The 14-alkyl- and 14-alkenyl-5β-methylindolomorphinan series provide δ-selective partial opioid agonists

Helvetica Chimica Acta

Volumn 86, Issue 3, 2003, Pages 793-798

  Grundt, Peter ^a   Martinez Bermejo, Fernando ^b   Lewis, John W ^a   Husbands, Stephen M ^a  

^a University of Bath   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; SYNTHESIS (CHEMICAL);

OPIOID BINDING;

AROMATIC COMPOUNDS;

5BETA METHYLINDOLOMORPHINAN DERIVATIVE; 6,7 DIDEHYDRO 4,5ALPHA EPOXY 5,17 DIMETHYL 14BETA (3 METHYLBUTYL)INDOLO[2',3':6,7]MORPHINAN 3 OL; 6,7 DIDEHYDRO 4,5ALPHA EPOXY 5,17 DIMETHYL 14BETA (3 PHENYLPROP 2 ENYL)INDOLO[2',3':6,7]MORPHINAN 3 OL; DELTA OPIATE RECEPTOR AGONIST; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; DRUG ACTIVITY; DRUG BINDING; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL;

EID: 0242584833     PISSN: 0018019X     EISSN: None     Source Type: Journal    
DOI: 10.1002/hlca.200390080     Document Type: Article

References (14)

1. E. J. Bilsky, S. N. Calderon, T. Wang, R. N. Bernstein, P. Davis, V. J. Hruby, R. W. McNutt, R. B. Rothman, K. C. Rice, F. Porreca, J. Pharmacol. Exp. Ther. 1995, 273, 359.
2. R. S. Rapaka, F. Porreca, Pharm. Res. 1991, 8, 1.
3. S. Mazumder, I. Nath, M. M. Dhar, Immunol. Lett. 1993, 35, 33.
4. R. V. House, P. T. Thomas, H. N. Bhargava, Peptides 1996, 17, 75.
5. P. S. Portoghese, M. Sultana, A. E. Takemori, J. Med. Chem. 1990, 33, 1714.
6. D. Biyashev, K. Monory, S. Benyhe, J. Schutz, M. Koch, H. Schmidhamme, A. Borsodi, Helv. Chim. Acta 2001, 84, 2015.
7. P. Grundt, A. R. Jales, J. R. Traynor, J. W. Lewis, S. M. Husbands, J. Med. Chem., in press.
8. J. H. Woods, G. Winger, J. R. Traynor, F. Medzihradsky, C. B. Smith, NIDA Res. Monogr. Series 1999, 179, 365.
9. K. W. Bentley, J. C. Ball, J. Org. Chem. 1958, 23, 1720.
10. P. Grundt, F. Martinez-Bermejo, J. W. Lewis, S. M. Husbands, Hev. Chim. Acta 2003, 86, in press.
11. L. Toll, I. P. Berzetei-Gurske, W. E. Polgar, S. R. Brandt, I. D. Adapa, L. Rodriguez, R. W. Schwartz, D. Haggart, A. O'Brien, A. White, J. M. Kennedy, K. Craymer, L. Farrington, J. S. Auh, NIDA Res. Monogr. Series 1998, 178, 440.
12. J. Lahsen, H. Schmidhammer, B. M. Rode, Helv. Chim. Acta 2001, 84, 3299.
13. J. R. Traynor, S. R. Nahorski, Mol. Pharmacol. 1995, 47, 848.
14. J. B. Thomas, R. N. Atkinson, R. B. Rothman, S. E. Fix, S. W. Mascarella, N. A. Vinson, H. Xu, C. M. Dersch, Y.-F. Lu, B. E. Cantrell, D. M. Zimmerman, F. I. Carroll, J. Med. Chem. 2001, 44, 2687 and ref. cit. therein.