Homocysteine as a modulator of platelet-derived growth factor action in vascular smooth muscle cells: A possible role for hydrogen peroxide

British Journal of Pharmacology

Volumn 122, Issue 2, 1997, Pages 269-274

  Nishio, Eisuke ^a   Watanabe, Yasuhiro ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

Atherosclerosis; Catalase; Glutathione peroxidase; Homocysteine; Mitosis; Platelet derived growth factor BB; Superoxide dismutase; Vascular smooth muscle cell

Indexed keywords

ACETYLCYSTEINE; CATALASE; GLUTATHIONE PEROXIDASE; HOMOCYSTEINE; HYDROGEN PEROXIDE; PLATELET DERIVED GROWTH FACTOR BB; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTIOXIDANTS; CELL DIVISION; CELLS, CULTURED; GLUTATHIONE PEROXIDASE; HOMOCYSTEINE; HYDROGEN PEROXIDE; MUSCLE, SMOOTH, VASCULAR; PLATELET-DERIVED GROWTH FACTOR; RATS; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 0030783147     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701391     Document Type: Article

References (28)

1. ASAHI, M., FUJII, J., SUZUKI, K., SKO, H.G., KUZUYA, T., HORI, M., TADA, M., FUJII, S. & TANIGUCHI, N. (1995). Inactivation of glutathione peroxidase by nitric oxide. J. Biol. Chem., 36, 21035-21039.
2. BLUM, J. & FRIDORICH, I. (1985). Inactivalion of glutathione peroxidase by superoxide radical. Arch. Biochem. Biophys., 247, 1-11.
3. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
4. CHEN, Q., OLASHAW, N. & WU, J. (1995). Participation of reactive oxygen species in the lysophosphatidic acid-stimulated mitogen-activated protein kinase kinase activation pathway. J. Biol. Chem., 270, 28499-28502.
5. CLARKE, R., DALY, L., ROBINSON, K., NAUGHTEN, E., CAHALANE, S., FOWLER, B. & GRAHAM, I. (1991). Hyperhomocysteinemia: an independent risk factor for vascular disease. N. Engl. J. Med., 324, 1149-1155.
6. FRIDORICH, I. (1985). Biological effects of the superoxide radical. Arch. Biochem. Biophys., 247, 1-11.
7. FUSTER, V., BADIMON, J.J. & BADIMON, L. (1992). Clinical-pathological correlations of coronary disease progression and regression. Circulation, 86, III-1-III-11.
8. GADIPARTHI, M.R. & BRADFORD, C.B. (1992). Active oxygen species stimulate vascular smooth muscle cell growth and protooncogene expression. Circ. Res., 70, 593-599.
9. GRISHAM, M.B. & MCORD, J.M. (1986). Cytotoxicity of reactive oxygen metabolites. In Physiology of Oxygen Radicals. Bethesda: American Physiological Society. 1,.
10. GUNZLER, W.A. & FLOHE, L. (1985). CRC Handbook of Methods for Oxygen Radical Research, Boca Raton, Florida: CRC press.
11. HARKER, L.A., SLICHTER, S.J., SCOTT, R. & RUSSEL, R. (1974). Homoeystinemia. Vascular injury and arterial thrombosis. N. Engl. J. Med., 291, 537-543.
12. HEINECKE, J.W., ROSEN, H., SUZUKI, L.A. & CHAIT, A. (1987). The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein in arterial smooth muscle cells. J. Biol. Chem., 21, 10098-10103.
13. HILDEBRANDT, A.G., ROOTS, I., TJOE, M. & HEINEMEYER, G. (1978). Hydrogen peroxide in hepatic microsomes. Methods Enzymol., 52, 342-350.
14. JANAT, M.F. & GENE, L. (1992). Transforming growth factor β1 is a powerful modulator of platelet-derived growth factor action in vascular smooth muscle cells. J. Cell. Physiol., 150, 232-242.
15. LO, Y.Y.C. & CRUZ, T.F. (1995). Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes. J. Biol. Chem., 270, 11727-11730.
16. 2 for platelet-derived growth factor signal transduction. Science, 270, 296-299.
17. MALINOW, M.R. (1990). Hyperhomocysteinemia. A common and easily reversible risk factor for occlusive atherosclerosis. Circulation, 81, 2004-2006.
18. MALINOW, M.R., NIETO, F.J., SZKLO, M., CHAMBLESS, L.E. & BOND, G. (1993). Carotid artery intimal-medial wall thickening and plasma homocysteine in asymptomatic adults. The Atherosclerosis Risk in Communities Study. Circulation, 87, 1107-1113.
19. MALINOW, M.R., SEXTON, G., AVERBUCH, M., GROSSMAN, M., WILSON D. & UPSON, B. (1990). Homocysteinemia in daily practice: levels in coronary artery disease. Coronary Art. Dis., 1, 215-220.
20. MCDONALD, L., BRAY, C., FIELD, C., LOVE, F. & DAVIES, B. (1964). Homocystinuria, thrombosis and the blood-plaelets. Lancet, 1, 745-746.
21. NISHIO, E., ARIMURA, S. & WATANABE, Y. (1996). Oxidized LDL induces apoptosis in cultured smooth muscle cells: A possible role for 7-ketocholesterol. Biochem. Biophys. Res. Commun., 223, 413-418.
22. STAMPFER, M.J. & MALINOW, M.R. (1995). Can lowering homocysteine levels reduce cardiovascular risk? N. Engl. J. Med., 332, 328-329.
23. TEIXEIRA, C.C., SHAPIRO, M., HATORI, M., RAJPUROHIT, R. & KOCH, C. (1996). Retinoic acid modulation of glutathione and cysteine metabolism in chondrocytes. Biochem. J., 314, 21-26.
24. TSAI, J.C., WANG, H., PERRELLA, M.A., YOSHIZUMI, M., NICHOLAS, E.S.S., TAN, L.C., HABER, E., CHAND, T.H.T., SCHLEGEL, R. & LEE, M.E. (1996). Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J. Clin. Invest., 97, 146-153.
25. UELAND, P.M. & REFSUM, H. (1989). Plasma homocysteine, a risk factor for vascular disease: plasma levels in healthy, disease and drug therapy. J. Lab. Clin. Med. 114, 473-501.
26. VESSEY, D.A. & LEE, K.H. (1993). Inactivation of enzymes of the glutathione antioxidant system by treatment of culture human keratinocytes with peroxides. J. Invest. Dermatol., 100, 829-833.
27. WALL, R.T., HARLAN, J.M., HARKER, L.A. & STRIKER, G.E. (1980). Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb. Res., 18, 113-121.
28. WANG, J., DUDMAN, N.P.B. & WILCKEN, D.E.L. (1993). Effects of homocysteine and related compounds on prostacyclin production by cultured vascular endothelial cells. Thromb. Haemostas., 70, 1047-1052.