells imposed by macrophages: a potential mechanism of antigen-specific peripheral lymphocyte deletion. J. Immunol. 156:523.
25. Munn, D. H., M. Zhou, J. T. Attwood, I. Bondarev, S. J. Conway; B. Marshall, C. Brown, and A. L. Mellor. 1998. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281:1191.
26. Miki, T., H. Sun, Y. Lee, A. Tandin, A. M. Kovscek, V. Subbotin, J. J. Fung, and L. A. Valdivia. 2001. Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts. Transplant. Proc. 33:129.
27. Sakurai, K., J. P. Zou, J. R. Tschetter, J. M. Ward, and G. M. Shearer. 2002. Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 129:186.
28. Friberg, M., R. Jennings, M. Alsarraj, S. Dessureault, A. Cantor, M. Extermenn. A. L. Mellor, D. H. Munn, and S. J. Antonia. 2002. Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection. Int. J. Cancer 101:151.
29. Mellor, A. L., D.B. Keskin, T. Johnson, P. Chandler, and D. H. Munn. 2002. Cells expressing indoleamine 2,3 dioxygenase inhibit T cell responses. J. Immunol. 168:3771.
30. Alexander, A. M., M. Crawford, S. Bertera, W. A. Rudert, O. Takikawa, P. D. Robbins, and M. Trucco. 2002. Indoleamine 2,3-dioxygenase expression in transplanted NOD islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes 51:356.
31. Miki, T., H. Sun, Y. Lee, A. Tandin, A. M. Kovscek, V. Subbotin, J. J. Fung, and L. A. Valdivia. 2001. Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts. Transplant. Proc. 33:129.
32. Harding, H. P., I. Novoa, Y. Zhang, H. Zeng, R. Wek, M. Schapira, and D. Ron. 2000. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 6:1099.
33. Dever, T. E. 2002. Gene-specific regulation by general translation factors. Cell 108:545.
34. Fernandez, J., I. Yaman, P. Sarnow, M. D. Snider, and M. Hatzoglou. 2002. Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the tranlation initiation factor eIF2α. J. Biol. Chem. 277:19198.
35. Bonney, E. A., and P. Matzinger. 1998. Much IDO about pregnancy. Nat. Med. 4:1128.
36. Ozaki, Y., M. P. Edelstein, and D. S. Duch. 1988. Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon γ. Proc. Natl. Acad. Sci. USA 85:1242.
37. Thomas, S. M., L. F. Garrity, C. R. Brandt, C. S. Schobert, G. S. Feng, M. W. Taylor, J. M. Carlin, and G. I. Byrne. 1993. IFN-γ-mediated antimicrobial response: indolemaine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplama growth. J. Immunol. 150:5529.
38. Pfefferkorn, E. R. 1984. Interferon γ blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc. Natl. Acad. Sci. USA 81:908.
39. Frumento, G., R. Rotondo, M. Tonetti, G. Damonte, U. Benatti, and G. B. Ferrara. 2002. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J. Exp. Med. 196:459.
40. Grant, R. S., H. Naif, S. J. Thuruthyil, N. Nasr, T. Littlejohn, O. Takikawa, and V. Kapoor. 2000. Induction of indoleamine 2,3-dioxygenase in primary human macrophages by human immunodeficiency virus type 1 is strain dependent. J. Virol. 74:4110.