Opioid binding and in vitro profiles of a series of 4-hydroxy-3-methoxyindolomorphinans. Transformation of a δ-selective ligand into a high affinity κ-selective ligand by introduction of a 5,14-substituted bridge

Journal of Medicinal Chemistry

Volumn 46, Issue 14, 2003, Pages 3174-3177

  Grundt, Peter ^a   Martinez Bermejo, Fernando ^b   Lewis, John W ^a   Husbands, Stephen M ^a  

^a University of Bath   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 3 METHOXYINDOLOMORPHINAN DERIVATIVE; MORPHINAN DERIVATIVE; OPIATE; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; LIGAND BINDING; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ANIMALS; BRIDGED COMPOUNDS; CHO CELLS; CRICETINAE; INDOLES; LIGANDS; MORPHINANS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU;

EID: 0038121688     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030801n     Document Type: Article

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