Endocrine disruptors in the environment: (IUPAC technical report)

Pure and Applied Chemistry

Volumn 75, Issue 5, 2003, Pages 631-681

  Lintelmann, J ^a   Katayama, A ^b   Kurihara, N ^c   Shore, L ^d   Wenzel, A ^e  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b NAGOYA UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d KIMRON VETERINARY INSTITUTE   (Israel)

^e FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4,4' ISOPROPYLIDENEDIPHENOL; ALKADIENE; ANDROGEN; ANDROSTANOLONE; BIPHENYL DERIVATIVE; CAMPHENE; CHLOROCYCLODIENE; CHLORPHENOTANE; DIURON; ENDOCRINE DISRUPTOR; ESTROGEN; GESTAGEN; HORMONE; HORMONE RECEPTOR; LINURON; METHOXYCHLOR; ORGANOTIN COMPOUND; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN; POLYCYCLIC AROMATIC HYDROCARBON; PREGNENOLONE; SEX HORMONE; STEROID; STEROID HORMONE; TESTOSTERONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCLOZOLIN;

DNA BINDING; DRUG PROTEIN BINDING; ENDOCRINE DISEASE; ENDOCRINE SYSTEM; ENVIRONMENTAL EXPOSURE; FISH; HORMONE RECEPTOR INTERACTION; HYDROPHILICITY; LIGAND BINDING; MAMMAL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; SEX DIFFERENTIATION; SEXUAL DEVELOPMENT;

EID: 0038193935     PISSN: 00334545     EISSN: None     Source Type: Journal    
DOI: 10.1351/pac200375050631     Document Type: Review

References (255)

1. R. M. Sharpe and N. E. Skakkebaek. Lancet 341, 1392-1395 (1993).
2. E. Dewailly, S. Dodin, R. Verreault, P. Ayolle, L. Sauve, J. Morin, J. Brisson. J. Nat. Cancer Inst. 86, 232-234 (1994).
3. European Workshop on the Impact of Endocrine Disruptors on Human Health and Wildlife. Report of Proceedings, 2-4 December, Weybridge, UK (1996).
4. EPA (U.S. Government Environmental Protection Agency). Endocrine Disruptor Screening Testing Advisory Committee (EDSTAC), final report (1998). Available at: 〈http//www.epa.gov/opptintr/opptindo/finalrept/htm〉.
5. T. M. Crisp, E. D. Cregg, R. L. Cooper, D. G. Anderson, K. P. Baetcke, J. L. Hoffmann, M. S. Morrow, D. L. Rodier, J. E. Schaeffer, L. W. Touart, M. G. Zeeman, Y. M. Patel, W. P. Wood. U.S. EPA/630/R-96/012, pp. 1-120 (1997).
6. T. M. Crisp, E. D. Clegg, R. L. Cooper, W. P. Wood, D. G. Anderson, K. P. Baetcke, L. Hoffmann, M. S. Morrow, D. J. Rodier, J. E. Schaeffer, L. W. Touart, M. G. Zeeman, Y. M. Patel. Environ. Health Perspect. 106, 11-56 (1998).
7. A. N. Brooks. Pure Appl. Chem. 70, 1633-1646 (1998).
8. A. Dawson. Pure Appl. Chem. 70, 1657-1669 (1998).
9. A. C. Nimrod and W. H. Benson. Crit. Rev. Toxicol. 26, 335-364 (1996).
10. L. E. Gray Jr., J. Ostby, C. Wolf, Ch. Lambright, W. Kelce. Toxicol. Chem. 17, 109-118 (1998).
11. K. Urich. Comparative Animal Biochemistry, Springer, Berlin (1994).
12. G. Löffler, P. E. Petrides. Biochemie und Pathobiochemie, Springer, Berlin (1997).
13. M. W. Eubanks. Environ. Health Perspect. 105, 82-487 (1997).
14. B. E. Gillesby and Th. R. Zacharewski. Environ. Toxicol. Chem. 17, 3-14 (1998).
15. G. G. Kuiper, E. Enmark, M. Pelto-Huikko, S. Nilsson, J. A. Gustafsson. Proc. Natl. Acad. Sci. USA 93, 5925-5930 (1996).
16. G. G. Kuiper, B. Carlsson K. Grandien. Endocrinology 138, 863-870 (1997).
17. P. M. Campell and T. E. Hutchinson. Environ. Toxicol. Chem. 17, 127-135 (1998).
18. D. M. Fry. Environ. Health Perspect. 103 (Suppl. 7), 165-171 (1995).
19. D. M. Fry and C. K. Toone. Science 213, 922-924 (1980).
20. W. R. Kelce, C. R. Stone, S. C. Laws, L. G. Gray, J. A. Kemppainen, E. M. Wilson. Nature 373, 581-585 (1995).
21. F. J. Janzen and G. L. Paukstis. Q. Rev. Biol. 66, 149-179 (1991).
22. D. Crews, J. M. Bergeron, J. A. McLachlan. Environ. Health Perspect. 103, 73-77 (1995).
23. T. Wibbels, J. J. Bull, D. Crews. J. Exp. Zool. 270, 71-78 (1994).
24. D. A. Crain, L. J. Guillette Jr., A. A. Rooney, D. B. Pickford. Environ. Health Perspect. 105, 528-533 (1997).
25. T. Wibbels, P. Gideon, J. J. Bull, D. Crews. Differentiation 53, 149-153 (1993).
26. D. E. Kime. In Fundamentals of Comparative Vertebrate Endocrinology, I. Chester-Jones, P. M. Ingleton, J. G. Phillips (Eds.), Plenum, New York (1987).
27. D. O. Norris, J. A. Carr, C. H. Summers, R. Featherstone. Gen. Comp. Endocrinol. 106, 348-355 (1997).
28. Reviewed in: D. O. Norris. In Hormones Reproduction in Fishes, Amphibians, and Reptiles, D. O. Norris and R. E. Jones (Eds.), pp. 327-357, Plenum, New York (1987).
29. R. A. Wallace and W. Bergink. Am. Zool. 14, 1159-1175 (1974).
30. I. P. Callard and S. M. Ho. In Fundamentals of Comparative Vertebrate Endocrinology, I. Chester-Jones, P. M. Ingleton, J. G. Phillips (Eds.), Plenum, New York (1987).
31. A. P. Scott and J. P. Sumpter. Gen. Comp. Endocrinol. 73, 46-58 (1989).
32. F. Yamazaki. Aquaculture 33, 329-354 (1983).
33. H. Takahashi. Bull. Fac. Fish. Hokkaido Univ. 28, 57-63 (1977).
34. OECDC (Organisation for Economic Co-operation and Development). Draft detailed review paper: "Appraisal of tests methods for sex-hormone disrupting chemicals", Paris (1997). Available at: 〈http://www.oecd.org/ehs/test/testlist.htm〉.
35. P. Matthiessen and J. P. Sumpter. In: Fish Ecotoxicology, T. Braunbeck, D. E. Hinton, B. Streit (Eds.), pp. 319-333, Birkhauser, Basel (1998).
36. M. A. Gray and C. D. Metcalfe. Environ. Toxicol. Chem. 16, 1082-1086 (1997).
37. G. Toft and E. Baatrup. Ecotox. Environ. Safety 48, 76-84 (2000).
38. S. Jobling, D. Sheahan, J.A. Osborne, P. Matthiessen, J. P. Sumpter. Environ. Toxicol. Chem. 15, 194-202 (1996).
39. V. L. Trudeau, R. E. Peter, B. D. Soley. Biol. Reprod. 48, 951-960 (1991).
40. J. P. Sumpter and S. Jobling. Environ. Health Perspect. 103 (Suppl. 7), 175-178 (1995).
41. P. L. DeFuhr, M. Crane, Ch. Ingersoll, L. Tattersfield. Endocrine Disruption in Invertebrates: Endocrinology, Testing, Assessment, SETAC Technical Publication Series (1999).
42. A. N. Wootton, C. Herrig, A. Wiseman, D. R. Livingstone, P. S. Goldfarb. Mar. Environ. Res. 39, 21-26 (1995).
43. D. Le Guellec, M-C. Thiard, J. P. R. Martin, A. Deray, L. Gomot, G. L. Adessi. Gen. Comp. Endocrinol. 66, 425-433 (1987).
44. C. Lupo di Prisco and F. Dessi-Fulgheri. Comp. Biochem. Physiol. 50B, 191-195 (1975).
45. H. Gottfried and R. I. Dorfman. Gen. Comp. Endocrinol. 15, 120-138 (1970).
46. C. Feral and S. Le Gall. In Molluscan Neuro-endocrinology, Proceedings of the International Minisymposium on Molluscan Endocrinology, J. Lever and H. H. Boer (Eds.), pp. 173-175, North Holland, Amsterdam (1983).
47. J. Joosse and W. P. M. Geraerts. The Mollusca, A. S. M. Saleuddin and K. M. Wilbur (Eds.), Vol. 4, Part 1, pp. 317-406, Academic, New York (1983).
48. N. Spooner, P. E. Gibbs, G. W. Bryan L. J. Goad. Mar. Environ. Res. 32, 37-49 (1991).
49. G. W. Bryan, D. A. Bright, L. G. Hummerstone, G. R. Burt. J. Mar. Biol. Ass. UK 73, 889-912 (1993).
50. C. Bettin, J. Oehlmann, E. Stroben. Helgol. Meersunters. 50, 299-317 (1996).
51. J. C. Cook, L. S. Mullin, S. R. Frame L. B. Biegel. Toxicol. Appl. Pharmacol. 119, 195-204 (1993).
52. J. Oehlmann, E. Stroben, U. Schulte-Oehlmann, B. Bauer, P. Fiorini, B. Markert. Fres. J. Anal. Chem. 354, 540-545 (1996).
53. S. Soontornchat, M. H. Li, P. S. Cooke, L. G. Hansen. Environ. Health Perspect. 102, 568-571 (1994).
54. S. Safe and V. Krishnan. Toxicol. Lett. 82/83, 731-736 (1995).
55. S. Safe, F. Wang, W. Porter, R. Duan, A. McDougal. Toxicol. Lett. 102-103, 343-347 (1998).
56. OECD (Organisation for Economic Co-operation Development). Draft detailed review paper: "Appraisal of test methods for sex-hormone disrupting chemicals", OECD Environ. Health Safety Publications (1997).
57. ECETOC (European Centre for Ecotoxicology and Toxicology of Chemicals). Document No. 33 ECETOC, Brussels (1996).
58. CEFIC: EMSG - The Endocrine Modulators Steering Group, established by the European Chemicals Industry: CEFIC Homepage: 〈http://www.cefic.be/Iri/emsg〉. ECETOC (European Centre for Ecotoxicology and Toxicology of Chemicals), Document No. 36 ECETOC, Brussels (1996).
59. J. T. Stevens, A. Tobia, J. C. Lamb IV, C. Tellone, F. O'Neal. J. Toxicol. Environ. Health. 50, 107-117 (1997).
60. J. T. Stevens, L. Machemer, K. H. Leist. J. Toxicol. Environ. Health, Part B 1, 59-79 (1998).
61. Scientific Committee on Plants on Endocrine disruption relevance in the context of Council Directive 91/414/EEC concerning the placing of plant protection products on the market (opinion expressed by the Scientific Committee on Plants on 2 December 1999).
62. OECD Environmental Directorate. News release from the first joint test guideline/risk assessment meeting on endocrine disruptors, 25 March 1998.
63. CSTEE - Scientific Committee on Toxicity, Ecotoxicity and the Environment of DG SANCO: Opinion on human and wildlife health effects of endocrine disrupting chemicals, with emphasis on wildlife and on ecotoxicology test methods (1999). Available at: 〈http://europa.eu.int/comm/food/Fs/sc/sct/out73_en.html〉.
64. R. J. Kavlock, G. P. Daston, C. Derosa, P. Fenner-Crisp, L. E. Gray, Jr, S. Kaattari, G. Lucier, M. Luster, M. J. Mac, C. Maczka, R. Miller, J. Moore, R. Rolland, G. Scott, D. M. Sheehan, T. Sinks, H. A. Tilson. Environ. Health Perspect. 104, 715-740 (1996).
65. G. T. Ankley, R. D. Johnson, N. E. Detenbeck, S. P. Bradbury, G. Toth, L. C. Folmar. Rev. Toxicol. Ser. B Environ. Toxicol. 1, 231-267 (1997).
66. EMWAT (1997): EMWAT- Expert Workshop on Endocrine Modulators and Wildlife: Assessment and Testing. (SETAC Europe/OECD/EC), Veldhofen, The Netherlands, 10-13 April 1997. L. Tattersfield et al. (Eds). SETAC-Europe Publication, Brussels (1997). Available at: 〈www.oecd.org/ehs/endocrin/Subpage/webfile.pdf〉.
67. G. Rippen. Umweltchemikalien, Ecobase Media Explorer (ECOMED), Verlagsgesellschaft, Landsberg (1998).
68. Available at: 〈http://nci.chemfinder.com/〉.
69. T. A. Ternes, P. Kreckel, J. Müller. Sci. Total Environ. 225, 91-99 (1999).
70. T. A. Ternes M. Stumpf, J. Müller, R.-D. Wilken, K. Haberer, M. Servos. Sci. Total Environ. 225, 81-90 (1999).
71. A. Turan. In: Endocrinically Active Chemicals in the Environment, Umweltbundesamt, UBA-Texte 3/96, pp. 15-21 (1996). Available at: 〈www.epa.gov/endocrine/Pubs/uba3_96.pdf〉.
72. H. H. Tabak, R. N. Bloomhuff, R. L. Bunch. Develop. Ind. Microbiol. 22, 497-519 (1981).
73. R. R. Velagaletti. Drug Infor. J. 250, 565-569 (1995).
74. L. S. Shore, M. Gurevich, M. Shemesh. Bull. Environ. Contam. Toxicol. 51, 361-366 (1993).
75. L. S. Shore, D. Correll, P. K. Chakroborty. In Animal Waste and the Land Water Interface, K. Steele (Ed.), pp. 49-56, Lewis, Boca Raton, FL (1995).
76. T. A. Ternes, M. Stumpf, J. Mueller, K. Haberer, R.-D. Wilken, M. Servos. Sci. Total Environ. 225, 81-90 (1999).
77. A. Belfroid, A. Van der Horst, A. D. Vethaak, A. J. Schäfer, G. B. J. Rijs, J. Wegener, W. P. Cofino. Sci. Total Environ. 225, 101-108 (1999).
78. M. Stumpf, T. A. Ternes, K. Haberer, W. Baumann. Vom Wasser 87, 251-261 (1996).
79. A. Wenzel, Th. Kuechler, J. Mueller. Konzentrationen oestrogen wirksamer Substanzen in Umweltmedien. Report, Project sponsored by the German Environmental Protection Agency (UBA), Project No 216 02 011/11 (in German) (1998).
80. C. Desbrow, E. Routledge, G. C. Brighty, J. Sumpter, M. Waldlock. Environ. Sci. Technol. 32, 1549-1558 (1998).
81. W. Mazur and H. Adlercreutz. Pure Appl. Chem. 70, 1759-1776 (1998).
82. H. Adlercreutz, K. Hockerstedt, C. Bannwart, S. Bloigu, E. Hamalainen, T. Fotsis, A. Ollus. J. Steroid Biochem. 27, 1135-1144 (1987).
83. T. J. O. Lundh, H. I. Pettersson, K. A. Martinsson. J. Agric. Food Chem. 38, 1530-1534 (1990).
84. N. R. Adams. Pure Appl. Chem. 70, 1855-1862 (1998).
85. K. L. Medlock, W. S. Branham, D. M. Sheehan. Proc. Soc. Exp. Biol. Med. 208, 307-313 (1995).
86. R. C. Santell, Y. C. Chang, M. G. Nair, W. G. Helferich. J. Nutr. 127, 253-269 (1997).
87. S. R. Milligan, A. V. Balasubramanian, J. C. Kalita. Environ. Health Perspect. 106, 22-26 (1998).
88. R. J. Miksicek. Proc. Soc. Exp. Biol. Med. 30, 212-217 (1995).
89. H. Robakowski. In Umwelt-Literaturrecherche: Landesanstalt für Umweltschutz Baden-Würtemberg, 1, Auflage, Karlsuhe, Germany (2000).
90. T. A. Ternes, T. Eggert, M. Meisenheimer. flanzliche Hormonell Wirksame Stoffe in der Aquatischen Umwelt und deren Verhalten bei der Trinkwasseraufbereitung. German BMBF-Forschungsvorhaben: 02-WU9735/1 (2001).
91. A. Wenzel, Ch. Schäfers, W. Böhmer. EU project No B6-7920/98/000015. Final report (2000).
92. P. Stahlschmidt-Allner, B. Allner, J. Römbke, Th. Knacker. Environ. Sci. Pollut. Res. 4, 155-162 (1997).
93. P. Mellanen, T. Petanen, J. Lehtimaki, S. Makela, G. Bylund, B. Holmbolm, E. Mannila, A. Oikari, R. Santti. Toxicol. Appl. Pharmacol. 136, 381-388 (1996).
94. L. Tremblay and G. Van Der Kraak. Environ. Toxicol. Chem. 18, 329-336 (1999).
95. L. Tremblay and G. Van Der Kraak. Aquatic Toxicol. 43, 149-162 (1998).
96. J. G. Liehr, A. Somasunderam, D. Roy. Pure Appl. Chem. 70, 1747-1758 (1998).
97. J. Römbke, Th. Knacker P. Stahlschmidt-Allner. Studie über Umweltprobleme im Zusammenhang mit Arzneimitteln. Umweltbundesamt, UBA-Texte 60/96 (1996).
98. H. H. Tabak and R. L. Bunch. Developments in Industrial Microbiology. 11, 367-376 (1970).
99. K. Norpoth, A. Nehrkorn, M. Kirchner, H. Holsen, H. Teipel. Zbl. Bakt. Hyg. I. Abt. Orig. B156, 500-511 (1973).
100. W. B. Gill, F. B. Schumacher, M. Bibbo, F. H. Stras, H. W. Schoenberg. J. Urol. 122, 36-39 (1979).
101. Appendix A. In Hormonally Active Agents in the Environment, National Academy Press, Washington, DC (1999).
102. H. K. Segner, K. Caroll, M. Fenske, C.R. Janssen, G. Maak, D. Pascoe, C. Schäfers, G. F. Vandenbergh, M. Watts, A. Wenzel. Ecotox. Environ. Safety (2001). Submitted for publication.
103. J. Bitman, H. C. Cecil, S. J. Harris, G. F. Fries. Science 162, 371-372 (1968).
104. J. Bitman and H. C. Cecil. J. Agr. Food. Chem. 18, 1180-1112 (1970).
105. R. J. Gellert, W. L. Heinrichs, R. Swerdloff. Neuroendocrinology 16, 123-130 (1974).
106. W. A. McBlain. Life Sci. 40, 215-221 (1987).
107. W. R. Kelce, C. R. Stone, S. C. Laws, L. E. Gray, J. A. Kemppalnen, E. M. Wilson. Nature 375, 581-585 (1995).
108. J. A. Nelson. Biochem. Pharmacol. 23, 447-451 (1974).
109. I. P. Kapoor, R. L. Metcalf, R. F. Nystrom, G. K. Sangha. J. Agr. Food. Chem. 18, 1145-1152 (1970).
110. D. Kupfer and W. H. Bulger. Fed. Proc. 46, 1864-1869 (1987).
111. W. W. Tullner. Science 133, 647-648 (1961).
112. D. Kupfer and W. H. Bulger. Fed. Proc. 46, 1864-1869 1987 (1987).
113. M. Gülden, A. Turan, H. Seibert. Research report 10204279, 98/66, Umweltbundesamt, Berlin (1998).
114. A. M. Soto, T. M. Lin, H. Justicia, R. M. Silvia, C. Sonnenschein. In Chemically Induced Alterations in Sexual Development: The Wildlife/Human Connection, T. Colborn and C. Clement (Eds.), pp. 295-309, Princeton Scientific, Princeton (1992).
115. S. F. Arnold, M. K. Robinson, A. C. Notides, L. J. Guiletteand, J. A. McLachlan. Environ. Health Perspect. 104, 544-548 (1996).
116. R. J. Gellert. Environ. Res. 16, 131-138 (1978).
117. B. Hammond, B.S. Katzenellenbogen, N. Krauthammer, J. McConnell. Proc. Natl. Acad. Sci. USA 76, 6641-6645 (1979).
118. J. Williams, K. Eckols, L. Uphouse. Toxicol. Appl. Pharmacol. 98, 413-421 (1989).
119. P. Thomas and J. Smith. Mar. Environ. Res. 35, 147-151 (1993).
120. H. K. Hundley. J. AOAC Int. 71, 875-892 (1988).
121. J. C. Cook, L. S. Mullin, S. R. Frame, L. B. Biegel. Toxicol. Appl. Pharmacol. 119, 195-204 (1993).
122. C. Lambright, J. Ostby, K. Bobseine, V. Wilson, A. K. Hotchkiss, P. C. Mann, L. E. Gray Jr. Toxicol. Sci., 56, 389-399 (2000).
123. R. Beyerle-Pfnür and J.-P. Lay. Chemosphere 21, 1087-1094 (1990).
124. C. I. Wong, W. R. Kelce, M. Sar, E. M. Wilson. J. Biol. Chem. 270, 19998-20003 (1995).
125. W. R. Kelce and E. M. Wilson. J. Mol. Med. 75, 198-207 (1997).
126. C. L. Waller, B. W. Juma, L. E. Gray Jr., W. R. Kelce. Toxicol. Appl. Pharmacol. 137, 219-227 (1996).
127. H. W. Vallack, D. J. Bakker, I. Brandt, E. Broström-Lundén, A. Brouwer, K. R. Bull, C. Gough, R. Guardans, I. Holoubek, B. Jansson, R. Koch, J. Kuylenstierna, A. Lecloux, D. Mackay, P. McCutcheon, P. Mocarelli, R. D. F. Taalman. Env. Tox. Pharm. 6, 143-175 (1998).
128. UN-ECE (United Nations Economic Social Council, Economic Commission for Europe). Draft Protocol to the Convention on Long-range Air Pollution on Persistent Organic Pollutants (EB.AIR/1998/2), Convention on Long-range Transboundary Air Pollution, UN-ECE, Geneva.
129. R. Tatsukawa, Y. Yamaguchi, M. Kawano, N. Kannan, S. Tanabe. In Long Range Transport of Pesticides, D. A. Kurtz (Ed.), pp. 127-141, Lewis, Chelsea, MI (1990).
130. W. M. J. Strachan. In Long Range Transport of Pesticides, D. A. Kurtz (Ed.), pp. 199-221, Lewis, Chelsea, MI (1990).
131. D. W. Kolpin, J. E. Barbash, R. J. Gilliom. Environ. Sci. Technol. 32, 558-566 (1998).
132. Environmental Agency Government of Japan. Chemicals Environments, Results of monitoring in water sediments (1998). Available at: 〈http://www.eic.or.jp/eanet/kurohon/1997/html1/suiteitxt.html〉 (In Japanese).
133. E. Y. Zeng, C. C. Yu, T. Kim. Environ. Sci. Technol. 33, 392-398 (1999).
134. D. B. Donald, J. Syrgiannis, R. W. Crosely, G. Holdsworth, B. Muir, A. Rosenberg, A. Sole, D. W. Shindler. Environ. Sci. Technol. 33, 1794-1798 (1999).
135. T. Heberer and U. Dunnbier. Environ. Sci. Technol. 33, 2346-2351 (1999).
136. C. M. Tate and J. S. Heiny. Arch. Environ. Contam. Toxicol. 30, 62-78 (1996).
137. B. T. Hargrave, W. P. Vass, P. E. Erickson, B. R. Fowler. Can. Tech. Rep. Fisheries Aquatic Sci. 1644, i-ix, 1-224 (1989).
138. C. H. Chan and L. H. Perkins. J. Great Lakes Res. 15, 465-475 (1989).
139. P. Y. Caux, R. A. Kent, G. T. Fan, C. Grande. Environ. Toxicol. Water Qual. 13, 1-41 (1998).
140. K. Bester and H. Huehnerfuss. Chemosphere 32, 1919-1928 (1996).
141. F. Santinelli, L. Cossignani, P. Damiani. Igiene Moderna 100, 1040-1064 (1993).
142. P. Cabras, A. Angioni, V. L. Garau, E. V. Minelli, M. Cabitza, M. Cubeddu. Ital. J. Food Sci. 10, 81-85 (1998).
143. P. Cabras, A. Angioni. V. L. Garau, E. V. Minelli, M. Melis, F. M. Pirisi. J. Agri. Food Chem. 45, 2248-2251 (1997).
144. U. Nilsson, T. Nybrant, M. Papantoni, L. Mathiasson. J. Agri. Food Chem. 44, 2878-2884 (1996).
145. E. K. Duursma and J. Carroll. Environmental Compartments. Equilibra and Assessment of Processes Between Air, Water, Sediments and Biota, Springer, Germany (1996).
146. M. H. Li, Y. D. Zhao, L. G. Hansen. Bull. Environ. Contam. Toxicol. 53, 583-590 (1994).
147. J. M. Bergeron, D. Crews, J. A. McLachlan. Environ. Health Perspect. 102, 780-781 (1994).
148. A. M. Soto, C. Sonnenschein, K. L. Chung, M. F. Fernandez, N. Olea, F. Olea Serrano. Environ. Health Perpect. 103 (Suppl. 7), 113-122 (1995).
149. K. S. Korach, P. Sarver, K. Chae, J. A. McLachlan, J. D. McKinney. Molec. Pharmacol. 33, 120-126 (1988).
150. WHO (World Health Organization). Environmental Health Criteria 140: Polychlorinated Biphenyls Terphenyls. WHO, Geneva (1993).
151. S. H. Safe. Crit. Rev. Toxicol. 24, 87-149 (1994).
152. Ministry of Construction, Government of Japan (1999). Available at: 〈http://www.moc.go.jp/river/horumon/990330-a〉 (in Japanese).
153. C. Agrell, L. Okla, P. Larsson, C. Backe, F. Wania. Environ. Sci. Technol. 33, 1149-1156 (1999).
154. H. Zhang, S. J. Eisenreich, T. R. Franz, J. E. Baker, J. H. Offenberg. Environ. Sci. Technol. 33, 2129-2137 (1999).
155. D. J. Vorhees, A. C. Cullen, L. M. Altshul. Environ. Sci. Technol. 33, 2151-2156 (1999).
156. M. Ahel, J. McEvoy, W. Giger. Environ. Pollut. 79, 243-248 (1993).
157. R. Ekelund, A. Berman, A. Granmo, M. Berggen. Environ. Pollut. 64, 107-120 (1990).
158. K. Yoshimura. J. Am. Oil Chem. Soc. 63, 1590-1596 (1996).
159. C. G. Naylor. Soap Cosmet. Chem. Spec. 68, 27-31 (1992).
160. A. C. Meldahl, K. Nithipatikom, J. J. Lech. Xenobiotica 26, 1167-1180 (1996).
161. T. F. Wheeler, J. R. Heim, M. R. LaTorre, A. B. Janes. J. Chromatogr. Sci. 35, 19-30 (1997).
162. B. D. Bhatt, J. V. Prasad, G. Kalpana, S. Ali. J. Chromatogr. Sci. 30, 203-210 (1992).
163. P. C. Lee and W. Lee. Bull. Environ. Contam. Toxicol. 57, 341-348 (1996).
164. M. Ahel and W. Giger. Chemosphere 26, 1461-1470 (1993).
165. A. M. Soto, H. Justicia, R. M. Silvia, C. Sonnenschein. Environ. Health Perspect. 92, 167-173 (1991).
166. P. C. Lee and W. Lee. Bull. Environ. Contam. Toxicol. 57, 341-348 (1996).
167. M. D. Shelby, R. R. Newbold, D. B. Tully, K. Chae, V. L. Davis. Environ. Health Perspect. 104, 1296-1300 (1996).
168. A. M. Soto, C. Sonnenschein, K. L. Chung, M. F. Fernandez, N. Olea, F. Olea Serrano. Environ. Health. Perspect. 103 (7), 113-122 (1995).
169. J. P. Sumpter and S. Jobling. Lancet 342, 124-125 (1993).
170. C. E. Purdom, P. A. Hardyman, V. E. Bye, N. C. Eno, C. R. Tyler, J. P. Sumpter. Chem. Ecol. 8, 275-285 (1994).
171. P. B. Dorn, J. P. Salanitro, S. H. Evans, I. Kravetz. Environ. Toxicol. Chem. 12, 1751-7162 (1993).
172. W. Giger and M. Abel. Chemosphere 26, 1471-1478 (1993).
173. P. H. Brunner, S. Capri, A. Marcomini, W. Giger. Wat. Res. 22, 1465-1472 (1988).
174. European Union Risk Assessment Report of 4-Nonylphenol (branched) and nonylphenol; CAS Nos 84852-15-2 and 25154-52-3, S.56; Draft of final report, April 2001.
175. H. B. Lee and T. E. Peart. Water Qual. Res. J. Can. 33, 389-402 (1998).
176. H. B. Lee, T. E. Peart, D. T. Bennie, R. J. Maguire. J. Chromatogr. 785, 385-394 (1997).
177. K. Fytianos, S. Pegiadou, N. Raikos, I. Eleftheriaids, H. Tsoukali. Chemosphere 35, 1423-1429 (1997).
178. M. A. Blackburn and M. J. Waldock. Water Res. 29, 1623-1629 (1995).
179. D. T. Benni, C.A. Sullivan, H. B. Lee, T. E. Peart, R. J. Maguire. Sci. Total. Environ. 193, 263-275 (1997).
180. E. R. Bennett and C. D. Metcalfe. Environ. Toxicol. Chem. 17, 1230-1235 (1998).
181. H. Fromme, Th. Otto, K. Pilz. German Federal Environmental Protection Agency, Project No 216 02 001/12. Final report, October 1998, Berlin.
182. D. Y. Shang, R. W. Macdonald, M. G. Ikonomou. Environ. Sci. Technol. 33, 1366-1372 (1999.
183. C. M. Lye, C. L. J. Frid, M. E. Gill, D. W. Cooper, D. M. Jones. Environ. Sci. Technol. 33, 1009-1014 (1999).
184. J. Dachs, D. A. Van Ry, S. J. Eisenreich. Environ. Sci. Technol. 33, 2676-2679 (1999).
185. J. W. Cook, E. C. Dodds, C. L. Hewett. Nature 131, 56-57 (1933).
186. S. L. Schneider, V. Alks, C. E. Morreal, D. K. Sinha, T. L. Dao. J. Natl. Cancer. Inst. 57, 1351-1354 (1976).
187. K. Chaloupka, V. Krishnan, S. Safe. Carcinogenesis 13, 2233-2239 (1992).
188. A. Bjøerseth (Ed.). Handbook of Polycyclic Aromatic Hydrocarbons, Marcel Dekker, New York (1993).
189. G. Rippen. Handbuch Umweltchemikalien. Ecomed, Landsberg/lech (1996).
190. M. B. Fernandes, M. A. Sicre, A. Boireau, J. Tronczynski. Mar. Pollut. Bull. 34, 857-867 (1997).
191. Environmental Agency Government of Japan. Chemicals Environments, Results of monitoring in water sediments (1998). Available at: 〈http://www.eic.or.jp/eanet/kurohon/1997/html1/suiteitxt.html〉.
192. F. Haeseler, D. Blanchet, V. Druelle, P. Werner, J.-P. Vandecasteele. Environ. Sci. Technol. 33, 825-830 (1999).
193. H. A. Bamford, J. H. Offenberg, R. K. Larsen, F.-C. Ko, J. E. Baker. Environ. Sci. Technol. 33, 2138-2144 (1999).
194. A. Leisewitz. UBA-Projekt Nr. 10601076. Im Auftrag des Umweltbundesamtes, Berlin (1997).
195. Health Council of The Netherlands. Hormone Disruptors in Ecosystems. The Hague, Health Council of The Netherlands, 1999/13E (1999).
196. R. Franse and P. de Voogt. Oestrogene verbindingen in het Nederlands milieu. ARISE-MTC University of Amsterdam, Amsterdam (in Dutch, Eng. summary) (1997).
197. Nordic Council of Ministers. Chemicals with Estrogen-like Effects. TemaNord 1996, ISBN 92 9120918X, Store Strandstraede 18, DK-1255 Copenhagen K., 580T (1996).
198. E. C. Dodds and W. Lawson. Nature 137, 996 (1936).
199. P. Perez, R. Pulgar, F. Olea-Serrano, M. Villalobos, A. Rivas, M. Metzler, V. Pedraza, N. Olea. Environ. Health Perspect. 106, 167-174 (1998).
200. S. Pawlowski, M. Islinger, A. Völkl, T. Braunbeck. Toxicol. in Vitro 14, 532-540 (2001).
201. E. D. Routledge and J. P. Sumpter. Environ. Toxicol. Chem. 15, 241-248 (1996).
202. S. C. Nagel, F. S. vom Saal, K. A. Thayer, M. G. Dhar, M. Boechler, W. V. Welshons. Environ. Health Perspect. 105, 70-76 (1997).
203. F. S. vom Saal, P. S. Cooke, D. L. Buchanan, P. Palanza, K. A. Thayer, S. Nagel, S. Parmigiani, W. V. Welshons. Toxicol. Ind. Health 14, 239-260 (1998).
204. National Toxicology Program, National Institute of Environmental Health Sciences. Endocrine Disruptors Low-Dose Peer Review (2001). Available at 〈http://ntp-server.niehs.nih.gov/htdocs/liason/ lowDoseWebPage.html〉.
205. C. Lindholst, K. L. Pedersen, S. N. Pedersen. Aquatic Toxicol. 48, 87-94 (2000).
206. W. Kloas, I. Lutz, R. Einspanier. Sci. Total Environ. 225, 59-68 (1999).
207. W. Summerfield, A. Goodson, I. Cooper. Food Add. Contam. 15, 818-830 (1998).
208. C. Sonnenschein and A. M. Soto. J. Steroid Biochem. Molecular Biol. 65, 143-150 (1998).
209. C. A. Staples, P. B. Dorn, G. M. Klecka, D. R. Branson, S. T. O'Block, L. R. Harris. Chemosphere 36, 2149-2173 (1998).
210. W. Summerfield, A. Goodson, I. Cooper. Food Add. Contam. 15, 818-830 (1988).
211. Y. Uematsu, M. Hirokado, K. Hirata, K. Ito, S. Suzuki. J. Food Hygienic Soc. Jpn. 39, 135-141 (1998).
212. H. Fromme, T. Küchler, T. Otto, K. Pilz, J. Müller, A. Wenzel. Water Res. 36, 1429-1438 (2001).
213. R. A. Rudel, S. J. Melly, P. W. Geno, G. Sun, J. G. Brody. Environ. Sci. Technol. 32, 861-869 (1998).
214. Environmental Agency Government of Japan. Chemicals Environments, Results of monitoring in air, water, sediments organisms (in Japanese) (1998). Available at: 〈http://www.eic.or.jp/eanet/kurohon/1997/html1/sankou4.html〉.
215. EPA (U.S. Environmental Protection Agency). Health Assessment Document for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Related Compounds. External review draft. EPA/600/BP-92/001 a (1994).
216. A. Schecter (Ed.). Dioxines and Health, Plenum, New York (1994).
217. S. Safe, B. Astroff, M. Harris, T. Zacharewski, R. Dickerson, M. Romkes, L. Biegel. Pharmacol. Toxicol. 69, 400-409 (1991).
218. U. G. Ahlborg, L. Lipworth, L. Titus-Ernstoff, C.-C. Hsieh, A. Hanberg, J. Baron, Trichopoulos, H.-O. Adami. Crit. Rev. Toxicol. 25, 463-531 (1995).
219. M. Romkes and S. Safe. Toxicol. Appl. Pharmacol. 92, 368-380 (1988).
220. L. Biegel and S. Safe. J. Steroid Biochem. Mol. Biol. 37, 725-732 (1990).
221. D. C. Spink, J. A. Johnson, S. P. Connor, K. M. Aldous, J. F. Gierthy. J. Toxicol. Environ. Health 41, 451-466 (1994).
222. M. Harris, T. Zacharewski, S. Safe. Cancer Res. 50, 3579-3584 (1990).
223. V. Krishnan and S. Safe. Toxicol. Appl. Pharmacol. 120, 55-61 (1993).
224. U. Quaß and M. Fermann. Identification of Relevant Industrial Sources of Dioxines Furans in Europe. (The European Dioxin Inventory). Final report, material no. 43, published by North Rhine-Westphalia State Environment Agency (LUA NRW) (1997).
225. R. Goetz, B. Steiner, P. Friesel, K. Roch, F. Walkow, V. Maass, H. Reincke, B. Stachel. Chemosphere 37, 1987-2002 (1998).
226. W. J. Gillespie and J. D. Abbott. Chemosphere 37, 1973-1985 (1998).
227. Environmental Agency Government of Japan. Results of the survey "Effects of long-term exposure to atmospheric dioxins" (in Japanese) (1998). Available at: 〈http://www.eic.or.jp/eanet/ dioxin/diox-taiki1.html〉.
228. S. Ohta, S. Kuriyama, T. Nakao, O., Aozawa, H. Miyata, M. Tanahashi. Organohalogen Compd. 32, 155-160 (1997).
229. Environmental Agency Government of Japan. What are dioxines? (in Japanese) (1999). Available at: 〈http://www.eic.or.jp/eanet/dioxin/whatdiox.html〉.
230. Environmental Agency Government of Japan. Results of the survey "Dioxines in waste water treatment plant aqueous environment" (1997). Available at: 〈http://www.eic.or.jp/eanet/dioxin/diox-taiki1.html〉.
231. P. C. Kearny, E. A. Woolson, C. P. Ellington. Environ. Sci. Technol. 6, 1017-1019 (1972).
232. C. H. Nauman and J. L. Schaum. Chemosphere 16, 1851-1856 (1987).
233. UBA 1992 Dioxinbelastung der Umwelt in der Bundesrepublik Deutschland - Meßprogramme, MeBwerte, Mebmethoden, Abschlussbericht der UAGI. "Meßprogramme" der Bund/lander-Arbeitsgruppe "Dioxin" (Texte 21/92).
234. EPA (U.S. Environmental Protection Agency). Environmental Levels of Dioxine in Soil, (Table B-1) "Estimating exposure to dioxine-like compounds", Vol. 2, p. B-3 (1994).
235. H. Fielder, C. Lau, K. Cooper, R. Andersson, S.-E. Kulp, C.Rappe, F. Howell, M. Bonner Organohalogen Compd. 24, 285-292 (1995).
236. WHO (World Health Organization). Concise International Assessment Document, No. 14, Tributyltin Oxide, WHO, Geneva, Switzerland (1999). Available at: 〈http://www.who.int/pcs/cicad/summaries/cicad_14.html〉.
237. K. Fent. Sci. Total Environ. 185, 151-159 (1996).
238. G. W. Bryan, D. A. Bright, L. G. Hummerstone, G. R. Burt. J. Mar. Biol. Assoc. UK 73, 889-912 (1993).
239. J. Oehlmann, U. Schulte-Oehlmann, E. Stroben, B. Bauer, C. Bettin, P. Fiorini. Androgene Effekte zinnorganischer Verbindungen bei Mollusken. UBA-Texte 65/95, 77-85 (1995).
240. C. Feral and S, LeGal. Proc. Intl. Minisymp. on Molluscan Endocrinology, J. Lever and H. H. Boer (Eds,), pp. 173-175, North Holland, Amsterdam (1983).
241. N, Spooner, P. E. Gibbs, G. W. Bryan, L. J. Goad. Mar. Environ. Res. 32, 37-49 (1991).
242. K. Kannan, A. L. Blankenship, P. D. Jones, J. P. Giesy. Human and Ecological Risk Assessment 6, 181-201 (2000).
243. K. S. Guruge and S. Tanabe. Mar. Pollut. Bull. 42, 179-186 (2001).
244. H. Iwata, S. Tanabe, T. Mizuno, R. Tatsukawa. Appl. Organomet. Chem. 11, 257-264 (1997).
245. S. Tanabe. Mar. Pollut. Bull. 39, 62-72 (1999).
246. C. Stewart and J. A. J. Thompson. Environ. Technol. 18, 1195-1202 (1997).
247. K. Fent and M. D. Muller. Environ. Sci. Technol. 25, 489-493 (1991).
248. P. M. Sarradin, A. Astruc, V. Desauziers, R. Pinel, M. Astruc. Environ. Tech. 12, 537-544 (1991).
249. K. Fent and J. Hunn. Environ. Sci. Technol. 25, 956-963 (1991).
250. K. Fent and J. Hunn. Environ. Toxicol. Chem. 14, 1123-1132 (1995).
251. C. Stewart and J. A. J. Thompson. Environ. Technol. 18, 1195-1202 (1997).
252. S. J. De Mora, C. Stewart, D. Phillips. Mar. Pollut. Bull. 30, 50-57 (1995).
253. R. F. Lee, A. O. Valkirs, P. F. Seligman. Environ. Sci. Technol. 23, 1515-1518 (1989).
254. K. Kannan and R. F. Lee. Environ. Toxicol. Chem. 15, 1492-1499 (1996).
255. Environmental Agency Government of Japan. Chemicals Environments, Results of monitoring in air, water, sediments organisms (1998) (in Japanese). Available at: 〈http://www.eic.or.jp/eanet〉.