Stem cell therapy for cerebral palsy

Expert Opinion on Biological Therapy

Volumn 3, Issue 4, 2003, Pages 541-549

  Bartley, John ^a   Carroll, James E ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Cerebral palsy; Embryonic stem cells; Marrow stromal cells; Neuron; Oligodendrocyte; Periventricular leukomalacia; Stem cells

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BIRTH INJURY; BRAIN DEVELOPMENT; BRAIN DISEASE; BRAIN INJURY; BRAIN ISCHEMIA; CELL TRANSFER; CELL TYPE; CEREBRAL PALSY; CHILDHOOD DISEASE; CHRONIC DISEASE; CHRONOTHERAPY; CLINICAL RESEARCH; CONTROLLED STUDY; DISEASE MODEL; ENCEPHALOMALACIA; HUMAN; HUMAN CELL; INCIDENCE; INTRACEREBRAL DRUG ADMINISTRATION; MOTOR DYSFUNCTION; NEUROLOGIC DISEASE; NEWBORN HYPOXIA; NONHUMAN; OLIGODENDROGLIA; PARENTERAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; POPULATION RISK; POSTNATAL DEVELOPMENT; PREMATURITY; REVIEW; SAFETY; STATISTICAL MODEL; STEM CELL TRANSPLANTATION; STROKE; SURVIVAL; WHITE MATTER;

ANIMALS; BONE MARROW CELLS; BRAIN; CELL DIFFERENTIATION; CELL LINE; CEREBRAL PALSY; HUMANS; NEURONS; STEM CELL TRANSPLANTATION; STROMAL CELLS;

ANIMALIA;

EID: 0037927556     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/eobt.3.4.541.21207     Document Type: Review

References (63)

1. FREED CR, GREENE PE, BREEZE RE et al.: Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. (2001) 344:710-719.
2. LEVISON SW, ROTHSTEIN RP, ROMANKO MJ, SNYDER MJ, MEYERS PL, VANNUCI SJ: Hypoxia/ischemia depletes the rat perinatal subventricular zone of oligodendrocyte progenitors and neural stem cells. Dev. Neurosci. (2001) 23:234-247.
3. BACK SA, LUO NL, BORENSTEIN NS, LEVINE JM, VOLPE JJ, KINNEY HC: Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury. J. Neurosci. (2001) 21:1302-1312.
4. VOLPE JJ: Neurobiology of periventricular leukomalacia in the premature infant. Pediatr. Res. (2001) 50:553-562. Excellent review of PVL.
5. ONO K, KAGAWA T, TSUMORI T, YOKOTA S, YASUI Y: Morphological changes and cellular dynamics of oligodendrocyte lineage cells in the developing vertebrate central nervous system. Dev. Neurosci. (2001) 23:346-355.
6. GRINSPAN J: Cells and signaling in oligodendrocyte development. J. Neuropath. Exp. Neurol. (2002) 61:297-306. Good discussion of oligodendrocyte development.
7. BELACHEW S, YUAN X, GALLO V: Unraveling oligodencrocyte origin and function by cell-specific transgenesis. Dev. Neurosci. (2001) 23:287-298.
8. SAVITZ SI, ROSENBAUM DM, DINSMORE JH, WECHSLER LR, CAPLAN LR: Cell transplantation for stroke. Ann. Neurol. (2002) 52:266-275. An up-to-date review of cell transplantation for stroke.
9. LIM DA, FLAMES N, COLLADO L, HERRERA DG: Investigating the use of primary adult subventricular zone neural precursor cells for neuronal replacement therapies. Brain Res. Bull. (2002) 57:759-764.
10. WEISSMAN IL, ANDERSON DJ, GAGE F: Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Ann. Rev. Cell Dev. Biol. (2001) 17:387-403. A general review of cell lineage development.
11. PARK KI, OUREDNIK J, OUREDNIK V et al.: Global gene and cell replacement strategies via stem cells. Gene Ther. (2002) 9:613-624.
12. SVENDSEN CN, SMITH AG: New prospects for human-stem cell therapy in the nervous system. Trends Neurosci. (1999) 22:357-264.
13. FLAX JD, AURORA S, YANG C et al.: Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nat. Biotechnol. (1998) 16:1033-1039. This paper outlines some of the possibilities for the use of neural stem cells.
14. ANTEL JP, NALBANTOGLU J, OLIVIER A: Neuronal progenitors learning from the hippocampus. Nat. Med. (2000) 6:249-250.
15. TAMAKI S, ECKERT K, HE D et al.: Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. J. Neurosci. Res. (2002) 69:976-986.
16. SVENDSON CN, CLARKE KJ, ROSSER AE, DUNNETT SB: Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system. Exp. Neurol. (1996) 137:376-388.
17. BUCHET D, BUC-CARON M, SABATE O, LACHAPELLE F, MALLET J: Long-term fate of human telencephalic progenitor cells grafted into the adult mouse brain: effects of previous amplification in vitro. J. Neurosci. Res. (2002) 68:276-283.
18. LIUS, QU Y, STEWART TJ et al.: Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc. Natl. Acad. Sci. USA (2000) 97(11):6126-6131.
19. ESPINOSA-JEFFREY A, BECKER-CATANIA SG, ZHAO PM, COLE R, EDMOND J, DEVELLIS J: Selective specification of CNS stem cells into oligodendroglial or neuronal lineage: cell culture and transport studies. J. Neurosci. Res. (2002) 6:810-825.
20. PALM K, SALIN-NORDSTROM T, LEVESQUE MF, NEUMAN T: Fetal and adult human CNS stem cells have similar molecular characteristics and developmental potential. Mol. Brain Res. (2000) 78:192-195.
21. JOHANSSON CB, MOMMA S, CLARKE DL, RISLING M, LENDAHL U, FRISEN J: Identification of a neural stem cell in the adult mammalian central nervous system. Cell (1999) 96:25-34.
22. REITZE RL, VALCANIS H, BROOKER GF, THOMAS T, VOSS AK, BARTLETT PF: Purification of a pluripotent neural stem cell from the adult mouse brain. Nature (2001) 412:736-739.
23. KONDO T, RAFF M: Oilogdendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science (2000) 289:1754-1757.
24. FERRARI A, EHLER E, NITSCH RM, GOTZ J: Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell types. FEBS Lett. (2000) 486:121-125.
25. PHILIPS MF, MUIR JK, SAATMAN KE et al.: Survival and integration of transplanted postmitotic human neurons following experimental brain injury in immunocompetent rats. J. Neurosurg. (1999) 90:116-124.
26. ENGLUND U, BJORKLUND A, WICTORIN K, LINDVALL O, KOKAIA M: Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proc. Natl. Acad. Sci. USA (2002) 99:17089-17094. This is a key paper demonstrating that the transplanted cells develop electrophysiological functions.
27. KONDZIOLKA D, WECHSLER L, GOLDSTEIN S et al.: Transplantation of cultured human neuronal cell for patients with stroke. Neurology (2000) 55:565-569.
28. KAPOS P, EHTESHAM M, KABOSHOVA A, BLACK KL, YU KS: Generation of neural progenitor cells from whole adult bone marrow. Exp. Neurol. (2002) 178:288-293.
29. MEZEY E, KEY S, VOGELSANG G, SZALAYOVA I, LANGE GD, CRAIN G: Transplanted bone marrow generates new neurons in human brains. Proc. Natl. Acad. Sci. USA (2003) 100:1364-1369. This is a key paper dealing with autopsy material from female recipients of male bone marrow transplants, which demonstrates the presence of donor-derived neurons in the brains of the recipients.
30. WOODBURY D, SCHWARZ EJ, PROCKOP DJ, BLACK IJ: Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. (2000) 61:364-370. This paper discusses the differentiating properties of MSCs.
31. KOPEN GC, PROCKOP DJ, PHINNEY DG: Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc. Natl. Acad. Sci. USA (1999) 96:10711-10716.
32. MEZEY E, CHANDROSS KJ, HARTA G, MAKI RA, MCKERCHER SR: Turning blood into brain: cells bearing neuronal antigens generated in vivo from ftom bone marrow. Science (2000) 290:1779-1782.
33. CHEN J, LI Y, CHOPP M: Intracerebral transplantation of bone marrow with BNDF after MCAo in rat. Neuropharm. (2000) 39:711-716.
34. LI Y, CHOPP M, CHEN J et al.: Intrastriatal transplantation of bone marrow nonhematopoietic cells improves after stroke in adult mice. J. Cerebral Blood Flow Metab. (2000) 20:1311-1319.
35. SANCHEZ-RAMOS JR: Neural cells derived from adult bone marrow and umbilical cord blood. J. Neurosci. Res. (2002) 69:880-893. This paper reviews the evidence that neural cells can be derived from bone marrow and cord blood.
36. AKIYAMA Y, RADTKE C, KOCSIS JD: Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells. J. Neurosci. (2002) 22:6623-6630.
37. HESS DC, HILL WD, MARTIN-STUDDARD A, CARROLL J, BRAILER J, CAROTHERS J: Bone marrow as a source of endothelial cells and NeuN-expressing cells after stroke. Stroke (2002) 33:1362-1368.
38. JAING Y, JAHAGIRDAR BN, REINHARDT RL et al.: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature (2002) 418:41-49.
39. CASTRO RF, JACKSON KA, GOODELL MA, ROBERTSON CS, LIU H, SHINE HD: Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science (2002) 297:1299.
40. ZHAO Y, GLESNE D, HUBERMAN E: A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proc. Natl. Acad. Sci. USA (2003) 100:2426-2431. This paper describes an excellent potential source of stem cens
41. BICKNESE AR, GOODWIN HS, QUINN CO, HENDERSON VC, CHIEN SN, WALL DA: Human umbilical cord blood cells can be induced to express mankers for neurons and glia. Cell Transplant. (2002) 11:264-261.
42. CHEN J, SANBERG PR, LI Y et al.: Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke (2001) 32:2682-2688.
43. ZIGOVA T, SONG S, WILLING AE et al.: Human umbilical cord blood cells express neural antigens after transplantation into the developing rat brain. Cell Transplant. (2002) 11:265-274.
44. MITCHELL K, WEISS M, MITCHELL B et al.: Matrix cells from Wharton's jelly form neurons and glia. Stem Cells 21:50-60.
45. MODO M, STROEMER RP, TANG E, PATEL S, HODGES H: Effects of implantation site of stem cell grafts on behavioral recovery from stroke damage. Stroke (2002) 33:2270-2278.
46. PARK KI, TENG YD, SNYDER EY: The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat. Biotech. (2002) 20(11):1111-1117.
47. REISS P, ZHANG C, SAATMAN KE et al.: Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury. Neurosurgery (2002) 51(4):1043-1054.
48. OGAWA Y, SAWAMOTO K, MIYATA T et al.: Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J. Neurosci. Res. (2002) 69:925-933.
49. TODA H, TAKAHASHI J, IWAKAMI N et al.: Grafting neural stem cells improved the impaired spatial recognition in ischemic rats. Neurosci. Lett. (2001) 316:9-12.
50. BORLONGAN CV, TAJIMA Y, TROJANOWSKI JQ, LEE VM-Y, SANBERG PR: Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats. Exp. Neurol. (1998) 149:310-321.
51. VIEZOVIC T, BEECH JS, STROEMER P, WATSON WP, HODGES H: Resolution of stroke deficits following contralateral grafts of conditionally immortal neuroepithelial stem cells. Stroke, (2001) 32:1012-1019.
52. VIRLEY D, RIDLEY RM, SINDEN JD et al.: Primary CA1 and conditionally immortal MHP36 cell grafts restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal CA1 field. Brain (1999) 122:2321-2335.
53. MAHMOUD A, LU D, YI L, CHEN JL, CHOPP M: Intracranial bone marrow transplantation after traumatic brain injury improves functional outcome in adult rats. J. Neurosurg. (2001) 94:589-595.
54. ZHAO LR, DUAN WM, REYES M, KEENE CD, VERFAILLIE CM, LOW WC: Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp. Neurol. (2002) 174:11-20.
55. LI Y, CHEN J, WANG L, LU M, CHOPP M: Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology (2001) 56:1666-1672.
56. CHEN J, LI Y, WANG L et al.: Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemic in rats. Stroke (2001) 32:1005-1011. This paper shows improvement in function after intravenous injection with only a few new neurons being incorporated, suggesting that the improvement might be related to factors other than the cells themselves.
57. LU D, SANDBERG PR, MAHMOOD A et al.: Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant. (2002) 11:275-281.
58. PLUCHINO S, QUATTRINI A, BRAMBILLA E et al.: Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature (2003) 422:688-694.
59. WAINWRIGHT MS, MARTIN PL, MORSE RP et al.: Human herpesvirus 6 limbic encephalitis after stem cell transplantation. Ann. Neurol. (2001) 50:612-619.
60. FARACI M, LANINO E, DINI G et al.: Severe neurologic complications after hematopoietic stem cell transplantation in children. Neurology (2002) 59:1895-1904.
61. GUERRERO A, PEREZ-SIMON JA, GUTIERREZ N et al.: Neurological complications after autologous stem cell transplantation. Eur. Neurol. (1999) 14:48-50.
62. CAO Q, BENTON RL, WHITTEMORE SR: Stem cell repair of central nervous system injury. J. Neurosci. Res. (2002) 68:501-510. Excellent review.
63. http://www.ninds.nih.gov/health_and_medical/pubs/cerebral_palsyhtr.htm NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE: Cerebral palsy: hope through research (2001). Excellent review of cerebral palsy.