메뉴 건너뛰기




Volumn 13, Issue 15, 1999, Pages 2061-2068

Analysis of HIV cross-resistance to protease inhibitors using a rapid single-cycle recombinant virus assay for patients failing on combination therapies

Author keywords

Cross resistance; HIV drug resistance; Phenotypic assay; Protease inhibitors

Indexed keywords

AMPRENAVIR; INDINAVIR; NELFINAVIR; PROTEINASE; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; VIRUS ENZYME;

EID: 0032750954     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199910220-00008     Document Type: Article
Times cited : (118)

References (43)
  • 1
    • 2442723342 scopus 로고    scopus 로고
    • Treatment of HIV infection with saquinavir, zidovudine, and zalcitabine
    • Collier A, Coombs R, Schoenfeld D, et al. Treatment of HIV infection with saquinavir, zidovudine, and zalcitabine. N Engl J Med 1996, 334:1011-1017.
    • (1996) N Engl J Med , vol.334 , pp. 1011-1017
    • Collier, A.1    Coombs, R.2    Schoenfeld, D.3
  • 2
    • 0030868897 scopus 로고    scopus 로고
    • Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    • Autran B, Carcelain G, Li TS, et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 1997, 277:112-116.
    • (1997) Science , vol.277 , pp. 112-116
    • Autran, B.1    Carcelain, G.2    Li, T.S.3
  • 3
    • 6844252894 scopus 로고    scopus 로고
    • Decrease of HIV-1 RNA levels in lymphoid tissue and peripheral blood during treatment with ritonavir, lamivudine and zidovudine. Ritonavir/3TC/ZDV Study Group
    • Notermans DW, Jurriaans S, de Wolf F, et al. Decrease of HIV-1 RNA levels in lymphoid tissue and peripheral blood during treatment with ritonavir, lamivudine and zidovudine. Ritonavir/3TC/ZDV Study Group. AIDS 1998, 12:167-173.
    • (1998) AIDS , vol.12 , pp. 167-173
    • Notermans, D.W.1    Jurriaans, S.2    De Wolf, F.3
  • 4
    • 0033035705 scopus 로고    scopus 로고
    • Protease inhibitor-containing regimens compared with nucleoside analogues alone in the suppression of persistent HIV-1 replication in lymphoid tissue
    • Ruiz L, van Lunzen J, Arno A, et al. Protease inhibitor-containing regimens compared with nucleoside analogues alone in the suppression of persistent HIV-1 replication in lymphoid tissue. AIDS 1999, 13:F1-F8.
    • (1999) AIDS , vol.13
    • Ruiz, L.1    Van Lunzen, J.2    Arno, A.3
  • 5
    • 2442732876 scopus 로고    scopus 로고
    • In vivo resistance to a HIV-1 proteinase inhibitor: Mutations, kinetics, and frequencies
    • Jacobsen H, Hanggi M, Ott M, et al. In vivo resistance to a HIV-1 proteinase inhibitor: mutations, kinetics, and frequencies. J Infect Dis 1996, 173:1-9.
    • (1996) J Infect Dis , vol.173 , pp. 1-9
    • Jacobsen, H.1    Hanggi, M.2    Ott, M.3
  • 6
    • 10344263394 scopus 로고    scopus 로고
    • Genetic correlates of in vivo viral resistance to indinavir, a HIV-1 protease inhibitor
    • Condra J, Holder D, Schlief W, et al. Genetic correlates of in vivo viral resistance to indinavir, a HIV-1 protease inhibitor. J Virol 1996, 70:8270-8276.
    • (1996) J Virol , vol.70 , pp. 8270-8276
    • Condra, J.1    Holder, D.2    Schlief, W.3
  • 7
    • 0030730288 scopus 로고    scopus 로고
    • Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure
    • Wong JK, Gunthard HF, Havlir DV, et al. Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure. Proc Natl Acad Sci USA 1997, 94:12574-12579.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12574-12579
    • Wong, J.K.1    Gunthard, H.F.2    Havlir, D.V.3
  • 8
    • 0028943992 scopus 로고
    • In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
    • Condra JH, Schleif WA, Blahy OM, et al. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 1995, 374:569-571.
    • (1995) Nature , vol.374 , pp. 569-571
    • Condra, J.H.1    Schleif, W.A.2    Blahy, O.M.3
  • 9
    • 7344249601 scopus 로고    scopus 로고
    • HIV protease genotype and viral sensitivity to HIV protease inhibitors following saquinavir therapy
    • Craig C, Race E, Sheldon J, et al. HIV protease genotype and viral sensitivity to HIV protease inhibitors following saquinavir therapy. AIDS 1998, 12:1611-1618.
    • (1998) AIDS , vol.12 , pp. 1611-1618
    • Craig, C.1    Race, E.2    Sheldon, J.3
  • 10
    • 0028288728 scopus 로고
    • Cross-resistance between AZT, ddl and other antiretroviral drugs in primary isolates of HIV-1
    • Cox SW, Aperia K, Sandstrom E, et al. Cross-resistance between AZT, ddl and other antiretroviral drugs in primary isolates of HIV-1. Antiviral Chem Chemother 1994, 5:7-12.
    • (1994) Antiviral Chem Chemother , vol.5 , pp. 7-12
    • Cox, S.W.1    Aperia, K.2    Sandstrom, E.3
  • 11
    • 0345486993 scopus 로고    scopus 로고
    • Patterns of resistance and cross-resistance to human immunodeficiency virus type 1 reverse transcriptase inhibitors in patients treated with the nonnucleoside reverse transcriptase inhibitor loviride
    • Miller V, de Bethune MP, Kober A, et al. Patterns of resistance and cross-resistance to human immunodeficiency virus type 1 reverse transcriptase inhibitors in patients treated with the nonnucleoside reverse transcriptase inhibitor loviride. Antimicrob Agents Chemother 1998, 42:3123-129.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 3123-3129
    • Miller, V.1    De Bethune, M.P.2    Kober, A.3
  • 12
    • 7844241226 scopus 로고    scopus 로고
    • Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries
    • Schmit JC, van Laethem K, Ruiz L, et al. Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries. AIDS 1998, 12:2007-2015.
    • (1998) AIDS , vol.12 , pp. 2007-2015
    • Schmit, J.C.1    Van Laethem, K.2    Ruiz, L.3
  • 13
    • 2642640455 scopus 로고    scopus 로고
    • Recent advances in antiretroviral therapy and HIV infection monitoring
    • Schmit JC, Weber B. Recent advances in antiretroviral therapy and HIV infection monitoring. Intervirology 1997, 40:304-321.
    • (1997) Intervirology , vol.40 , pp. 304-321
    • Schmit, J.C.1    Weber, B.2
  • 15
    • 0008551334 scopus 로고    scopus 로고
    • Correlation of baseline phenotypic drug susceptibility with 16 week virologic response in a pilot combination therapy study in HIV-infected patietns who failed indinavir therapy
    • Lake Maggiore. Italy, June [abstact 53]
    • Deeks SC, Parkin N, Petropôulos CJ, et al. Correlation of baseline phenotypic drug susceptibility with 16 week virologic response in a pilot combination therapy study in HIV-infected patietns who failed indinavir therapy. 2nd International Workshop on HIV Drug Resistance and Treatment Strategies. Lake Maggiore. Italy, June 1998 [abstact 53].
    • (1998) 2nd International Workshop on HIV Drug Resistance and Treatment Strategies
    • Deeks, S.C.1    Parkin, N.2    Petropôulos, C.J.3
  • 17
    • 0003247871 scopus 로고    scopus 로고
    • Predictors of antiviral response to saquinavir/ritonavir therapy in a clinical cohort who have failed prior protease inhibitors: A comparison of clinical characteristics, antiretroviral drug history and HIV genotype
    • Lake Maggiore, Italy, June [abstract 54]
    • Zolopa AR, Shafer RW, Warford A, et al. Predictors of antiviral response to saquinavir/ritonavir therapy in a clinical cohort who have failed prior protease inhibitors: a comparison of clinical characteristics, antiretroviral drug history and HIV genotype. Second International Workshop on HIV Drug Resistance and Treatment Strategies. Lake Maggiore, Italy, June 1998 [abstract 54].
    • (1998) Second International Workshop on HIV Drug Resistance and Treatment Strategies
    • Zolopa, A.R.1    Shafer, R.W.2    Warford, A.3
  • 19
    • 0033009094 scopus 로고    scopus 로고
    • Impact of resistance mutations on virologic response to salvage therapy
    • Lorenzi P, Opravil M, Hirschel B, et al. Impact of resistance mutations on virologic response to salvage therapy. AIDS 1999, 13:F17-F21.
    • (1999) AIDS , vol.13
    • Lorenzi, P.1    Opravil, M.2    Hirschel, B.3
  • 20
    • 0030027268 scopus 로고    scopus 로고
    • Selection in vitro of an HIV-1 variant resistant to both lamivudine (3TC) and zidovudine
    • Goulden MG, Cammack N, Hopewell PL, Penn CR, Cameron JM. Selection in vitro of an HIV-1 variant resistant to both lamivudine (3TC) and zidovudine [letter]. AIDS 1996, 10:101-102.
    • (1996) AIDS , vol.10 , pp. 101-102
    • Goulden, M.G.1    Cammack, N.2    Hopewell, P.L.3    Penn, C.R.4    Cameron, J.M.5
  • 21
    • 0029028067 scopus 로고
    • Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy
    • Larder BA, Kemp SD, Harrigan PR. Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy. Science 1995, 269:696-699.
    • (1995) Science , vol.269 , pp. 696-699
    • Larder, B.A.1    Kemp, S.D.2    Harrigan, P.R.3
  • 22
    • 0030840407 scopus 로고    scopus 로고
    • Mutations in the pol gene of human immunodeficiency virus type 1 in infected patients receiving didanosine and hydroxyurea combination therapy
    • de Antoni A, Foli A, Lisziewicz J, Lori F. Mutations in the pol gene of human immunodeficiency virus type 1 in infected patients receiving didanosine and hydroxyurea combination therapy. J Infect Dis 1997, 176:899-903.
    • (1997) J Infect Dis , vol.176 , pp. 899-903
    • De Antoni, A.1    Foli, A.2    Lisziewicz, J.3    Lori, F.4
  • 23
    • 0030818643 scopus 로고    scopus 로고
    • Lamivudine-resistant HIV-1 variants (184V) require multiple amino acid changes to become co-resistant to zidovudine in vivo
    • Nijhuis M, Schuurman R, de jong D, et al. Lamivudine-resistant HIV-1 variants (184V) require multiple amino acid changes to become co-resistant to zidovudine in vivo J Infect Dis 1997, 176:398-405.
    • (1997) J Infect Dis , vol.176 , pp. 398-405
    • Nijhuis, M.1    Schuurman, R.2    De Jong, D.3
  • 24
    • 0031925680 scopus 로고    scopus 로고
    • A novel polymorphism at codon 333 of human immunodeficiency virus type 1 reverse transcriptase can facilitate dual resistance to zidovudine and L-2′,3′-dideoxy-3′-thiacytidine
    • Kemp SD, Shi C, Bloor S, et al. A novel polymorphism at codon 333 of human immunodeficiency virus type 1 reverse transcriptase can facilitate dual resistance to zidovudine and L-2′,3′-dideoxy-3′-thiacytidine. J Virol 1998, 72:5093-5098.
    • (1998) J Virol , vol.72 , pp. 5093-5098
    • Kemp, S.D.1    Shi, C.2    Bloor, S.3
  • 25
    • 0033552832 scopus 로고    scopus 로고
    • Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 resistant to multiple nucleoside analogues
    • de Jong JJ, Goudsmit J, Lukashov V, et al. Insertion of two amino acids combined with changes in reverse transcriptase containing tyrosine-215 of HIV-1 resistant to multiple nucleoside analogues. AIDS 1999, 13:75-80.
    • (1999) AIDS , vol.13 , pp. 75-80
    • De Jong, J.J.1    Goudsmit, J.2    Lukashov, V.3
  • 27
    • 15444377672 scopus 로고    scopus 로고
    • Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
    • Molla A, Korneyeva M, Gao Q, et al. Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nat Med 1996, 2:760-766.
    • (1996) Nat Med , vol.2 , pp. 760-766
    • Molla, A.1    Korneyeva, M.2    Gao, Q.3
  • 28
    • 0029731556 scopus 로고    scopus 로고
    • Mutational anatomy of an HIV-1 protease variant conferring cross- resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity
    • Schock HB, Garsky VM, Kuo LC. Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity. J Biol Chem 1996, 271:31957-1963.
    • (1996) J Biol Chem , vol.271 , pp. 31957-31963
    • Schock, H.B.1    Garsky, V.M.2    Kuo, L.C.3
  • 29
    • 0032552167 scopus 로고    scopus 로고
    • Correlation of response to treatment and HIV genotypic changes during phase III trials with saquinavir and reverse transcriptase inhibitor combination therapy
    • Race E, Gilbert SM, Sheldon JG, et al. Correlation of response to treatment and HIV genotypic changes during phase III trials with saquinavir and reverse transcriptase inhibitor combination therapy. AIDS 1998, 12:1465-1474.
    • (1998) AIDS , vol.12 , pp. 1465-1474
    • Race, E.1    Gilbert, S.M.2    Sheldon, J.G.3
  • 30
    • 0032889457 scopus 로고    scopus 로고
    • Constrained evolution of human immunodeficiency virus type 1 protease during sequential therapy with two distinct protease inhibitors
    • Dulioust A, Paulous S, Guillemot L, et al. Constrained evolution of human immunodeficiency virus type 1 protease during sequential therapy with two distinct protease inhibitors. J Virol 1999, 73:850-854.
    • (1999) J Virol , vol.73 , pp. 850-854
    • Dulioust, A.1    Paulous, S.2    Guillemot, L.3
  • 31
    • 0028085161 scopus 로고
    • Recombinant virus assay: A rapid, phenotypic assay for assessment of drug susceptibility of HIV-1 isolates
    • Kellam P, Larder B. Recombinant virus assay: a rapid, phenotypic assay for assessment of drug susceptibility of HIV-1 isolates. Antimicrob Agents Chemother 1994, 38:23-30.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 23-30
    • Kellam, P.1    Larder, B.2
  • 32
    • 0029816733 scopus 로고    scopus 로고
    • HIV-1 drug susceptibility determination by using recombinant viruses generated from patient sera tested in a cell-killing assay
    • Boucher C, Keulen W, Bommel T, et al. HIV-1 drug susceptibility determination by using recombinant viruses generated from patient sera tested in a cell-killing assay. Antimicrob Agents Chemother 1996, 40:2404-2409.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2404-2409
    • Boucher, C.1    Keulen, W.2    Bommel, T.3
  • 33
    • 0030816830 scopus 로고    scopus 로고
    • A recombinant retroviral system for rapid in vivo analysis of human immunodeficiency virus type 1 susceptibility to reverse transcriptase inhibitors
    • Shi C, Mellors JW. A recombinant retroviral system for rapid in vivo analysis of human immunodeficiency virus type 1 susceptibility to reverse transcriptase inhibitors. Antimicrob Agents Chemother 1997, 41:2781-2785.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 2781-2785
    • Shi, C.1    Mellors, J.W.2
  • 34
    • 0344474694 scopus 로고    scopus 로고
    • A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs
    • Hertogs K, de Bethune MP, Miller V, et al. A rapid method for simultaneous detection of phenotypic resistance to inhibitors of protease and reverse transcriptase in recombinant human immunodeficiency virus type 1 isolates from patients treated with antiretroviral drugs. Antimicrob Agents Chemother 1998, 42:269-276.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 269-276
    • Hertogs, K.1    De Bethune, M.P.2    Miller, V.3
  • 35
    • 0032581588 scopus 로고    scopus 로고
    • Sexual transmission of an HIV-1 variant resistant to multiple reverse-transcriptase and protease inhibitors
    • Hecht FM, Grant RM, Petropoulos CJ, et al. Sexual transmission of an HIV-1 variant resistant to multiple reverse-transcriptase and protease inhibitors. N Engl J Med 1998, 339:307-311.
    • (1998) N Engl J Med , vol.339 , pp. 307-311
    • Hecht, F.M.1    Grant, R.M.2    Petropoulos, C.J.3
  • 36
    • 0031979696 scopus 로고    scopus 로고
    • Characterization and use of a recombinant retroviral system for the analysis of drug resistant HIV
    • Medina DJ, Tung PP, Nelson CJ, et al. Characterization and use of a recombinant retroviral system for the analysis of drug resistant HIV. J Virol Meth 1998, 71:169-176.
    • (1998) J Virol Meth , vol.71 , pp. 169-176
    • Medina, D.J.1    Tung, P.P.2    Nelson, C.J.3
  • 37
    • 0027965903 scopus 로고
    • HIV-1 reverse transcription. A termination step at the center of the genome
    • Chameau P, Mirambeau G, Roux P, et al. HIV-1 reverse transcription. A termination step at the center of the genome. J Mol Biol 1994, 241:651-662.
    • (1994) J Mol Biol , vol.241 , pp. 651-662
    • Chameau, P.1    Mirambeau, G.2    Roux, P.3
  • 38
    • 0031946007 scopus 로고    scopus 로고
    • Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo
    • Zennou V, Mammano F, Paulous S, Mathez D, Clavel F. Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo. J Virol 1998, 72:3300-3306.
    • (1998) J Virol , vol.72 , pp. 3300-3306
    • Zennou, V.1    Mammano, F.2    Paulous, S.3    Mathez, D.4    Clavel, F.5
  • 39
    • 0025718563 scopus 로고
    • A sensitive method for the detection of β-galactisidase in transfected mammailian cells
    • Eustice D, Feldman P, Colberg-Poley A, Buckery R, Neubauer R. A sensitive method for the detection of β-galactisidase in transfected mammailian cells. BioTechniques 1991, 11:739-743.
    • (1991) BioTechniques , vol.11 , pp. 739-743
    • Eustice, D.1    Feldman, P.2    Colberg-Poley, A.3    Buckery, R.4    Neubauer, R.5
  • 40
    • 0002658306 scopus 로고
    • The median-effect principle and the combination index for quantitation of synergism and antagonism
    • Edited by Chou T-C, Rideout J. Academic Press, New York
    • Chou T-C. The median-effect principle and the combination index for quantitation of synergism and antagonism. In Synergism and Antagonism in Chemotherapy. Edited by Chou T-C, Rideout J. Academic Press, New York; 1991:61-102.
    • (1991) Synergism and Antagonism in Chemotherapy , pp. 61-102
    • Chou, T.-C.1
  • 41
    • 0000342562 scopus 로고    scopus 로고
    • Mutations in retroviral genes associated with drug resistance
    • Schinazi RF, Larder BA, Mellors JW. Mutations in retroviral genes associated with drug resistance. Int Antiviral News 1997, 5:129-137.
    • (1997) Int Antiviral News , vol.5 , pp. 129-137
    • Schinazi, R.F.1    Larder, B.A.2    Mellors, J.W.3
  • 42
    • 0008547476 scopus 로고    scopus 로고
    • Patterns of cross-resistance amoung protease inhibitors in over 1500 clinical isolates. Comparison of genotypic and phenotypic resistance profiles
    • Lake Maggiore, Italy, June [abstact 70]
    • Hertogs K, Kemp S, Bloor S, et al. Patterns of cross-resistance amoung protease inhibitors in over 1500 clinical isolates. Comparison of genotypic and phenotypic resistance profiles. Second International Workshop on HIV Drug Resistance and Treatment Strategies. Lake Maggiore, Italy, June 1998 [abstact 70].
    • (1998) Second International Workshop on HIV Drug Resistance and Treatment Strategies
    • Hertogs, K.1    Kemp, S.2    Bloor, S.3
  • 43
    • 0030769354 scopus 로고    scopus 로고
    • Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites
    • Zhang YM, Imamichi H, Imamichi T, et al. Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites. J Virol 1997, 71:6662-6670.
    • (1997) J Virol , vol.71 , pp. 6662-6670
    • Zhang, Y.M.1    Imamichi, H.2    Imamichi, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.