Coexistence of two distinct secretion mutations (P5T and I97L) in hepatitis B virus core produces a wild-type pattern of secretion

Journal of Virology

Volumn 77, Issue 13, 2003, Pages 7673-7676

  Chua, Pong Kian ^a   Wen, Yu Mei ^b   Shih, Chiaho ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; HEPATITIS B VIRUS; NONHUMAN; PRIORITY JOURNAL; SECRETION; VIRION; VIRUS CORE; VIRUS ISOLATION; VIRUS MUTATION;

BASE SEQUENCE; CELL LINE; DNA PRIMERS; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HUMANS; MUTATION;

EID: 0037790884     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.13.7673-7676.2003     Document Type: Article

References (33)

1. Akarca, U. S., and A. S. Lok. 1995. Naturally occurring hepatitis B virus core gene mutations. Hepatology 22:50-60.
2. Asahina, Y., N. Enomoto, Y. Ogura, M. Kurosaki, I. Sakuma, N. Izumi, F. Marumo, and C. Sato. 1996. Sequential changes in full-length genomes of hepatitis B virus accompanying acute exacerbation of chronic hepatitis B. J. Hepatol. 25:787-794.
3. Bottcher, B., S. A. Wynne, and R. A. Crowther. 1997. Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy. Nature 386:88-91.
4. Chang, S. F., H. J. Netter, M. Bruns, R. Schneider, K. Frolich, and H. Will. 1999. A new avian hepadnavirus infecting snow geese (Anser caerulescens) produces a significant fraction of virions containing single-stranded DNA. Virology 262:39-54.
5. Chuang, W. L., M. Omata, T. Ehata, O. Yokosuka, Y. Ito, F. Imazeki, S. N. Lu, W. Y. Chang, and M. Ohto. 1993. Precore mutations and core clustering mutations in chronic hepatitis B virus infection. Gastroenterology 104:263-271.
6. Chuang, W. L., M. Omata, T. Ehata, O. Yokosuka, and M. Ohto. 1993. Concentrating missense mutations in core gene of hepatitis B virus. Evidence for adaptive mutation in chronic hepatitis B virus infection. Dig. Dis. Sci. 38:594-600.
7. Conway, J. F., N. Cheng, A. Zlotnick, P. T. Wingfield, S. J. Stahl, and A. C. Steven. 1997. Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy. Nature 386:91-94.
8. Crowther, R. A., N. A. Kiselev, B. Bottcher, J. A. Berriman, G. P. Borisova, V. Ose, and P. Pumpens. 1994. Three-dimensional structure of hepatitis B virus core particles determined by electron cryomicroscopy. Cell 77:943-950.
9. Ehata, T., M. Omata, W. L. Chuang, O. Yokosuka, Y. Ito, K. Hosoda, and M. Ohto. 1993. Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis. J. Clin. Investig. 91:1206-1213.
10. Ehata, T., M. Omata, O. Yokosuka, K. Hosoda, and M. Ohto. 1992. Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection. J. Clin. Investig. 89:332-338.
11. Ganem, D., and R. Schneider. 2001. Hepadnaviridae: the viruses and their replication, p. 2923-2970. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 4th ed. Lippincott Williams & Wilkins, Philadelphia, Pa.
12. Gunther, S., S. Baginski, H. Kissel, P. Reinke, D. H. Kruger, H. Will, and H. Meisel. 1996. Accumulation and persistence of hepatitis B virus core gene deletion mutants in renal transplant patients are associated with end-stage liver disease. Hepatology 24:751-758.
13. Hosono, S., P. C. Tai, W. Wang, M. Ambrose, D. G. Hwang, T. T. Yuan, B. H. Peng, C. S. Yang, C. S. Lee, and C. Shih. 1995. Core antigen mutations of human hepatitis B virus in hepatomas accumulate in MHC class II-restricted T cell epitopes. Virology 212:151-162.
14. Koschel, M., D. Oed, T. Gerelsaikhan, R. Thomssen, and V. Bruss. 2000. Hepatitis B virus core gene mutations which block nucleocapsid envelopment. J. Virol. 74:1-7.
15. Lee, Y. I., G. M. Hur, D. J. Suh, and S. H. Kim. 1996. Novel pre-C/C gene mutants of hepatitis B virus in chronic active hepatitis: naturally occurring escape mutants. J. Gen. Virol. 77:1129-1138.
16. Le Pogam, S., and C. Shih. 2002. Influence of a putative intermolecular interaction between core and the pre-S1 domain of the large envelope protein on hepatitis B virus secretion. J. Virol. 76:6510-6517.
17. Le Pogam, S., T. T.-T. Yuan, G. K. Sahu, S. Chatterjee, and C. Shih. 2000. Low-level secretion of human hepatitis B virus virions caused by two independent, naturally occurring mutations (P5T and L60V) in the capsid protein. J. Virol. 74:9099-9105.
18. Lin, X., Z. M. Ma, X. Yao, Y. P. Zhang, and Y. M. Wen. 2002. Replication efficiency and sequence analysis of full-length hepatitis B virus isolates from hepatocellular carcinoma tissues. Int. J. Cancer 102:487-491.
19. Lin, X., Z.-H. Yuan, L. Wu, J.-P. Ding, and Y.-M. Wen. 2001. A single amino acid in the reverse transcriptase domain of hepatitis B virus affects virus replication efficiency. J. Virol. 75:11827-11833.
20. Ou, J. H. 1997. Molecular biology of hepatitis B virus e antigen. J. Gastroenterol. Hepatol. 12:S178-S187.
21. Ponsel, D., and V. Bruss. 2003. Mapping of amino acid side chains on the surface of hepatitis B virus capsids required for envelopment and virion formation. J. Virol. 77:416-422.
22. Shih, C. 2003. Functional significance of naturally occurring hepatitis B virus variants, p. 23-41. In S. Locarnini and C. L. Lai (ed.), Human virus guides - human hepatitis B viruses. International Medical Press, London, United Kingdom.
23. Suk, F.-M., M.-H. Lin, M. Newman, S. Pan, S.-H. Chen, J.-D. Liu, and C. Shih. 2002. Replication advantage and host factor-independent phenotypes attributable to a common naturally occurring capsid mutation (I97L) in human hepatitis B virus. J. Virol. 76:12069-12077.
24. Summers, J., and W. S. Mason. 1982. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29:403-415.
25. Takahashi, K., Y. Akahane, K. Hino, Y. Ohta, and S. Mishiro. 1998. Hepatitis B virus genomic sequence in the circulation of hepatocellular carcinoma patients: comparative analysis of 40 full-length isolates. Arch. Virol. 143:2313-2326.
26. Tencza, M. G., and J. E. Newbold. 1997. Heterogeneous response for a mammalian hepadnavirus infection to acyclovir: drug-arrested intermediates of minus-strand viral DNA synthesis are enveloped and secreted from infected cells as virion-like particles. J. Med. Virol. 51:6-16.
27. Uchida, T., T. T. Aye, S. O. Becker, M. Hirashima, T. Shikata, F. Komine, M. Moriyama, Y. Arakawa, S. Takase, and S. Mima. 1993. Detection of precore/core-mutant hepatitis B virus genome in patients with acute or fulminant hepatitis without serological markers for recent HBV infection. J. Hepatol. 18:369-372.
28. Uchida, T., T. T. Aye, T. Shikata, M. Yano, H. Yatsuhashi, M. Koga, and S. Mima. 1994. Evolution of the hepatitis B virus gene during chronic infection in seven patients. J. Med. Virol. 43:148-154.
29. Wynne, S. A., R. A. Crowther, and A. G. Leslie. 1999. The crystal structure of the human hepatitis B virus capsid. Mol. Cell 3:771-780.
30. Yaginuma, K., Y. Shirakata, M. Kobayashi, and K. Koike. 1987. Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA. Proc. Natl. Acad. Sci. USA 84:2678-2682.
31. Yuan, T. T.-T., G. K. Sahu, W. E. Whitehead, R. Greenberg, and C. Shih. 1999. The mechanism of an immature secretion phenotype of a highly frequent naturally occurring missense mutation at codon 97 of human hepatitis B virus core antigen. J. Virol. 73:5731-5740.
32. Yuan, T. T.-T., and C. Shih. 2000. A frequent, naturally occurring mutation (P130T) of human hepatitis B virus core antigen is compensatory for immature secretion phenotype of another frequent variant (I97L). J. Virol. 74:4929-4932.
33. Yuan, T. T.-T., P.-C. Tai, and C. Shih. 1999. Subtype-independent immature secretion and subtype-dependent replication deficiency of a highly frequent, naturally occurring mutation of human hepatitis B virus core antigen. J. Virol. 73:10122-10128.