The effect of homocysteine on DNA synthesis in cultured human vascular smooth muscle

Atherosclerosis

Volumn 136, Issue 1, 1998, Pages 169-173

  Tang, Lilong ^a   Mamotte, Cyril D S ^a   Van Bockxmeer, Frank M ^a   Taylor, Roger R ^a  

^a ROYAL PERTH HOSPITAL   (Australia)

Author keywords

Cell culture; DNA synthesis; Homocysteine; Vascular smooth muscle

Indexed keywords

DNA; HOMOCYSTEINE; TRITIUM;

AMINO ACID BLOOD LEVEL; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DNA SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RISK FACTOR; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA REPLICATION; HOMOCYSTEINE; HUMANS; MUSCLE, SMOOTH, VASCULAR; RATS;

EID: 0031827720     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(97)00208-6     Document Type: Article

References (16)

1. McCully K.S. Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis. Am J Pathol. 56:1969;111-128.
2. Ueland P.M., Refsum H. Plasma homocysteine, a risk factor for vascular disease: Plasma levels in health, disease and drug therapy. J Lab Clin Med. 114:1989;473-501.
3. Boushey C.J., Beresford S.A.A., Omenn G.S., Motulsky A.G. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J Am Med Assoc. 274:1995;1049-1057.
4. Stamler J.S., Osborne J.A., Jaraki O., Rabbani L.E., Mullins M., Singel D., Loscalzo J. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 91:1993;308-318.
5. Tsai J.C., Perrella M.A., Yoshizumi M., Hsieh C.M., Haber E., Schlegel R., Lee M.E. Promotion of vascular smooth muscle cell growth by homocysteine: link to atherosclerosis. Proc Natl Acad Sci USA. 91:1994;6369-6373.
6. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:1993;801-809.
7. Ubbink J.B., Vermaak W.J.H., Bissbort S. Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr Biomed Appl. 565:1991;441-446.
8. Malinow M.R., Nieto F.J., Szklo M., Chambless L.E., Bond G. Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The atherosclerosis risk in communities study. Circulation. 87:1993;1107-1113.
9. Selhub J., Jacques P.F., Bostom A.G., D'Agostino R.B., Wilson P.W.F., Belanger A.J., O'Leary D.H., Wolf P.A., Schaefer E.J., Rosenberg I.H. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. New Engl J Med. 332:1995;286-291.
10. McCully K.S. Homocysteine and vascular disease. Nat Med. 2:1996;386-389.
11. Ewadh M.J., Tudball N., Rose F.A. Homocysteine, uptake by human umbilical vein endothelial cells in culture. Biochim Biophys Acta. 1054:1990;263-266.
12. Dudman N.P.B., Hicks C., Lynch J.F., Wilcken D.E.L., Wang J. Homocysteine thiolactone disposal by human arterial endothelial cells and serum in vitro. Arterioscler Thromb. 11:1991;663-670.
13. Blundell G., Jones B.G., Rose F.A., Tudball N. Homocysteine mediated endothelial cell toxicity and its amelioration. Atherosclerosis. 122:1996;163-172.
14. Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest. 98:1996;5-7.
15. Lentz S.R., Sobey C.G., Piegors D.J., Bhopatkar M.Y., Faraci F.M., Malinow M.R., Heistad D.D. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest. 98:1996;24-29.
16. Tawakol A., Omland T., Gerhard M., Wu J.T., Creager M.A. Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation. 95:1997;1119-1121.