Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils

FASEB Journal

Volumn 12, Issue 12, 1998, Pages 1109-1123

  Pouliot, Marc ^a,f   Gilbert, Caroline ^a   Borgeat, Pierre ^b   Poubelle, Patrice E ^b   Bourgoin, Sylvain ^b   Créminon, Christophe ^c   Maclouf, Jacques ^d   McColl, Shaun R ^e   Naccache, Paul H ^b  

^a LAVAL UNIVERSITY   (Canada)

^b Faculty of Medicine   (Australia)

^c Institut National de la Recherche Agronomique   (France)

^d HÔPITAL LARIBOISIÈRE   (France)

^e UNIVERSITY OF ADELAIDE   (Australia)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cyclooxygenase; Dexamethasone; Lipopolysaccharide; Thromboxane

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLOHEXIMIDE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; ENZYME INHIBITOR; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; THROMBOXANE A2;

ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; NEUTROPHIL; NORTHERN BLOTTING; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SIGNAL TRANSDUCTION;

EID: 0031689787     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.12.12.1109     Document Type: Article

References (65)

1. Cassatella, M. A. (1995) The production of cytokines by polymorphonuclear neutrophils. Immunol. Today 16, 21-26
2. Simmons, P. M., Salmon, J. A., and Moncada, S. (1983) The release of leukotriene B4 during experimental inflammation. Biochem. Pharmacol. 32, 1353-1359
3. Pouliot, M., Mcdonald, P. P., Khamzina, L., Borgeat, P., and McColl, S. R. (1994) Granulocyte-macrophage colony-stimulating factor enhances 5-lipoxygenase levels in human polymor-phonuclecar leukocytes. J. Immunol. 152, 851-858
4. Pouliot, M., Mcdonald, P. P., Borgeat, P., and McColl, S. R. (1994) Granulocyte macrophage colony-stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils. J. Exp. Med. 179, 1225-1232
5. Zurier, R. B., and Sayadoff, D. M. (1975) Release of prostaglandins from human polymorphonuclear leukocytes. Inflammation 1, 93
6. Goldstein, I. M., Malmsten, C. L., Kindahl, H., Kaplan, H. B., Radmark, O., Samuelsson, B., and Weissmann, G. (1978) Thromboxane generation by human peripheral blood polymorphonuclear leukocytes. J. Exp. Med. 148, 787-792
7. Dvorak, A. M., Morgan, E., Schleimer, R. P., Ryeom, S. W., Lichtenstein, L. W., and Weller, P. F. (1992) Ultrastructural immunogold localization of prostaglandin endoperoxide synthase (cyclooxygenase) to non-membrane-bound cytoplasmic lipid bodies in human lung mast cells, alveolar macrophages, type II pneumocytes, and neutrophils. J. Histochem. Cytochem. 40, 759-769
8. Herrmann, F., Lindemann, A., Gauss, J., and Mertelsmann, R. (1990) Cytokine-stimulation of prostaglandin synthesis from endogenous and exogenous arachidonic acids in polymorphonuclear leukocytes involving activation and new synthesis of cyclooxygenase. Eur. J. Immunol. 20, 2513-2516
9. Patrignani, P., Panara, M. R., Greco, A., Fusco, O., Natoli, C., Iacobelli, S., Cipollone, F., Ganci, A., Créminon, C., Maclouf, J., and Patrono, C. (1994) Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. J. Pharmacol. Exp. Ther: 271, 1705-1712
10. Smith, W. L., Borgeat, P., and Fitzpaltrick, F. A. (1991) The eicosanoids: cyclooxygenase, lipoxygenase and epoxygenase pathways. In Biochemistry of Lipids, Lipoproteins and Membranes (Vance, D. E., and Vance, J., eds) pp. 297-325, Elsevier, New York.
11. Vane, J. R., and Bolting, R. M. (1996) Mechanism of action of anti-inflammatory drugs. Scand. J. Rheumatol. 102, 9-21
12. O'Banion, M. K., Sadowski, H. B., Winn, V., and Young, D. A. (1991) A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J. Biol. Chem. 266, 23261-23267
13. Smith, W. L., Garavito, R. M., and Dewitt, D. L. (1996) Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2 [Review]. J. Biol. Chem. 271, 33157-33160
14. Crofford, L. J. (1997) Cox-1 and cox-2 tissue expression - implications and predictions. J. Rheumatol. 24, 15-19
15. O'Banion, M. K., Winn, V. D., and Young, D. A. (1992) cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc. Natl. Acad, Sci. USA 89, 4888-4892
16. Seibert, K., Zhang, Y., Leahy, K., Hauser, S., Masferrer, J., Perkins, W., Lee, L., and Isakson, P. (1994) Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA 91, 12013-12017
17. Dinchuk, J. E., Car, B. D., Focht, R. J., Johnston, J. J., Jaffee, B. D., Covington, M. B., Contel, N. R., Eng, V. M., Collins, R. J., Czerniak, P. M., Gorry, S. A., and Trzaskos, J. M. (1995) Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase 2. Nature (London) 378, 406-409
18. Herschman, H. R. (1996) Prostaglandin synthase 2 [Review]. Biochim. Biophys. Acta 1299, 125-140
19. Hla, T., and Neilson, K. (1992) Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. USA 89, 7384-7388
20. Masferrer, J. L., Zweifel, B. S., Manning, P. T., Hauser, S. D., Leahy, K. M., Smith, W. G., Isakson, P. C., and Seibert, K. (1994) Selective inhibition of inducible cyclooxygenase-2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. USA 91, 3228-3232
21. Tomlinson, A., Appleton, I., Moore, A. R., Gilroy, D. W., Willis, D., Mitchell, J. A., and Willoughby, D. A. (1994) Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. Br. J. Pharmacol. 113, 693-698
22. Niiro, H., Otsuka, T., Izuhara, K., Yamaoka, K., Ohshima, K., Tanabe, T., Hara, S., Nemoto, Y., Tanaka, Y., Nakashima, H., and Niho, Y. (1997) Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils. Blood 89, 1621-1628
23. Boyum, A. (1968) Isolation of mononuclear cells and granulocytes from human peripheral blood. Scand. J. Clin. Lab. Invest. 21, 77-89
24. Habib, A., Creminon, C., Frobert, Y., Grassi, J., Pradelles, P., and Maclouf, J. (1993) Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2. J. Biol. Chem. 268, 23448-23454
25. Margalit, A., Duffin, K. L., and Isakson, P. C. (1996) Rapid quantitation of a large scope of eicosanoids in two models of inflammation: development of an elcctrospray and tandem mass spectrometry method and application to biological studies. Anal. Biochem. 235, 73-81
26. Pradelles, P., Grassi, J., and Maclouf, J. (1985) Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay. Anal. Chem. 57, 1170-1173
27. Jones, D. A., Carlton, D. P., McIntyre, T. M., Zimmerman, G. A., and Prescott, S. M. (1993) Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J. Biol. Chem. 268, 9049-9054
28. Otto, J. C., Dewitt, D. L., and Smith, W. L. (1993) N-glycosylation of prostaglandin endoperoxide synthases-1 and synthases-2 and their orientations in the endoplasmic reticulum. J. Biol. Chem. 268, 18234-18242
29. Pouliot, M., Buillargeon, J., Lee, J. C., Cleland, L. G., and James, M. J. (1997) Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase. J. Immunol. 158, 4930-4937
30. Ridley, S. H., Sarsfield, S. J., Lee, J. C., Bigg, H. F., Cawston, T. E., Taylor, D. J., Dewitt, D. L., and Saklatvala, J. (1997) Actions of IL-1 are selectively controlled by p38 mitogen-activatcd protein kinase - regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels. J. Immunol. 158, 3165-3173
31. Chabot, M. C., Mcphail, L. C., Wykle, R. L., Kennerly, D. A., and McCall, C. E. (1992) Comparison of diglyceridc production from choline-containing phosphoglycerides in human neutrophils stimulated with N-formylmethionyl-leucylphenylalanine, ionophore A23187 or phorbol 12-myristate 13-acetate. Biochem. J. 286, 693-699
32. Bonser, R. W., Thompson, N. T., Randall, R. W., and Garland, L. G. (1989) Phospholipase D activation is functionally linked to Superoxide generation in the human neutrophil. Biochem. J. 264, 617-620
33. Glaser, K. B., and Lock, Y. W. (1995) Regulation of prostaglandin H synthase 2 expression in human monocytes by the marine natural products manoalide and scalaradial - novel effects independent of inhibition of lipid mediator production. Biochem. Pharmacol. 50, 913-922
34. Angel, J., Berenbaum, F., Ledenmat, C., Nevalainen, T., Masliah, J., and Fournier, C. (1994) Interleukin-1-induced prostaglandin E2 biosynthesis in human synovial cells involves the activation of cytosolic phospholipase A2 and cyclooxygenase-2. Eur. J. Biochem. 226, 125-131
35. Crofford, L. J., Wilder, R. L., Ristimaki, A. P., Sano, H., Remmers, E. F., Epps, H. R., and Hla, T. (1994) Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J. Clin. Invest. 93, 1095-1101
36. Godessart, N., Camacho, M., Lopez-Belmonte, J., Anton, R., Garcia, M., Demoragas, J. M., and Vila, L. (1996) prostaglandin H-synthase-2 is the main enzyme involved in the biosynthesis of octadecanoids from linoleic acid in human dermal fibroblasts stimulated with interleukin-1-beta. J. Invest. Dermatol. 107, 726-732
37. Dayton, E. T., and Major, E. O. (1996) Recombinant human interleukin 1-beta induces production of prostaglandins in primary human fetal astrocytes and immortalized human fetal astrocyte cultures. J. Neuroimmunol. 71, 11-18
38. Albert, T. J., Su, H. C., Zimmerman, P. D., Iams, J. D., and Kniss, D. A. (1994) Interleukin-1-beta regulates the inducible cyclooxygenase in amnion-derived wish cells. Prostaglandins 48, 401-416
39. Lyons-Giordano, B., Pratta, M. A., Galbraith, W., Davis, G. L., and Arner, E. (1993) Interleukin-1 differentially modulates chondrocyte expression of cyclooxygenase-2 and phospholipase A2. Exp. Cell. Res. 206, 58-62
40. Vigano, T., Habib, A., Hernandez, A., Bonazzi, A., Boraschi, D., Lebret, M., Cassina, E., Maclouf, J., Sala, A., and Folco, G. (1997) Cyclooxygenase-2 and synthesis of PGE2 in human bronchial smooth-muscle cells. Am. J. Resp. Critical Care Med. 155, 864-808
41. Akarasereenont, P., and Thiemermann, C. (1996) The induction of cyclo-oxygenase-2 in human pulmonary epithelial cell culture (A549) activated by IL-1-beta is inhibited by tyrosine kinase inhibitors. Biochem. Biophys, Res. Commun. 220, 181-185
42. Rzymkiewicz, D., Leingang, K., Baird, N., and Morrison, A. R. (1994) Regulation of prostaglandin endoperoxide synthase gene expression in rat mesengial cells by interleukin-1β. Am. J. Physiol. 266, F39-F45
43. Yucellindberg, T., Ahola, H., Nilsson, S., Carlstedtduke, J., and Modeer, T. (1995) Interleukin-1-beta induces expression of cyclooxygenase-2 mRNA in human gingival fibroblasts. Inflammation 19, 549-560
44. Sato, T., Morita, K., Sakaguchi, K., Nakahama, K. I., Smith, W. L., Dewitt, D. L., and Murota, S. I. (1996) Involvement of prostaglandin endoperoxide H synthase-2 in osteoclast-like cell formation induced by interleukin-1-beta. J. Bone Min. Res. 11, 392-400
45. Surette, M. E., Palmantier, R., Gosselin, J., and Borgeat, P. (1993) Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability-involvement of the CD14 antigen. J. Exp. Med. 178, 1347-1355
46. Karin, M., and Hunter, T. (1995) Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr. Biol. 5, 747-757
47. Masferrer, J. L., and Seibert, K. (1994) Regulation of prostaglandin synthesis by glucocorticoids. Receptor 4, 25-30
48. Pilbeam, C. C., Kawaguchi, H., Hadeka, Y., Voznesensky, O., Alander, C. B., and Raisz., L. G. (1993) Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells. J. Biol. Chem. 268, 25643-25049
49. Potestio, F. A., Zakar, T., and Olson, D. M. (1988) Glucocorticoids stimulate prostaglandin synthesis in human amnion cells by a receptor-mediated mechanism. J. Clin. Endocrinol. Metab. 67, 1200-1210
50. Zakar, T., and Olson, D. M. (1989) Dexamethasone stimulates arachidonic acid conversion to prostaglandin E2 in human cells. J. Dev. Physiol. 12, 269-272
51. Zakar, T., Hirst, J. J., Mijovic, J. E., and Olson, D. M. (1995) Glucocorticoids stimulate the expression of prostaglandin endoperoxide H synthase-2 in amnion cells. Endocrinology 136, 1610-1619
52. Ristimaki, A., Narko, K., and Hla, T. (1996) Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone - evidence for post-transcriptional regulation. Biochem. J. 318, 325-331
53. Fletcher, B. S., Kujubu, D. A. , Perrin, D. M., and Herschman, H. R. (1992) Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. J. Biol. Chem. 267, 4338-4344
54. Sirois, J., Levy, L. O., Simmons, D. L., and Richards, J. S. (1993) Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions. J. Biol. Chem. 268, 12199-12206
55. Inoue, H., Yokohama, C., Hara, S., Tone, Y., and Tanabe, T. (1995) Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element. J. Biol. Chem. 270, 24965-24971
56. Yamamoto, K., Arakawa, T., Ueda, N., and Yamatoto, S. (1995) Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J. Biol. Chem. 270, 31315-31320
57. Kosaka, T., Miyata, A., Ihara, H., Hara, S., Sugimoto, T., Takeda, O., Takahashi, E., and Tanabe, T. (1994) Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2. Eur. J. Biochm. 221, 889-897
58. Xie, W., and Hershman, H. R. (1995) v-Src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor. J. Biol. Chem. 270, 27622-27628
59. Della Bianca, V., Grzeskowiak, M., Lissandrini, D., and Rossi, F. (1991) Source and role of diacylglycerol formed during phagocytosis of opsonized yeast particles and associated respiratory burst in human neutrophils. Biochim. Biophys. Res. Commun, 177, 948-955
60. Reinhold, S. L., Prescott, S. M., Zimmerman, G. A., and MeIntyre, T. M. (1990) Activation of human neutrophil phospholipase D by three separable mechanisms. FASEB J. 4, 208-214
61. Bauldry, S. A., Bass, D. A., Cousart, S. L., and McCall, C. E. (1991) Tumor necrosis factor alpha priming of phospholipase D in human neutrophils. Correlation between phosphatidic acid production and superoxide generation. J. Biol. Chem. 266, 4173-4179
62. L'Heureux, G. P., Bourgoin, S., Jean, N., McColl, S. R., and Naccache, P. H. (1995) Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity. Blood 85, 522-531
63. Sciorra, V. A., and Daniel, L. W. (1996) PhospholipaseD-derived products in the regulation of 12-O-tetradecanoylphorbol-13-acetate-stimulated prostaglandin synthesis in Madin-Darby canine kidney cells. J. Biol. Chem. 271, 14226-14232
64. Mollideno, F., Gajate, C., and Flores, I. (1994) Involvement of phospholipase D in the activation of transcription factor AP-1 in human T lymphoid Jurkat cells. J. Immunol 153, 2457-2469
65. Maloney, C. G., Kutchera, W. A., Albertine, K. H., Mcintyre, T. M., Prescott, S. M., and Zimmerman, G. A. (1998) Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils. J. Immunol. 160, 1402-1410