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Volumn 270, Issue 11, 2003, Pages 2521-2531

A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells

Author keywords

Homocysteine; Phosphorylation; Platelet derived growth factor (PDGF); Proliferation; Smooth muscle cell

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; GENE PRODUCT; GROWTH FACTOR; HOMOCYSTEINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR; PROTEIN SERINE THREONINE KINASE; PROTEIN SMAP8; UNCLASSIFIED DRUG;

EID: 0037765996     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03626.x     Document Type: Article
Times cited : (23)

References (43)
  • 1
    • 0028918123 scopus 로고
    • Can lowering homocysteine levels reduce cardiovascular risk?
    • Stampfer, M.J. & Malinow, M.R. (1995) Can lowering homocysteine levels reduce cardiovascular risk? N. Engl. J. Med. 332, 328-329.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 328-329
    • Stampfer, M.J.1    Malinow, M.R.2
  • 2
    • 0027445293 scopus 로고
    • Homocysteine and marginal vitamin deficiency. The importance of adequate vitamin intake
    • Stampfer, M.J. & Willett, W.C. (1993) Homocysteine and marginal vitamin deficiency. The importance of adequate vitamin intake. J. Am. Med. Assoc. 270, 2726-2727.
    • (1993) J. Am. Med. Assoc. , vol.270 , pp. 2726-2727
    • Stampfer, M.J.1    Willett, W.C.2
  • 4
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • Selhub, J., Jacques, P.F., Wilson, P.W., Rush, D. & Rosenberg, I.H. (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. J. Am. Med. Assoc. 270, 2693-2698.
    • (1993) J. Am. Med. Assoc. , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Wilson, P.W.3    Rush, D.4    Rosenberg, I.H.5
  • 6
    • 0027523674 scopus 로고
    • Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study
    • Malinow, M.R., Nieto, F.J., Szklo, M., Chambless, L.E. & Bond, G. (1993) Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study. Circulation 87, 1107-1113.
    • (1993) Circulation , vol.87 , pp. 1107-1113
    • Malinow, M.R.1    Nieto, F.J.2    Szklo, M.3    Chambless, L.E.4    Bond, G.5
  • 8
    • 0028232177 scopus 로고
    • Identical genotypes in siblings with different homocystinuric phenotypes: Identification of three mutations in cystathionine beta-synthase using an improved bacterial expression system
    • de Franchis, R., Kozich, V., McInnes, R.R. & Kraus, J.P. (1994) Identical genotypes in siblings with different homocystinuric phenotypes: identification of three mutations in cystathionine beta-synthase using an improved bacterial expression system. Hum. Mol. Genet. 3, 1103-1108.
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 1103-1108
    • De Franchis, R.1    Kozich, V.2    McInnes, R.R.3    Kraus, J.P.4
  • 9
    • 0028170335 scopus 로고
    • Characterization of a cystathionine beta-synthase allele with three mutations in cis in a patient with B6 nonresponsive homocystinuria
    • Marble, M., Geraghty, M.T., de Franchis, R., Kraus, J.P. & Valle, D. (1994) Characterization of a cystathionine beta-synthase allele with three mutations in cis in a patient with B6 nonresponsive homocystinuria. Hum. Mol. Genet. 3, 1883-1886.
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 1883-1886
    • Marble, M.1    Geraghty, M.T.2    De Franchis, R.3    Kraus, J.P.4    Valle, D.5
  • 10
    • 0030910663 scopus 로고    scopus 로고
    • Characterisation of five missense mutations in the cystathionine beta-synthase gene from three patients with B6-nonresponsive homocystinuria
    • Dawson, P.A., Cox, A.J., Emmerson, B.T., Dudman, N.P., Kraus, J.P. & Gordon, R.B. (1997) Characterisation of five missense mutations in the cystathionine beta-synthase gene from three patients with B6-nonresponsive homocystinuria. Eur. J. Hum. Genet. 5, 15-21.
    • (1997) Eur. J. Hum. Genet. , vol.5 , pp. 15-21
    • Dawson, P.A.1    Cox, A.J.2    Emmerson, B.T.3    Dudman, N.P.4    Kraus, J.P.5    Gordon, R.B.6
  • 11
    • 0032235155 scopus 로고    scopus 로고
    • Mutational analysis of the cystathionine beta-synthase gene: A splicing mutation, two missense mutations and an insertion in patients with homocystinuria. Mutations in brief, 120
    • Online
    • Gordon, R.B., Cox, A.J., Dawson, P.A., Emmerson, B.T., Kraus, J.P. & Dudman, N.P. (1998) Mutational analysis of the cystathionine beta-synthase gene: a splicing mutation, two missense mutations and an insertion in patients with homocystinuria. Mutations in brief, 120. Online. Hum. Mutat. 11, 332.
    • (1998) Hum. Mutat. , vol.11 , pp. 332
    • Gordon, R.B.1    Cox, A.J.2    Dawson, P.A.3    Emmerson, B.T.4    Kraus, J.P.5    Dudman, N.P.6
  • 12
    • 0033007594 scopus 로고    scopus 로고
    • Four novel mutations in the cystathionine beta-synthase gene: Effect of a second linked mutation on the severity of the homocystinuric phenotype
    • de Franchis, R., Kraus, E., Kozich, V., Sebastio, G. & Kraus, J.P. (1999) Four novel mutations in the cystathionine beta-synthase gene: effect of a second linked mutation on the severity of the homocystinuric phenotype. Hum. Mutat. 13, 453-457.
    • (1999) Hum. Mutat. , vol.13 , pp. 453-457
    • De Franchis, R.1    Kraus, E.2    Kozich, V.3    Sebastio, G.4    Kraus, J.P.5
  • 14
    • 0030789201 scopus 로고    scopus 로고
    • Homocysteine signal cascade: Production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells
    • Dalton, M.L., Gadson, P.F. Jr, Wrenn, R.W. & Rosenquist, T.H. (1997) Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells. FASEB J. 11, 703-711.
    • (1997) FASEB J. , vol.11 , pp. 703-711
    • Dalton, M.L.1    Gadson P.F., Jr.2    Wrenn, R.W.3    Rosenquist, T.H.4
  • 15
    • 0031827720 scopus 로고    scopus 로고
    • The effect of homocysteine on DNA synthesis in cultured human vascular smooth muscle
    • Tang, L., Mamotte, C.D., Van Bockxmeer, F.M. & Taylor, R.R. (1998) The effect of homocysteine on DNA synthesis in cultured human vascular smooth muscle. Atherosclerosis 136, 169-173.
    • (1998) Atherosclerosis , vol.136 , pp. 169-173
    • Tang, L.1    Mamotte, C.D.2    Van Bockxmeer, F.M.3    Taylor, R.R.4
  • 17
    • 0033188148 scopus 로고    scopus 로고
    • Homocysteine induces DNA synthesis and proliferation of vascular smooth muscle cells by a hydrogen peroxide-independent mechanism
    • Taha, S., Azzi, A. & Ozer, N.K. (1999) Homocysteine induces DNA synthesis and proliferation of vascular smooth muscle cells by a hydrogen peroxide-independent mechanism. Antioxid. Redox. Signal 1, 365-369.
    • (1999) Antioxid. Redox. Signal , vol.1 , pp. 365-369
    • Taha, S.1    Azzi, A.2    Ozer, N.K.3
  • 18
    • 0033938469 scopus 로고    scopus 로고
    • Homocysteine stimulates MAP kinase in bovine aortic smooth muscle cells
    • Woo, D.K., Dudrick, S.J. & Sumpio, B.E. (2000) Homocysteine stimulates MAP kinase in bovine aortic smooth muscle cells. Surgery 128, 59-66.
    • (2000) Surgery , vol.128 , pp. 59-66
    • Woo, D.K.1    Dudrick, S.J.2    Sumpio, B.E.3
  • 19
    • 0034009713 scopus 로고    scopus 로고
    • Homocyst(e)ine induces calcium second messenger in vascular smooth muscle cells
    • Mujumdar, V.S., Hayden, M.R. & Tyagi, S.C. (2000) Homocyst(e)ine induces calcium second messenger in vascular smooth muscle cells. J. Cell Physiol. 183, 28-36.
    • (2000) J. Cell Physiol. , vol.183 , pp. 28-36
    • Mujumdar, V.S.1    Hayden, M.R.2    Tyagi, S.C.3
  • 20
    • 0033980003 scopus 로고    scopus 로고
    • Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models
    • Chen, C., Halkos, M.E., Surowiec, S.M., Conklin, B.S., Lin, P.H. & Lumsden, A.B. (2000) Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models. J. Surg. Res. 88, 26-33.
    • (2000) J. Surg. Res. , vol.88 , pp. 26-33
    • Chen, C.1    Halkos, M.E.2    Surowiec, S.M.3    Conklin, B.S.4    Lin, P.H.5    Lumsden, A.B.6
  • 22
    • 0029860742 scopus 로고    scopus 로고
    • Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes
    • Kokame, K., Kato, H. & Miyata, T. (1996) Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J. Biol. Chem. 271, 29659-29665.
    • (1996) J. Biol. Chem. , vol.271 , pp. 29659-29665
    • Kokame, K.1    Kato, H.2    Miyata, T.3
  • 25
    • 0032188908 scopus 로고    scopus 로고
    • Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage
    • Kurdistani, S.K., Arizti, P., Reimer, C.L., Sugrue, M.M., Aaronson, S.A. & Lee, S.W. (1998) Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage. Cancer Res. 58, 4439-4444.
    • (1998) Cancer Res. , vol.58 , pp. 4439-4444
    • Kurdistani, S.K.1    Arizti, P.2    Reimer, C.L.3    Sugrue, M.M.4    Aaronson, S.A.5    Lee, S.W.6
  • 27
    • 0035307347 scopus 로고    scopus 로고
    • Characterization of the human NDRG gene family: A newly identified member, NDRG4, is specifically expressed in brain and heart
    • Zhou, R.H., Kokame, K., Tsukamoto, Y., Yutani, C., Kato, H. & Miyata, T. (2001) Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. Genomics 73, 86-97.
    • (2001) Genomics , vol.73 , pp. 86-97
    • Zhou, R.H.1    Kokame, K.2    Tsukamoto, Y.3    Yutani, C.4    Kato, H.5    Miyata, T.6
  • 28
    • 0026301763 scopus 로고
    • A novel system for large-scale sequencing of cDNA by PCR amplification
    • Okubo, K., Hori, N., Matoba, R., Niiyama, T. & Matsubara, K. (1991) A novel system for large-scale sequencing of cDNA by PCR amplification. DNA Seq. 2, 137-144.
    • (1991) DNA Seq. , vol.2 , pp. 137-144
    • Okubo, K.1    Hori, N.2    Matoba, R.3    Niiyama, T.4    Matsubara, K.5
  • 29
    • 0026947554 scopus 로고
    • Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression
    • Okubo, K., Hori, N., Matoba, R., Niiyama, T., Fukushima, A., Kojima, Y. & Matsubara, K. (1992) Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression. Nat. Genet. 2, 173-179.
    • (1992) Nat. Genet. , vol.2 , pp. 173-179
    • Okubo, K.1    Hori, N.2    Matoba, R.3    Niiyama, T.4    Fukushima, A.5    Kojima, Y.6    Matsubara, K.7
  • 30
    • 0037036080 scopus 로고    scopus 로고
    • Identification of a novel smooth muscle associated protein, smap2, upregulated during neointima formation in a rat carotid endarterectomy model
    • Nishimoto, S., Hamajima, Y., Toda, Y., Toyoda, H., Kitamura, K. & Komurasaki, T. (2002) Identification of a novel smooth muscle associated protein, smap2, upregulated during neointima formation in a rat carotid endarterectomy model. Biochim. Biophys. Acta 1576, 225-230.
    • (2002) Biochim. Biophys. Acta , vol.1576 , pp. 225-230
    • Nishimoto, S.1    Hamajima, Y.2    Toda, Y.3    Toyoda, H.4    Kitamura, K.5    Komurasaki, T.6
  • 31
    • 0037197680 scopus 로고    scopus 로고
    • Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells
    • Ohki, T., Hongo, S., Nakada, N., Maeda, A. & Takeda, M. (2002) Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells. Brain Res. Dev. Brain Res. 135, 55-63.
    • (2002) Brain Res. Dev. Brain Res. , vol.135 , pp. 55-63
    • Ohki, T.1    Hongo, S.2    Nakada, N.3    Maeda, A.4    Takeda, M.5
  • 32
    • 0033006387 scopus 로고    scopus 로고
    • N-myc-dependent repression of ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant
    • Shimono, A., Okuda, T. & Kondoh, H. (1999) N-myc-dependent repression of ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant. Mech. Dev. 83, 39-52.
    • (1999) Mech. Dev. , vol.83 , pp. 39-52
    • Shimono, A.1    Okuda, T.2    Kondoh, H.3
  • 33
    • 0031010657 scopus 로고    scopus 로고
    • Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone
    • Lin, T.M. & Chang, C. (1997) Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone. Proc. Natl Acad. Sci. USA 94, 4988-4993.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 4988-4993
    • Lin, T.M.1    Chang, C.2
  • 35
    • 0022552919 scopus 로고
    • Endothelial cell injury due to copper-catalyzed hydrogen peroxide
    • Starkebaum, G. & Harlan, J.M. (1986) Endothelial cell injury due to copper-catalyzed hydrogen peroxide. J. Clin. Invest. 77, 1370-1376.
    • (1986) J. Clin. Invest. , vol.77 , pp. 1370-1376
    • Starkebaum, G.1    Harlan, J.M.2
  • 36
    • 0023572209 scopus 로고
    • Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
    • Bohmann, D., Bos, T.J., Admon, A., Nishimura, T., Vogt, P.K. & Tjian, R. (1987) Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238, 1386-1392.
    • (1987) Science , vol.238 , pp. 1386-1392
    • Bohmann, D.1    Bos, T.J.2    Admon, A.3    Nishimura, T.4    Vogt, P.K.5    Tjian, R.6
  • 37
    • 0023782359 scopus 로고
    • The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes
    • Chiu, R., Boyle, W.J., Meek, J., Smeal, T., Hunter, T. & Karin, M. (1988) The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54, 541-552.
    • (1988) Cell , vol.54 , pp. 541-552
    • Chiu, R.1    Boyle, W.J.2    Meek, J.3    Smeal, T.4    Hunter, T.5    Karin, M.6
  • 38
    • 0030783147 scopus 로고    scopus 로고
    • Homocysteine as a modulator of platelet-derived growth factor action in vascular smooth muscle cells: A possible role for hydrogen peroxide
    • Nishio, E. & Watanabe, Y. (1997) Homocysteine as a modulator of platelet-derived growth factor action in vascular smooth muscle cells: a possible role for hydrogen peroxide. Br. J. Pharmacol. 122, 269-274.
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 269-274
    • Nishio, E.1    Watanabe, Y.2
  • 39
    • 0030273271 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF): Actions and mechanisms in vascular smooth muscle
    • Hughes, A.D., Clunn, G.F., Refson, J. & Demoliou-Mason, C. (1996) Platelet-derived growth factor (PDGF): actions and mechanisms in vascular smooth muscle. General Pharmacol. 27, 1079-1089.
    • (1996) General Pharmacol. , vol.27 , pp. 1079-1089
    • Hughes, A.D.1    Clunn, G.F.2    Refson, J.3    Demoliou-Mason, C.4
  • 40
    • 0033577854 scopus 로고    scopus 로고
    • Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells
    • Hayashi, K., Takahashi, M., Kimura, K., Nishida, W., Saga, H. & Sobue, K. (1999) Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells. J. Cell Biol. 145, 727-740.
    • (1999) J. Cell Biol. , vol.145 , pp. 727-740
    • Hayashi, K.1    Takahashi, M.2    Kimura, K.3    Nishida, W.4    Saga, H.5    Sobue, K.6
  • 41
    • 0033756163 scopus 로고    scopus 로고
    • A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster
    • Huang, A.M. & Rubin, G.M. (2000) A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Genetics 156, 1219-1230.
    • (2000) Genetics , vol.156 , pp. 1219-1230
    • Huang, A.M.1    Rubin, G.M.2
  • 42
    • 0034768013 scopus 로고    scopus 로고
    • Ras1 interacts with multiple new signaling and cytoskeletal loci in Drosophila eggshell patterning and morphogenesis
    • Schnorr, J.D., Holdcraft, R., Chevalier, B. & Berg, C.A. (2001) Ras1 interacts with multiple new signaling and cytoskeletal loci in Drosophila eggshell patterning and morphogenesis. Genetics 159, 609-622.
    • (2001) Genetics , vol.159 , pp. 609-622
    • Schnorr, J.D.1    Holdcraft, R.2    Chevalier, B.3    Berg, C.A.4
  • 43
    • 0032814144 scopus 로고    scopus 로고
    • Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization
    • Stewart, S., Sundaram, M., Zhang, Y., Lee, J., Han, M. & Guan, K.L. (1999) Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol. Cell Biol. 19, 5523-5534.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 5523-5534
    • Stewart, S.1    Sundaram, M.2    Zhang, Y.3    Lee, J.4    Han, M.5    Guan, K.L.6


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