Pathogenesis of mucous cell metaplasia in a murine asthma model

American Journal of Pathology

Volumn 162, Issue 6, 2003, Pages 2069-2078

  Reader, J Rachel ^a,b   Tepper, Jeffrey S ^b   Schelegle, Edward S ^a   Aldrich, Melinda C ^b   Putney, Lei F ^a   Pfeiffer, Juergen W ^b   Hyde, Dallas M ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENENTECH INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOXURIDINE; ETHIDIUM; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTHMA; BASEMENT MEMBRANE; CELL DEATH; CELL LABELING; CELL PROLIFERATION; CILIATED EPITHELIUM; CLARA CELL; CONTROLLED STUDY; ELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; MALE; METAPLASIA; MOUSE; MUCOUS CELL; MUCUS; MUCUS SECRETION; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL;

EID: 0037906343     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64338-6     Document Type: Article

References (52)

1. Chetta A, Foresi A, Del Donno M, Bertorelli G, Pesci A, Olivieri D: Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest 1997, 111:852-857
2. Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM: Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000, 161:1720-1745
3. Holgate ST: Inflammatory and structural changes in the airways of patients with asthma. Respir Med 2000, 94(Suppl D):S3-S6
4. Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Kimura I: Mucus hypersecretion and eosinophils in bronchoalveolar lavage fluid in adult patients with bronchial asthma. J Asthma 1993, 30:257-262
5. Busse W, Elias J, Sheppard D, Banks-Schlegel S: Airway remodeling and repair. Am J Respir Crit Care Med 1999, 160:1035-1042
6. Wilson JW, Bamford TL: Assessing the evidence for remodelling of the airway in asthma. Pulm Pharmacol Ther 2001, 14:229-247
7. Holgate ST, Lackie PM, Davies DE, Roche WR, Walls AF: The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma. Clin Exp Allergy 1999, 29:90-95
8. Holgate ST, Lackie P, Wilson S, Roche W, Davies D: Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma. Am J Respir Crit Care Med 2000, 162:S113-S117
9. Hamilton LM, Davies DE, Wilson SJ, Kimber I, Dearman RJ, Holgate ST: The bronchial epithelium in asthma - much more than a passive barrier. Monaldi Arch Chest Dis 2001, 56:48-54
10. 3) on release of pro-inflammatory mediators from bronchial epithelial cell cultures of atopic asthmatics and nonasthmatics. Clin Exp Allergy 1997, 27:1369
11. Kraft M: The distal airways: are they important in asthma? Eur Respir J 1999, 14:1403-1417
12. Saetta M, Di Stefano A, Rosina C, Thiene G, Fabbri LM: Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 1991, 143:138-143
13. Rudmann DG, Moore MW, Tepper JS, Aldrich MC, Pfeiffer JW, Hogenesch H, Tumas DB: Modulation of allergic inflammation in mice deficient in TNF receptors. Am J Physiol 2000, 279:L1047-L1057
14. Plopper CG, Mariassy AT, Lollini LO: Structure as revealed by airway dissection A comparison of mammalian lungs. Am Rev Respir Dis 1983, 128:S4-S7
15. Hsu SM, Raine L, Fanger H: The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase techniques. Am J Clin Pathol 1981, 75:816-821
16. Bolender RP, Hyde DM, Dehoff RT: Lung morphometry: a new generation of tools and experiments for organ, tissue, cell, and molecular biology. Am J Physiol 1993, 265:L521-L548
17. Baddeley AJ, Gundersen HJ, Cruz-Orive LM: Estimation of surface area from vertical sections. J Microsc 1986, 142:259-276
18. Weibel ER: Stereological Methods: Practical Methods for Biological Morphometry. London, Academic Press Inc., 1979, pp 204-206
19. Postlethwait EM, Joad JP, Hyde DM, Schelegle ES, Bric JM, Weir AJ, Putney LF, Wong VJ, Velsor LW, Plopper CG: Three-dimensional mapping of ozone-induced acute cytotoxicity in tracheobronchial airways of isolated perfused rat lung. Am J Respir Cell Mol Biol 2000, 22:191-199
20. Van Winkle LS, Buckpitt AR, Nishio SJ, Isaac JM, Plopper CG: Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice. Am J Physiol 1995, 269:L800-L818
21. Haley KJ, Sunday ME, Wiggs BR, Kozakewich HP, Reilly JJ, Mentzer SJ, Sugarbaker DJ, Doerschuk CM, Drazen JM: Inflammatory cell distribution within and along asthmatic airways. Am J Respir Crit Care Med 1998, 158:565-572
22. Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T: Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 1985, 131:599-606
23. Beasley R, Roche WR, Roberts JA, Holgate ST: Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989, 139:806-817
24. Jeffery PK, Wardlaw AJ, Nelson FC, Collins JV, Kay AB: Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 1989, 140:1745-1753
25. James AL, Carroll N: The pathology of fatal asthma. Inflammatory Mechanisms in Asthma. Edited by ST Holgate, WW Busse. New York, Marcel Dekker, 1998, pp 1-26
26. Montefort S, Roberts JA, Beasley R, Holgate ST, Roche WR: The site of disruption of the bronchial epithelium in asthmatic and non-asthmatic subjects. Thorax 1992, 47:499-503
27. Woltmann G, Ward RJ, Symon FA, Rew DA, Pavord ID, Wardlaw AJ: Objective quantitative analysis of eosinophils and bronchial epithelial cells in induced sputum by laser scanning cytometry. Thorax 1999, 54:124-130
28. Schelegle ES, Gershwin LJ, Miller LA, Fanucchi MV, Van Winkle LS, Gerriets JP, Walby WF, Omlor AM, Buckpitt AR, Tarkington BK, Wong VJ, Joad JP, Pinkerton KB, Wu R, Evans MJ, Hyde DM, Plopper CG: Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae). Am J Pathol 2001, 158:333-341
29. Lozewicz S, Wells C, Gomez E, Ferguson H, Richman P, Devalia J, Davies RJ: Morphological integrity of the bronchial epithelium in mild asthma. Thorax 1990, 45:12-15
30. Carroll N, Elliot J, Morton A, James A: The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 1993, 147: 405-410
31. Montefort S, Diukanovic R, Holgate ST, Roche WR: Ciliated cell damage in the bronchial epithelium of asthmatics and non-asthmatics. Clin Exp Allergy 1993, 23:185-189
32. Blyth DI, Pedrick MS, Savage TJ, Hessel EM, Fattah D: Lung inflammation and epithelial changes in a murine model of atopic asthma. Am J Respir Cell Mol Biol 1996, 14:425-438
33. Haile S, Lefort J, Joseph D, Gounon P, Huerre M, Vargaftig BB: Mucous cell metaplasia and inflammatory cell recruitment are dissociated in allergic mice after antibody- and drug-dependent cell depletion in a murine model of asthma. Am J Respir Cell Mol Biol 1999, 20:891-902
34. Trifilieff A, El Hashim A, Bertrand C: Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment. Am J Physiol 2000, 279:L1120-L1128
35. Eum SY, Haile S, Lefort J, Huerre M, Vargaftig BB: Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness. Proc Natl Acad Sci USA 1995, 92:12290-12294
36. Malm-Erjefalt M, Persson CG, Erjefalt JS: Degranulation status of airway tissue eosinophils in mouse models of allergic airway inflammation. Am J Respir Cell Mol Biol 2001, 24:352-359
37. Denzler KL, Borchers MT, Crosby JR, Cieslewicz G, Hines EM, Justice JP, Cormier SA, Lindenberger KA, Song W, Wu W, Hazen SL, Gleich GJ, Lee JJ, Lee NA: Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation. J Immunol 2001, 167:1672-1682
38. Erjefalt JS, Greiff L, Andersson M, Matsson E, Petersen H, Linden M, Ansari T, Jeffery PK, Persson CG: Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airways. Am J Respir Crit Care Med 1999, 160:304-312
39. Erjefalt JS, Andersson M, Greiff L, Korsgren M, Gizycki M, Jeffery PK, Persson GA: Cytolysis and piecemeal degranulation as distinct modes of activation of airway mucosal eosinophils. J Allergy Clin Immunol 1998, 102:286-294
40. Gleich GJ: Mechanisms of eosinophil-associated inflammation. J Allergy Clin Immunol 2000, 105:651-663
41. Salmon M, Walsh DA, Koto H, Barnes PJ, Chung KF: Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling. Eur Respir J 1999, 14:633-641
42. Palmans E, Kips JC, Pauwels RA: Prolonged allergen exposure induces structural airway changes in sensitized rats. Am J Respir Crit Care Med 2000, 161:627-635
43. Panettieri Jr RA, Murray RK, Eszterhas AJ, Bilgen G, Martin JG: Repeated allergen inhalations induce DNA synthesis in airway smooth muscle and epithelial cells in vivo. Am J Physiol 1998, 274: L417-L424
44. Wang ZL, Walker BA, Weir TD, Yarema MC, Roberts CR, Okazawa M, Pare PD, Bai TR: Effect of chronic antigen and beta 2 agonist exposure on airway remodeling in guinea pigs. Am J Respir Crit Care Med 1995, 152:2097-2104
45. Williams CM, Galli SJ: Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 2000, 192:455-462
46. Druilhe A, Wallaert B, Tsicopoulos A, Lape e Silva JR, Tillie-Leblond I, Tonnel AB, Pretolani M: Apoptosis, proliferation, and expression of Bcl-2, Fas, and Fas ligand in bronchial biopsies from asthmatics. Am J Respir Cell Mol Biol 1998, 19:747-757
47. Demoly P, Simony-Lafontaine J, Chanez P, Pujol JL, Lequeux N, Michel FB, Bousquet J: Cell proliferation in the bronchial mucosa of asthmatics and chronic bronchitis. Am J Respir Crit Care Med 1994, 150:214-217
48. Vignola AM, Chiappara G, Siena L, Bruno A, Gagliardo R, Merendino AM, Polla BS, Arrigo AP, Bonsignore G, Bousquet J, Chanez P: Proliferation and activation of bronchial epithelial cells in corticosteroid-dependent asthma. J Allergy Clin Immunol 2001, 108:738-746
49. Tepper JS, Yuan F, Pfeiffer JW, Aldrich MC: Airflow obstruction in murine allergic inflammation: the effectiveness of albuterol vs dexamethasone. Am J Respir Crit Care Med 1998, 157(Suppl 3):A822
50. Blyth DI, Pedrick MS, Savage TJ, Bright H, Beesley JE, Sanjar S: Induction, duration, and resolution of airway goblet cell hyperplasia in a murine model of atopic asthma: effect of concurrent infection with respiratory syncytial virus and response to dexamethasone. Am J Respir Cell Mol Biol 1998, 19:38-54
51. Pack RJ, Al Ugaily LH, Morris G: The cells of the tracheobronchial epithelium of the mouse: a quantitative light and electron microscope study. J Anat 1981, 132:71-84
52. Ordonez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Dolganov G, Fahy JV: Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 2001, 163:517-523