Structure-based identification of binding sites, native ligands and potential inhibitors for G-protein coupled receptors

Proteins: Structure, Function and Genetics

Volumn 51, Issue 3, 2003, Pages 423-433

  Cavasotto, Claudio N ^a,b   Orry, Andrew J W ^a   Abagyan, Ruben A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NONE   (United States)

Author keywords

Flexible ligand receptor docking; Internal coordinate mechanics; Ligand binding pocket prediction; Orphan G protein coupled receptor; Protein ligand docking; Rational drug design; Seven transmembrane receptor; Virtual ligand screening

Indexed keywords

BACTERIORHODOPSIN; BINDING PROTEIN; CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; MEMBRANE PROTEIN; RETINAL; RHODOPSIN;

AB INITIO CALCULATION; ARTICLE; BINDING SITE; COVALENT BOND; CRYSTAL STRUCTURE; DRUG DESIGN; GEOMETRY; LIGAND BINDING; METHODOLOGY; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN CONFORMATION; SCORING SYSTEM; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ANIMALS; BACTERIORHODOPSINS; BINDING SITES; CATTLE; GTP-BINDING PROTEINS; LIGANDS; MEMBRANE PROTEINS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; RHODOPSIN;

BOVINAE;

EID: 0037963157     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10362     Document Type: Article

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