Suppression of hepatocyte nuclear factor-4α by acyl-CoA thioesters of hypolipidemic peroxisome proliferators

Biochemical Pharmacology

Volumn 61, Issue 9, 2001, Pages 1057-1062

  Hertz, Rachel ^a   Sheena, Vered ^a   Kalderon, Bella ^a   Berman, Ina ^a   Bar Tana, Jacob ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

Apo C III; Fibrates; Hypolipidemic drugs; Lipoproteins; Medica; PPAR

Indexed keywords

ACYL COENZYME A; ANTILIPEMIC AGENT; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; APOLIPOPROTEIN C3; CLOFIBRIC ACID; DICARBOXYLIC ACID; HEPATOCYTE NUCLEAR FACTOR 4; NAFENOPIN; PEROXISOME PROLIFERATOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ESTERIFICATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HYPOLIPEMIA; KNOCKOUT MOUSE; LIVER CELL; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION;

ANIMALS; ANTILIPEMIC AGENTS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; COS CELLS; DNA-BINDING PROTEINS; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; LIVER; PALMITIC ACIDS; PEROXISOME PROLIFERATORS; PHOSPHOPROTEINS; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0035342271     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00578-0     Document Type: Article

References (20)

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2. Hepatocyte nuclear factor 4 (HNF-4)
3. Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α
4. Dietary influences on serum lipids and lipoproteins
5. Inhibition of lipid synthesis by β,β′-tetramethyl-substituted C14-C22 α,ω dicarboxylic acids in the rat in vivo
6. Hypolipidaemic drugs are activated to acyl-CoA esters in isolated rat hepatocytes. Detection of drug activation by human liver homogenates and by human platelets
7. TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4
8. Isolation and quantitation of long-chain acyl-coenzyme A esters in brain tissue by solid phase extraction
9. Ligand-induced alteration of the protease sensitivity of retinoid-X receptor alpha
10. Inhibition of acyl-CoA synthetase by triacsins
11. Analysis of long chain fatty acyl coenzyme A thioesters by negative ion fast-atom bombardment mass spectrometry and tandem mass spectrometry
12. Mode of action of peroxisome proliferators as hypolipidemic drugs: Suppression of apolipoprotein C-III
13. Transcriptional activation by amphipathic carboxylic peroxisome proliferators is induced by the free acid rather than the acyl-CoA derivative
14. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptor α and δ
15. Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates
16. The effect of β,β′-methyl-substituted hexadecanedioic acid on plasma VLDL metabolism in rats: Role of apolipoprotein C-III
17. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
18. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
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