Phosphorylation of RTP, an ER stress-responsive cytoplasmic protein

Biochemical and Biophysical Research Communications

Volumn 272, Issue 3, 2000, Pages 641-647

  Agarwala, Kishan Lal ^a   Kokame, Koichi ^a   Kato, Hisao ^a   Miyata, Toshiyuki ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Differentiation; Drg1; GRP78; Homocysteine; Ndr1; Phosphorylation; Proliferation; Protein kinase A; RTP; Stress protein

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYTOPLASM PROTEIN; HEAT SHOCK PROTEIN; HOMOCYSTEINE;

ARTICLE; CELL DENSITY; CELL FUNCTION; CELL GROWTH; ENDOPLASMIC RETICULUM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRESS; UMBILICAL VEIN;

EID: 0034674282     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2833     Document Type: Article

References (24)

1. Clarke R., Daly L., Robinson K., Naughten E., Cahalane S., Fowler B., Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N. Engl. J. Med. 324:1991;1149-1155.
2. Duell P. B., Malinow M. R. Homocyst(e)ine: An important risk factor for atherosclerotic vascular disease. Curr. Opin. Lipidol. 8:1997;28-34.
3. Kokame K., Kato H., Miyata T. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J. Biol. Chem. 271:1996;29659-29665.
4. van Belzen N., Dinjens W. N., Diesveld M. P., Groen N. A., van der Made A. C., Nozawa Y., Vlietstra R., Trapman J., Bosman F. T. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms. Lab. Invest. 77:1997;85-92.
5. 2+ compounds. Cancer Res. 58:1998;2182-2189.
6. Kurdistani S. K., Arizti P., Reimer C. L., Sugrue M. M., Aaronson S. A., Lee S. W. Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage. Cancer Res. 58:1998;4439-4444.
7. Lin T. M., Chang C. Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone. Proc. Natl. Acad. Sci. USA. 94:1997;4988-4993.
8. Shimono A., Okuda T., Kondoh H. N-myc-dependent repression of Ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant. Mech. Dev. 83:1999;39-52.
9. Kräuter-Canham R., Bronner R., Evrard J.-L., Hahne G., Friedt W., Steinmetz A. A transmitting tissue- and pollen-expressed protein from sunflower with sequence similarity to the human RTP protein. Plant Science. 129:1997;191-202.
10. Sato N., Kokame K., Shimokado K., Kato H., Miyata T. Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others. J. Biochem. 123:1998;1119-1126.
11. 2+ in the regulation of nickel-inducible Cap43 gene expression. Toxicol. Appl. Pharmacol. 160:1999;127-132.
12. Piquemal D., Joulia D., Balaguer P., Basset A., Marti J., Commes T. Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells. Biochim. Biophys. Acta. 1450:1999;364-373.
13. Xu B., Lin L., Rote N. S. Identification of a stress-induced protein during human trophoblast differentiation by differential display analysis. Biol. Reprod. 61:1999;681-686.
14. Ulrix W., Swinnen J. V., Heyns W., Verhoeven G. The differentiation-related gene 1, Drg1, is markedly upregulated by androgens in LNCaP prostatic adenocarcinoma cells. FEBS Lett. 455:1999;23-26.
15. Yu J., Zhang L., Hwang P. M., Rago C., Kinzler K. W., Vogelstein B. Identification and classification of p53-regulated genes. Proc. Natl. Acad. Sci. USA. 96:1999;14517-14522.
16. Salnikow K., Blagosklonny M. V., Ryan H., Johnson R., Costa M. Carcinogenic nickel induces genes involved with hypoxic stress. Cancer Res. 60:2000;38-41.
17. Kokame K., Kato H., Miyata T. Nonradioactive differential display cloning of genes induced by homocysteine in vascular endothelial cells. Methods. 16:1998;434-443.
18. Yamauchi Y., Hongo S., Ohashi T., Shioda S., Zhou C., Nakai Y., Nishinaka N., Takahashi R., Takeda F., Takeda M. Molecular cloning and characterization of a novel developmentally regulated gene, Bdm1, showing predominant expression in postnatal rat brain. Brain. Res. Mol. Brain. Res. 68:1999;149-158.
19. Okuda T., Kondoh H. Identification of new genes Ndr2 and Ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem. Biophys. Res. Commun. 266:1999;208-215.
20. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
21. Kaufman R. J. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 13:1999;1211-1233.
22. Wang X. Z., Lawson B., Brewer J. W., Zinszner H., Sanjay A., Mi L. J., Boorstein R., Kreibich G., Hendershot L. M., Ron D. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol. Cell. Biol. 16:1996;4273-4280.
23. 2+ and phorbol esters. Nature. 317:1985;546-549.
24. van der Griend R., Haas F. J., Duran M., Biesma D. H., Meuwissen O. J., Banga J. D. Methionine loading test is necessary for detection of hyperhomocysteinemia. J. Lab. Clin. Med. 132:1998;67-72.