Useful markers for predicting severity and monitoring progression of acute pancreatitis

Pancreatology

Volumn 3, Issue 2, 2003, Pages 115-127

  Werner, Jens ^a   Hartwig, Werner ^a   Uhl, Waldemar ^a   Müller, Christophe ^a   Büchler, Markus W ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Acute pancreatitis; Diagnostics; Marker; Monitoring, progression; Prediction, severity; Review

Indexed keywords

AMYLASE; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CARBOXYPEPTIDASE; CELL ADHESION MOLECULE; CYTOKINE; ELASTASE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GRANULOCYTE COLONY STIMULATING FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 18; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; PADGEM PROTEIN; PHOSPHOLIPASE A; PHOSPHOLIPASE A2; PROCALCITONIN; PROTEINASE; PROTEINASE INHIBITOR; SERUM AMYLOID A; TRIACYLGLYCEROL LIPASE; TRYPSINOGEN; TRYPSINOGEN ACTIVATION PEPTIDE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; ASSAY; COCHRANE LIBRARY; COMPLEMENT FACTOR; DISEASE COURSE; DISEASE MARKER; DISEASE SEVERITY; HEMOCONCENTRATION; HOSPITAL ADMISSION; HUMAN; INFLAMMATION; LEUKOCYTE; LEUKOCYTE ACTIVATION; MEDLINE; OXIDATIVE STRESS; PANCREAS NECROSIS; PATHOGENESIS; PREDICTION; PRIORITY JOURNAL; REVIEW;

EID: 0037737978     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000070079     Document Type: Review

References (132)

1. Steinberg W, Tenner S: Acute pancreatitis. N Engl J Med 1994;330:1198-1210.
2. Barie PS: A critical review of antibiotic prophy-laxis in severe acute pancreatitis. Am J Surg 1996;172:38-43.
3. Bradley EL: A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 1992. Arch Surg 1993;128:586-590.
4. Deitch EA, Goodman ER: Prevention of multiple organ failure. Surg Clin North Am 1999;79: 1471-1488.
5. Schmidt S, Uhl W, Friess H, et al: The role of infection in acute pancreatitis. Gut 1999;45: 311-316.
6. Tenner S, Sica G, Hughes M, et al: Relationship of necrosis to organ failure in severe acute pancreatitis. Gastroenterology 1997;113:899-903.
7. Lankisch P, Pflichthofer D, Lehnick D: No strict correlation between necrosis and organ failure in acute pancreatitis. Pancreas 2000;20: 319-322.
8. Widdison AL, Karanjia ND: Pancreatic infection complicating acute pancreatitis. Br J Surg 1993;80:148-154.
9. Beger HG, Bittner R, Block S, Büchler M: Bacterial contamination of pancreatic necrosis - A prospective clinical study. Gastroenterology 1986;91:433-441.
10. Büchler MW, Gloor B, Müller CA, et al: Acute necrotizing pancreatitis: Treatment strategy according to the status of infection. Ann Surg 2000;232:619-626.
11. Heath D, Alexander D, Wilson C, et al: Which complications of acute pancreatitis are most lethal? A prospective multicenter clinical study of 719 episodes. Gut 1995;36:478.
12. Gullo A, Berlot G: Ingredients of organ dysfunction or failure. World J Surg 1996;20:430-436.
13. Neoptolemos JP, Raraty M, Finch M, Sutton R: Acute pancreatitis: The substantial human and financial cases. Gut 1998;42:886-891.
14. Bradley EL: Operative vs. non-operative management in sterile necrotizing pancreatitis. HPB Surg 1997;10:188-191.
15. Rau B, Pralle U, Uhl W, et al: Management of sterile necrosis in instances of severe acute pancreatitis. J Am Coll Surg 1995;181:279.
16. Fernandez-del Castillo C, Rattner DW, Makary MA, et al: Debridement and closed packing for the treatment of necrotizing pancreatitis. Ann Surg 1998;228:676-684.
17. Banks S: Clinical course of acute pancreatitis: What has changed in recent years; in Büchler M, Uhl W, Friess H, Malfertheiner P (eds): Acute Pancreatitis, Novel Concepts in Biology and Treatment. Berlin-Vienna, Blackwell Science, 1999, pp 163-169.
18. Beger HG, Büchler M, Bittner R, et al: Necrosectomy and postoperative local lavage in necrotizing pancreatitis. Br J Surg 1988;75:207-212.
19. Tsiotos GG, Luque-de Leon E, Sarr MG: Long-term outcome of necrotizing pancreatitis treated by necrosectomy. Br J Surg 1998;85: 1650-1653.
20. Sharma VK, Howden CW: Prophylactic antibiotic sepsis and mortality in acute necrotizing pancreatitis: A meta-analysis. Pancreas 2001; 22:28-31.
21. Golub R, Siddiqi F, Pohl D: Role of antibiotics in acute pancreatitis: A meta-analysis. J Gastrointest Surg 1998;2:496-503.
22. Neoptolemos JP, Carr-Locke DL, London NJ, et al: Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones. Lancet 1988;ii:979-983.
23. Fölsch UR, Nitsche R, Ludtke R, et al: Early ERCP and papillotomy compared with conservative treatment for acute biliary pancreatitis. The German Study Group on Acute Biliary Pancreatitis. N Engl J Med 1997;336:237-242.
24. Fan ST, Lai EC, Mok FP, et al: Early treatment of acute biliary pancreatitis by endoscopic papillotomy. N Engl J Med 1993;328:282-232.
25. Larvin M, McMahon M: APACHE II score for assessment and monitoring of acute pancreatitis. Lancet 1989;ii:201-205.
26. Corfield AP, Cooper MJ, Williamson RCN: Prediction of severity in acute pancreatitis. A prospective comparison of three prognostic indices. Lancet 1985;ii:403-406.
27. Balthazar E, Robinson D, Megibow A, Ranson J: Acute pancreatitis: Value of CT in establishing prognosis. Radiology 1990;174:331-336.
28. Kemppainen E, Sainio V, Haapiainen R, et al: Early localization of necrosis by contrast-enhanced computed tomography can predict outcome in severe acute pancreatitis. Br J Surg 1996;83:924-929.
29. Ranson J, Rifkind K, Roses D, et al: Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet 1974; 139:69-81.
30. Wilson C, Heath DI, Imrie CW: Prediction of outcome in acute pancreatitis: A comparative study of APACHE II, clinical assessment and multiple factor scoring systems. Br J Surg 1990; 77:1260-1264.
31. Toh S, Phillips S, Johnson C: A prospective audit against management of acute pancreatitis in the south of England. Gut 2000;46:239-243.
32. Dervenis C, Johnson CD, Bassi C, et al: Diagnosis, objective assessment of severity, and management of acute pancreatitis. Int J Pancreatol 1999;25:195-200.
33. Pezzilli R, Billi P, Miglioli M, Gullo L: Serum amylase and lipase concentrations and lipase/amylase ratio in assessment of etiology and severity of acute pancreatitis. Dig Dis Sci 1993; 38:1265-1269.
34. Gumaste VV, Roditis M, Mehta D, Dave PB: Serum lipase in nonpancreatic abdominal pain versus acute pancreatitis. Am J Surg 1993;88: 2051-2055.
35. Malfertheiner P, Büchler MW, Stanescu A, et al: Serum elastase 1 in inflammatory pancreatic and gastrointestinal diseases and in renal insufficiency. A comparison with other pancreatic enzymes. Int J Pancreatol 1987;2:159-170.
36. Clavien P, Burgan S, Moossa A: Serum enzymes and other laboratory tests in acute pancreatitis. Br J Surg 1989;76:1234-1243.
37. Flamion B, Delhaye M, Horanyi Z, et al: Comparison of elastase-1 with amylase, lipase, and trypsin-like immunoreactivity in the diagnosis of acute pancreatitis. Am J Gastroenterol 1987; 82:532-535.
38. Tokes P: Biochemical tests in pancreatic disease. Curr Opin Gastroenterol 1991;7:709-711.
39. Moeller-Petersen J, Klaecke M, Dati F: Evaluation and comparison of cathodic trypsin-like immunoreactivity, pancreatic lipase and pancreatic isoamylase in the diagnosis of acute pancreatitis in 849 consecutive patients with acute abdominal pain. Clin Chim Acta 1986; 157:151-165.
40. Itkonen O, Koivunen E, Hurme M, et al: Time-resolved immunofluorometric assays for trypsinogen-1 and 2 in serum reveal preferential elevation of trypsinogen-2 in pancreatitis. J Lab Clin Med 1990;115:712-718.
41. Hedström J, Sainio V, Kemppainen E, et al: Serum complex of trypsin 2 and alpha 1 anti-trypsin as diagnostic and prognostic marker of acute pancreatitis: Clinical study in consecutive patients (see comments). BMJ 1996;313: 333-337.
42. Sainio V, Puolakkainen P, Kemppainen E, et al: Serum trypsinogen-2 in the prediction of outcome in acute necrotizing pancreatitis. Scand J Gastroenterol 1996;31:818-824.
43. Appelros S, Petersson U, Toh S, et al: Activation peptide of carboxypeptidase B and anionic trypsinogen as early predictors of the severity of acute pancreatitis. Br J Surg 2001;88:216-221.
44. Hedström J, Sainio V, Kemppainen E, et al: Urine-trypsinogen-2 as a marker of acute pancreatitis. Clin Chem 1996;42:685-690.
45. Hedström J, Korvuo A, Kenkimäki P, et al: Urinary trypsinogen-2 test strip for acute pancreatitis. Lancet 1996;347:729-731.
46. Kylänpää-Bäck ML, Kemppainen E, Puolak-kainen P, et al: Reliable screening for acute pancreatitis with rapid urine trypsinogen-2 test strip. Br J Surg 2000;87:49-52.
47. Pezzilli R, Morselli-Labate A, D'Alessandro A, Barakat B: Time-course and clinical value of the urine trypsinogen-2 dipstick test in acute pancreatitis. Eur J Gastroenterol Hepatol 2001;13:269-274.
48. Talamini G, Bassi C, Falconi M: Risk of death from acute pancreatitis. Int J Pancreatol 1996; 19:15-24.
49. Baillargeon JD, Orav J, Ramagopal V: Hemoconcentration as an early risk factor for necrotizing pancreatitis. Am J Gastroenterol 1998; 93:2130-2134.
50. Brown A, Orav J, Banks PA: Hemoconcentration is an early marker for organ failure and necrotizing pancreatitis. Pancreas 2000;20: 367-372.
51. Lankisch PG, Mahlke R, Blum T, et al: Hemoconcentration: An early marker of severe and/or necrotizing pancreatitis. Am J Gastroenterol 2001;96:2081-2085.
52. McMahon MJ, Playforth MJ, Pickford IR: A comparative study of methods for the prediction of severity attacks of acute pancreatitis. Br J Surg 1980;67:22-25.
53. Borgström A, Appelros S, Müller CA, et al: Role of activation peptides from pancreatic proenzymes in the diagnosis and prognosis of acute pancreatitis. Surgery 2002;131:125-129.
54. Steer ML: Frank Brooks memorial lecture: The early intraacinar cell events which occur during acute pancreatitis. Pancreas 1998;17:31-37.
55. Luthen R, Grendell JH, Niederau C, Haussinger D: Trypsinogen activation and glutathione content are linked to pancreatic injury in models of biliary acute pancreatitis. Int J Pancreatol 1998;24:193-202.
56. Werner J, Saghir M, Warshaw A, et al: Alcoholic pancreatitis in rats: Injury from nonoxidative metabolites of ethanol. Am J Physiol 2002;283:G65-G73.
57. Fernandez-del Castillo C, Schmidt J, Warshaw AL, Rattner DW: Interstitial protease activation is the central event in progression to necrotizing pancreatitis. Surgery 1994;116:497-504.
58. Hartwig W, Werner J, Jiminez RE, et al: Trypsin and activation of circulating trypsinogen contribute to pancreatitis associated lung injury. Am J Physiol 1999;277:G1008-G1016.
59. Gorelick FS, Matovcik LM: Lysosomal enzymes and pancreatitis. Gastroenterology 1995;109:620-625.
60. Warshaw AL: Damage prevention versus damage control in acute pancreatitis. Gastroenterology 1993;104:1216-1219.
61. Steer ML, Meldolesi J: The cell biology of experimental pancreatitis. N Engl J Med 1987; 316:144-150.
62. Ohlsson K, Balldin G, Bohe M, et al: Pancreatic proteases and antiproteases in pancreatic disease: Biochemical, pathophysiological and clinical aspects. Int J Pancreatol 1988;3:67-78.
63. Heath DI, Cruickshank A, Gudgeon AM, et al: The relationship between pancreatic enzyme release and activation and the acute-phase protein response in patients with acute pancreatitis. Pancreas 1995;10:347-353.
64. Werner J, Dragotakes SC, Fernandez-del Castillo C, et al: Technetium-99m-labeled white blood cells: A new method to define the local and systemic role of leukocytes in acute experimental pancreatitis. Ann Surg 1998;227:86-94.
65. Mithofer K, Fernandez-del Castillo C, Frick TW, et al: Increased intrapancreatic trypsinogen activation in ischemia-induced experimental pancreatitis. Ann Surg 1995;221:364-371.
66. Werner J, Laposata M, Fernandez-del Castillo C, et al: Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology 1997;113: 286-294.
67. Dominguez-Munoz JE, Carballo F, Garcia MJ, et al: Monitoring of serum proteinase-antiprotease balance and systemic inflammatory response in prognostic evaluation of acute pancreatitis. Dig Dis Sci 1993;38:507-513.
68. McMahon M, Bowen M, Mayer A, Cooper F: Relation of alpha2-macroglobulin and other antiproteases to the clinical features of acute pancreatitis. Am J Surg 1984;147:164-170.
69. Wilson C, Heads A, Shenkin A, Imrie CW: C-reactive protein, antiproteases and complement factors as objective markers of severity in acute pancreatitis. Br J Surg 1989;76:177-181.
70. Büchler MW, Malfertheiner P, Schoetensack C, et al: Sensitivity of antiproteases, complement factors and C-reactive protein in detecting pancreatic necrosis: Results of a prospective clinical trial. Int J Pancreatol 1986;1:227-235.
71. Hurley PR, Cook A, Jehanli A, et al: Development of radioimmunoassays for free tetra-L-aspartyl-L-lysine trypsinogen activation peptides (TAP). J Immunol Methods 1988;111: 195-203.
72. Gudgeon AM, Heath DI, Hurley P, et al: Trypsinogen activation peptides assay in the early prediction of severity of acute pancreatitis. Lancet 1990;335:4-8.
73. Tenner S, Fernandez-del Castillo C, Warshaw A, et al: Urinary trypsinogen activation peptide (TAP) predicts severity in patients with acute pancreatitis. Int J Pancreatol 1997;21:105-110.
74. Kemppainen E, Mayer J, Puolakkainen P, et al: Plasma trypsinogen activation peptide in patients with acute pancreatitis. Br J Surg 2001; 88:679-680.
75. Banks P, Carr-Locke D, Slivka A, et al: Urinary trypsinogen activation peptides (TAP) are not increased in mild ERCP-induced pancreatitis. Pancreas 1996;12:294-297.
76. Neoptolemos J, Kemppainen E, Mayer J, et al: Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: A multicenter study. Lancet 2000;355:1955-1960.
77. Schmidt J, Fernandez-del Castillo C, Rattner DW, et al: Trypsinogen-activation peptides in experimental rat pancreatitis: Prognostic implications and histopathologic correlates. Gastroenterology 1992;103:1009-1016.
78. Mithofer K, Warshaw AL, Frick TW, et al: Calcium administration augments pancreatic injury and ectopic trypsinogen activation after temporary systemic hypotension in rats. Anesthesiology 1995;83:1266-1273.
79. Windsor JA: Search for prognostic markers for acute pancreatitis. Lancet 2000;355:1924-1925.
80. Burgos F, Salva M, Villegas V, et al: Analysis of the activation process of porcine procarboxypeptidase B and determination of the sequence of its activation segment. Biochemistry 1991; 30:4082-4089.
81. Appelros S, Thim L, Borgstrom A: Activation peptide of carboxypeptidase B in serum and urine in acute pancreatitis. Gut 1998;42:97-102.
82. Pezzilli R, Morselli-Labate AM, Barbieri AR, Plate L: Clinical usefulness of the serum carboxypeptidase B activation peptide in acute pancreatitis. JOP 2000;1:58-68.
83. Müller C, Appelros S, Uhl W, et al: Serum levels of procarboxypeptidase B and its activation peptide in patients with acute pancreatitis and non-pancreatic-diseases. Gut 2002;51:229-235.
84. Beechy-Newman N, Rae D, Sumar N, Hermon-Taylor J: Stratification of severity in acute pancreatitis by assay of trypsinogen and 1-prophospholipase A2 activation peptides. Digestion 1995;56:271-278.
85. Rae D, Sumar N, Beechy-Newman N, et al: Type 1 prophospholipase A2 propeptide immunoreactivity is released from granulocytes. Clin Biochem 1995;28:71-78.
86. Bonham MJ, Abu-Zidan FM, Simovic MO, et al: Early ascorbic acid depletion is related to the severity of acute pancreatitis. Br J Surg 1999;86:1296-1301.
87. Sweiry JH, Mann GE: Role of oxidative stress in the pathogenesis of acute pancreatitis. Scand J Gastroenterol 1996;31:10-15.
88. Rinderknecht H: Fatal pancreatitis, a consequence of excessive leukocyte stimulation? Int J Pancreatol 1988;3:105-112.
89. Schönberg MH, Büchler M, Younes M, et al: Effect of antioxidant treatment in rats with acute hemorrhagic pancreatitis. Dig Dis Sci 1994;39:1034-1040.
90. Dabrowski A, Gabryelewicz A, Wereszczyns-ka-Siematkowska U, Chyczewski L: Oxygen derived free radicals in cerulein-induced acute pancreatitis. Scand J Gastroenterol 1988;23: 1245-1252.
91. Weiss SJ: Tissue destruction by neutrophils. N Engl J Med 1989;320:586-590.
92. Zidan FM, Bonham MJ, Windsor JA: Severity of acute pancreatitis: A multivariate analysis of oxidative stress markers and modified Glasgow criteria. Br J Surg 2000;87:1019-1023.
93. Lankisch PG: Serum complement factors in human acute pancreatitis. Hepatogastroenterology 1981;28:261-263.
94. Büchler M, Malfertheiner P, Schoetensack C, et al: Sensitivity of antiproteases, complement factors and C-reactive protein in detecting pancreatic necrosis: Results of a prospective clinical study. Int J Pancreatol 1986;1: 227-235.
95. Uhl W, Büchler MW, Malfertheiner P, et al: PMN-elastase in comparison with CRP, anti-proteases, and LDH as indicators of necrosis in human acute pancreatitis. Pancreas 1991; 6:253-259.
96. Dominguez-Munoz JE, Carbello F, Garcia MJ: Clinical usefulness of polymorphonu-clear elastase in predicting the severity of acute pancreatitis: Results of a multicenter study. Br J Surg 1991;78:1230-1234.
97. Gross V, Schölmerich J, Leser HG: Granulocyte elastase in assessment of severity of acute pancreatitis: Comparison with acute phase proteins C-reactive protein, alpha 1 antitryp-sin and protease inhibitor a2-macroglobulin. Dig Dis Sci 1990;35:97-105.
98. Wereszczynska-Siemiatkowska S, Dabrowski A, Jedynak M, Gabryelewicz A: Oxidative stress as an early prognostic factor in acute pancreatitis: Its correlation with PLA2 and PMN-elastase in different severity forms. Pancreas 1998;17:163-168.
99. Tsukahara Y, Morisaki T, Horita Y, et al: Phospholopase A2 mediates nitric oxide production by alveolar macrophages and acute lung injury in pancreatitis. Ann Surg 1999; 229:385-392.
100. Büchler M, Malfertheiner P, Schadlich H, et al: Prognostic value of serum phospholipase A2 in acute pancreatitis. Klin Wochenschr 1989;67:186-189.
101. Puolakkainen P, Valtonen V, Paananen A, Schröder T: C-reactive protein (CRP) and serum phospholipase A2 in the assessment of acute pancreatitis. Gut 1987;28:764-771.
102. Bird NC, Goodman AJ, Johnson AG: Serum phospholipase A2 activity in acute pancreatitis: An early guide to severity. Br J Surg 1989; 76:731-732.
103. Makela A, Kuusi T, Schröder T: Serum phos-pholipase A2, amylase, lipase and urinary amylase activities in relation to the severity of acute pancreatitis. Eur J Surg 1997;163:915-922.
104. Schröder T, Kivilaakso E, Kinnunen P, Lem-pinen M: Serum phospholipase A2 in human acute pancreatitis. Scand J Gastroenterol 1980;15:633-636.
105. Nevalainen TJ, Eskola JU, Aho AJ, et al: Immunoreactive phospholipase A2 in serum in acute pancreatitis and pancreatic cancer. Clin Chem 1985;31:1116-1120.
106. Matsuda Y, Ogawa M, Nishijima J, et al: Usefulness of determination of serum immunoreactive pancreatic phospholipase A2 content for early identification of severe acute pancreatitis. Hepatogastroenterology 1986;33:214-216.
107. Nevalainen TJ, Gronroos JM, Kortesuo PT: Pancreatic and synovial type phospholipases A2 in serum samples from patients with severe acute pancreatitis. Gut 1993;34:1133-1136.
108. Müller CA, Uhl W, Printzen G, et al: Role of procalcitonin and granulocyte colony stimulating factor in the early prediction of infected necrosis in severe acute pancreatitis. Gut 2000;46:233-238.
109. Paajanen H, Laato M, Jaakkola M, et al: Serum tumor necrosis factor compared with C-reactive protein in the early assessment of severity of acute pancreatitis. Br J Surg 1995; 82:271-273.
110. DeBeaux AC, Goldie AS, Ross JA, et al: Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis. Br J Surg 1996;83: 349-353.
111. Messmann H, Grüne S, Sitter-Heinisch A, et al: TNF and TNF receptors p55 and p75 in acute mild and severe pancreatitis. Gastroen-terology 1997;112:464.
112. Kylänpää-Bäck ML, Takala A, Kemppainen EA, et al: Procalcitonin, soluble interleukin-2 receptor, and soluble E-selectin in predicting the severity of acute pancreatitis. Crit Care Med 2001;29:63-69.
113. Salomone T, Boni P, Serra C: The soluble interleukin-2 receptor, peripheral blood, and reticulocyte fractions in acute pancreatitis. Int J Pancreatol 1996;20:197-203.
114. Pezzilli R, Billi P, Miniero R, et al: Serum interleukin 6, interleukin 8 and alpha-2 microglobulin in early assessment of severity in acute pancreatitis. Dig Dis Sci 1995;40:2341-2348.
115. Heath DI, Cruickshank A, Gudgeon M, et al: Role of interleukin-6 in mediating the acute phase protein response and potential as an early means of severity assessment in acute pancreatitis. Gut 1993;34:41-45.
116. Leser HG, Gross V, Scheibenbogen C, et al: Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis. Gastroenterology 1991;101:782-785.
117. Messmann H, Vogt W, Holstege A, et al: Post-ERP pancreatitis as a model for cytokine induced acute phase response in acute pancreatitis. Gut 1997;40:80-85.
118. Messmann H, Vogt W, Falk W, et al: Interleukins and their antagonists but not TNF and its receptors are released in post-ERP pancreatitis. Eur J Gastroenterol Hepatol 1998;10: 611-617.
119. Rau B, Baumgart K, Paszkowski AS, et al: Clinical relevance of caspase-1 activated cytokines in acute pancreatitis: High correlation of serum interleukin-18 with pancreatic necrosis and systemic complications. Crit Care Med 2001;29:1556-1562.
120. Powell JJ, Siriwardena AK, Fearon KC: Endothelial derived selectins in the development of organ dysfunction in pancreatitis. Crit Care Med 2001;29:567-572.
121. Frossard JL, Saluja A, Bhagat L, et al: The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology 1999;116:694-701.
122. Werner J, Z'Graggen K, Fernandez-del Castillo C, et al: Specific therapy for local and systemic complications of acute pancreatitis with monoclonal antibodies against ICAM-1. Ann Surg 1999;229:834-840.
123. Kaufmann P, Tilz GP, Smolle KH, et al: Increased plasma concentrations of circulating intercellular adhesion molecule-1 (cICAM-1) in patients with necrotizing pancreatitis. Immunobiology 1996;195:209-219.
124. Büchler M, Malfertheiner P, Schoetensack C, et al: Sensitivity of antiproteases, complement factors and C-reactive protein in detecting pancreatic necrosis: Results of a prospective study. Int J Pancreatol 1986;37:227-235.
125. Viedma JA, Perez-Mateo M, Dominguez-Munoz JE, Carbello F: Role of interleukin-6 in acute pancreatitis: Comparison with C-reactive protein and phospholipase A. Gut 1992;33:1264-1267.
126. Dervenis C: Assessments of severity and management of acute pancreatitis based on the Santorini consensus conference report. JOP 2000;1:178-192.
127. Malle E, Steinmetz A, Raynes JG: Serum amyloid A: An acute phase protein and apolipoprotein. Atherosclerosis 1993;102:131-146.
128. Rau B, Steinbach G, Baumgart K, et al: Serum amyloid A versus C-reactive protein in acute pancreatitis: Clinical value of an alternative acute-phase reactant. Crit Care Med 2000;28:736-742.
129. Mayer J, Raraty M, Slavin J, et al: Serum amyloid A is a better early predictor of severity than C-reactive protein in acute pancreatitis. Br J Surg 2002;89:163-171.
130. Oezcueruemez-Porsch M, Kunz D, Hardt PD: Diagnostic relevance of interleukin pattern, acute-phase proteins, and procalcitonin in early phase of post-ERCP pancreatitis. Dig Dis Sci 1998;43:1763-1769.
131. Rau B, Steinbach G, Gansauge F: The potential role of procalcitonin and interleukin-8 in the prediction of infected necrosis in acute pancreatitis. Gut 1997;41:832-840.
132. Kylänpää-Bäck ML, Takala A, Kemppainen EA, et al: Procalcitonin strip test in the early detection of severe acute pancreatitis. Br J Surg 2001;88:222-227.