Influence of asimadoline, a new κ-opioid receptor agonist, on tubular water absorption and vasopressin secretion in man

British Journal of Clinical Pharmacology

Volumn 50, Issue 3, 2000, Pages 227-235

  Kramer, H J ^a   Uhl, W ^b   Ladstetter, B ^b   Backer A ^a  

^a UNIVERSITY OF BONN   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

Opioid agonist; Asimadoline; Atrial natriuretic peptide; Endothelin; Free water clearance; Renal function; Vasopressin

Indexed keywords

ARGIPRESSIN; ASIMADOLINE; ATRIAL NATRIURETIC FACTOR; CREATININE; CYCLIC AMP; ENDOTHELIN 1; KAPPA OPIATE RECEPTOR AGONIST; PLACEBO; SODIUM CHLORIDE;

ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIURETIC ACTIVITY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG TOLERABILITY; ELECTROLYTE URINE LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUID BALANCE; GAS CHROMATOGRAPHY; GLOMERULUS FILTRATION RATE; HEART RATE; HUMAN; HUMAN EXPERIMENT; KIDNEY TUBULE ABSORPTION; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; URINE VOLUME; VASOPRESSIN RELEASE; WATER ABSORPTION;

ACETAMIDES; ADULT; ANALGESICS, OPIOID; ATRIAL NATRIURETIC FACTOR; CROSS-OVER STUDIES; CYCLIC AMP; DOUBLE-BLIND METHOD; ENDOTHELIN-1; HUMANS; KIDNEY FUNCTION TESTS; KIDNEY TUBULES; MALE; PYRROLIDINES; RECEPTORS, OPIOID, KAPPA; VASOPRESSINS;

EID: 0033813577     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00256.x     Document Type: Article

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