Rescue of MODY-1 by agonist ligands of hepatocyte nuclear factor-4α

Journal of Biological Chemistry

Volumn 278, Issue 25, 2003, Pages 22578-22585

  Hertz, Rachel ^a   Ben Haim, Nadav ^a   Petrescu, Anca D ^b   Kalderon, Bella ^a   Berman, Inna ^a   Eldad, Naama ^a   Schroeder, Friedhelm ^b   Bar Tana, Jacob ^a  

^a HEBREW UNIVERSITY   (Israel)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; FATTY ACIDS; MUTAGENESIS;

LIGANDS;

BIOCHEMISTRY;

FATTY ACID; GLUTAMINE; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LIGAND; UNCLASSIFIED DRUG;

AGONIST; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIGAND BINDING; MATURITY ONSET DIABETES MELLITUS; MISSENSE MUTATION; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; TRANSACTIVATION;

ACYL COENZYME A; AMINO ACID SUBSTITUTION; ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CERCOPITHECUS AETHIOPS; COS CELLS; DIABETES MELLITUS, TYPE 2; DNA-BINDING PROTEINS; HELA CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; KINETICS; LIGANDS; MUTATION, MISSENSE; PHOSPHOPROTEINS; RECOMBINANT PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; VARIATION (GENETICS);

ANIMALIA;

EID: 0038265502     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212138200     Document Type: Article

References (43)

1. Sladek, F. M., Zhong, W., Lai, E., and Darnell, J. E., Jr. (1990) Genes Dev. 4, 2353-2365
2. Sladek, F. M. (1994) Liver Gene Expression (Tronche, F., and Yaniv, M., eds) pp. 207-230, VRG Landes Co., Austin, TX
3. Duncan, S. A., Nagy, A., and Chan, W. (1997) Development 124, 279-287
4. Stoffel, M., and Duncan, S. A. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 13209-13214
5. Li, J., Ning, G., and Duncan, S. A. (2000) Genes Dev. 14, 464-474
6. Shih, D. Q., Dansky, H. M., Fleisher, M., Assmann, G., Fajans, S. S., and Stoffel, M. (2000) Diabetes 49, 832-837
7. Wang, H. Y., Maechler, P., Antinozzi, P. A., Hagenfeldt, K. A., and Wollheim, C. B. (2000) J. Biol. Chem. 275, 35953-35959
8. Hayhurst, G. P., Lee, Y. H., Lambert, G., Ward, J. M., and Gonzalez, F. J. (2001) Mol. Cell. Biol. 21, 1393-1403
9. Yamagata, K., Oda, N., Kaisaki, P. J., Menzel, S., Furuta, H., Vaxillaire, M., Southam, L., Cox, R. D., Lathrop, G. M., Boriraj, V. V., Chen, X. N., Cox, N. J., Oda, Y., Yano, H., LeBeau, M. M., Yamada, S., Nishigori, H., Takeda, J., Fajans, S. S., Hattersley, A. T., Iwasaki, N., Hansen, T., Pedersen, O., Polonsky, K. S., Turner, R. C., Velho, G., Chevre, J. C., Froguel, P., and Bell, G. I. (1996) Nature 384, 458-460
10. Hani, E., Suaud, L., Boutin, P., Chevre, J. C., Durand, E., Philippi, A., Demenais, F., Vionnet, N., Furuta, H., Velho, G., Bell, G. I., Laine, B., and Froguel, P. (1998) J. Clin. Invest. 101, 521-526
11. Suaud, L., Hemimou, Y., Formstecher, P., and Laine, B. (1999) Diabetes 48, 1162-1167
12. Navas, M. A., Munoz-Elias, E. J., Kim, J., Shih, D., and Stoffel, M. (1999) Diabetes 48, 1459-1465
13. Lausen J, Thomas H, Lemm I, Bulman M, Borgschulze M, Lingott A, Hatterseley, A. T., and Ryffel, G. U. (2000) Nucleic Acids Res. 28, 430-437
14. Eeckhoute, J., Formstecher, P., and Laine, B. (2001) Mol. Endocrinol. 15, 1200-1210
15. Laine, B., Eeckhoute, J., Suaud, L., Briche, I., Furuta, H., Bell, G. I., and Formstecher, P. (2000) FEBS Lett. 479, 41-45
16. Yang, Q., Yamagata, K., Yamamoto, K., Cao, Y., Miyagawa, J., Fukamizu, A., Hanafusa, T., and Matsuzawa, Y. (2000) Diabetologia 43, 520-524
17. Ryffel, G. U. (2001) J. Mol. Endocrinol. 27, 11-29
18. Doria, A., and Plengvidhya, N. (2000) Curr. Opin. Endocrinol. Diabetes 7, 203-210
19. Bartoov-Shifman, R., Hertz, R., Wang, H. Y., Wollheim, C. B., Bar-Tana, J., and Walker, M. D. (2002) J. Biol. Chem. 277, 25914-25919
20. Zannis, V. I., Kan, H. Y., Kritis, A., Zanni, E., and Kardassis, D. (2001) Front. Biosci. 6, 456-504
21. Hertz, R., Magenheim, J., Berman, I., and Bar-Tana, J. (1998) Nature 392, 512-516
22. Hertz, R., Sheena, V., Kalderon, B., Berman, I., and Bar-Tana J. (2001) Biochem. Pharmacol. 61, 1057-1062
23. Petrescu, A. D., Hertz, R., Bar-Tana, J., Schroeder, F., and Kier, A. B. (2002) J. Biol. Chem. 277, 23988-23999
24. Wisely, G. B., Miller, A. B., Davis, R. G., Thomquest, A. D., Jr., Johnson, R., Spitzer, T., Sefler, A., Shearer, B., Moore, J. T., Miller, A. B., Willson, T. M., and Williams, S. P. (2002) Structure (Lond.) 10, 1225-1234
25. Dhe-Paganon, S., Duda, K., Iwamoto, M., Chi, Y. I., and Shoelson, S. E. (2002) J. Biol. Chem. 277, 37973-37976
26. Rajas, F., Gautier, A., Bady, I., Montano, S., and Mithieux, G. (2002) J. Biol. Chem. 277, 15736-15744
27. Yoshida, E., Aratani, S., Itou, H., Miyagishi, M., Takiguchi, M., Osumu, T., Murakami, K., and Fukamizu, A. (1997) Biochem. Biophys. Res. Commun. 241, 664-669
28. Wang, J. C., Stafford, J. M., and Grannder, D. K. (1998) J. Biol. Chem. 273, 30847-30850
29. Dell, H., and Hadzopoulou-Cladaras, M. (1999) J. Biol. Chem. 274, 9013-9021
30. Yoon, J. C., Puigserver, P., Chen, G. X., Donovan, J., Wu, Z. D., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., Newgard, C. B., and Spiegelman, B. M. (2001) Nature 413, 131-138
31. Kunkel, T. A., Roberts, J. D., and Zakour, R. A. (1987) Methods Enzymol. 154, 367-382
32. Hertz, R., Bishara-Shieban, J., and Bar-Tana, J. (1995) J. Biol. Chem. 270, 13470-13475
33. Segel, I. H. (1981) Enzyme Kinetics, p. 365-375, John Wiley & Sons, Inc., New York
34. Bulman, M. P., Dronsfield, M. J., Frayling, T., Appleton, M., Bain, S. C., Ellard, S., and Hattersley, A. T. (1997) Diabetologia 40, 859-862
35. Moller, A. M., Urhammer, S. A., Dalgaard, L. T., Reneland, R., Berglund, L., Hansen, T., Clausen, J. O., Lithell, H., and Pedersen, O. (1997) Diabetologica 40, 980-983
36. Vivat, V., Zechel, C., Wurtz, J. M., Bourguet, W., Kagechika, H., Umemiya, H., Shudo, K., Moras, D., Gronemeyer, H., and Chambon, P. (1997) EMBO J. 16, 5697-5709
37. Bourguet, W., Vivat, V., Wurtz, J. M., Chambon, P., Gronemeyer, H., and Moras, D. (2000) Mol. Cell 5, 289-298
38. Kistanova, E., Dell, H., Tsantili, P., Falvey, E., Cladaras, C., and Hadzopoulou-Cladaras, M. (2001) Biochem. J. 356, 635-642
39. Egea, P. F., Mitschler, A., and Moras, D. (2002) Mol. Endocrinol. 16, 987-997
40. Radominska-Pandya, A., and Chen, G. (2002) Biochemistry 41, 4883-4890
41. Mata de Urquiza, A., Liu, S., Sjoberg, M., Zetterstrom. R. H., Griffiths, W., Sjovall, J., and Perlmann, T. (2000) Science 290, 2140-2144
42. Takeda, T., Suzuki, S., Liu, R. T., and DeGroot, L. J. (1995) J. Clin. Endocrinol. Metab. 80, 2033-2040
43. Gardezi, S. A., Nguyen, C., Malloy, P. J., Posner, G. H., Feldman, D., and Peleg, S. (2001) J. Biol. Chem. 276, 29148-29156