Conjugated linoleic acid and body fat adiposity;Ácido linoleico conjugado y grasa corporal

Nutricion Clinica y Dietetica Hospitalaria

Volumn 23, Issue 2, 2003, Pages 9-18

  Zulet, M A ^a,b   Wabitsch, M ^a   Marti A ^b   Martinez J A ^b  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Adipocyte; Adipose tissue; Body fat; Conjugated linoleic acid; Fatty acid

Indexed keywords

LEPTIN; LINOLEIC ACID; LINOLEIC ACID CONJUGATE; UNCLASSIFIED DRUG;

ADIPOCYTE; BODY COMPOSITION; BODY FAT; CELL DIFFERENTIATION; CELL PROLIFERATION; DIET SUPPLEMENTATION; ENERGY EXPENDITURE; FOOD INTAKE; GENETICS; HEALTH STATUS; HUMAN; LIPID METABOLISM; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; REVIEW;

ANIMALIA;

EID: 0038240805     PISSN: 02116057     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (73)

1. Zulet MA, Forga L, Astiasarán I, Martínez M. Nutrición y metabolismo lipídico: aspectos dietéticos. Nutr Clin, 1998; XVIII:47-56.
2. Zulet MA, Barber A, Garcin H, Higueret P, Martínez JA. Alterations in carbohydrate and lipid metabolism induced by a diet rich in coconut oil and cholesterol in a rat model. J Am Coll Nutr, 1999; 18(1):36-42.
3. Petridou E, Zavras AI, Lefatzis D, Dessypris N, Laskaris G, Dokianakis G, Segas J, Douglas CW, Diehl SR, Trichopoulos D. The role of diet and specific micronutrients in the etiology of oral carcinoma. Cancer, 2002; 4(11):2981-2988.
4. Chin SF, Storkson JM, Albright K. T, Cook ME, Pariza MW. Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. J Nutr, 1994; 124:2344-2349.
5. Park Y, Albright KT, Liu W, Storkson JM, Cook ME, Pariza MW. Effect of conjugated linoleic acid on body composition in mice. Lipids, 1997; 32(8):853-858.
6. MacDonald HB. Conjugated linoleic acid and disease prevention: a review of current knowledge. J Am Coll Nutr, 2000; 19:111S-118S.
7. Ip C, Jiang C, Thompson HJ, Scimeca JA. Retention of conjugated linoleic acid in the mammary gland is associated with tumor inhibition during the post-initiation phase of carcinogenesis. Carcinogenesis, 1997; 18:755-759.
8. Kritchevsky D, Tepper SA, Wright S et al. Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits. J Am Coll Nutr, 2000; 19:472S-477S.
9. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr, 2000; 130:2943-2948.
10. Watkins BA, Seifert MF. Conjugated linoleic acid and bone biology. J Am Coll Nutr, 2000; 19(4):478S-486S.
11. Miller CC, Park Y, Pariza MW, Cook ME. Feeding conjugated linolenic acid to animals partially overcomes catabolic responses due to endotoxin injection. Biochem Biophys Res Commun, 1994; 198:1107-1112.
12. DeLany JP, Blohm F, Tructt AA et al. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am J Physiol, 1999; 276:R1172-R1179.
13. Stangl GI. High dietary levels of a conjugated linoleic acid mixture alter hepatic glycerophospholipid class profile and cholesterol-carrying serum lipoproteins of rats. J Nutr Biochem, 2000; 11(4):184-191.
14. Wiegand BR, Parrish FC Jr, Swan JE, Larsen ST, Baas TJ. Conjugated linoleic acid improves feed efficiency, decreases subcutaneous fat, and improves certain aspects of meat qualiy in stress-genotype pigs. J Anim Sci, 2001; 79(8):2187-2195.
15. Corino C, Mourot J, Magni S, Pastorelli G, Rosi F. Influence of dietary conjugated linoleic acid on growth, meat quality, lipogenesis, plasma leptin and physiological variables of lipid metabolism in rabbits. J Anim Sci, 2002; 80(4):1020-1028.
16. Whigham LD, Cook ME, Atkinson RL. Conjugated linoleic acid: implications for human health. Pharmacol Res, 2000; 42(6):503-510.
17. Kelly GS. Conjugated linoleic acid: a review. Altern. Med. Rev. 2001; 6(4):367-382.
18. Pariza MW, Park Y, Cook ME. The biologically active isomers of conjugated linoleic acid. Prog Lipid Res, 2001; 40(4):283-298.
19. Kramer JKG, Parodi PW, Jensen RG, Mossoba MM, Yurawecz MP, Adlof RO. Rumenic acid: a proposed common name for the major conjugated linoleic acid isomer found in natural products (Letter to the Editor). Lipids, 1998;33:835.
20. Griinari JM, Bauman DE. Biosynthesis of conjugated linoleic acid and its incorporation into meat and milk ruminants. En, Advances in Conjugated linoleic acid Research, Volume 1. Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson G (eds). Pp. 180-200. AOCS Press, 1999.
21. Santora JE, Palmquist DL, Roetrig KL. Trans-vaccenic acid is desaturated to conjugated linoleic acid in mice. J Nutr, 2000; 130:208-215.
22. Lin H, Boylston TD, Chang MJ, Luedecke LO, Schultz TD. Survey of conjugated linoleic acid contents of dairy products. J Dairy Sci, 1995; 78:2358-2365.
23. Lavillonniere F, Martin JC, Bougnoux P, Sebedio JL. Analysis of conjugated linoleic acid isomers and content in French cheoses. J Am Oil Chem Soc, 1998; 75:343-352.
24. Dhiman TR, Anand GR, Satter LD, Pariza MW. Conjugated linoleic acid content of milk from cows fed different diets. J Dairy Sci, 1999; 82:2146-2156.
25. Ma DW, Wierzbicki AA, Field CJ, Clandinin MT. Conjugated linoleic acid in Canadian dairy and beef products. J Agric Food Chem, 1999; 47:1956-1960.
26. Chouinard PY, Corneau L, Butler WR, Chilliard Y, Drackley JK, Bauman DE. Effect of dietary lipid source on conjugated linoleic acid concentrations in milk fat. J Dairy Sci, 2001; 84(3):680-690.
27. Abu-Ghazaleh AA, Schingocthe DJ, Hippen AR. Conjugated linoleic acid and other beneficial fatty acids in milk fat from cows fed soyboan meal, fish meal, or both. J Dairy Sci, 2001; 84(8):1845-1850.
28. Fogerty AC, Ford GL, Svoronos D. Octadeca-9, 11-dienoic acid in foodstuffs and in the lipids of human blood and breast milk. Nutr Rep Int, 1988; 38:937-944.
29. Huang YC, Luedecke L.O., Shultz TD. Effect of cheddar cheese consumption on the plasma conjugated linoleic acid concentration in men. Nutr Res, 1994; 14:373-386.
30. Jiang J, Wolk A, Vessby B. Relation between the intake of milk fat and the ocurrence of conjugated linoleic acid in human adipose tissae. Am J Clin Nutr, 1999; 70(1):21-27.
31. Salminen I, Mutanen M, Jaubiainen M, Aro A. Dietary trans fatty acids increase conjugated linoleic acid levels in human serum. Nutr Biochem, 1998; 9:93-98.
32. Herbel BK, McGuire MK, McGuire MA, Shultz TD. Safflowor oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. Am J Clin Nutr, 1998; 67:332-337.
33. Park Y, Storkson JM, Albright KJ et al. Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids, 1999; 34(3):235-241.
34. Brown JM, Halvorsen YD, Lea-Currie YR, Geigerman C, McIntosh M. Trans-10, cis-12, but not cis-9, trans-11, conjugated linoleic acid attenuates lipogenesis in primary cultures of stromal vascular cells from human adipose tissue. J Nutr, 2001; 131(9):2316-2321.
35. Lin Y, Kreeft A, Schuurbiers JA, Draijer R. Different effects of conjugated linoleic acid isomers on lipoprotein lipase activity in 3T3-L1 adipocytes. J Nutr Biochem, 2001; 12(3):183-189.
36. West DB, Delany JP, Camet PM, Blohm F, Tructt AA, Scimeca J. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am J Physiol, 1998; 275(3Pt2):R667-672.
37. West DB, Blohm F, Truett AA, DeLany JP. Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expresion. J Nutr, 2000; 130:2471-2477.
38. Azain MJ, Hausman DB, Sisk MB et al. Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J. Nutr. 2000; 130:1548-1554.
39. Stangl GI. Conjugated linoleic acids exhibit a strong fat-to-lean partitioning effects, reduce serum VLDL lipids and redistribute tissue lipis in food-restricted rats. J Nutr, 2000; 130:1140-1146.
40. Ostrowska E, Muralitharan M, Cross RF, Bauman D.E. and Dunshea F.R. Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. J Nutr, 1999; 129:2037-2042.
41. Tischendorf F, Schone F, Kirchheim U, Jahreis G. Influence of a conjugated linoleic acid mixture on growth, organ weights, carcass traits and meat quality in growing pigs. J. Anim. Physiol. Anim Nutr, 2002; 86 (34):117-128.
42. Joo ST, Lee JI, Ha YL, Park GB. Effects of dietary conjugated linoleic acid on fatty acid composition, lipid oxidation, color, and water-holding capacity of pork loin. J Anim Sci, 2002; 80(1):108-112.
43. Meadus WJ, MacInnis R, Dugan ME. Prolonged dietary treatment with conjugated linoleic acid stimulates porcine muscle peroxisome proliferator activated receptor gamma and glutamine-fructose aminotransferase gene expression in vivo. J Mol Endocrinol, 2002; 28(2):79-86.
44. Sisk MB, Hausman DB, Martin RJ, Azain MJ. Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats. J Nutr, 2001; 131(6):1668-1674.
45. De Deckere EA, van Amelsvoort JM, McNeill GP, Jones P. Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. Br J Nutr, 1999; 82(4):309-317.
46. Gavino VC, Gavino G, Leblanc MJ, Tuchweber B. An isomeric mixture of conjugated linoleic acids but not pure cis-9, trans -11-octadecadienoic acid affects body weight gain and plasma lipids in hamsters. J Nutr, 2000; 130:27-29.
47. Szymczyk B, Pisulewski PM, Szczurek W, Hanczakowski P. Effects of conjugated linoleic acid on growth performance, feed conversion efficiency, and subsequent carcass quality in broiler chickens. Br J Nutr, 2001; 85(4):465-473.
48. Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res, 2001; 29(5):392-396.
49. Riserus U, Berglund L, Vessby B. Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Int J Obes Relat Metab Disord, 2001; 25(8):1129-1135.
50. Atkinson RL. Conjugated linoleic acid for altering body composition and treating obesity. En, Advances in Conjugated linoleic acid Research, Volume 1. Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson G (eds). Pp. 328-353. AOCS Press, 1999.
51. Zambell KL, Keim NL, Van Loan MD, Gale B, Benito P, Kelly DS, Nelson GJ. Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure. Lipids, 2000; 35(7):777-82.
52. Medina EA, Horn WF, Keim NL, Havel PJ, Benito P, Kelly DS, Nelson GJ, Erickson KL. Conjugated linoleic acid supplementation in humans: effects on circulating leptin concentrations and appetite. Lipids, 2000; 35(7):783-788.
53. Bee G. Dietary conjugated linoleic acids alter adipose tissue and milk lipids of pregnant and lactating sows. J Nutr, 2000; 130:2292-2298.
54. Wiegand BR, Sparks JC, Parrish FC Jr, Zimmerman DR. Duration of feeding conjugated linoleic acid influences growth performance, carcass traits, and meat quality of inishing barrows. J Anim Sci, 2002; 80(3):637-643.
55. Thiel-Cooper RL, Parrish FC Jr, Sparks JC, Wiegand BR, Ewan RC. Conjugated linoleic acid changes swine performance and carcass composition. J Anim Sci, 2001; 79(7):1821-1828.
56. Bee G. Dietary conjugated linoleic acid consumption during pregnancy and lactation influences growth and tissue composition in weaned pigs. J Nutr, 2000; 130:2981-2989.
57. Rahman SM, Wang Y, Yotsumoto H, Cha J, Han S, Inoue S, Yanagita T. Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, an beta-oxidation of fatty acid in OLETF rats. Nutrition, 2001; 17(5):385-390.
58. Dugan MER, Aalhus JL, Schaefer AL, Kramer JKG. The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs. Can J Anim Sci, 1997; 77:723-725.
59. Kang K, Pariza MW. Trans-10, c-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. Biochem Biophys Res Comun, 2001; 287(2):377-382.
60. DeLany JP, West DB. Changes in body composition with conjugated linoleic acid. J Am Coll Nutr, 2000; 19(4):487S-493S.
61. Terpstra AH, Beynen AC, Everts H, Kocsis S, Katan MB, Zock PL. The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta. J Nutr, 2002; 132(5):940-945.
62. Ohnuki K, Haramizu S, Oki K, Ishihara K, Fushiki T. A single oral administration of conjugated linoleic acid enhanced energy metabolims in mice. Lipids, 2001; 36(6):583-587.
63. Rodríguez E, Ribot J, Palou A. Trans-10, cis-12, but not cis-9, trans-11 CLA isomer, inhibits brown adipocyte thermogenic capacity. Am J Physiol Regul. Integr Comp Physiol, 2002; 282(6):R1789-R1797.
64. Brodie AE, Manning VA, Ferguson KR, Jewell DE, Hu CY. Conjugated linoleic acid inhibits differentiation of pre- and post-confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells. J Nutr, 1999; 129(3):602-606.
65. Evans M, Geigerman C, Cook J, Curtis L, Kuebler B, McIntosh M. Conjugated linoleic acid supresses triglyceride accumulation and induces apoptosis in 3T3-L1 preadipocytes. Lipids, 2000; 35(8):899-910.
66. Satory DL, Smith SB. Conjugated linoleic acid inhibits proliferation but stimulates lipid filling of murine 3T3-L1 preadipocytes. J Nutr, 1999; 129(1):92-97.
67. Evans M, Park Y, Pariza M, Curtis L, Kuebler B, McIntosh M. Trans-10, cis-12 conjugated linoleic acid reduces triglyceride content while differentially affecting peroxisome proliferator activated receptor gamma 2 and aP2 expression in 3T3-L1 preadipocytes. Lipids, 2001; 36(11):1223-1232.
68. Choi Y, Kim Y, Han Y, Park Y, Pariza M, Ntambi J. The trans-10, cis-12 Isomer of conjugated linoleic acid downregulates Stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. J Nutr, 2000; 130;1920-1924.
69. Evans M, Lin X, Odle J, McIntosh M. Trans-10, cis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes. J Nutr, 2002; 132(3):450-455.
70. Zambell KL, Horn WF, Keim NL. Conjugated linoleic acid supplementation in humans: effects on fatty acid and glycerol kinetics. Lipids, 2001; 36(8):767-772.
71. Tsuboyama-Kasaoka N, Takahashi M, Tanomura K et al. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes, 2000; 49:1534-1542.
72. Miner JL, Cederberg CA, Nielsen MK, Chen X, Baile CA. Conjugated linoleic acid (CLA), body fat and apoptosis. Obes Res, 2001; 9(2):129-134.
73. Poulos SP, Sisk M, Hausman DB, Azain MJ, Hausman GJ. Pre-and postuatal dietary conjugated linoleic acid alters adipose development, body weight gain and body composition in Sprague-Dawley rats. J Nutr, 2001; 131(10):2722-2731.