Vascular endothelial growth factor and p53 expressions in liver and abdominal metastases from colon cancer

Tumor Biology

Volumn 24, Issue 2, 2003, Pages 77-81

  Cascinu, Stefano ^a   Graziano, Francesco ^b,g   Catalano, Vincenzo ^c   Barni, Sandro ^e   Giordani, Paolo ^c   Baldelli, Anna Maria ^c   Staccioli, Maria Pia ^c   Rossi, Cristina ^c   Brenna, Angelo ^f   Valenti, Andrea ^d   Muretto, Pietro ^c   Catalano, Giuseppina ^c  

^a Parma Hospital   (Italy)

^b Hospital of Urbino   (Italy)

^c SAN SALVATORE HOSPITAL   (Italy)

^d UNIVERSITY OF MESSINA   (Italy)

^e TREVIGLIO HOSPITAL   (Italy)

^f Department of Pediatrics   (Italy)

^g UNIVERSITY OF URBINO   (Italy)

Author keywords

Angiogenesis; Colorectal neoplasms; Hypoxia; p53; Vascular endothelial growth factor

Indexed keywords

PROTEIN P53; TUMOR MARKER; VASCULOTROPIN;

ABDOMINAL CANCER; ADULT; AGED; ARTICLE; CANCER TISSUE; COLON CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; FEMALE; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MALE; METASTASIS; MICROENVIRONMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; UPREGULATION;

EID: 0037633525     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000071080     Document Type: Article

References (47)

1. Folkman J: Angiogenesis-dependent diseases. Semin Oncol 2001;28:536-542.
2. Ferrara N, Davis-Smyth T: The biology of vascular endothelial growth factor. Endocr Rev 1997;18:4-25.
3. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM: Expression of vascular endothelial growth factor, its receptor, KDR correlates with vascularity, metastasis and proliferation of human colon cancer. Cancer Res 1995;55:3964-3968.
4. Graziano F, Catalano V, Baldelli AM, Cascinu S: Prognostic biomarkers in resected colorectal cancer: Implications for adjuvant chemotherapy. Expert Rev Anticancer Ther 2001;1:247-257.
5. Shweiki D, Neeman M, Itin A, Keshet E: Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implications for tumor angiogenesis. Proc Natl Acad Sci USA 1995;92:768-772.
6. Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992;359:843-845.
7. Mukhopadhyay D, Tsiokas L, Sukhatme V: Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res 1995;55:6161-6165.
8. Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, Sasazuki T, Kerbel RS: Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis. Cancer Res 1995;55:4575-4580.
9. Nishizaki M, Fujiwara T, Tanida T, Hizuta A, Nishimori H, Tokino T, Nakamura Y, Bouvet M, Roth JA, Tanaka N: Recombinant adenovirus expressing wild-type p53 is antiangiogenic: A proposed mechanism for bystander effect. Clin Cancer Res 1999;5:1015-1023.
10. Mineta H, Miura K, Ogino T, Takebayashi S, Misawa K, Ueda Y: Vascular endothelial growth factor (VEGF) expression correlates with p53 and ki-67 expressions in tongue squamous cell carcinoma. Anticancer Res 2002;22:1039-1044.
11. Yuan A, Yu CJ, Luh KT, Kuo SH, Lee YC, Yang PC: Aberrant p53 expression correlates with expression of vascular endothelial growth factor mRNA and interleukin-8 mRNA and neoangiogenesis in non-small-cell lung cancer. J Clin Oncol 2002;20:900-910.
12. Fujisawa T, Watanabe J, Akaboshi M, Ohno E, Kuramoto H: Immunohistochemical study on VEGF expression in endometrial carcinoma - comparison with p53 expression, angiogenesis and tumor histologic grade. J Cancer Res Clin Oncol 2001;127:668-674.
13. Linderholm BK, Lindahl T, Holmberg L, Klaar S, Lennerstrand J, Henriksson R, Bergh J: The expression of vascular endothelial growth factor correlates with mutant p53 and poor prognosis in human breast cancer. Cancer Res 2001;61:2256-2260.
14. Fontanini G, Boldrini L, Calcinai A, Chine S, Lucchi M, Mussi A, Angeletti CA, Basolo F, Bevilacqua G: Thrombospondins I and II messenger RNA expression in lung carcinoma: Relationship with p53 alterations, angiogenic growth factors and vascular density. Clin Cancer Res 1999;5:155-161.
15. Maeda K, Kang SM, Onoda N, Ogawa M, Sawada T, Nakata B, Kato Y, Chung YS, Sowa M: Expression of p53 and vascular endothelial growth factor associated with tumor angiogenesis and prognosis in gastric cancer. Oncology 1998;55:594-599.
16. Kang SM, Maeda K, Onoda N, Chung YS, Nakata B, Nishiguchi Y, Sowa M: Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis. Int J Cancer 1997;74:502-507.
17. Fontanini G, Vignati S, Lucchi M, Mussi A, Calcinai A, Boldrini L, Chine S, Silvestri V, Angeletti CA, Basolo F, Bevilacqua G: Neoangiogenesis and p53 protein in lung cancer: Their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression. Br J Cancer 1997;75:1295-1301.
18. Takahashi Y, Bucana CD, Cleary KR, Ellis LM: p53, vessel count and vascular endothelial growth factor expression in human colon cancer. Int J Cancer 1998;79:34-38.
19. Saito H, Tujitani S, Ikeguchi M, Maeta M, Kaibara N: Neoangiogenesis and relationship to nuclear p53 accumulation and vascular endothelial growth factor expression in advanced gastric carcinoma. Oncology 1999;57:164-172.
20. Giatromanolaki A, Koukourakis MI, Kakolyris S, Turley H, O'Byrne K, Scott PA, Pezzella F, Georgoulias V, Harris AL, Gatter KC: Vascular endothelial growth factor, wild-type p53 and angiogenesis in early operable non-small cell lung cancer. Clin Cancer Res 1998;4:3017-3024.
21. Maeda T, Matsumura S, Hiranuma H, Jikko A, Furukawa S, Ishida T, Fuchihata H: Expression of vascular endothelial growth factor in human oral squamous cell carcinoma: Its association with tumor progression and p53 gene status. J Clin Pathol 1998;51:771-775.
22. Lee JS, Kim HS, Jung JJ, Park CS, Lee MC: Expression of vascular endothelial growth factor in renal cell carcinoma and the relation to angiogenesis and p53 protein expression. J Surg Oncol 2001;77:55-60.
23. Strohmeyer D, Rossing C, Bauerfeind A, Kaufmann O, Schlechte H, Bartsch G, Loening S: Vascular endothelial growth factor and its correlation with angiogenesis and p53 expression in prostate cancer. Prostate 2000;45:216-224.
24. Konishi T, Huang CL, Adachi M, Taki T, Inufusa H, Kodama K, Kohno N, Miyake M: The K-rasregulates vascular endothelial growth factor gene expression in non-small-cell lung cancer. Int J Oncol 2000;16:501-511.
25. Ambs S, Bennet WP, Merriam WG, Ogunfusika MO, Oser SM, Khan MA, Jones RT, Harris CC: Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53. Br J Cancer 1998;78:233-239.
26. Wynter CV, Simms LA, Buttenshaw RL, Biden KG, Young J, Leggett BA, Conrad RJ, Schoch EM, Jass JR, Praga Pillay S: Angiogenic factor VEGF is decreased in human colorectal neoplasms showing DNA microsatellite instability. J Pathol 1999;189:319-325.
27. Agani F, Kirsch DG, Friedman SL, Kastan MB, Semenza GL: p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. Cancer Res 1997;57:4474-4477.
28. Laderoute KR, Alacorn RM, Brody MD, Calaogan JM, Chen EY, Knapp AM, Yun Z, Denko NC, Giaccia AJ: Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Clin Cancer Res 2000;6:2941-2950.
29. Cascinu S, Graziano F, Catalano V, Staccioli MP, Barni S, Giordani P, Rossi MC, Baldelli AM, Muretto P, Valenti A, Catalano G: Differences of vascular endothelial growth factor (VEGF) expression between liver and abdominal metastases from colon cancer. Implications for the treatment with VEGF inhibitors. Clin Exp Metastasis 2000;18:651-655.
30. Dachs GU, Chaplin DJ: Microenvironmental control of gene expression: Implications for tumor angiogenesis, progression and metastasis. Semin Radiat Oncol 1998;8:208-216.
31. Dachs GU, Tozer GM: Hypoxia modulated gene expression: Angiogenesis, metastasis and therapuetic exploitation. Eur J Cancer 2000;36:1649-1660.
32. De Jaeger K, Merlo FM, Kavanagh MC, Fyles AW, Hedley D, Hill RP: Heterogeneity of tumor oxygenation: Relationship to tumor necrosis, tumor size and metastasis. Int J Radiat Oncol Biol Phys 1998;42:717-721.
33. Molls M, Feldmann HJ, Fuller J: Oxygenation of locally advanced recurrent rectal cancer, soft tissue sarcoma and breast cancer. Adv Exp Med Biol 1994;345:459-463.
34. Cascinu S, Staccioli MP, Gasparini G, Giordani P, Catalano V, Ghiselli R, Rossi C, Baldelli AM, Graziano F, Saba V, Muretto P, Catalano G: Expression of vascular endothelial growth factor can predict event-free survival in stage II colon cancer. Clin Cancer Res 2000;6:2803-2807.
35. Baas IO, Mulder JW, Offerhaus GJ, Vogelstein B, Hamilton SR: An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms. J Pathol 1994;172:5-12.
36. McLeod HL, Murray GI: Tumour markers of prognosis in colorectal cancer. Br J Cancer 1999;79:191-203.
37. Dameron KM, Volpert OV, Tainsky MA, Bouck N: Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 1994;265:1502-1504.
38. Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS, Sukhatme VP: Hypoxia induction of human vascular endothelial growth factor expression through c-Src activation. Nature 1995;375:577-581.
39. Levy AP, Levy NS, Goldberg MA: Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem 1996;271:2746-2753.
40. An WG, Kanekal M, Simon MC, Maltepe E, Blagosklonny MV, Neckers LM: Stabilization of wild-type p53 by hypoxia-inducible factor 1-alpha. Nature 1998;392:405-408.
41. Reiher FK, Ivanovich M, Huang H, Smith ND, Bouck NP, Campbell SC: The role of hypoxia and p53 in the regulation of angiogenesis in bladder cancer. J Urol 2001;165:2075-2081.
42. Fukumura D, Yuan F, Monsky WL, Chen Y, Jain RK: Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. Am J Pathol 1997;151:679-688.
43. Mooteri S, Rubin D, Leugrans S, Jakate S, Drab E, Saclarides T: Tumor angiogenesis in primary and metastatic colorectal cancers. Dis Colon Rectum 1996;39:1073-1080.
44. Berney CR, Yang JL, Fisher RJ, Russell PJ, Crowe PJ: Vascular endothelial growth factor expression is reduced in liver metastasis from colorectal cancer and correlates with urokinase-type plasminogen activator. Anticancer Res 1998;18:973-978.
45. Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL: HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001;21:3995-4004.
46. Shaheen RM, Davis DW, Liu W, Zebrowski BK, Wilson MR, Bucana CD, McConkey DJ, McMahon G, Ellis LM: Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and epithelial cell apoptosis. Cancer Res 1999;59:5412-5416.
47. Bouvet M, Ellis LM, Nishizaki M, Fujiwara T, Liu W, Bucana CD, Fang B, Lee JJ, Roth JA: Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. Cancer Res 1998;58:2288-2292.