The pars tuberalis: The missing link in the photoperiodic regulation of prolactin secretion?

Journal of Neuroendocrinology

Volumn 12, Issue 4, 2000, Pages 287-295

  Morgan, P J ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GONADORELIN; LUTEINIZING HORMONE; MELATONIN; MELATONIN RECEPTOR; PROLACTIN;

EARLY RESPONSE GENE; HUMAN; HYPOPHYSIS; HYPOPHYSIS PARS TUBERALIS; NONHUMAN; PHOTOPERIODICITY; PRIORITY JOURNAL; PROLACTIN RELEASE; REVIEW;

ANIMALS; GENE EXPRESSION; MELATONIN; PHOTOPERIOD; PITUITARY GLAND, ANTERIOR; PROLACTIN; RECEPTORS, CELL SURFACE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, MELATONIN; SEASONS;

EID: 0034100724     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2000.00459.x     Document Type: Review

References (89)

1. Leong D, Frawley LS, Neill LD. Neuroendocrine control of prolactin secretion. Ann Rev Physiol 1983; 45: 109-127.
2. Dannies PS. A new releasing factor? With biotechnology and a little bit of luck. Endocrinology 1997; 138: 5085-5086.
3. Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M. A prolactin-releasing peptide in the brain. Nature 1998; 393: 272-276.
4. Murai I, Ben-Jonathan N. Posterior pituitary lobectomy abolishes the suckling-induced rise in prolactin (PRL): evidence for a PRL-releasing factor in the posterior pituitary. Endocrinology 1987; 121: 205-211.
5. Thomas GB, Cummins JT, Canny BJ, Rundle SE, Griffin N, Katsahambas S, Clarke IJ. The posterior pituitary regulates prolactin, but not adrenocorticotropin or gonadotropin, secretion in the sheep. Endocrinology 1989; 125: 2204-2211.
6. Samson WK, Martin L, Mogg RJ, Fulton RJ. A nonoxytocinergic prolactin releasing factor and a nondopaminergic prolactin inhibiting factor in bovine neurointermediate lobe extracts: in vitro and in vivo studies. Endocrinology 1990; 126: 1610-1617.
7. Lincoln GA, Clarke IJ. Photoperiodically-induced cycles in secretion of prolactin in hypothalamo-pituitary disconnected rams: evidence for translation of the melatonin signal in the pituitary gland. J Neuroendocrinol 1994; 6: 251-250.
8. Morgan PJ, King TP, Lawson W, Slater D, Davidson G. Ultrastructure of melatonin-responsive cells in the ovine pars tuberalis. Cell Tissue Res 1991; 263: 529-534.
9. Stoeckel ME, Porte A. Fine structure and development of the pars tuberalis in mammals. In: Motta PM, ed. Ultrastructure of Endocrine Cells and Tissues. Boston: Martinus-Nijhoff, 1984: 29-39.
10. Wittkowski WH, Schulze-Bonhage AH, Bockers TM. The pars tuberalis of the hypophysis: a modulator of the pars distalis? Acta Endocrinol 1992; 126: 285-290.
11. Vanecek J, Pavlik A, Illnerova H. Hypothalamic melatonin receptor sites revealed by autoradiography. Brain Res 1987; 435: 359-363.
12. Weaver DR, Namboodiri MAA, Reppert SM. Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain. FEBS Lett 1988; 228: 123-127.
13. Williams LM, Morgan PJ. Demonstration of melatonin-binding sites on the pars tuberalis of the rat. J Endocrinol 1988; 119: R1-R3.
14. Morgan PJ, Williams LM, Davidson G, Lawson W, Howell E. Melatonin receptors in the ovine pars tuberalis: characterization and autoradiographical localization. J Neuroendocrinol 1989; 1: 1-4.
15. Morgan PJ, Barrett P, Howell HE, Helliwell R. Melatonin receptors: localization, molecular pharmacology and physiological significance. Neurochem Int 1994; 24: 101-146.
16. Klein DC, Coon SL, Roseboom PH, Weller JL, Bernard M, Gastel JA, Zatz M, Iuvone PM, Rodriguez IR, Begay V, Falcon J, Cahill GM, Cassone VM, Baler R. The melatonin rhythm-generating enzyme: molecular regulation of serotonin-N-acetyltransferase in the pineal gland. Rec Prog Horm Res 1997; 52: 307-357.
17. Hastings MH. Neuroendocrine rhythms. Pharmacol Ther 1991; 50: 35-71.
18. Bartness TJ, Powers JB, Hastings MH, Bittman EL, Goldman BD. The timed infusion paradigm for melatonin delivery: what has it taught us about the melatonin signal, its reception, and the photoperiodic control of seasonal responses? J Pineal Res 1993; 15: 161-190.
19. Morgan PJ, Williams LM. The pars tuberalis of the pituitary: a gateway for neuroendocrine output. Rev Reprod 1996; 1: 153-161.
20. Morgan PJ, Mercer JG. Control of seasonality by melatonin. Proc Nutr Soc 1994; 53: 483-493.
21. Skinner DC, Robinson JE. Melatonin-binding sites in the gonadotroph-enriched zona tuberalis of ewes. J Reprod Fertil 1995; 104: 243-250.
22. Skinner DC, Robinson JE. The pars tuberalis of the ewe: No effect of season or ovariectomy on the distribution, density or presence of immunoreactive cells. Cell Tissue Res 1996; 284: 117-123.
23. Morgan PJ, Barrett P, Davidson G, Lawson W, Hazlerigg D. p72, a marker protein for melatonin action in ovine pars tuberalis: its regulation by protein kinase A and protein kinase C and differential secretion relative to prolactin. Neuroendocrinology 1994; 59: 325-335.
24. Helliwell RJA, Williams LM. Melatonin binding sites in the ovine brain and pituitary: characterization during the oestrous cycle. J Neuroendocrinol 1992; 4: 287-294.
25. Skinner DC, Robinson JE. Luteinising hormone secretion from the perifused ovine pars tuberalis and pars distalis: effects of gonadotropin-releasing hormone and melatonin. Neuroendocrinology 1997; 66: 263-270.
26. Nakazawa K, Marubayashi U, McCann SM. Mediation of the short-loop negative feedback of luteinizing hormone (LH) on LH-releasing hormone release by melatonin-induced inhibition of LH release from the pars tuberalis. Proc Natl Acad Sci USA 1991; 88: 7576-7579.
27. Skinner DC, Evans NP, Malpaux B. Does a short loop feedback mechanism for the control of luteinizing hormone secretion exist in the ewe? Endocrinology 1997; 138: 4220-4226.
28. Helliwell RJA, Williams LM. The development of melatonin-binding sites in the ovine fetus. J Endocrinology 1994; 142: 475-484.
29. Williams LM, Martinoli MG, Titchener LT, Pelletier G. The ontogeny of central melatonin binding sites in the rat. Endocrinology 1991; 128: 2083-2090.
30. Vanecek J. The melatonin receptors in rat ontogenesis. Neuroendocrinology 1988; 48: 201-203.
31. Vanecek J, Kosar E. Ontogenesis of melatonin receptors in anterior pituitary and pars tuberalis of Golden hamsters. Physiol Res 1994; 43: 379-382.
32. Martin JE, Klein DC. Melatonin inhibition of the neonatal pituitary response to luteinizing-releasing factor. Science 1976; 191: 301-302.
33. Martin JE, Sattler C. Selectivity of melatonin pituitary inhibition for luteinizing hormone-releasing hormone. Neuroendocrinology 1982; 34: 112-116.
34. Malpaux B, Daveau A, Maurice F, Locatelli A, Thiery JC. Evidence that melatonin binding sites in the pars tuberalis do not mediate the photoperiodic actions of melatonin on LH and prolactin secretion in ewes. J Reprod Fertil 1994; 101: 625-632.
35. Malpaux B, Skinner DC, Maurice F. The ovine pars tuberalis does not appear to be targeted by melatonin to modulate luteinizing hormone secretion, but may be important for prolactin release. J Neuroendocrinol 1995; 7: 199-206.
36. Malpaux B, Daveau A, Maurice-Mandon F, Duarte G, Chemineau P. Evidence that melatonin acts in the premammillary hypothalamic area to control reproduction in the ewe: presence of binding sites and stimulation of luteinizing hormone secretion by in situ microimplant delivery. Endocrinology 1998; 139: 1508-1516.
37. Lincoln GA, Clarke IJ. Absence of photoperiodic modulation of gonadotrophin secretion in HPD rams following chronic pulsatile infusion of Gnrh. J Neuroendocrinol 1998; 10: 461-471.
38. Maywood ES, Hastings MH. Lesions of the iodomelatonin-binding sites of the mediobasal hypothalamus spare the lactotropic, but block the gonadotropic response of male Syrian hamsters to short photoperiod and to melatonin. Endocrinology 1995; 136: 144-153.
39. Maywood ES, Bittman EL, Hastings MH. Lesions of the melatonin-and androgen-responsive tissue of the dorsomedial nucleus of the hypothalamus block the gonadal response of male Syrian hamsters to programmed infusions of melatonin. Biol Reprod 1996; 54: 470-477.
40. Houghton DC, Young IR, McMillen IC. Response of prolactin to different photoperiods after surgical disconnection of the hypothalamus and pituitary in sheep fetuses. J Reprod Fertil 1995; 104: 199-206.
41. Steger RW, Bartke A, Goldman BD, Scares MJ, Talamantes F. Effects of short photoperiod on the ability of golden hamster pituitaries to secrete prolactin and gonadotropins in vitro. Biol Reprod 1983; 29: 872-878.
42. Meunier M, Brebion P, Chene N, Servely JL, Martinet L. In-vitro secretion of prolactin and growth hormone in the presence of melatonin by pituitary gland from mink kept under long or short days. J Endocrinol 1988; 119: 287-292.
43. Badura LL, Goldman BD. Anterior pituitary release of prolactin is inhibited by exposure to short photoperiod. J Neuroendocrinol 1997; 9: 341-345.
44. Lincoln GA, Clarke IJ. Evidence that melatonin acts in the pituitary gland through a dopamine-independent mechanism to mediate effects of daylength on the secretion of prolactin in the ram. J Neuroendocrinol 1995; 7: 637-643.
45. Lincoln GA, Tortonese DJ. Does melatonin act on dopaminergic pathways in the mediobasal hypothalamus to mediate effects of photoperiod on prolactin secretion in the ram? Neuroendocrinology 1995; 62: 425-433.
46. Morgan PJ, Webster CA, Mercer JG, Ross AW, Hazlerigg DG, Maclean A, Barrett P. The ovine pars tuberalis secretes a factor(s) that regulates gene expression in both lactotrophic and nonlactotrophic pituitary cells. Endocrinology 1996; 137: 4018-4026.
47. Hazlerigg DG, Hastings MH, Morgan PJ. Production of a prolactin releasing factor by the ovine pars tuberalis. J Neuroendocrinol 1996; 8: 489-492.
48. Houben H, Denef C. Bioactive peptides in anterior pituitary cells. Peptides 1994; 15: 547-582.
49. Stoeckel ME, Hindelang C, Klein MJ, Poissonnier M, Felix JM. Early expression of the glyoprotein hormone α-subunit in the pars tuberalis of the rat pituitary gland during ontogenesis. Neuroendocrinology 1993; 58: 616-624.
50. Stoeckel ME, Hindelang C, Klein MJ, Poissonnier M, Felix JM. Expression of the α-subunit of glycoprotein hormones in the pars tuberalis-specific glandular cells in rat, mouse and guinea pig. Cell Tissue Res 1994; 278: 617-624.
51. Bockers TM, Bockmann J, Fauteck JD, Kreutz MR, Bock R, Wittkowski W. Pars tuberalis-specific cells in the ovine pituitary do express the common alpha-chain of glycoprotein hormones: an in situ hybridization and immunocytochemical study. Eur J Endocrinology 1994; 131: 540-546.
52. Bockers TM, Bockmann J, Fauteck JD, Wittkowski W, Sabel BA, Kreutz MR. Evidence for gene transcription of adenohypophyseal hormones in the ovine PT. Neuroendocrinology 1996; 63: 16-27.
53. Bockmann J, Bockers TM, Vennemann B, Niklowitz P, Muller J, Wittkowski W, Sabel B, Kreutz MR. Short photoperiod-dependent down-regulation of thyrotropin-alpha and -beta in hamster pars tuberalis-specific cells is prevented by pinealectomy. Endocrinology 1996; 137: 1804-1813.
54. Begeot M, Hemming FJ, Dubois PM. Induction of pituitary lactotrope differentiation by luteinizing hormone α subunit. Science 1984; 226: 566-568.
55. Blithe DL, Richards RG, Skarulis MC. Free alpha molecules from pregnancy stimulate secretion of prolactin from human decidual cells: a novel function for free alpha in pregnancy. Endocrinology 1991; 129: 2257-2259.
56. Ferrara N, Schweigerer L, Neufeld G, Mitchell R, Gospodarowicz D. Pituitary follicular cells produce basic fibroblast growth factor. Proc Natl Acad Sci USA 1987; 84: 5773-5777.
57. Graham ES, Hazlerigg DG, Morgan PJ. Evidence for regulation of basic fibroblast growth factor gene expression by photoperiod and melatonin in the ovine pars tuberalis. Mol Cell Endocrinol 1999; 156: 45-53.
58. 3 cells. Mol Cell Endocrinol 1995; 114: 117-125.
59. Stachowiak MK, Moffett J, Joy A, Puchacz E, Florkiewicz R, Stachowiak EK. Regulation of bFGF gene expression and subccllular distribution of bFGF protein in adrenal medullary cells. J Cell Biol 1994; 127: 203-223.
60. Reppert SM, Weaver DR, Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron 1994; 13: 1177-1185.
61. Barrett P, Conway S, Jockers R, Strosberg AD, Guardiola B, Delagrange P, Morgan PJ. Cloning and functional analysis of a polymorphic variant of the ovine Mel 1a melatonin receptor. Biochim Biophys Acta 1997; 1356: 299-307.
62. Drew JE, Barrett P, Williams LM, Conway S, Morgan PJ. The ovine melatonin-related receptor: cloning and preliminary distribution and binding studies. J Neuroendocrinol 1998; 10: 651-662.
63. Hazlerigg DG, Thompson M, Hastings MH, Morgan PJ. Regulation of mitogen-activated protein kinase in the pars tuberalis of the ovine pituitary: interactions between melatonin, insulin-like growth factor-1, and forskolin. Endocrinology 1996; 137: 210-218.
64. Morgan PJ, Hastings MH, Thompson M, Barrett P, Lawson W, Davidson G. Intracellular signalling in the ovine pars tuberalis: an investigation using aluminium fluoride and melatonin. J Mol Endocrinol 1991; 7: 137-144.
65. Morgan PJ, Lawson W, Davidson G, Howell HE. Melatonin inhibits cyclic AMP in cultured ovine pars tuberalis cells. J Mol Endocrinol 1989; 5: R3-R8.
66. McNulty S, Morgan PJ, Thompson M, Davidson G, Lawson W, Hastings MH. Phospholipases and melatonin signal transduction in the ovine pars tuberalis. Mol Cell Endocrinol 1994; 99: 73-79.
67. Ross AW, Webster CA, Thompson MG, Barrett P, Morgan PJ. A novel interaction between inhibitory melatonin receptors and PKC-dependent signal transduction in ovine pars tuberalis cells. Endocrinology 1998; 139: 1723-1730.
68. Ross AW, Barrett P, Mercer JG, Morgan PJ. Melatonin suppresses the induction of AP-1 transcription factor components in the pars tuberalis of the pituitary. Mol Cell Endocrinol 1996; 123: 71-80.
69. Sun ZS, Albrecht U, Zhuchenko O, Bailey J, Eichele G, Lee CC, RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell 1997; 90: 1003-1011.
70. Tei H, Okamura H, Shigeyoshi Y, Fukahara C, Ozawa C, Hirose M, Sakaki Y. Circadian oscillation of a mammalian homologue of the Drosophila period gene. Nature 1997; 389: 512-516.
71. Morgan PJ, Ross AW, Graham ES, Adam C, Messager S, Barrett P. oPer1 is an early response gene under photoperiodic regulation in the ovine pars tuberalis. J Neuroendocrinol 1998; 10: 319-323.
72. Messager S, Ross AW, Barret P, Morgan PJ. Decoding photoperiod time through Per1 and ICER gene amplitude. Proc Natl Acad Sci USA 1999; 96: 9938-9943.
73. Morgan PJ, Davidson G, Lawson W, Barrett P. Both pertussis toxin-sensitive and insensitive G-proteins link melatonin receptor to inhibition of adenylale cyclase in the ovine pars tuberalis. J Neuroendocrinol 1990; 2: 773-776.
74. Carlson LL, Weaver DR, Reppert SM. Melatonin signal transduction in hamster brain: inhibition of adenylyl cyclase by pertussis toxin-sensitive G protein. Endocrinology 1989; 125: 2670-2676.
75. Brydon L, Rocka F, Petit L, de Coppet P, Tissot M, Barrett P, Morgan P, Nanoff C, Strosberg AD, Jockers R. Dual signalling of human Mel 1a melatonin receptors via Gi2, Gi3 and Gq/11 proteins. Mol Endocrinol 1999; in press.
76. Yung LY, Tsim ST, Wong YH. Stimulation of cAMP accumulation by the cloned Xenopus melatonin receptor through G(i) and G(z) proteins. FEBS Lett 1995; 372: 99-102.
77. Hazlerigg DG, Gonzalez-Brito A, Lawson W, Hastings MH, Morgan PJ. Prolonged exposure to melatonin leads to time-dependent sensitization of adenylate cyclase and down-regulates melatonin receptors in pars tuberalis cells of ovine pituitary. Endocrinology 1993; 132: 285-292.
78. Hazlerigg DG, Hastings MH, Morgan PJ. The recovery of ovine pars tuberalis cells from melatonin-induced sensitization is a slow, protein synthesis-dependent phenomenon. J Endocrinol 1994; 142: 127-138.
79. Bates MD, Senogles SE, Bunzow JR, Liggett SB, Civelli O, Caron MG. Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. Mol Pharmacol 1991; 39: 55-63.
80. Sharma SK, Klee WA, Nirenberg M. Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance. Proc Natl Acad Sci USA 1975; 72: 3092-3096.
81. Reisine TD, Takahashi JS. Somatostatin pretreatment desensitizes somatostatin receptors linked to adenylate cyclase and facilitates the stimulation of cyclic adenosine 3′: 5′-monophosphate accumulation in anterior pituitary tumour cells. J Neurosci 1984; 4: 812-819.
82. Fleming JV, Barrett P, Coon SL, Klein DC, Morgan PJ. Ovine arylalkylamine N-acetyltransferase (AANAT) in the pineal and piuitary glands: differences in function and regulation. Endocrinology 1998; 140: 972-978.
83. Lincoln GA. Correlation with changes in horns and pelage, but not reproduction, of seasonal cycles in the secretion of prolactin in rams of wild, feral and domesticated breeds of sheep. J Reprod Fertil 1990; 90: 285-296.
84. Dicks P, Russel AJ, Lincoln GA. The role of prolactin in the reactivation of hair follicles in relation to moulting in cashmere goats. J Endocrinol 1994; 143: 441-448.
85. Badura LL, Goldman BD. Prolactin-dependent seasonal changes in pelage: role of the pineal gland and dopamine. J Exp Zool 1992; 261: 27-33.
86. Curlewis JD. Seasonal prolactin secretion and its role in seasonal reproduction: a review. Reprod Fertil Dev 1992; 4: 1-23.
87. Nelson RJ, Moffatt CA, Goldman BD. Reproductive and nonreproductive responsiveness to photoperiod in laboratory rats. J Pineal Res 1994; 17: 123-131.
88. Maes M, Mommen K, Hendrickx D, Peeters D, D'Hondt P, Ranjan R, De Meyer F, Scharpe S. Components of biological variation, including seasonality, in blood concentrations of TSH, TT3, FT4, PRL, cortisol and testosterone in healthy volunteers. Clin Endocrinol 1997; 46: 587-598.
89. Hamada J, Seto H, Miura M, Kuratsu J, Ushio Y. Suprasellar pituitary adenoma arising from the pars tuberalis: case report. Neurosurgery 1990; 27: 647-649.