The genetic relationship to periodontal disease

Periodontology 2000

Volumn 32, Issue , 2003, Pages 36-49

  Nares, Salvador ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; DNA; FC RECEPTOR; FORMYLMETHIONYLLEUCYLPHENYLALANINE; ISOPROTEIN; LIGAND; RNA; FORMYLPEPTIDE RECEPTOR; HLA ANTIGEN; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 1; RECEPTOR;

ALLELE; ALTERNATIVE RNA SPLICING; AUTOSOMAL DOMINANT INHERITANCE; AUTOSOMAL RECESSIVE INHERITANCE; AUTOSOME; BIOTECHNOLOGY; DIZYGOTIC TWINS; EXON; FRAMESHIFT MUTATION; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; GENETIC POLYMORPHISM; GENOME; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HLA SYSTEM; HOMOZYGOSITY; HUMAN; IMMUNE SYSTEM; IMPLANTATION; INTRON; MOLECULAR CLONING; MOLECULAR PHYLOGENY; MONOZYGOTIC TWINS; PERIODONTAL DISEASE; PERIODONTICS; PHENOTYPE; POPULATION RESEARCH; REVIEW; RNA SPLICING; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE; X CHROMOSOME LINKAGE; GENETICS; HUMAN GENOME PROJECT; IMMUNOLOGY; NOMENCLATURE; PERIODONTITIS; RACE; TOOTH IMPLANTATION; TWINS;

CONTINENTAL POPULATION GROUPS; DENTAL IMPLANTS; HLA ANTIGENS; HUMAN GENOME PROJECT; HUMANS; INTERLEUKIN-1; PERIODONTITIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, IGG; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PEPTIDE; TERMINOLOGY; TWIN STUDIES;

EID: 0038262812     PISSN: 09066713     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0906-6713.2002.03204.x     Document Type: Review

References (96)

1. Abbas AK, Lichtman AH, Pober JS. The major histocompatibility complex. In: Abbas AK, ed. Cellular and Molecular Immunology. Philadelphia: WB Sanders, 1997: 97-114.
2. Armitage GC, Wu Y, Wang HY, Sorrell J, di Giovine FS, Duff GW. Low prevalence of a periodontitis-associated interleukin-1 composite genotype in individuals of Chinese heritage. J Periodontol 2000: 71: 164-171.
3. Baltimore D. Our genome unveiled. Nature 2001: 409: 814-816.
4. Bazrafshani MR, Hajeer AH, Ollier WER, Thornhill MH. IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS). Genes Immun 2002: 3: 302-305.
5. Bonfil JJ, Dillier FL, Mercier P, Reviron D, Foti B, Sambuc R, Brodeur JM, Sedarat C. A "case control" study on the role of HLA DR4 in severe periodontitis. Identification of types and subtypes using molecular biology (PCR.SSO). J Clin Periodontol 1999: 26: 77-84.
6. Brown LJ, Löe H. Prevalence, extent, severity and progression of periodontal disease. Periodontol 2000 1993: 2: 57-71.
7. Caffesse RG, De La Rosa MR, De La Rosa MG, Mota LF. Prevalence of interleukin 1 periodontal genotype in a Hispanic dental population. Quintessence Int 2002: 33: 190-194.
8. Caffesse RG, De La Rosa MR, De La Rosa MG, Weltman R. Effect of interleukin-1 gene polymorphism in a periodontally healthy Hispanic population treated with mucogingival surgery. J Clin Periodontol 2002: 29: 177-181.
9. Cattabriga M, Rotundo R, Muzzi L, Nieri M, Verrocchi G, Cairo F, Pini Prato G. Retrospective evaluation of the influence of the interleukin-1 genotype on radiographic bone levels in treated periodontal patients over 10 years. J Periodontol 2001: 72: 767-773.
10. Cianciola LJ, Genco RJ, Patters MR, McKenna J, van Oss CJ. Defective polymophonuclear leukocyte function in a human periodontal disease. Nature 1977: 265: 445-447.
11. Clark RA, Page RC, Wilde G. Defective neutrophil chemotaxis in juvenile periodontitis. Infect Immun 1977: 18: 694-700.
12. Clark WB, Löe H. Mechanism of initiation and progression of periodontal disease. Periodontol 2000 1993: 2: 72-82.
13. Collins FS. Shattuck Lecture: medical and societal consequences of the Human Genome Project. N Engl J Med 1999: 341: 28-37.
14. Collins FS, McKusick VA. Implications of the Human Genome Project for medical science. J Am Med Assoc 2001: 285: 540-544.
15. Colombo AP, Eftimiadi C, Ahffajee AD, Cugini MA, Socransky SS. Serum IgG2, Gm(23) allotype and FCgamma RIIa and FCgammaRIIIb receptors in refractory periodontal disease. J Clin Periodontol 1998: 25: 465-474.
16. Cullinan MP, Westerman B, Hamlet SM, Palmer JE, Faddy MJ, Lang NP, Seymour GJ. A longitudinal study of interleukin-1 gene polymorphisms and the periodontal disease in a general adult population. J Clin Periodontol 2001: 28: 1137-1144.
17. Czarnik AW. Illuminating the SNP genomic code. Mod Drug Disc 1998: November/December: 49-54.
18. Diehl SR, Wang Y, Brooks CN, Burmeister JA, Califano W, Wang S, Schenkein HA. Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis. J Periodontol 1999: 70: 418-430.
19. De Sanctis M, Zucchelli G. Interleukin-1 gene polymorphisms and long-term stability following guided tissue regeneration therapy. J Periodontol 2000: 71: 606-613.
20. Dowsett SA, Archila L, Segreto VA, Eckert GJ, Kowolik MJ. Periodontal disease status of an indigenous population of Guatemala, Cental America. J Clin Periodontol 2001: 28: 663-671.
21. Ehmke B, Kress W, Karch H, Grimm T, Klaiber B, Flemmig TF. Interleukin-1 haplotype and periodontal disease progression following therapy. J Clin Periodontol 1999: 26: 810-813.
22. Engebretson SP, Lamster IB, Herrera-Abreu M, Celenti RS, Timms JM, Chaudhary AG, di Giovine FS, Kornman KS. The influence of interleukin gene polymorphism on expression of interleukin-1beta and tumor necrosis factor-alpha in periodontal tissue and gingival crevicular fluid. J Periodontol 1999: 70: 567-573.
23. Engebretson SP, Grbic JT, Singer R, Lamster IB. IL-1β profiles in periodontal disease. J Clin Periodontol 2002: 29: 48-53.
24. Fu Y, Korostoff JM, Fine DH, Wilson ME. Fcγ receptor genes as risk markers for localized aggressive periodontitis in African Americans. J Periodontol 2002: 73: 517-523.
25. Galbraith GM, Hendley TM, Sanders JJ, Palesch Y, Pandey JP. Polymorphic cytokine genotypes as markers of disease severity in adult periodontitis. J Clin Periodontol 1999: 26: 705-709.
26. Gore EA, Sanders JJ, Pandey JP, Palesch Y, Galbraith GM. Interleukin-1 beta +3953 allele 2: association with disease status in adult periodontitis. J Clin Periodontol 1998: 25: 781-785.
27. Grant SFA, Reid DM, Blake G, Herd R, Fogelman I, Ralston SH. Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nat Genet 1996: 14: 203-205.
28. Greenstein G, Hart TC. A critical assessment of interleukin-1 (IL-1) genotyping when used in a genetic susceptibility test for severe chronic periodontitis. J Periodontol 2002: 73: 231-247.
29. Gustke CJ, Stein SH, Hart TC, Hoffman WH, Hanes PJ, Russell CM, Schuster GS, Watson SC. HLA-DR alleles are associated with IDDM, but not with impaired neutrophil chemotaxis in IDDM. J Dent Res 1998: 77: 1497-1503.
30. Gwinn MR, Sharma A, De Nardin E. Single nucleotide polymorphisms of the n-formyl peptide receptor in localized juvenile periodontitis. J Periodontol 1999: 70: 1194-1201.
31. Hart TC, Kornman KS. Genetic factors on the pathogenesis of periodontitis. Periodontol 2000 1997: 14: 202-215.
32. Hart TC, Zhang Y, Gorry MC, Hart S, Cooper M, Marazita ML, Marks JM, Cortelli JR, Pallos D. A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. Am J Hum Genet 2002: 70: 943-954.
33. Hodge PJ, Riggio MP, Kinane DF. Failure to detect an association with IL-1 genotypes in European Caucasians with generalized early onset periodontitis. J Clin Periodontol 2001: 28: 430-436.
34. Hoffmann SC, Stanley EM, Cox ED, DiMercurio BS, Koziol DE, Harlan DM, Kirk AD, Blair PJ. Ethnicity greatly influences gene polymorphism distribution. Am J Transplant 2002: 2: 560-567.
35. Hudson KL, Rothenberg KH, Andrews LB, Kahn MJE, Collins FS. Genetic discrimination and health insurance: an urgent need for reform. Science 1995: 270: 391-393.
36. International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 2001: 409: 860-921.
37. Izakovičová Hollá L, Fassmann A, Vaš ků A, Znojil V, Vaně KJ, Vácha J. Interactions of lymphotoxin α (TNF-β), angiotensin-converting enzyme (ACE), and endothelin-1 (ET-1) gene polymorphisms in adult periodontitis. J Periodontol 2001: 72: 85-89.
38. Kasperk CH, Borcsok I, Schairer HU, Schneider U, Nawroth PP, Niethard FU, Ziegler R. Endothelin-1 is a potent regulator of human bone metabolism in vitro. Calcif Tissue Int 1997: 60: 368-374.
39. King MC, Wilson AC. Evolution at two levels in humans and chimpanzees. Science 1975: 188: 107-116.
40. Kobayashi T, Westerdaal NA, Miyazaki A, van der Pol WL, Suzuki T, Yoshie H, van de Winkel JG, Hara K. Relevance of immunoglobulin G Fc receptor polymorphism to recurrence of adult periodontitis in Japanese patients. Infect Immun 1997: 65: 3556-3560.
41. Kobayashi T, Sugita N, van der Pol WL, Nunokawa Y, Westerdaal NA, Yamamoto K, van de Winkel JG, Yoshie H. J Periodontol 2000: 71: 1425-1432.
42. Kobayashi T, van der Pol WL, van de Winkel JG, Hara K, Sugita N, Westerdaal NA, Yoshie H, Horigome T. Relevance of IgG receptor IIIb (CD16) polymorphism of Porphymonas gingivalis: implications for the pathogenesis of adult periodontitis. J Periodontal Res 2000: 35: 65-73.
43. Kobayashi T, Yamamoto K, Sugita N, van der Pol WL, Yusuda K, Kananko S, van de Winkel JG, Yoshie H. J Periodontol 2001: 72: 1324-1331.
44. Kocher T, Sawaf H, Fanghanel J, Timm R, Meisel P. Association between bone loss in periodontal disease and polymorphism of N-acetyltransferase (NAT2). J Clin Periodontol 2002: 29: 21-27.
45. Koene HR, Kleijer M, Algra J et al. FcγRIIIa-158V/F polymorphism influences the binding ogf IgG by natural killer cell FcγRIIIa, independently of the FcγRIIIa-48L/R/H phenotype. Blood 1997: 90: 1109-1114.
46. Kornman KS, Crane A, Wang HY, di Giovine FS, Newman MG, Pirk FW, Wilson TG Jr, Higginbottom FL, Duff GW. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 1997: 24: 72-77.
47. Kwok PY, Gu Z. SNP libraries: why and how are we building them? Mol Med Today 1999: 12: 538-543.
48. Laine ML, Farŕe MA, García-González MA, van Dijk LJ, Ham AJ, Winkel EG, Crusius JBA, Vandenbroucke JP, van Winkelhoff AJ, Peña AS. Polymorphisms of the interleukin-1 gene family, oral microbial pathogens, and smoking in adult periodontitis. J Dent Res 2001: 80: 1695-1699.
49. Lang NP, Tonetti MS, Suter J, Sorrell J, Duff GW, Kornman KS. Effect of interleukin-1 gene polymorphisms on gingival inflammation assessed by bleeding on probing in a periodontal maintenance population. J Periodontal Res 2000: 35: 102-107.
50. Lavine WS, Maderazo EG, Stolman J, Ward PA, Cogen RB, Greenblatt I, Robertson PB. Impaired neutrophil chemotaxis in patients with juvenile and rapidy progressing periodontitis. J Periodontal Res 1979: 14: 10-19.
51. Lerner UH. Regulation of bone metabolism by the kallikrein-kinin system, the coagulation cascade, and acute-phase reactants. Oral Surg Oral Med Oral Pathol 1994: 78: 481-494.
52. th edn. New York: WH Freeman, 2000: 254-293.
53. Löe H, Brown LJ. Early-onset periodontitis in the United States of America. J Periodontol 1989: 62: 608-616.
54. Mark LL, Haffajee AD, Socransky SS, Kent RL Jr, Guerrero D, Komman K, Newman M, Stashenko P. Effect of the interleukin-1 genotype on monocyte IL-1 beta expression in subjects with adult periodontitis. J Periodontal Res 2000: 35: 172-177.
55. McDaniel TF, Garner CD, Miller DL, Jones RM. Comparing periodontal disease in identical twins: a case report. J Dent Hyg 1999: 73: 30-35.
56. McDevitt MJ, Wang HY, Knobelman C, Newman MG, di Giovine FS, Timms J, Duff GW, Kornman KS. Interleukin-1 genetic association with periodontitis in clinical practice. J Periodontol 2000: 71: 156-163.
57. Meisel P, Timm R, Sawaf H, Fanghanel J, Siegmund W, Kocher T. Polymorphism of the N-acetyltransferase (NAT2), smoking and the potential risk of periodontal disease. Arch Toxicol 2000: 74: 343-348.
58. Meisel P, Carlsson LE Sawaf H, Fanghaenel J, Greinacher A, Kocher T. Polymorphisms of Fc gamma-receptors RIIa, RIIIa, and RIIIb in patients with adult periodontitis. Genes Immunol 2001: 2: 258-262.
59. Meisel P, Siegemund A, Dombrowa S, Sawaf H, Fanghaenel J, Kocher T. Smoking and polymorphisms of the interleukin-1 gene cluster (IL-1alpha, IL-1beta and IL-1RN) in patients with periodontal disease. J Periodontol 2002: 73: 27-32.
60. Michalowicz BS, Aeppli D, Virag JG, Klump DG, Hinrichs JE, Segal NL, Bouichard TJ Jr, Pihlstrom BL. Periodontal findings in adult twins. J Periodontol 1991: 62: 293-299.
61. Michalowicz BS, Wolff LF, Klump D, Hinrichs JE, Aeppli DM, Bouchard TJ Jr, Pihlstrom BL. Periodontal bacteria in adult twins. J Periodontol 1999: 70: 263-273.
62. Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, Brooks CN, Koertge TE, Califano JV, Burmeister JA, Schenkein HA. Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol 2000: 71: 1699-1707.
63. Mitchell RS, Bell JC. Clinical implications of isoniazid blood levels in pulmonary tuberculosis. New Engl J Med 1957: 257: 1066-1070.
64. Morrison NA, Yeoman R, Kelly PJ, Eisman JA. Contribution of trans-acting factor alleles to normal physiological variability: Vitamin D receptor gene polymorphisms and circulating osteocalcin. Proc Natl Acad Sci USA 1992: 89: 6665-6669.
65. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA. Prediction of bone density from vitamin D receptor alleles. Nature 1994: 367: 284-287.
66. Nosaka Y, Tachi Y, Shimpuku H, Kawamura T, Ohura K. Association of calcitonin receptor gene polymorphisms with early marginal bone loss around endosseous implants. Int J Oral Maxillofac Implants 2002: 17: 38-43.
67. Ohyama H, Takashiba S, Oyaizu K, Nagai A, Naruse T, Inoko H, Kurihara H, Murayama Y. HLA Class II genotypes associated with early-onset periodontitis: DQB1 molecule primarily confers susceptibility to the disease. J Periodontol 1996: 67: 888-894.
68. st European Workshop on Periodontology. 1994: 23-41.
69. Papapanou PN, Neiderud AM, Sandros J, Dahlen G. Interleukin-1 gene polymorphism and periodontal status. A case-control study. J Clin Periodontol 2001: 28: 389-396.
70. Parkhill JM, Hennig BJ, Chapple IL, Heasman PA, Taylor JJ. Association of interleukin-1 gene polymorphisms with early-onset periodontitis. J Clin Periodontol 2000: 27: 682-689.
71. Peacock AJ, Dawes KE, Shock A, Gray AJ, Reeves JT, Laurent GJ. Endothelin-1 and endothelin-3 induce chemotaxis and replication of pulmonary artery fibroblasts. Am J Respir Cell Mol Biol 1992: 7: 492-499.
72. Peltonen L, McKusick VA. Genomics and medicine. Dissecting human disease in the postgenomic era. Science 2001: 291: 1224-1229.
73. Pennisi E. So many choices, so little money. Science 2001: 294: 82-85.
74. Rogers MA, Figliomeni L, Baluchova K, Tan AE, Davies G, Henry PJ, Price P. Do interleukin-1 polymorphisms predict the development of periodontitis or the success of dental implants? J Periodontal Res 2002: 37: 37-41.
75. Ronderos M, Pihlstrom BL, Hodges JS. Periodontal disease among indigenous people in the Amazon rain forest. J Clin Periodontol 2001: 28: 995-1003.
76. Rothenberg K, Fuller B, Rothstein M, Duster T, Ellis Kahn MJ, Cunningham R, Fine B, Hudson K, King MC, Murphy P, Swergold G, Collins F. Genetic information and the work-place: legislative approaches and policy challenges. Science 1997: 275: 1755-1757.
77. Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole SG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, McPherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 2001: 409: 928-933.
78. Shirodaria S, Smith J, McKay IJ, Kennett CN, Hughes FJ. Polymorphisms in the IL-1A gene are correlated with levels of interleukin-1alpha protein in gingival crevicular fluid of teeth with severe periodontal disease. J Dent Res 2000: 79: 1864-1869.
79. Socransky SS, Haffajee AD, Smith C, Duff GW. Microbiological parameters associated with IL-1 gene polymorphisms in periodontitis patients. J Clin Periodontol 2000: 27: 810-818.
80. Stephens JC, Schneider JA, Tanguay DA, Choi J, Acharya T, Stanley SE, Jiang R, Messer CJ, Chew A, Han JH, Duan J, Carr JL, Lee MS, Koshy B, Kumar AM, Zhang G, Newell WR, Windemuth A, Xu C, Kalbfleisch TS, Shaner SL, Arnold K, Schulz V, Drysdale CM, Nandabalan K, Judson RS, Ruano G, Vovis GF. Haplotype variation and linkage disequilibrium in 313 human genes. Science 2001: 293: 489-493.
81. Sugita N, Yamamoto K, Kobayashi T, van der Pol W, Horigome T, Yoshie H, van de Winkel JG, Hara K. Relevance of FCgamma RIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients. Clin Exp Immunol 1999: 117: 350-354.
82. Sugita N, Kobayashi T, Ando Y, Yoshihara A, Yamamoto K, van de Winkel JG, Miyazaki H, Yoshie H. Increased frequency of FcgammaRIIIb-NA1 allele in periodontitis-resistant subjects in an elderly Japanese population. J Dent Res 2001: 80: 914-918.
83. Takahashi K, Ohyama H, Kitanaka M, Sawa T, Mineshiba J, Nishimura F, Arai H, Takashiba S, Murayama Y. Heterogeneity of host immunological risk factors in patients with aggressive periodontitis. J Periodontol 2001: 72: 425-437.
84. Takashiba S, Ohyama H, Oyaizu K, Kogoe-Kato N, Murayama Y. HLA genetics for diagnosis of susceptibility to early-onset periodontitis. J Periodontal Res 1999: 34: 374-378.
85. Thomson WM, Edwards SJ, Dodson-Le DP, Tompkins GR, Poulton R, Knight DA, Braithwaite AW. IL-1 genotype and adult periodontitis among young New Zealanders. J Dent Res 2001: 80: 1700-1703.
86. U.S. Department of Health and Human Services. The Human Genome Project. Bethesda, MD: U.S. Department of Health and Human Services, National Human Genome Research Institute, National Institutes of Health, USA, 2002. www.genome.gov.
87. van der Pol WL, van de Winkel LGL. IgG receptor polymorphisms: Risk factors for disease. Immunogenetics 1998: 48: 222-232.
88. van de Winkel JGJ, Capel PJA. Human IgG Fc receptor heterogeneity: Molecular aspects and clinical implications. Immunol Today 1993: 14: 215-221.
89. Van Dyke TE, Horoszewicz HU, Cianciola LJ, Genco RJ. Neutrophil chemotaxis dysfunction in human periodontitis. Infect Immun 1980: 27: 124-132.
90. Walker SJ, Van Dyke TE, Rich S, Kornman KS, di Giovine FS, Hart TC. Genetic polymorphisms of the IL-1alpha and IL-1beta genes in African-American LJP patients and an African-American control population. J Periodontol 2000: 71: 723-728.
91. Wilson TG, Nunn M. The relationship between the interleukin-1 periodontal genotype and implant loss. Initial data. J Periodontol 1999: 70: 724-729.
92. Wu J, Edberg JC, Redecha PB, Bansal V, Guyre PM, Coleman K, Salmon JE, Kimberly RP. A novel polymorphism of FcγRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. J Clin Invest 1997: 100: 1059-1070.
93. Xiao S, Yu C, Chou X, Yuan W, Wang Y, Bu L, Fu G, Qian M, Yang J, Shi Y, Hu L, Han B, Wang Z, Huang W, Liu J, Chen Z, Zhao G, Kong X. Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet 2001: 27: 201-204.
94. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988: 332: 411-415.
95. Yoshihara A, Sugita N, Yamamoto K, Kobayashi T, Miyazaki H, Yoshi H. Analysis of vitamin D and FCgamma receptor polymorphisms in Japanese patients with generalized early-onset periodontitis. J Dent Res 2001: 80: 2051-2054.
96. Zhang X, Zhao J, Li C, Gao S, Qiu C, Liu P, Wu G, Qiang B, Lo WH, Shen Y. DSPP mutation in dentinogenesis imperfecta Shields type II. Nat Genet 2001: 27: 151-152.