Human immunity to M. tuberculosis: T cell subsets and antigen processing

Tuberculosis

Volumn 83, Issue 1-3, 2003, Pages 98-106

  Boom, W H ^a,b   Canaday, David H ^a   Fulton, Scott A ^a   Gehring, Adam J ^a   Rojas, Roxana E ^a   Torres, Marta ^a  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH FACTOR; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MYCOBACTERIUM ANTIGEN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; BACTERIAL SURVIVAL; CELL INTERACTION; CONFERENCE PAPER; CYTOKINE PRODUCTION; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE RESPONSE; IMMUNITY; IMMUNOCOMPETENT CELL; LYMPHOCYTE FUNCTION; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TUBERCULOSIS;

EID: 0038182036     PISSN: 14729792     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1472-9792(02)00054-9     Document Type: Conference Paper

References (77)

1. Boom WH. The role of T cell subsets in M. tuberculosis infection. Infectious Agents Dis 1996;5:73-81.
2. Raviglione MC, Snider Jr. DE, Kochi A. Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic [see comments]. JAMA 1995;273:220-6.
3. Barnes PF, Bloch AB, Davidson P, Snider D. Tuberculosis in patients with human immunodeficiency virus infection. N Engl J Med 1991;324:1644-50.
4. Hopewell PC. Impact of human immunodeficiency virus infection on the epidemiology, clinical features, management, and control of tuberculosis. Clin Infect Dis 1992;15:540-7.
5. Orme IM, Collins FM. Protection against Mycobacterium tuberculosis infection by adoptive transfer. J Exp Med 1983;158:74-83.
6. Muller I, Cobbold S, Waldmann H, Kaufmann SH. Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells. Infect Immun 1987;55(9):2037-41.
7. Pedrazzini T, Hug K, Louis JA. Importance of L3T4+ and Lyt-2+ cells in the immunologic control of infection with Mycobacterium bovis strain bacillus Calmette-Guerin in mice. Assessment by elimination of T cell subsets in vivo. J Immunol 1987;139(6):2032-7.
8. Caruso AMN, Serbina N, et al. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis. J Immunol 1999;162(9):5407-16.
9. Ladel CH, Daugelat S, et al. Immune response to Mycobacterium bovis bacille Calmette Guerin infection in major histocompatability complex I- and II-deficient knock-out mice: contribution of CD4+ and CD8+ T cells to acquired resistance. Eur J Immunol 1995;25:377-84.
10. Boom WH, Wallis RS, Chervenak KA. Human Mycobacterium tuberculosis-reactive CD4+ T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear phagocytes. Infect Immun 1991;59(8):2737-43.
11. Haanen JB, de-Waal-Malefijt R, Res PC, Kraakman EM, Ottenhoff TH, de-Vries RR, Spits H. Selection of a human T helper type 1-like T cell subset by mycobacteria. J Exp Med 1991;174(3):583-92.
12. Hansen PW, Petersen CM, Povlsen JV, Kristensen T. Cytotoxic human HLA class II restricted purified protein derivative reactive T lymphocyte clones. Scand J Immunol 1987;25:295-303.
13. Mustafa AS, Godal T. BCG-induced suppressor T cells optimal conditions for in vitro induction and mode of action. Clin Exp Immunol 1985;62(3):474-81.
14. Kumararatne DS, Pithie AS, Drysdale P, Gaston JS, Kiessling R, Iles PB, Ellis CJ, Innes J, Wise R. Specific lysis of mycobacterial antigen-bearing macrophages by class II MHC-restricted polyclonal T cell lines in healthy donors or patients with tuberculosis. Clin Exp Immunol 1990;80(3):314-23.
15. Ottenhoff TH, Ab BK, Van-Embden JD, Thole JE, Kiessling R. The recombinant 65-kD heat shock protein of Mycobacterium bovis Bacillus Calmette-Guerin/M. tuberculosis is a target molecule for CD4+ cytotoxic T lymphocytes that lyse human monocytes. J Exp Med 1988;168(5):1947-52.
16. Hancock GE, Cohn ZA, Kaplan G. The generation of antigen-specific, major histocompatability complex-restricted cytotoxic T lymphocytes of the CD4+ phenotype. J Exp Med 1989;169:909-19.
17. Tsukaguchi K, Balaji KN, et al. CD4+ alpha-beta T cell and gamma delta T cell responses to Mycobacterium tuberculosis: similarities and differences in antigen recognition cytotoxic effector function and cytokine production. J Immunol 1995;154:1786-96.
18. Tsukaguchi K, de Lance B, et al. Differential regulation of IFN-gamma, TNF-alpha, and IL-10 production by CD4(+) alphabetaTCR+ T cells and vdelta2(+) gammadelta T cells in response to monocytes infected with Mycobacterium tuberculosis-H37Ra. Cell Immunol 1999;194(1):12-20.
19. Canaday DH, Wilkinson RJ, Li Q, Harding CV, Silver RF, Boom WH. CD4+ and CD8+ Tcells kill intracellular M. tuberculosis by a perforin and FAS/FASL independent mechanism. J Immunol 2001;167:2734-42.
20. Jouanguy E, Altare F, et al. Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guerin infection. N Engl J Med 1996;335(26):1956-61.
21. Jouanguy E, Lamhamedi-Cherradi S, et al. Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guerin infection and a sibling with clinical tuberculosis. J Clin Invest 1997;100(11):2658-64.
22. Flynn JL, Chan J, et al. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 1993;178(6):2249-54.
23. Cooper AM, Dalton DK, et al. Disseminated tuberculosis in interferon-gamma gene-disrupted mice. J Exp Med 1993;178:2243-7.
24. Douvas GS, Looker DL, et al. Gamma interferon activates human macrophages to 4become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria. Infect Immun 1985;50(1):1-8.
25. Silver RF, Li Q, et al. Lymphocyte-dependent inhibition of growth of virulent Mycobocterium tuberculosis H37Rv within human monocytes: requirement for CD4 + T cells in purified protein derivative-positive, but not in purified protein derivative-negative subjects. J Immunol 1998;160(5):2408-17.
26. de Jong R, Altare F, Haagen IA, Elferink DG, Boer T, van Breda Vriesman PJ, Kabel PJ, Draaisma JM, van Dissel JT, Kroon FP, Casanova JL, Ottenhoff TH. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 1998;280:1435-8.
27. Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, Schwieterman WD, Siegel JN, Braun MM. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 2001;345:1098-104.
28. Havlir DV, Wallis RS, Boom WH, Daniel TM, Chervenak K, Ellner JJ. Human immune response to Mycobacterium tuberculosis antigens. Infect Immun 1991;59(2):665-70.
29. Schoel B, Gulle H, Kaufmann SH. Heterogeneity of the repertoire of T cells of tuberculosis patients and healthy contacts to Mycobacterium tuberculosis antigens separated by high-resolution techniques. Infect Immun 1992;60(4):1717-20.
30. Wiker HG, Harboe M. The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis. Microbiol Rev 1992;56(4):648-61.
31. Sorensen AL, Nagai S, Houen G, Andersen P, Andersen A. Purification and characterization of a low-molecular-mass T cell antigen secreted by Mycobacterium tuberculosis. Infect Immun 1995;63:1710-7.
32. Dillon DC, Alderson MR, Day CH, Bement T, Campos-Neto A, Skeiky YA, Vedvick T, Badaro R, Reed SG, Houghton R. Molecular and immunological characterization of Mycobacterium tuberculosis CFP-10, an immunodiagnostic antigen missing in Mycobacterium bovis BCG. J Clin Microbiol 2000;38:3285-90.
33. Skeiky YA, Lodes MJ, Guderian JA, Mohamath R, Bement T, Alderson MR, Reed SG. Cloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosis. Infect Immun 1999;67:3998-4007.
34. Dillon DC, Alderson MR, Day CH, Lewinsohn DM, Coler R, Bement T, Campos-Neto A, Skeiky YA, Orme IM, Roberts A, Steen S, Dalemans W, Badaro R, Reed SG. Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family. Infect Immun 1999;67:2941-50.
35. Surcel HM, Troye-Blomberg M, Paulie S, Andersson G, Moreno C, Pasvol G, Ivanyi J. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens. Immunology 1994;81:171-6.
36. Harris DP, Vordermeier HM, Friscia G, Roman E, Surcel HM, Pasvol G, Moreno C, Ivanyi J. Genetically permissive recognition of adjacent epitopes from the 19-kDa antigen of Mycobacterium tuberculosis by human and murine T cells. J Immunol 1993;150(11):5041-50.
37. Belisle JT, Vissa VD, et al. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 1997;276(5317):1420-2.
38. Silver RF, Wallis RS, Ellner JJ. Mapping of T cell epitopes of the 30-kDa alpha antigen of Mycobacterium bovis BCG in PPD-positive individuals. J Immunol 1994;154:4665.
39. Tan JS, Canaday DH, Boom WH, Balaji KN, Schwander SK, Rich EA. Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4+ and CD8+ cytotoxic T cells and relative resistance of alveolar macrophages to lysis. J Immunol 1997;159:290-7.
40. + cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway. J Immunol 1999;162:372-9.
41. Turner J, Dockrell H. Stimulation of human peripheral blood mononuclear cells with live Mycobacterium bovis BCG activates cytolytic CD8+ T cells in vitro. Immunology 1996;87(3):339-42.
42. Mohagheghpour N, Gammon D, et al. CTL response to Mycobacterium tuberculosis: identification of an immunogenic epitope in the 19-kDa lipoprotein. J Immunol 1998;161(5):2400-6.
43. Lalvani A, Brookes R, et al. Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis. Proc Natl Acad Sci USA 1998;95(1):270-5.
44. Smith SM, Brookes R, et al. Human CD8+ CTL specific for the mycobacterial major secreted antigen 85A. J Immunol 2000;165(12):7088-95.
45. Geluk A, van Meijgaarden KE, et al. Identification of major epitopes of Mycobacterium tuberculosis AG85B that are recognized by HLA-A*0201-restricted CD8+ T cells in HLA-transgenic mice and humans. J Immunol 2000;165(11):6463-71.
46. Flyer DC, Ramakrishna V, Miller C, et al., Identification by mass spectrometry of CD8(+)-T-cell Mycobacterium tuberculosis epitopes within the Rv0341 gene product. Infect Immun 2002;70:2926-32.
47. Havlir DV, Ellner JJ, Chervenak KA, Boom WH. Selective expansion of human gamma delta T cells by monocytes infected with live Mycobacterium tuberculosis. J Clin Invest 1991;87(2):729-33.
48. Dieli F, Troye-Blomberg M, Ivanyi J, Fournie JJ, Krensky AM, Bonneville M, Peyrat MA, Caccamo N, Sireci G, Salerno A. Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2T lymphocytes. J Infect Dis 2001;184:1082-5.
49. Kabelitz D, Bender A, Schondelmaier S, Schoel B, Kaufmann SH. A large fraction of human peripheral blood gamma/delta+ T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein. J Exp Med 1990;171(3):667-79.
50. Barnes PF, Grisso CL, Abrams JS, Band H, Rea TH, Modlin RL. Gamma delta T lymphocytes in human tuberculosis. J Infect Dis 1992;165(3):506-12.
51. Hoft DF, Brown RM, et al. Bacille Calmette-Guerin vaccination enhances human gamma delta T cell responsiveness to mycobacteria suggestive of a memory-like phenotype. J Immunol 1998;161(2):1045-54.
52. Li B, Rossman MD, et al. Disease-specific changes in gammadelta T cell repertoire and function in patients with pulmonary tuberculosis. J Immunol 1996;157(9):4222-9.
53. Shen Y, Zhou D, Qiu L, Lai X, Simon M, Shen L, Kou Z, Wang Q, Jiang L, Estep J, Hunt R, Clagett M, Sehgal PK, Li Y, Zeng X, Morita CT, Brenner MB, Letvin NL, Chen ZW. Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections. Science 2002;295:2255-8.
54. Rojas R, Boom WH. Gamma delta T cells and HIV-1 infection. In: Cellular aspects of HIV infection. Cytometric cellular analysis series, New York, NY: p. 147-205. 2001. Wiley-Liss Press.
55. Constant P, Davodeau F, Peyrat MA, et al. Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands. Science 1994;264(5156):267-70.
56. Tanaka Y, Morita C, Tanaka Y, Nieves E, Brenner MB, Bloom BM. Natural and synthetic non-peptide antigens recognized by human gamma delta T cells. Nature 1995;375:155-8.
57. Sicard H, Fournie JJ. Metabolic routes as targets for immunological discrimination of host and parasite. Infect Immun 2000;68(8):4375-7.
58. Morita CT, Beckman EM, Bukowski JF, et al. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells. Immunity 1995;3(4):495-507.
59. Lang F, Peyrat MA, Constant P, et al. Early activation of human V gamma 9V delta 2 T cell broad cytotoxicity and TNF production by nonpeptidic mycobacterial ligands. J Immunol 1995;154(11):5986-94.
60. Ulrichs T, Porcelli SA. CD1 proteins: targets of T cell recognition in innate and adaptive immunity. Rev Immunogenet 2000;2:416-32.
61. Sturgill-Koszycki S, Sclesinger P, Chakraborty P, et al. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 1994;263:678.
62. Medzhitov R, Janeway Jr. CA. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997;91:295-8.
63. Yoshimura A, Lien E, et al. Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor. J Immunol 1999;1633(1):1-5.
64. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Akira S. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 1999;11:443-51.
65. Means TK, Wang S, Lien E, Yoshimura A, Golenbock D, Fenton M. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol 1999;163:3920-7.
66. Brightbill HD, Libraty DH, Krutzik SR. Host Defense Mechanisms Triggered by Microbial Lipoproteins through the Toll-like Receptors. Science 1999;285:732-6.
67. Hirsch CS, Toossi Z, Johnson JL, et al. Augmentation of apoptosis and interferon-gamma production at sites of active Mycobacterium tuberculosis infection in human tuberculosis. J Infect Dis 2001;183:779-88.
68. Hirsch CS, Toossi Z, Vanham G, et al. Apoptosis and T cell hyporesponsiveness in pulmonary tuberculosis. J Infect Dis 1999;179:945-53.
69. Ramachandra L, Noss EN, Boom WH, Harding CV. Processing of M. tuberculosis antigen 85B involves intra-phagosomal formation of peptide: MHC-II complexes and is inhibited by live bacilli that decrease phagosome maturation. J Exp Med 2001;194:1421-32.
70. Gercken J, Pryjma J, et al. Defective antigen presentation by Mycobacterium tuberculosis-infected monocytes. Infect Immun 1994;62(8):3472-8.
71. VanHeyningen TK, Collins HL, et al. IL-6 produced by macrophages infected with Mycobacterium species suppresses T cell responses. J Immunol 1997;158(1):330-7.
72. Hmama Z, Gabathuler R, Jefferies WA, de Jong G, Reiner NE. Attenuation of HLA-DR expression by mononuclear phagocytes infected with Mycobacterium tuberculosis is related to intracellular sequestration of immature class II heterodimers. J Immunol 1998;161:4882-93.
73. Hussain S, Zwilling BS, Lafuse WP. Mycobacterium avium infection of mouse macrophages inhibits IFN-gamma Janus kinase-STAT signaling and gene induction by down-regulation of the IFN-gamma receptor. J Immunol 1999;163:2041-8.
74. Ting LM, Kim AC, Cattamanchi A, Ernst JD. Mycobacterium tuberculosis inhibits IFN-γ transcriptional responses without inhibiting activation of STAT1. J Immunol 1999;163:3898-906.
75. Wojciechowski W, DeSanctis J, et al. Attenuation of MHC class II expression in macrophages infected with Mycobacterium bovis bacillus Calmette-Guerin involves class II transactivator and depends on the Nramp1 gene. J Immunol 1999;163(5):2688-96.
76. Noss EH, Sellati TJ, Radolf JD, Belisle J, Golenbock DT, Boom WH, Harding CV. Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19 kD lipoprotein of M. tuberculosis. J Immunol 2001;167:910-8.
77. Gehring A, Rojas R, Canaday D, et al. Inhibition of human MHC-II antigen processing by 19 kD lipoprotein of M. tuberculosis. Submitted.