Chronic obstructive pulmonary disease (COPD): New insights on the events leading to pulmonary inflammation

Sarcoidosis Vasculitis and Diffuse Lung Diseases

Volumn 20, Issue 1, 2003, Pages 3-7

  Agostini, Carlo ^a   Trentin, Livio ^a   Adami, Fausto ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Chemokines; COPD; Immunopathogenesis; Tc1 cell

Indexed keywords

ANTIINFLAMMATORY AGENT;

CELL COUNT; CELL INFILTRATION; CELL MIGRATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISABILITY; HISTORY OF MEDICINE; HUMAN; INFLAMMATION; INFLAMMATORY CELL; LUNG PARENCHYMA; LYMPHOID TISSUE; MACROPHAGE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PHENOTYPE; PNEUMONIA; PRIORITY JOURNAL; REVIEW;

BENZOIC ACIDS; BRONCHOALVEOLAR LAVAGE FLUID; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; INFLAMMATION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037878067     PISSN: 11240490     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (29)

1. Barnes PJ: Chronic obstructive pulmonary disease. New Engl J Med 2000; 343: 269-80.
2. Wedzicha JA: Exacerbations: etiology and pathophysiologic mechanisms. Chest 2002; 121: 136S-141S.
3. Siafakas NM, Tzonzaki EG: Few smokers develop COPD. Why? Respir Med 2002; 96: 615-24.
4. Reynolds HY: Sampling local respiratory tract sites for inflammation. Sarcoidosis Vasc Diffuse Lung Dis 2001; 18: 138-48.
5. Fireman E: Induced sputum: opening a new window to the lung. Sarcoidosis Vasc Diffuse Lung Dis 2001; 18: 263-71.
6. Saetta M, Baraldo S, Corbino L, et al: CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160: 711-7.
7. O'Shaughnessy TC, Ansari TW, Barnes NC, Jeffery PK: Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1. Am J Respir Crit Care Med 1997; 155: 852-7.
8. Maestrelli P, Saetta M, Mapp CE, Fabbri LM: Remodeling in response to infection and injury. Airway inflammation and hypersecretion of mucus in smoking subjects with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164: S76-80.
9. Tetley TD: Macrophages and the pathogenesis of COPD. Chest 2002; 121: 156S-159S.
10. Woolhouse IS, Bayley DL, Stockley RA: Sputum chemotactic activity in chronic obstructive pulmonary disease: effect of alpha(1)-antitrypsin deficiency and the role of leukotriene B(4) and interleukin 8. Thorax 2002; 57: 709-14.
11. Yamamoto C, Yoneda T, Yoshikawa M, et al: Airway inflammation in COPD assessed by sputum levels of interleukin-8. Chest 1997; 112: 505-10.
12. Stockley RA: Neutrophils and protease/antiprotease imbalance. Am J Respir Crit Care Med 1999; 160: S49-52.
13. Barnes PJ: Potential novel therapies for chronic obstructive pulmonary disease. Novartis Found Symp 2001; 234: 255-67.
14. Russell RE, Thorley A, Culpitt SV, et al: Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases. Am J Physiol Lung Cell Mol Physiol 2002; 283: L867-73.
15. Pabst R, Schuster M, Tschemig T: Lymphocyte dynamics in the pulmonary microenvironment: implications for the pathophysiology of pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1999; 16: 197-202.
16. Wilkes DS, Twigg HL: 3rd. B-lymphocytes in the lung: a topic to be revisited. Sarcoidosis Vasc Diffuse Lung Dis 2001; 18: 34-49.
17. Saetta M, Baraldo S, Turato G, et al: CDS+ T-lymphocytes in the lymph nodes of smokers with mild COPD. Sarcoidosis Vasc Diffuse Lung Dis 2003; 20: 28-32.
18. Saetta M, Mariani M, Panina-Bordignon P, et al: Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002; 165: 1404-9.
19. Agostini C, Cassatella M, Zambello R, et al: Involvement of the IP-10 chemokine in sarcoid granulomatous reactions. J Immunol 1998; 161: 6413-20.
20. Agostini C, Facco M, Siviero M, et al: CXC chemokines IP-10 and mig expression and direct migration of pulmonary CD8+/CXCR3+ T cells in the lungs of patients with HIV infection and T-cell alveolitis. Am J Respir Crit Care Med 2000; 162: 1466-73.
21. Agostini C, Calabrese F, Rea F, et al: CXCR3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection. Am J Pathol 2001; 158: 1703-11.
22. Sozzani S, Mantovani A, Allavena P: Control of dendritic cell migration by chemokines. Forum 1999; 9: 325-38.
23. Sozzani S, Allavena P, Vecchi A, Mantovani A Chemokines and dendritic cell traffic. J Clin Immunol 2000; 20: 151-60.
24. Agostini C: Cytokine and chemokine blockade as immunointervention strategy for the treatment of diffuse lung diseases. Sarcoidosis Vasc Diffuse Lung Dis 2001; 18: 18-22.
25. Aaron SD, Angel JB, Lunau M, et al: Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 163: 349-55.
26. Crooks SW, Bayley DL, Hill SL, Stockley RA: Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis: the role of leukotriene B4. Eur Respir J 2000; 15: 274-80.
27. Baughman RP, Lower EE: Infliximab for refractory sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2001; 18: 70-4.
28. Eid AA, Ionescu AA, Nixon LS, et al: Inflammatory response and body composition in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164: 1414-8.
29. Agostini C, Miorin M, Semenzato G: Gene expression profile analysis by DNA microarrays: a new approach to assess functional genomics in diseases. Sarcoidosis Vasc Diffuse Lung Dis 2002; 19: 5-9.