Frank Brooks Memorial Lecture: The early intraacinar cell events which occur during acute pancreatitis

Pancreas

Volumn 17, Issue 1, 1998, Pages 31-37

  Steer, Michael L ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; CATHEPSIN B; CERULETIDE; ENZYME PRECURSOR; HYDROLASE; LYSOSOME ENZYME; PANCREAS ENZYME; TRYPSINOGEN;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; CONTROLLED STUDY; EDEMA; ENZYME ACTIVATION; ENZYME RELEASE; INFECTION; INFLAMMATION; ISCHEMIA; NONHUMAN; PANCREAS NECROSIS; PRIORITY JOURNAL; RAT; REVIEW;

EID: 0031842261     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199807000-00003     Document Type: Review

References (20)

1. Lombardi B, Estes LW, Longnecker DW. Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet. Am J Pathol 1975;79:465-80
2. Lampel M, Kern H. Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch 1977;373:97-117.
3. Kaiser A, Saluja A, Sengupta A, Saluja M, Steer ML. Relationship between severity, necrosis and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 1995;38:C1295-304.
4. Senninger N, Moody FG, Van Buren DH, Coelho JCU, Li YF. Effect of biliary obstruction on pancreatic exocrine secretion in conscious opossums. Surg Forum 1984;35:226-8.
5. Saluja A, Saito I, Saluja M, et al. In vivo rat pancreatic acinar cell function during supramaximal stimulation with caerulein. Am J Physiol 1985;249(12):G702-10.
6. Powers RE, Saluja AK, Houlihan MJ, Steer ML. Diminished agonist-stimulated inositol trisphosphate generation blocks stimulatus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis. J Clin Invest 1986;77:1668-74.
7. Saluja A, Saluja M, Printz H, Zavernick A, Sengupta A, Steer ML. Experimental pancreatitis in mediated by low-affinity cholecystokinin receptors that inhibit digestive enzyme secretion. Proc Natl Acad Sci USA 1989;86:8968-71.
8. Palade G. Intracellular aspects of the process of protein secretion. Science 1975;189:347-58.
9. Kornfield S. Trafficking of lysosomal enzymes in normal and disease states. J Clin Invest 1986;77:1-6.
10. Greenbaum LA, Hirschkowitz A. Endogenous cathepsin activated trypsinogen in extracts of dog pancreas. Proc Soc Exp Biol Med 1961;107:74-6.
11. Figarella C, Miszczuk-Jamska B, Barrett AJ. Possible lysosomal activation of pancreatic zymogens: activation of both human trypsinogen by cathepsin B and spontaneous acid activation of human trypsinogen 1. Biol Chem Hoppe Seyler 1988;369:293-8.
12. Lerch MM, Saluja AK, Dawra R, Saluja M, Steer ML. The effect of chloroquine administration on two experimental models of acute pancreatitis. Gastroenterology 1993;104:1768-79.
13. Saluja A, Sadamitsu H, Saluja M, Powers RE, Meldolesi J, Steer ML. Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitis. Am J Physiol 1987;253(16):G508-16.
14. Watanabe O, Baccino FM, Steer ML, Meldolesi J. Supramaximal caerulein stimulation of the ultrastructure of rat pancreatic acinar cell: early morphological changes during the development of experimental pancreatitis. Am J Physiol 1984;246:G457-67.
15. Lerch M, Saluja A, Runzi M, Dawra R, Steer M. Luminal endocytosis and intracellular targeting of acinar cells during early biliary pancreatitis in the opossum. J Clin Invest 1995;95:2222-31.
16. Grady T, Saluja A, Kaiser A, Steer M. Pancreatic edema and intrapancreatic activation of trypsinogen during secretagogue-induced pancreatitis precedes glutathione depletion. Am J Physiol 1996;271:G20-6.
17. Steer ML, Meldolesi J. The cell biology of experimental pancreatitis. N Engl J Med 1987;316:144-50.
18. Steer ML. Recent insights into the etiology and pathogenesis of acute biliary pancreatitis. AJR 1995;164:811-4.
19. Saluja A, Steer D. Lerch M, Dawra R, Saluja M, Steer M. Failure of the cathepsin B inhibitor, E-64, to protect against caerulein and CDE-diet induced pancreatitis. Pancreas 1991;6:718.
20. Saluja AK, Donovan EA, Yamanaka K, Yamaguchi Y, Hofbauer B, Steer ML. Caerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B. Gastroenterology 1997;113:304-10.