-
1
-
-
0002972370
-
Cerebroprotective effects of NS-7, a novel pyrimidine derivative, in rats after permanent middle cerebral artery occlusion
-
Aoki Y., Shibahara R., Itoh Y., Ukai Y., Yoshikuni Y., and Kimura K. (1997) Cerebroprotective effects of NS-7, a novel pyrimidine derivative, in rats after permanent middle cerebral artery occlusion. Jpn. J. Pharmacol. (Suppl.) 73, 90.
-
(1997)
Jpn. J. Pharmacol. (Suppl.)
, vol.73
, pp. 90
-
-
Aoki, Y.1
Shibahara, R.2
Itoh, Y.3
Ukai, Y.4
Yoshikuni, Y.5
Kimura, K.6
-
2
-
-
0025871373
-
A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices
-
Arai A., Vanderklish P., Kessler M., Lee K., and Lynch G. (1991) A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices. Brain Res. 555, 276-280.
-
(1991)
Brain Res.
, vol.555
, pp. 276-280
-
-
Arai, A.1
Vanderklish, P.2
Kessler, M.3
Lee, K.4
Lynch, G.5
-
3
-
-
0029045611
-
Induction of calpain-mediated spectrin fragments by pathogenic treatments in long-term hippocampal slices
-
Bahr B. A., Tiriveedhi S., Park G. Y., and Lynch G. (1995) Induction of calpain-mediated spectrin fragments by pathogenic treatments in long-term hippocampal slices. J. Pharmacol. Exp. Ther. 273, 902-908.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.273
, pp. 902-908
-
-
Bahr, B.A.1
Tiriveedhi, S.2
Park, G.Y.3
Lynch, G.4
-
4
-
-
0028292190
-
Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage
-
Bartus R. T., Baker K. L., Heiser A. D., Sawyer S. D., Dean R. L., Elliott P. J., and Straub J. A. (1994a) Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J. Cereb. Blood Flow Metab. 14, 537-544.
-
(1994)
J. Cereb. Blood Flow Metab.
, vol.14
, pp. 537-544
-
-
Bartus, R.T.1
Baker, K.L.2
Heiser, A.D.3
Sawyer, S.D.4
Dean, R.L.5
Elliott, P.J.6
Straub, J.A.7
-
5
-
-
0028020515
-
Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration
-
Bartus R. T., Hayward N. J., Elliott P. J., Sawyer S. D., Baker K. L., Dean R. L., Akiyama A., Straub J. A., Harbeson S. L., Li Z., and Powers J. (1994b) Calpain inhibitor AK295 protects neurons from focal brain ischemia. Effects of postocclusion intra-arterial administration. Stroke 25, 2265-2270.
-
(1994)
Stroke
, vol.25
, pp. 2265-2270
-
-
Bartus, R.T.1
Hayward, N.J.2
Elliott, P.J.3
Sawyer, S.D.4
Baker, K.L.5
Dean, R.L.6
Akiyama, A.7
Straub, J.A.8
Harbeson, S.L.9
Li, Z.10
Powers, J.11
-
6
-
-
0028850474
-
Time-related neuronal changes following middle cerebral artery occlusion: Implications for therapeutic intervention and the role of calpain
-
Bartus R. T., Dean R. L., Cavanaugh K., Eveleth D., Carriero D. L., and Lynch G. (1995) Time-related neuronal changes following middle cerebral artery occlusion: implications for therapeutic intervention and the role of calpain. J. Cereb. Blood Flow Metab. 15, 969-979.
-
(1995)
J. Cereb. Blood Flow Metab.
, vol.15
, pp. 969-979
-
-
Bartus, R.T.1
Dean, R.L.2
Cavanaugh, K.3
Eveleth, D.4
Carriero, D.L.5
Lynch, G.6
-
7
-
-
0022483434
-
Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination
-
Bederson J. B., Pitts L. H., Tsuji M., Nishimura M. C., Davis R. L., and Bartkowski H. (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17, 472-476.
-
(1986)
Stroke
, vol.17
, pp. 472-476
-
-
Bederson, J.B.1
Pitts, L.H.2
Tsuji, M.3
Nishimura, M.C.4
Davis, R.L.5
Bartkowski, H.6
-
8
-
-
0017184389
-
Rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principles of protein-dye binding
-
Bradford M. A. (1976) Rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal. Biochem. 72, 248-254.
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.A.1
-
9
-
-
0029015969
-
Delayed antagonism of calpain reduces excitotoxicity in cultured neurons
-
Brorson J. R., Marcuccilli C. J., and Miller R. J. (1995) Delayed antagonism of calpain reduces excitotoxicity in cultured neurons. Stroke 26, 1259-1267.
-
(1995)
Stroke
, vol.26
, pp. 1259-1267
-
-
Brorson, J.R.1
Marcuccilli, C.J.2
Miller, R.J.3
-
10
-
-
0028171089
-
2+-channel blocker prevents CA1 injury 24 h following severe forebrain ischemia and reduces infarction following focal ischemia
-
2+-channel blocker prevents CA1 injury 24 h following severe forebrain ischemia and reduces infarction following focal ischemia. J. Cereb. Blood Flow Metab. 14, 903-910.
-
(1994)
J. Cereb. Blood Flow Metab.
, vol.14
, pp. 903-910
-
-
Buchan, A.M.1
Gertler, S.Z.2
Li, H.3
Xue, D.4
Huang, Z.-G.5
Chaundy, K.E.6
Bernes, K.7
Lesiuk, H.J.8
-
11
-
-
0025470262
-
Cerebral hypoxia: Some new approaches and unanswered questions
-
Choi D. W. (1990) Cerebral hypoxia: some new approaches and unanswered questions. J. Neurosci. 10, 2493-2501.
-
(1990)
J. Neurosci.
, vol.10
, pp. 2493-2501
-
-
Choi, D.W.1
-
12
-
-
0024829451
-
Excitatory amino acid receptors in the vertebrate central nervous system
-
Collingridge G. and Lester R. A. (1989) Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 40, 143-210.
-
(1989)
Pharmacol. Rev.
, vol.40
, pp. 143-210
-
-
Collingridge, G.1
Lester, R.A.2
-
14
-
-
0027874438
-
Pharmacological protection of CNS white matter during anoxia: Actions of phenytoin, carbamazepine and diazepam
-
Fern R., Ransom B. R., Stys P. K., and Waxman S. G. (1993) Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam. J. Pharmacol. Exp. Ther. 266, 1549-1555.
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.266
, pp. 1549-1555
-
-
Fern, R.1
Ransom, B.R.2
Stys, P.K.3
Waxman, S.G.4
-
15
-
-
0028947743
-
Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudate putamen and the cortex
-
Garcia J. H., Liu K.-F., and Ho K.-L. (1995) Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudate putamen and the cortex. Stroke 26, 636-643.
-
(1995)
Stroke
, vol.26
, pp. 636-643
-
-
Garcia, J.H.1
Liu, K.-F.2
Ho, K.-L.3
-
16
-
-
0028587095
-
The neuroprotective effects of the decahydroisoquinoline, LY 215490; a novel AMPa antagonist in focal ischaemia
-
Gill R. and Lodge D. (1994) The neuroprotective effects of the decahydroisoquinoline, LY 215490; a novel AMPA antagonist in focal ischaemia. Neuropharmacology 33, 1529-1536.
-
(1994)
Neuropharmacology
, vol.33
, pp. 1529-1536
-
-
Gill, R.1
Lodge, D.2
-
17
-
-
0027531309
-
Limiting ischemic injury by inhibition of excitatory amino acid release
-
Graham S. H., Chen J., Sharp F. R., and Simon R. P. (1993) Limiting ischemic injury by inhibition of excitatory amino acid release. J. Cereb. Blood Flow Metab. 13, 88-97.
-
(1993)
J. Cereb. Blood Flow Metab.
, vol.13
, pp. 88-97
-
-
Graham, S.H.1
Chen, J.2
Sharp, F.R.3
Simon, R.P.4
-
18
-
-
0028362182
-
Neuroprotective effect of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion
-
Graham S. H., Chen J., Lan J., Leach M. J., and Simon R. P. (1994) Neuroprotective effect of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion. J. Pharmacol. Exp. Ther. 269, 854-859.
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.269
, pp. 854-859
-
-
Graham, S.H.1
Chen, J.2
Lan, J.3
Leach, M.J.4
Simon, R.P.5
-
19
-
-
0028098014
-
Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia
-
Hong S.-C., Goto Y., Lanzino G., Soleau S., Kassell N. F., and Lee K. S. (1994) Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia. Stroke 25, 663-669.
-
(1994)
Stroke
, vol.25
, pp. 663-669
-
-
Hong, S.-C.1
Goto, Y.2
Lanzino, G.3
Soleau, S.4
Kassell, N.F.5
Lee, K.S.6
-
20
-
-
0025184647
-
Suppressive effect of E-64c on ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats
-
Inuzuka T., Tamura A., Sato S., Kirino T., Toyoshima I., and Miyatake T. (1990) Suppressive effect of E-64c on ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. Brain Res. 526, 177-179.
-
(1990)
Brain Res.
, vol.526
, pp. 177-179
-
-
Inuzuka, T.1
Tamura, A.2
Sato, S.3
Kirino, T.4
Toyoshima, I.5
Miyatake, T.6
-
21
-
-
0025731595
-
Degradation of microtubule-associated protein 2 and brain spectrin by calpain: A comparative study
-
Johnson G. V. W., Litersky J. M., and Jope R. S. (1991) Degradation of microtubule-associated protein 2 and brain spectrin by calpain: a comparative study. J. Neurochem. 56, 1630-1638.
-
(1991)
J. Neurochem.
, vol.56
, pp. 1630-1638
-
-
Johnson, G.V.W.1
Litersky, J.M.2
Jope, R.S.3
-
22
-
-
0027136017
-
A new family of neurotransmitter transporters: The high-affinity glutamate transporters
-
Kanai Y., Smith C. P., and Hediger M. A. (1993) A new family of neurotransmitter transporters: the high-affinity glutamate transporters. FASEB J. 7, 1450-1459.
-
(1993)
FASEB J.
, vol.7
, pp. 1450-1459
-
-
Kanai, Y.1
Smith, C.P.2
Hediger, M.A.3
-
23
-
-
0028340999
-
Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate
-
Kiedrowski L., Wroblewski J. T., and Costa E. (1994) Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate. Mol. Pharmacol. 45, 1050-1054.
-
(1994)
Mol. Pharmacol.
, vol.45
, pp. 1050-1054
-
-
Kiedrowski, L.1
Wroblewski, J.T.2
Costa, E.3
-
24
-
-
0024515583
-
Limited proteolysis of protein kinase C by calcium-activated neutral protease (calpain)
-
Kishimoto A., Mikawa K., Hashimoto K., Yasuda I., Tanaka S., Tominaga M., Kuroda T., and Nishizuka Y. (1989) Limited proteolysis of protein kinase C by calcium-activated neutral protease (calpain). J. Biol. Chem. 264, 4088-4092.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 4088-4092
-
-
Kishimoto, A.1
Mikawa, K.2
Hashimoto, K.3
Yasuda, I.4
Tanaka, S.5
Tominaga, M.6
Kuroda, T.7
Nishizuka, Y.8
-
25
-
-
0028325880
-
Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient
-
Koch R. A. and Barish M. E. (1994) Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient. J. Neurosci. 14, 2585-2593.
-
(1994)
J. Neurosci.
, vol.14
, pp. 2585-2593
-
-
Koch, R.A.1
Barish, M.E.2
-
26
-
-
0027287896
-
BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage
-
Leach M. J., Swan J. H., Eisenthal D., Libiol M. D., and Nobbs M. (1993) BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 24, 1063-1067.
-
(1993)
Stroke
, vol.24
, pp. 1063-1067
-
-
Leach, M.J.1
Swan, J.H.2
Eisenthal, D.3
Libiol, M.D.4
Nobbs, M.5
-
27
-
-
0028940581
-
Sodium channel blockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists
-
Lynch J. J., Yu S. P., Canzoniero L. M. T., Sensi S. L., and Choi D. W. (1995) Sodium channel blockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists. J. Pharmacol. Exp. Ther. 273, 554-560.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.273
, pp. 554-560
-
-
Lynch, J.J.1
Yu, S.P.2
Canzoniero, L.M.T.3
Sensi, S.L.4
Choi, D.W.5
-
28
-
-
0028091767
-
+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia
-
+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia. Stroke 25, 2476-2482.
-
(1994)
Stroke
, vol.25
, pp. 2476-2482
-
-
Lysko, P.G.1
Webb, C.L.2
Yue, T.-L.3
Gu, J.-L.4
Feuerstein, G.5
-
29
-
-
0025257513
-
Physiological and pathophysiological roles of excitatory amino acids during central nervous system development
-
McDonald J. W. and Johnston M. V. (1990) Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res. 15, 41-70.
-
(1990)
Brain Res.
, vol.15
, pp. 41-70
-
-
McDonald, J.W.1
Johnston, M.V.2
-
30
-
-
0026783329
-
Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87
-
Meldrum B. S., Swan J. H., Leach M. J., Millan M. H., Gwinn R., Kadota K., Graham S. H., Chen J., and Simon R. P. (1992) Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87. Brain Res. 593, 1-6.
-
(1992)
Brain Res.
, vol.593
, pp. 1-6
-
-
Meldrum, B.S.1
Swan, J.H.2
Leach, M.J.3
Millan, M.H.4
Gwinn, R.5
Kadota, K.6
Graham, S.H.7
Chen, J.8
Simon, R.P.9
-
31
-
-
0029671032
-
Brain μ-calpain autolysis during global cerebral ischemia
-
Neumar R. W., Hagle S. M., DeGracia D. J., Krause G. S., and White B. C. (1996) Brain μ-calpain autolysis during global cerebral ischemia. J. Neurochem. 66, 421-424.
-
(1996)
J. Neurochem.
, vol.66
, pp. 421-424
-
-
Neumar, R.W.1
Hagle, S.M.2
DeGracia, D.J.3
Krause, G.S.4
White, B.C.5
-
32
-
-
0025052336
-
The release and uptake of excitatory amino acids
-
Nicholls D. and Attwell D. (1990) The release and uptake of excitatory amino acids. Trends Pharmacol. Sci. 11, 462-468.
-
(1990)
Trends Pharmacol. Sci.
, vol.11
, pp. 462-468
-
-
Nicholls, D.1
Attwell, D.2
-
34
-
-
0027215039
-
Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo
-
Rami A. and Krieglstein J. (1993) Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo. Brain Res. 609, 67-70.
-
(1993)
Brain Res.
, vol.609
, pp. 67-70
-
-
Rami, A.1
Krieglstein, J.2
-
35
-
-
0027365768
-
Spatial resolution of fodrin proteolysis in postischemic brain
-
Saido T. C., Yokota M., Nagao S., Yamaura I., Tani E., Tsuchiya T., Suzuki K., and Kawashima S. (1993) Spatial resolution of fodrin proteolysis in postischemic brain. J. Biol. Chem. 268, 25239-25243.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 25239-25243
-
-
Saido, T.C.1
Yokota, M.2
Nagao, S.3
Yamaura, I.4
Tani, E.5
Tsuchiya, T.6
Suzuki, K.7
Kawashima, S.8
-
36
-
-
0028088153
-
Calpain: New perspectives in molecular diversity and physiological-pathological involvement
-
Saido T. C., Sorimachi H., and Suzuki K. (1994) Calpain: new perspectives in molecular diversity and physiological-pathological involvement. FASEB J. 8, 814-822.
-
(1994)
FASEB J.
, vol.8
, pp. 814-822
-
-
Saido, T.C.1
Sorimachi, H.2
Suzuki, K.3
-
37
-
-
0030941528
-
Blockade of voltage-sensitive sodium channels by NS-7, a novel neuroprotective compound, in the rat brain
-
in press
-
Shimidzu T., Itoh Y., Tatsumi S., Hayashi S., Ukai Y., Yoshikuni Y., and Kimura K. (1997) Blockade of voltage-sensitive sodium channels by NS-7, a novel neuroprotective compound, in the rat brain. Naunyn Schmiedebergs Arch. Pharmacol. (in press).
-
(1997)
Naunyn Schmiedebergs Arch. Pharmacol.
-
-
Shimidzu, T.1
Itoh, Y.2
Tatsumi, S.3
Hayashi, S.4
Ukai, Y.5
Yoshikuni, Y.6
Kimura, K.7
-
39
-
-
0342580445
-
2+ channel blocking actions of NS-7, a novel cerebroprotective compound
-
2+ channel blocking actions of NS-7, a novel cerebroprotective compound. Jpn. J. Pharmacol. (Suppl.) 73, 193.
-
(1997)
Jpn. J. Pharmacol. (Suppl.)
, vol.73
, pp. 193
-
-
Suma, C.1
Hayashi, S.2
Shimizu, T.3
Ukai, Y.4
Yoshikuni, Y.5
Kimura, K.6
-
40
-
-
0025251185
-
Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake
-
Szatkowski M., Barbour B., and Attwell D. (1990) Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature 348, 443-446.
-
(1990)
Nature
, vol.348
, pp. 443-446
-
-
Szatkowski, M.1
Barbour, B.2
Attwell, D.3
-
41
-
-
0019868418
-
Focal cerebral ischemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion
-
Tamura A., Graham D. I., McCulloch J., and Teasdale G. M. (1981) Focal cerebral ischemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 1, 53-60.
-
(1981)
J. Cereb. Blood Flow Metab.
, vol.1
, pp. 53-60
-
-
Tamura, A.1
Graham, D.I.2
McCulloch, J.3
Teasdale, G.M.4
-
43
-
-
0027985454
-
2+ chelators
-
2+ chelators. J. Cereb. Blood Flow Metab. 14, 911-923.
-
(1994)
J. Cereb. Blood Flow Metab.
, vol.14
, pp. 911-923
-
-
Tymianski, M.1
Spigelman, I.2
Zhang, L.3
Carlen, P.L.4
Tator, C.H.5
Charlton, M.P.6
Wallace, M.C.7
-
44
-
-
0027988820
-
Calpain inhibition: An overview of its therapeutic potential
-
Wang K. K. W. and Yuen P.-W. (1994) Calpain inhibition: an overview of its therapeutic potential. Trends Pharmacol. Sci. 15, 412-419.
-
(1994)
Trends Pharmacol. Sci.
, vol.15
, pp. 412-419
-
-
Wang, K.K.W.1
Yuen, P.-W.2
|