Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: A 28-day inhalation study

Toxicological Sciences

Volumn 41, Issue 1, 1998, Pages 29-41

  McKim Jr , James M ^a   Wilga, Paul C ^a   Kolesar, Gary B ^a   Choudhuri, Supratim ^a   Madan, Ajay ^b   Dochterman, Leland W ^a   Breen, John G ^a   Parkinson, Andrew ^b   Mast, Richard W ^c   Meeks, Robert G ^a  

^a DOW CORNING CORPORATION   (United States)

^b XenoTech LLC   (United States)

^c EVEREST CONSULTING ASSOCIATES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; EPOXIDE HYDROLASE; GLUCURONOSYLTRANSFERASE; SILOXANE; CYP3A1 PROTEIN, RAT; CYTOCHROME P450 1A1; IMMUNOLOGICAL ADJUVANT; OCTAMETHYLCYCLOTETRASILOXANE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INDUCTION; FEMALE; IMMUNOREACTIVITY; INHALATION; LIVER; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; ENZYMOLOGY; FISCHER 344 RAT; INHALATIONAL DRUG ADMINISTRATION; LIVER MICROSOME; WESTERN BLOTTING;

ANIMALIA;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INHALATION; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; EPOXIDE HYDROLASES; FEMALE; GLUCURONOSYLTRANSFERASE; MALE; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; RATS; RATS, INBRED F344; SILOXANES;

EID: 0031594803     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1997.2398     Document Type: Article

References (73)

1. Annelin, R. B., and Frye, C. L. (1989). The piscene bioconcentration characterization of cyclic and linear oligomeric permethylsiloxanes. Sci. Total Environ. 83, 1-11.
2. Annelin, R. B. (1990). A 14-day aquatic toxicity test with rainbow trout with octamethylcyclotetrasiloxane under flow-through conditions at two temperatures. TSCA Docket OPTS-42071B. Toxic Substances Control Act Public Docket Office, Washington, DC.
3. Annelin, R. B. (1992). An 18-day aquatic toxicity test of octamethylcyclotetrasiloxane in rainbow trout of different size under flow-through saturated conditions. TSCA Docket OPTS-42071B. Toxic Substances Control Act Public Docket Office, Washington, DC.
4. Annelin, R. B. (1993). A 16-day aquatic toxicity test of octamethylcyclotetrasiloxane in fathead minnows (Pimephales promelas) under flow-through conditions at 12°C. TSCA Docket OPTS-42071B. Toxic Substances Control Act Public Docket Office, Washington, DC.
5. Arlotto, M. P., Greenway, D. J., and Parkinson, A. (1989). Purification of two isozymes of rat liver microsomal cytochrome P-450 with testosterone 7α-hydroxylase activity. Arch. Biochem. Biophys. 270, 441-457.
6. Arlotto, M. P., Sonderfan, A. J., McKinney, M. M., and Parkinson, A. (1986). Digitoxin metabolism by liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase and its role in the protection of rats from digitoxin toxicity by pregnenolone-16α-carbonitrile. Arch. Biochem. Biophys. 251, 188-197.
7. Bock, K. W., Burchell, B., Dutton, G. J., Hanninen, O., Mulder, G. J., Owens, I. S., Siest, G., and Tephly, R. (1983). UDP-glucuronyl transferase activities: Guidelines for consistent interim terminology and assay conditions. Biochem. Pharmacol. 32, 953-955.
8. Bookstaff, R. C., Skare, J. A., Murphy, V. A., Minnema, D. J., and Parkinson, A. (1995). Effects of doxylamine succinate (DOX) on thyroid hormone balance and enzyme induction in mice and rats. Toxicologist 15(1), 118.
9. Burke, M. D., Thompson, S., Elcombe, C. R., Halpert, J., Haaparanta, T., and Mayer, R. T. (1985). Ethoxy-pentoxy,-, and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochrome P450. Biochem. Pharmacol. 34, 3337-3345.
10. Burke, M. D., Thompson, S., Weaver, R. J., Wolf, R. C., and Mayer, R. T. (1994). Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem. Pharmacol. 48, 923-936.
11. Butler, W. H. (1978). Long-term effects of phenobarbitone-Na on male fischer rats. Br. J. Cancer 37, 418-423.
12. Clemmesen, J., and Hjalgrim-Jensen, S. (1978). Is phenobarbital carcinogenic? A follow-up of 8078 epileptics. Ecotoxicol. Environ. Saf. 1, 457-470.
13. Dain, J. G., and Nicoletti, J. (1995). Metabolic pathways o 4-[(3-methoxyphenyl)methyl]-2,2,6,6-tetramethyl-1-oxa-4-aza-2,6- disilacyclohexane (MPSC) hydrochloride, a silicon-containing xenobiotic, in rat, dog, and man. Xenobiotica 25, 951-961.
14. Diwan, B. A., Ward, J. M., Anderson, L. M., Hagiwara, A., and Rice, J. M. (1986). Lack of effect of phenobarbital on hepatocellular carcinogenesis initiated by N-nitrosodiethylamine or methylazoxymethanol acetate in male Syrian golden hamsters. Toxicol Appl. Pharmacol. 86, 298-307.
15. Donato, M. T., Gomex-Lechon, M. J., and Castell, J. V. (1990). Effect of xenobiotics on monooxygenase activities in cultured human hepatocytes. Biochem. Pharmacol. 39, 1321-1326.
16. Dutton, G. J., Leakey, J. E. A., and Pollard, M. R. (1981). Assays for UDP-glucuronosyltransferase activities. Methods Enzymol. 77, 383-391.
17. Dutton, D. R., and Parkinson, A. (1989). Reduction of 7-alkoxyresorufins by NADPH-cytochrome P450 reductase and its differential effects on their O-dealkylation by rat liver microsomal cytochrome P450. Arch. Biochem. Biophys. 268, 617-629.
18. Fackler, P. H., Dionne, E., Hartley, D. A., and Haemlink, J. L. (1995). Bioconcentration by fish of a highly volatile silicone compound in a totally enclosed aquatic exposure system. Environ. Toxicol. Chem. 14, 1649-1656.
19. Fessenden, R. J., and Hartman, R. A. (1970). Metabolic fate of phenyltrimethylsilane and phenyldimethylsilane. J. Med. Chem. 13, 52-54.
20. Franklin, M. R. (1972). Use of antifoams in drug metabolism studies in vitro. Biochem. Pharmacol 21, 2697-2703.
21. Gemzik, B., Halvorson, M. R., and Parkinson, A. (1990). Pronounced and differential effects of ionic strength and pH on testosterone oxication by membrane-bound and purified forms of rat liver microsomal cytochrome P-450. J. Steroid Biochem. 35, 429-440.
22. Giera, D. D., and Van Lier, R. B. (1991). A convenient method for the determination of hepatic lauric acid w-oxidation based on solvent partition. Fundam. Appl. Toxicol. 16, 348-355.
23. Gill, S. S., Ota, K., and Hammock, B. D. (1983). Radiometrie assays for mammalian epoxide hydrolases and glutathione S-transferase. Anal Biochem. 131, 272-282.
24. Griffin, R. J., Dudley, C. N., and Cunningham, M. L. (1996). Biochemical effects of the mouse hepatocarcinogen oxazepam: Similarities to phenobarbital. Fundam. Appl. Toxicol. 29, 147-154.
25. Guengerich, F. P. (1994). Analysis and characterization of enzymes. In Principles and Methods of Toxicology, third edition (A. Wallace Hayes, Ed.), pp. 1259-1301. Raven, New York.
26. Hammock, B. D., Moody, D. E., and Sevanian, A. (1985). Epoxide hydrolases in the catabolism of sterols and isoprenoids. Methods Enzymol. 111, 303-311.
27. Hobson, J. F., and Silberhorn (1995). Existing chemical testing for environmental fate and effects under TSCA section 4: A case study with octamethylcyclotetrasiloxane (OMCTS). Environ. Toxicol Chem. 14, 1635-1638.
28. Isquith, A., Matheson, D., and Slesinski, R. (1988). Genotoxicity studies on selected organosilicon compounds: In vitro assays. Food Chem. Toxicol. 26, 255-261.
29. Kocarek, T. A., Schuetz, E. G., and Guzelian, P. S. (1990). Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes. Mol. Pharmacol. 38, 440-444.
30. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
31. Langer, J. G., Gan, B. K., Liu, R. H., Baugh, L. D., Chand, L. D., Weng, J. L., Edwards, C., and Walia, A. S. (1991). Enzymatic digestion, solid phase extraction and gas chromatography/mass spectrometry of derivatized intact oxazepam in urine. Clin. Chem. 37, 1595-1601.
32. Leach, L. J., and Spiegel, C. J. (1958). An animal inhalation exposure unit for toxicity screening. Am. Ind. Hyg. Assoc. J. 19, 66-68.
33. Lehmann, R. G., Varaprath, S., and Frye, C. L. (1994). Fate of silicone degradation products (silanols) in soil. Environ. Toxicol Chem. 13, 1061-1064.
34. Linder, M. W., and Prough, R. A. (1993). Developmental aspects of glucocorticoid regulation of polycyclic aromatic hydrocarbon-inducible enzymes in rat liver. Arch. Biochem. Biophys. 302, 92-102.
35. Lu, A. Y. H., and Levin, W. (1972). Pariai purification of cytochrome P450 and cytochrome P448 from rat liver microsomes. Biochem. Biophys. Res. Commun. 46, 1334-1339.
36. Lubet, R. A., Mayer, R. T., Cameron, J. W., Nims, R. W., Burke, M. D., Wolff, T., and Guengerich, F. P. (1985). Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P450 by phenobarbital and other xenobiotics in the rat. Arch. Biochem. Biophys. 238, 43-48.
37. Lubet, R. A., SYI, J. L., Nelson, J. O., and Nims, R. W. (1990). Induction of hepatic cytochrome P-450 mediated alkoxyresorufin 0-dealkylase activities in different species by prototype P-450 inducers. Chem. Biol. Inter. 75, 325-339.
38. Lubet, R. A., Dragnev, K. H., Chauhan, D. P., Nims, R. W., Diwan, B. A., Ward, J. M., Jones, C. R., Rice, J. M., and Miller, M. S. (1992). A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr rat: Effects of chemicals of varied structure. Biochem. Pharmacol. 43, 1067-1078.
39. Meeks, R. G., Thevenaz, Ph., and Mast, R. W. (1995). 1-Month repeated dose inhalation toxicity study with octamethylcyclotetrasiloxane in rats. Toxicologist 15(1), 182.
40. Miller, R. R., Letts, R. L., Potts, W. J., and McKenna, M. J. (1980). Improved methodology for generating controlled test atmospheres. Am. Ind. Hyg. Assoc. J. 41, 844-846.
41. Mueller, J. A., Toro, D. M., and Maiello, J. A. (1995). Fate of octamethylcyclotetrasiloxane (OMTCS) in the atmosphere and in sewage treatment plants as an estimation of aquatic exposure. Environ. Toxicol. Chem. 14, 1657-1666.
42. Nims, R. W., Lubet, R. A., Jones, C. R., and Mellini, D. W. (1993). Comparative pharmacodynamics of CYP2B induction by phenobarbital in the male and female F344/NCr rat. Biochem. Pharmacol. 45, 521-526.
43. Olsen, J. H., Boice, J. D., Jr., Jensen, J. P. A., Fraumeni, J. F., Jr. (1989). Cancer among epileptic patients exposed to anticonvulsant drugs. J. Natl. Cancer Inst. 81, 803-808.
44. Olsen, J. H., Boice, J. D., Jr., and Fraumeni, J. F., Jr. (1990). Cancer in children of epileptic mothers and the possible relation to maternal anticonvulsant therapy. Br. J. Cancer 62, 996-999.
45. Olsen, J. H., Wallin, H., Boice, J. D., Jr., Rask, K., Schulgen, G., and Fraumeni, J. F., Jr. (1993). Phenobarbital, drug metabolism, and human cancer. Cancer Epidemiol. 2, 449-452.
46. Omura, T., and Sato, R. (1964). The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239, 2370-2378.
47. Parkinson, A. (1996). Biotransformation of Xenobiotics. In Casserett and Doull's Toxicology. The Basic Science of Poisons, fifth edition (C. D. Klaassen, Ed.), McGraw-Hill, New York.
48. Parkinson, A., Clement, R. P., Casciano, C. N., and Cayen, M. N. (1992). Evaluation of loratadine as an inducer of liver microsomal cytochrome P450 in rats and mice. Biochem. Pharmacol. 43, 2169-2180.
49. Parkinson, A., and Gemzik, B. G. (1991). Production and purification of antibodies against rat liver P450 enzymes. Methods Enzymol. 206, 233-245.
50. Pearce, R. E., Mcintyre, C. J., Madan, A., Sanzgiri, U., Draper, A. H., Bullock, P. L., Cook, D. C., Burton, L. A., Latham, J., Nevins, C., and Parkinson, A. (1996). Effects of freeze, thawing, and storing human liver microsomes on cytochrome P450 activity. Arch. Biochem. Biophys. 331, 145-169.
51. Phillips, A. H., and Langdon, R. G. (1962). Hepatic triphosphopyridine nucleotide-cytochrome c reductase isolation, characterization, and kinetic studies. J. Biol. Chem. 237, 2652-2660.
52. 4) following nose-only vapor inhalation exposure in the rat. Toxicologist 15 (No. 1), 194.
53. 4) in male and female rats following repeated nose-only vapor inhalation exposure. Toxicologist 30 (No. 1 part 2), 16.
54. Prough, R. A., Burke, M. D., and Mayer, R. T. (1978). Direct fluorometric methods for measuring mixed function oxidase activity. Methods Enzymol. LII, 372-377.
55. Roberts, C. J. C., Jackson, L., Halliwell, M., and Branch, R. A. (1976). The relationship between liver volume, antipyrine clearance and indocyanine green clearance before and after phenobarbitone administration in man. Br. J. Clin. Pharmacol. 3, 907-913.
56. Romano, M. C., Straub, K. M., Yodis, L. A. P., Eckardt, R. D., and Newton, J. F. (1988). Determination of microsomal lauric acid hydroxylase activity by HPLC with flow-through radiochemical quantitation. Anal. Biochem. 170, 83-93.
57. Rutten, A. A. J. J. L., Falk, H. E., Catsburg, J. F., Worteboer, H. M., Blaauboer, B. J., Doom, L., Vanleeuwen, F. X. R., Theelen, R., and Rietjens, I. M. C. M. (1992). Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations: Standardization of assay conditions. Arch. Toxicol. 66, 237-244.
58. Saito, R., Chandar, N., Janosky, J. E., and Lombardi, B. (1990). No enhancement by phenobarbital of the hepatocarcinogenicity of a cholinedevoid diet in the rat. Res. Commun. Chem. Pathol. Pharmacol. 69, 197-207.
59. 4) in F-344 rats: Effect of classical inducing agents. Toxicologist 30(1), 15.
60. Shirts, S. B., Annegers, J. F., Hauser, W. A., and Kurland, L. T. (1986). Cancer incidence in a cohort of patients with seizure disorders. J. Natl. Cancer Inst. 77, 83-87.
61. Silver, S. D. (1946). Constant gassing chambers: Principles influencing design and operation. J. Lab. Clin. Med. 31, 1153-1161.
62. Skare, J. A., Murphy, V. A., Bookstaff, R. C., Thompson, G. A., Heise, M. A., Horowitz, Z. D., Powell, J. H., Parkinson, A., and St. Peter, J. V. (1995). Safety assessment of OTC drugs: Doxylamine succinate. Arch. Toxicol. Suppl. 17, 326-340.
63. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F, H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., and Klenk, D. C. (1985). Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85.
64. Sonderfan, A. J., Arlotto, M. P., Dutton, D. R., McMillen, S. M., and Parkinson, A. (1987). Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450. Arch. Biochem. Biophys. 255, 27-41.
65. Sousa, J. V., McNamara, P. C., Putt, A. E., Machado, M. W., Surprenant, D. C., Hamelink, J. L., Kent, D. J., Silberhorn, E. M., and Hobson, J. F. (1995). Effects of octamethylcyclotetrasiloxane (OMTCS) on freshwater and marine organisms. Environ. Toxicol. Chem. 14, 1639-1647.
66. Stark, F. O., Falender, J. R., and Wright, A. P. (1982). Silicones. In Comprehensive Organometallic Chemistry: The Synthesis, Reactions, and Structures of Organometallic Compounds (G. Wilkinson, F. G. A. Stone, and E. W. Abel, Eds.), pp. 306-360. Pergamon Press, New York.
67. Thomas, P. E., Reik, L. M., Ryan, D. E., and Levin, W. (1983). Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochrome P450c and P-450d, by structurally diverse xenobiotics. J. Biol. Chem. 258, 4590-4598.
68. Thorpe, E., and Walker, A. I. T. (1973). The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, β-BHC and γ-BHC. Food Cosmet. Toxicol. 11, 433-442.
69. Towbin, H., Staehelin, T., and Gordon, J. (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedures and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354.
70. Williams, G. M. (1980). Classification of genotoxic and epigenetic hepatocarcinogens using liver culture assays. Ann. NY Acad. Sci. 349, 273-282.
71. Whysner, J., Ross, P. M., and Williams, G. M. (1996). Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion. Pharmacol. Ther. 71, 153-191.
72. Yeowell, H. N., Linko, P., Hodgson, E., and Goldstein, J. A. (1985). Induction of specific cytochrome P450 isozymes by methylenedioxypnenyl compounds and antagonism by 3-methylcholanthrene. Arch. Biochem. Biophys. 3, 408-419.
73. Young, W. S., and Lietman, P. S. (1978). Chloramphenicol glucuronyl transferase: Assay, ontogeny and inducibility. J. Pharmacol. Exp. Ther. 204, 203-211.