Hybrid antibiotics

Folia Microbiologica

Volumn 48, Issue 1, 2003, Pages 17-25

  Behal V ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; MULTIENZYME COMPLEX;

BACTERIAL GENE; BACTERIUM; BIOSYNTHESIS; ENZYMOLOGY; GENETIC ENGINEERING; GENETIC RECOMBINATION; GENETICS; METABOLISM; METHODOLOGY; REVIEW;

ANTI-BACTERIAL AGENTS; BACTERIA; GENES, BACTERIAL; GENETIC ENGINEERING; MULTIENZYME COMPLEXES; RECOMBINATION, GENETIC;

EID: 0037929063     PISSN: 00155632     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02931272     Document Type: Review

References (30)

1. ARISAVA A., KAWAMURA N., NARITA T., KOJIMA I., OKAMURA K., TSUNEKAWA H., YOSHIKA T., OKAMOTO R.: Direct fermentative production of acetyltylosins by genetically-engineered strain of Streptomyces fradiae. J.Antibiot. 49, 349-354 (1996).
2. BĚHAL V.: Enzymes of secondary metabolism in microorganisms. Trends Biochem.Sci. 11, 88-91 (1986).
3. BĚHAL V: Bioactive products from Streptomyces. Adv.Appl.Microbiol. 47, 113-156 (2000).
4. BĚHAL V.: Nontraditional microbial bioactive metabolites. Folia Microbiol. 46, 363-370 (2001).
5. BENTLEY R., BENNETT J.W.: Constructing polyketides: from collie to combinatorial biosynthesis. Ann.Rev.Microbiol. 35, 1-28 (1999).
6. BOMAN H.G., WADE D., BOMAN I.A., WAHLIN B., MERRIFIELD R.B.: Antibacterial and antimalarial properties of peptides that are cecropin-melittin hybrids. FEBS Lett. 259, 103-106 (1989).
7. BYCROFT M., WEISSMAN K.J., STAUNTON J., LEADLAY P.F.: Efficient purification and kinetic characterization of bimodular derivative of erythromycin polyketide synthase. Eur.J.Biochem. 267, 520-526 (2000).
8. CHU Y., RENNO D., SAUNDERS G.: Detection of proteins which binds specifically to the upstream region the pchAB gene in Penicillium chrysogenum. Curr.Genet. 27, 184-189 (1995).
9. DIEZ B., MELLADO E., RODRIGUEZ M., FOUCES R., BARREDO J.-L.: Recombinant microorganisms for industrial production of antibiotics. Biotechnol.Bioeng. 55, 216-226 (1997).
10. DONADIO S., STAVER M.J., MCALPINE J.B., SWANSON S.J., KATZ L.: Modular organization of genes required for complex polyketide biosynthesis. Science 252, 675-679 (1991).
11. FENG B., FRIENDLING E., MARZLUF G.A.: Nuclear DNA-binding proteins which recognize the intergenic control region of penicillin biosynthetic genes. Curr.Genet. 27, 357-358 (1995).
12. IKEDA H., NONOMIYA T., USAMI M., OHTA T., OMURA S.: Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. Biochemistry 96, 9509-9514 (1999).
13. JEZ J.M., BOWMAN M.E., NOEL J.P.: Expanding the biosynthetic repertoire of plant type III polyketide synthase by altering starter molecule specificity. Proc.Nat.Acad.Sci.USA 99, 5319-5324 (2002).
14. KHOSLA C., GOKHALE R.J., JAKOBSEN J.R., CANE D.J.: Tolerance and specificity of polyketide synthases. Ann.Rev.Biochem. 68, 219-253 (1999).
15. KIM H.-S., HONG Y.-S., KIM Y.-H., YOO O.-J., LEE J.-J.: New anthracycline metabolites produced by aklavinone 11-hydroxylase gene in Streptomyces galilaeus ATCC 31133. J.Antibiot. 49, 355-360 (1996).
16. MALPARTIDA F., HOPWOOD D.A.: Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host. Nature 309, 462-464 (1984).
17. MARSDEN A.F.A., WILKINSON B., CORTÉS J., DUNSTER N.J., STAUNTON J., LEADLAY P.F.: Engineering broader specificity into an antibiotic-producing polyketide synthase. Science 279, 199-202 (1998).
18. MARTIN R., STERNER O., ALVAREZ M.A., DECLERCQ E., BAILEY J.E., MINAS W.: Collinone, a new recombinant angular polyketide antibiotic made by an engineered Streptomyces strain. J.Antibiot. 54, 239-249 (2001).
19. MCDANIEL R., EBERT-KOSHLA S., FU D., HOPWOOD D.A, KHOSLA C.: Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase. Proc.Nat.Acad.Sci.USA 91, 11542-11546 (1994).
20. MCDANIEL R., KAO C.M., FU H., HEVEZI P., GUSTAFSSON C., BETLACH M., ASHLEY G., CANE D.E., KHOSLA C.: Gain-of-function mutagenesis of a modular polyketide synthase. J.Am.Chem.Soc. 119, 4309-4310 (1997).
21. MIYAMOTO Y., OHTA S., JOHDO O., NAGAMATSU Y., YOSHIMOTO A.: Production of a new anthracycline 4-O-methylepelmycin by heterologous expression of dnrK in epelmycin-producing Streptomyces violaceus. J.Antibiot. 53, 828-836 (2000).
22. MOROI Y., MAYHEW M., TRCKA J., HOE M.H., TAKECHI Y., HARTL F.U., ROTHAM J.E., HOUGHTON A.N.: Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70. Proc.Nat.Acad.Sci.USA 97, 3485-3490 (2000).
23. NIEMI J., YLIHOKO K., HAKALA J., PARSSINEN R., KOPIO A., MANTSALA P.: Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes Streptromyces purpurascens in Streptomyces galilaeus. Microbiology 140, 1351-1358 (1994).
24. OH H., HEDBERG M., WADE D., EDLUND C.: Activities of synthetic hybrid peptides against anaerobic bacteria: aspects of methodology and stability. Antimicrob.Agents Chemother. 44, 68-72 (2000).
25. PACEY M.S., DIRLAM J.P., GELDART J.W., LEADLAY P.F., MCARTHUR H.A.I., MCCORMICK E.L., MONDEY R.A., O'CONNELL T.N., STAUNTON J.: Novel erythromycins from recombinant Saccharopolyspora erythrea strain NRRL 2338 pIG1. - I. Fermentation, isolation and biological activity. J.Antibiot. 51, 1029-1034 (1998).
26. PIEPER R., LUO G., CANE D.E., KHOSLA C.: Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases. Nature 378, 263-378 (1995).
27. SCHUPP T., TOUPET C., CLUZEL B., NEFF S., HILL S., BESK J.J., LIGON J.M.: A Sorangium cellulosum (myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic soraphen A: cloning, characterization, and homology to polyketide synthase genes from actinomycetes. J.Bacteriol. 177, 3673-3679 (1995).
28. SMITH D.J., BULL J.H., EDWARDS J., TURNER G.: Amplification of the isopenicillin-A synthetase gene in a strain of Penicillium chrysogenum producing high levels of penicillin. Mol.Gen.Genet. 216, 492-497 (1989).
29. TANG L., SHAH S., CHUNG L., CARNEY J., KATY L., KHOSLA C., JULIEN B.: Cloning and heterologous expression of the epothilone gene cluster. Science 287, 640-643 (2000).
30. WEBER J.M., LEUNG J.O., SWANSON S.J., IDLER K.B., MCALPINE J.B.: An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythrea. Science 252, 114-117 (1991).