Closed-chamber inhalation pharmacokinetic studies with hexamethyldisiloxane in the rat

Inhalation Toxicology

Volumn 15, Issue 6, 2003, Pages 589-617

  Dobrev, Ivan D ^a,c   Reddy, Micaela B ^a   Plotzke, Kathleen P ^b   Varaprath, Sudarsanan ^b   McNett, Debra A ^b   Durham, Jeremy ^b   Andersen, Melvin E ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b DOW CORNING CORPORATION   (United States)

^c ENVIRON INTERNATIONAL CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DIETHYLDITHIOCARBAMIC ACID; HEXAMETHYLDISILOXANE; PHENOBARBITAL; SILOXANE; UNCLASSIFIED DRUG; VOLATILE ORGANIC COMPOUND;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONCENTRATION RESPONSE; DIFFUSION; INHALATION; LIPID STORAGE; LIPOPHILICITY; LIVER METABOLISM; MALE; NONHUMAN; PARTITION COEFFICIENT; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; TECHNIQUE;

ANIMALIA;

EID: 0037764003     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370390205083     Document Type: Article

References (31)

1. Abraham, K., Krowke, R., and Neubert, D. 1988. Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch. Toxicol. 62:359-368.
2. Andersen, M. E. 1981. A physiologically based toxicokinetic description of the metabolism of inhaled gases and vapors: Analysis at steady state. Toxicol. Appl Pharmacol. 60: 509-526.
3. Andersen, M. E., Mills, J. J., Gargas, M. L., Kedderis, L. B., Birnbaum, L. S., Neubert, D., and Greenlee, W. F. 1993. Modeling receptor-mediated processes with dioxin: Implications for pharmacokinetics and risk assessment. J. Risk Anal. 13:25-34.
4. Andersen, M. E., Sarangapani, R., Reitz, R. H., Gallavan, R. H., Dobrev, I. D., and Plotzke, K. P. 2001. Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats. Toxicol. Sci. 60:214-231.
5. Brown, R. P., Delp, M. D., Lindstedt, S. L., Rhomberg, L. R., and Beliles, R. P. 1997. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health 13:407-484.
6. Cassidy, S., Dotti, A., Kolesar, G. B., Dochterman, L. W., Meeks, R. G., and Chevlier, H. J. 2001. Hexamethyldisiloxane: A 13 week subchronic whole-body vapor inhalation toxicity study in Fischer 344 rats. Int. J. Toxicol. 20:391-399.
7. Collins, A. S., Summer, S. C. J., Borghoff, S. J., and Medinsky, M. A. 1999. A physiological model for tert-amyl methyl ether and tert-amyl alcohol: Hypothesis testing of model structures. Toxicol. Sci. 49:15-28.
8. Dobrev, I. D., Andersen, M. E., and Yang, R. S. H. 2001. Assessing interactions thresholds for trichloroethylene in combination with tetrachloroethylene and 1,1,1-trichloroethane using gas uptake studies and PBPK modeling. Arch. Toxicol. 75:134-144.
9. Filser, J. G. 1992. The closed chamber technique - Uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors. Arch. Toxicol. 66:1-10.
10. Filser, J. G., and Bolt, H. M. 1979. Pharmacokinetics of halogenated ethylenes in rats. Arch. Toxicol. 42: 123-136.
11. Fisher, J. W., Whittaker, T. A., Taylor, D. H., Clewell, H. J. III, and Andersen, M. E. 1989. Physiologically based pharmacokinetic modeling of the pregnant rat: A multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. Toxicol. Appl. Pharmacol. 99:395-414.
12. Gerlowski, L. E., and Jain, R. K. 1983. Physiologically based pharmacokinetic modeling: Principles and applications. J. Pharm. Sci. 72:1103-1127.
13. Houston, J. B., Upshall, D. G., and Bridges, J. W. 1974. A reevaluation of the importance of partition coefficients in the gastrointestinal absorption of nutrients. J. Pharmacol. Exp. Ther. 189:244-254.
14. Kharash, E. D., Hankins, D. C., Jubert, C., Thummel, K. E., and Taraday, J. K. 1999. Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: Evidence for specificity toward P-450 2E1. Drug Metab. Dispos. 27:717-723.
15. Krishnan, K., Andersen, M. E., Clewell, H. J., and Yang, R. S. H. 1994. Physiologically based pharmacokinetic modeling of chemical mixtures. In Toxicology of chemical mixtures: Case studies, mechanisms, and novel approaches, ed. R. S. H. Yang, pp. 399-437. San Diego, CA: Academic Press.
16. McKim, J. M., Wilga, P. C., Kolesar, G. B., Choudhuri, S., Madan, A., Dochterman, L. W., Breen, J. G., Parkinson, A., Mast, R. W., and Meeks, R. G. 1998. Evaluation of octamethylcyclotetrasiloxane (D-4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: A 28-day inhalation study. Toxicol. Sci. 41:29-41.
17. McKim, J. M., Kolesar, G. B., Jean, P. A., Meeker, L. S., Wilga, P. C., Schoonhoven, R., Swenberg, J. A., Goodman, J. I., Gallavan, R. H., and Meeks, R. G. 2001a. Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital. Toxicol. Appl. Pharmacol. 172:83-92.
18. McKim, J. M., Wilga, P. C., Breslin, W. J., Plotzke, K. P., Gallavan, R. H., and Meeks, R. G. 2001b. Potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) in immature rats using the uterotrophic assay. Toxicol. Sci. 63:37-46.
19. Nakajima, T., Okino, T., Okuyama, S., Kaneko, T., Yonekura, I., and Sato, A. 1988. Ethanol-induced enhancement of trichloroethylene metabolism and hepatotoxicity: Difference from the effect of phenobarbital. Toxicol. Appl. Pharmacol. 94:227-237.
20. Nakajima, T., Elovaara, E., Okino, T., Gelboin, H. V., Klockars, M., Riihimaki, V., Aoyama, T., and Vainio, H. 1995. Different contributions of cytochrome P450 2E1 and P450 2B1/2 to chloroform hepatotoxicity in rat. Toxicol. Appl. Pharmacol. 133:215-222.
21. Plotzke, K. P., Crofoot, S. D., Ferdinandi, E. S., Beattie, J. G., Reitz, R. H., McNett, D. A., and Meeks, R. G. 2000. Disposition of radioactivity in Fischer 344 rats after single and multiple inhalation exposure to [C-14]octamethylcyclotetrasiloxane ([C-14]D-4). Drug Metab. Dispos. 28:192-204.
22. Ramsey, J. C., and Andersen, M. E. 1984. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73:159-175.
23. Reddy, M. B., Utell, M. J., Morrow, P. E., Dobrev, I. D., Varaprath, S., Plotzke, K. P., and Andersen, M. E. 2003. Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane (D4) in humans during rest and exercise. Toxicol. Sci. 72:3-18.
24. Reitz, R. H., McDougal, J. N., Nolan, R. D., and Schumann, A. M. 1988. Physiologically based parmacokinetic modeling with methylchloroform implications for interspecies, high dose/low dose and dose route extrapolations. Toxicol. Appl. Pharmacol. 95:185-199.
25. Roth, W. L., Weber, L. W., Stahl, B. U., and Rozman, K. 1993. A pharmacodynamic model for triglyceride transport and deposition during feed deprivation or following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat. Toxicol. Appl. Pharmacol. 120:126-137.
26. Roth, W. L., Ernst, S., Weber, L. W. D., Kerecsen, L., and Rozman, K. K. 1994. A pharmacodynamically responsive model of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) transfer between liver and fat at low and high doses. Toxicol. Appl. Pharmacol. 127:151-162.
27. Sarangapani, R., Teeguarden, J., Plotzke, K. P., McKim, J. M., and Andersen, M. E. 2002. Dose-response modeling of cytochrome P450 induction in rats by octamethylcyclotetrasiloxane. Toxicol. Sci. 67:159-172.
28. Sarangapani, R., Teeguarden, J., Andersen, M. E., J., Reitz, R. H., and Plotzke, K. P. 2003. Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: Analysis using physiologically based pharmacokinetic model. Toxicol. Sci. 71:41-52.
29. Varaprath, S., Salyers, K. L., Plotzke, K. P., and Nanavati, S. 1999. Identification of metabolites of octamethylcyclotetrasiloxane (D-4) in rat urine. Drug Metab. Dispos. 27:1267-1273.
30. Varaprath, S., Seaton, M., McNett, D., Cao, L., and Plotzke, K. P. 2000. Quantitative determination of octamethylcyclotetrasiloxane (D-4) in extracts of biological matrices by gas chromatography-mass spectrometry. Int. J. Environ. Anal. Chem. 77:203-219.
31. Varaprath, S., McMahon, J. M., and Plotzke, K. P. 2003. Metabolites of hexamethyldisiloxane and decamethylcyclopentasiloxane in Fischer 344 rat urine - A comparison of a linear and a cyclic siloxane. Drug Metab. Dispos. 31:206-214.