Heterogeneous response for a mammalian hepadnavirus infection to acyclovir: Drug-arrested intermediates of minus-strand viral DNA synthesis are enveloped and secreted from infected cells as virion-like particles

Journal of Medical Virology

Volumn 51, Issue 1, 1997, Pages 6-16

  Tencza, Michael G ^a   Newbold, John E ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

antiviral; DNA replication; hepatitis B virus; morphogenesis

Indexed keywords

ACICLOVIR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; DNA VIRUS; DRUG EFFECT; MAMMAL; NONHUMAN; VIRUS INHIBITION; VIRUS PARTICLE; VIRUS REPLICATION;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; BLOTTING, SOUTHERN; CENTRIFUGATION, DENSITY GRADIENT; DNA REPLICATION; DNA, VIRAL; DNA-DIRECTED DNA POLYMERASE; HEPATITIS B; HEPATITIS B VIRUS, WOODCHUCK; LIVER; MARMOTA; RNA PROBES; VIREMIA; VIRUS ASSEMBLY; VIRUS REPLICATION;

EID: 0031030499     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199701)51:1<6::AID-JMV2>3.0.CO;2-C     Document Type: Article

References (29)

1. Chang C, Enders G, Sprengel R, Peters N, Varmus HE and Ganem D (1987): Expression of the precore region of an avian hepatitis B virus is not required for viral replication. Journal of Virology 61:3322-3325.
2. Civitico GM, Locarnini SA (1994): The half-life of duck hepatitis B virus supercoiled DNA in congenitally infected primary hepatocyte cultures. Virology 203:81-89.
3. Drouet J, Courouce-Bauty AM, Thevenoux AM, Soulier JB, Chanard J, Vallee, G, Funk-Bretano JL (1975): Kinetics of HbsAg in man. Biomedicine 22:158-166.
4. Elion GB (1993): Acyclovir: discovery, mechanism of action, and selectivity. Journal of Medical Virology (Supplement)1:S2-S6.
5. Fiume L, Busi C, Mattioli A, Spinelli C, Spinosa G (1989): A conjugate of acyclovir monophosphate with lactosaminated albumin releases the phosphorylated drug in liver cells. Naturwissenschaften 76:74-76.
6. Fourel I, Cullen JM, Saputelli J, Aldrich CE, Schaffer P, Averett DR, Pugh J, Mason WS (1994): Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks. Journal of Virology 68:8321-8330.
7. Furman PA, McGuirt PV, Keller PM, Fyfe JA, Elion EB (1980): Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information. Virology 102:420-430.
8. Galibert F, Chen TN, Mandart E (1982): Nucleotide sequence of a cloned woodchuck hepatitis virus genome: comparison with the hepatitis B virus sequence. Journal of Virology 41:51-65.
9. Ganem D, Varmus HE (1987): The molecular biology of the hepatitis B viruses. Annual Review of Biochemistry 56:651-693.
10. Hirt B (1967): Selective extraction of polyoma DNA from infected mouse cell cultures. Journal of Molecular Biology 26:365-369.
11. Lien J-M, Aldrich CE, Mason WS (1986): Evidence that a capped oligoribonucleotide is the primer for duck hepatitis B virus plus-strand DNA synthesis. Journal of Virology 57:229-236.
12. Melton RH, Krieg PA, Rebagliati MR, Maniatis R, Zinn K, Green MR (1984): Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Research 12:7035-7057.
13. Miller RH, Robinson WS (1984): Hepatitis B virus forms in nuclear and cytoplasmic fractions of infected human liver. Virology 137:390-399.
14. Newbold JE, Xin H, Tencza M, Sherman G, Dean J, Bowden S, Locarnini S (1995): The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes. Journal of Virology 69:3350-3357.
15. Oberhaus SM, Newbold JE (1993): Detection of DNA polymerase activities associated with purified duck hepatitis B virus core particles by using an activity gel assay. Journal of Virology 67:6558-6566.
16. Oberhaus SM, Newbold JE (1995): Detection of an RNase H activity associated with hepadnaviruses. Journal of Virology 69:5697-5704.
17. Radziwill G, Tucker W, Schaller H (1990): Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity. Journal of Virology 64:613-620.
18. Schlicht HJ, Salfeld J, Schaller H (1987): The duck hepatitis B virus Pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation. Journal of Virology 61:3701-3709.
19. Scotto J, Hadchouel M, Wain-Hobson S, Sonigo P, Courouce A, Tiollais P, Brechot C (1985): Hepatitis B virus DNA in Dane particles: evidence for the presence of replicative intermediates. Journal of Infectious Diseases 151:610-617.
20. Sells MA, Chen M, Acs G (1987): Production of hepatitis B virus particles in HepG2 cells transfected with cloned hepatitis B virus DNA. Proceedings of the National Academy of Sciences USA 84:1005-1009.
21. Summers J (1981): Three recently described animal virus models for human hepatitis B virus. Hepatology 1:179-183.
22. Summers J, Mason WS (1982): Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29:403-415.
23. Summers J, Smith PM, Huang M, Yu M (1991): Morphogenetic and regulatory effects of mutations in the envelope proteins of an avian hepadnavirus. Journal of Virology 65:1310-1317.
24. Tencza MG, Newbold JE (1995): Small differences in electrophoretic mobility among circularly permuted sequence isomers of duck hepatitis B virus linear, single-stranded DNA. FEMS Microbiology Letters 129:163-168.
25. Tsiquaye KN, Collins P, Zuckerman AJ (1986): Antiviral activity of the polybasic anion, suramin and acyclovir in Hepadnavirus infection. Journal of Antimicrobial Chemotherapy 18 (Supplement B):223-228.
26. Vinograd J, Lebowitz J, Watson R (1968): Early and late helix-coil transitions in closed circular DNA. The number of superhelical turns in polyoma DNA. Journal of Molecular Biology 33:173-197.
27. Weber M, Bronsema V, Bartos H, Bosserhoff A, Bartenshlager R, Schaller H (1994): Hepadnavirus P protein utilizes a tyrosine residue in the TP domain to prime reverse transcription. Journal of Virology 68:2994-2999.
28. Yaginuma K, Shirakata Y, Kobayashi M, Koike K (1987): Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA. Proceedings of the National Academy of Sciences of the USA 84:2678-2682.
29. Zoulim F, Seeger C (1994): Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase. Journal of Virology 68:6-13.