Expression of the β-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissue

Journal of Neuroimmunology

Volumn 108, Issue 1-2, 2000, Pages 192-200

  Simpson, Julie ^a   Rezaie, Payam ^b   Newcombe, Jia ^c   Cuzner, M Louise ^c   Male, David ^d   Woodroofe, M Nicola ^a  

^a SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d OPEN UNIVERSITY   (United Kingdom)

Author keywords

Chemokine receptors; Astrocytes; Macrophages; Multiple sclerosis; Th1 cells

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR3;

ADULT; AGED; ARTICLE; ASTROCYTE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MACROPHAGE; MALE; MICROGLIA; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; TH1 CELL;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODY SPECIFICITY; ASTROCYTES; CD4-POSITIVE T-LYMPHOCYTES; CENTRAL NERVOUS SYSTEM; CHEMOKINE CCL2; CHEMOTAXIS, LEUKOCYTE; CHRONIC DISEASE; CYTOKINES; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIGANDS; MACROPHAGES; MALE; MATCHED-PAIR ANALYSIS; MICROGLIA; MIDDLE AGED; MONOCYTE CHEMOATTRACTANT PROTEINS; MULTIPLE SCLEROSIS; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; RECURRENCE;

EID: 0034256028     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(00)00274-5     Document Type: Article

References (35)

1. Andjelkovic, A.V., Spencer, D.D., Pachter, J.S., 1999. Visualization of chemokine binding sites on human brain microvessels. J. Cell Biol. 145, 403-412.
2. Baggiolini, M., 1998. Chemokines and leukocyte trafficking. Nature 392, 565-568.
3. Balashov, K.E., Rottman, J.B., Weiner, H.L., Hancock, W.W., 1999. CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1 alpha and IP-10 are expressed in demyelinating brain lesions. Proc. Natl. Acad. Sci. USA 96, 6873-6878.
4. Bleul, C.C., Wu, L., Hoxie, J.A., Springer, T.A., Mackay, C.R., 1997. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. USA 94, 1925-1930.
5. Boddeke, E.W.G.M., Ingeborg, I., Frentzel, S., Gourmala, N.G., Harrison, J.K., Buttini, M., Spleiss, O., Gebicke-Harter, P., 1999. Cultured rat microglia express functional β-chemokine receptors. J. Neuroimmunol. 98, 176-184.
6. Bonecchi, R., Bianchi, G., Bordignon, R.P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P.A., Mantovani, A., Sinigalia, F., 1998. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 187, 129-134.
7. Broder, C.C., Collman, R.G., 1997. Chemokine receptors and HIV J. Leukocyte Biol. 62, 20-29.
8. Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P.D., Wu, L.J., Mackay, C.R., Larosa, G., Newman, W., Gerard, N., Gerard, C., Sodroski, J., 1996. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85, 1135-1148.
9. Cross, A.K., Woodroofe, M.N., 1999. Chemokines induce migration and changes in actin polymerisation in adult rat microglia and a human foetal cell line in vitro. J. Neurosci. Res. 55, 17-23.
10. Combadiere, C., Ahuja, S.K., Tiffany, A.L., Murphy, P.M., 1996. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1α, MIP-1β and RANTES. J. Leuk. Biol. 60, 147-152.
11. Deng, H.K., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Dimarzio, P., Marmon, S., Sutton, R.E., Hill, C.M., Davis, C.B., Peiper, S.C., Schall, T.J., Littman, D.R., 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661-666.
12. Glabinski, A., Tani, M., Streiter, R., Tuohy, V., Ransohoff, R.M., 1997. Synchronous synthesis of α- and β-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of experimental autoimmune encephalomyelitis. Am. J. Pathol. 150, 617-630.
13. Harkness, K.A., Cross, A.K., Davies-Jones, G.A.B., Sussman, J.D., Woodroofe, M.N., 1998. An in-vitro study of β-chemokine expression in the central nervous system. Immunology 95 (S1), 57.
14. He, J.L., Chen, Y.Z., Farzan, M., Choe, H.Y., Ohagen, A., Gartner, S., Busciglio, J., Yang, X.Y., Hofmann, W., Newman, W., Mackay, C.R., Sodroski, J., Gabuzda, D., 1997. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 385, 645-649.
15. Jiang, Y., Salafranca, M.N., Adhikari, S., Xia, Y., Feng, L., Sonntag, M.K., deFiebre, C.M., Pennel, N.A., Streit, W.J., Harrison, J.K., 1998. Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis. J. Neuroimmunol. 86, 1-12.
16. Klein, R.S., Williams, K.C., Alvarez-Herandez, X., Westmoreland, S., Force, T., Lackner, A.A., Luster, A.D., 1999. Chemokine receptor expression and signalling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS. J. Immunol. 163, 1636-1646.
17. Kunkel, S.L., 1999. Promiscuous chemokine receptors and their redundant ligands play an enigmatic role during HIV-1 infection. Am. J. Resp. Cell Mol. Biol. 20, 859-860.
18. Lassmann, H., Raine, C.S., Antel, J., Prineas, J.W, 1998. Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna. J. Neuroimmunol. 86, 213-217.
19. McManus, C., Berman, J.W., Brett, F.M., Staunton, H., Farrell, M., Brosnan, C., 1998a. MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridisation study. J. Neuroimmunol. 86, 20-29.
20. McManus, C., Brosnan, C., Berman, J., 1998b. Cytokine induction of MIP-1 alpha and MIP-1 beta in human fetal microglia. J. Immunol. 160, 1449-1455.
21. Perry, V.H., Bell, M.D., Brown, H.C., Matyszak, M.K., 1995. Inflammation in the nervous system. Curr. Opin. Neurobiol. 5, 636-641.
22. Qin, S., Rottman, J.B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A.E., Moser, B., MacKay, C.R., 1998. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J. Clin. Invest. 101, 746-754.
23. Rezaie, P., Cairns, N.J., Male, D.K., 1997. Expression of adhesion molecules on human fetal cerebral vessels: relationship to microglial colonisation during development. Dev. Brain Res. 104, 175-189.
24. Rollins, B.J., 1997. Chemokines. Blood 90, 909-928.
25. Sallusto, F., Lenig, D., Mackay, C.R., Lanzavecchia, A., 1998. Flexible programs of chemokine receptor expression on human polarised T helper 1 and 2 lymphocytes. J. Exp. Med. 187, 875-883.
26. Sallusto, F., Kremmer, E., Palermo, B., Hoy, A., Ponath, P., Qin, S.X., Forster, R., Lipp, M., Lanzavecchia, A., 1999. Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur. J. Immunol. 29, 2037-2045.
27. Simpson, J.E., Newcombe, J., Cuzner, M.L., Woodroofe, M.N., 1998. Expression of monocyte chemoattractant protein-1 and other β-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. J. Neuroimmunol. 84, 238-244.
28. Simpson, J.E., Newcombe, J., Cuzner, M.L., Woodroofe, M.N., 2000. Expression of the interferon-γ-inducible chemokines IP-10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions. J. Neuropathol. Appl. Neurobiol. 26, 133-142.
29. Sørensen, T., Ransohoff, R.M., 1998. Biology and pathogenesis of multiple sclerosis. Semin. Neurol. 18, 287-295.
30. Sørensen, T.L., Tani, M., Jensen, J., Pierce, V., Lucchinetti, C., Folcik, V.A., Qin, S., Rottman, J., Sellebjerg, F., Streiter, R.M., Fredenksen, J.L., Ransohoff, R.M., 1999. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J. Clin. Invest. 103, 807-815.
31. VanderVoorn, P., Tekstra, J., Beelen, R.H.J., Tensen, C.P., VanderValk, P., DeGroot, C.J.A., 1999. Expression of MCP-1 by reactive astrocytes in demyelinating multiple sclerosis lesions. Am. J. Pathol. 154, 45-51.
32. Westmoreland, S.V., Rottman, J.B., Williams, K.C., Lackner, A.A., Sasseville, V.G., 1998. Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis. Am. J. Pathol. 152, 659-665.
33. Woodroofe, M.N., Cross, A.K., Harkness, K.A., Simpson, J.E., 1999. The role of chemokines in the pathogenesis of multiple sclerosis. Adv. Exp. Med. Biol. 468, 135-150.
34. Xia, M., Qin, S., Wu, L., Mackay, C.M., Hyman, B.T., 1998. Immunohistochemical study of the β-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am. J. Pathol. 153, 31-37.
35. Zlotnik, A., Morales, J., Hedrick, J.A., 1999. Recent advances in chemokines and chemokine receptors. Crit. Rev. Immunol. 19, 1-47.