Insulin signal transduction and glucose transport in human adipocytes: Effects of obesity and low calorie diet

Diabetologia

Volumn 45, Issue 8, 2002, Pages 1128-1135

  Bjornholm M ^a,b   Al Khalili, L ^a,b   Dicker, A ^a,b   Naslund E ^a,c   Rossner S ^a,b   Zierath, J ^a   Arner, P ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c DANDERYD HOSPITAL   (Sweden)

Author keywords

Glucose transport; GLUT4; Insulin receptor; Insulin receptor substrates; PI 3 kinase

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE;

ADIPOCYTE; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN SENSITIVITY; LOW CALORY DIET; MOLECULAR DYNAMICS; OBESITY; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION; STIMULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADIPOCYTES; ADULT; BIOLOGICAL TRANSPORT; CELL EXTRACTS; ENERGY INTAKE; FEMALE; GLUCOSE; HUMANS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MIDDLE AGED; OBESITY; OSMOLAR CONCENTRATION; PHOSPHOPROTEINS; PROTEINS; SIGNAL TRANSDUCTION;

EID: 0036373357     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-0875-9     Document Type: Article

References (31)

1. Banting lecture. Insulin action, diabetogenes, and the cause of type II diabetes
2. Genetic determinants of type 2 diabetes
3. Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes
4. Decreased insulin-stimulated 3-O-methylglucose transport in in vitro incubated muscle strips from type II diabetic subjects
5. An in vitro human skeletal muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects
6. Effect of metformin on glucose transport in isolated skeletal muscle obtained from Type II diabetic patients and healthy individuals
7. Exercise training in obese diabetic patients
8. Regulation of lipolysis in fat cells of obese women during long-term hypocaloric diet
9. The insulin signalling system: A network of docking protein that mediate insulin action
10. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
11. Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
12. Insulin receptor substrate (IRS) is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
13. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
14. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
15. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
16. Fasting mediated alteration studies of insulin action on lipolysis and lipogenesis in obese women
17. Metabolism of isolated cells. I. Effects of hormones on glucose metabolism and lipolysis
18. Kinetic parameters of transport of 3-O-methyl glucose in adipocytes
19. A simple free fat cell bioassay for insulin
20. Characterization of insulin resistance after surgery
21. Regional differences in insulin inhibition of non-esterified fatty acid release from human adipocytes: Relation to insulin receptor phosphorylation and intracellular signaling through the insulin receptor substrate-1 pathway
22. Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phophatidylinositol 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects
23. Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss
24. Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity
25. Expression of the splice variants of the p85α regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients
26. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
27. Defective regulation of phosphoinositide 3-kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients
28. Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
29. Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM
30. Evidence for a major role of skeletal muscle lipolysis in the regulation of lipid oxidation during caloric restriction in vivo
31. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver