Costimulation through OX40 is crucial for induction of an alloreactive human T-cell response

Immunology

Volumn 109, Issue 2, 2003, Pages 226-231

  Ukyo, Naoya ^a   Hori, Toshiyuki ^a,b   Yanagita, Soshi ^a   Ishikawa, Takayuki ^a   Uchiyama, Takashi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 FC; HYBRID PROTEIN; INTERLEUKIN 2; LEUKOCYTE ANTIGEN; LIGAND; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ALLOIMMUNITY; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ANTIGEN PURIFICATION; ARTICLE; BLOOD CELL; COCULTURE; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VITRO STUDY; INHIBITION KINETICS; LYMPHOCYTE PROLIFERATION; MEASUREMENT; MIXED LYMPHOCYTE REACTION; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; SUPERNATANT; T LYMPHOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD27; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; COCULTURE TECHNIQUES; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; IMMUNOCONJUGATES; INTERLEUKIN-2; ISOANTIGENS; LYMPHOCYTE CULTURE TEST, MIXED; MEMBRANE GLYCOPROTEINS; MONOCYTES; OX40 LIGAND; RECEPTORS, IMMUNOLOGIC; RECEPTORS, OX40; RECEPTORS, TUMOR NECROSIS FACTOR;

EID: 0037505503     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2003.01648.x     Document Type: Article

References (22)

1. Steinmann RM, Gutchinov B, Witmer MD, Nussenzweig MC. Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J Exp Med 1983; 157:613-27.
2. Caux C, Vanbervliet B, Massacrier C, Azuma M, Okumura K, Lanier LL, Banchereau J. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J Exp Med 1994; 180:1841-7.
3. Tanaka H, Demeure CE, Rubio M, Delespesse G, Saefati M. Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors: role of stimulator/responder ratio. J Exp Med 2000; 192:405-12.
4. + T cells. J Immunol 1999; 163:3597-604.
5. Aicher A, Hayden-Ledbetter M, Brady WA et al. Characterization of human inducible costimulator ligand expression and function. J Immunol 2000; 164:4689-96.
6. Gramaglia I, Weinberg AD, Lemon M, Croft M. Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J Immunol 1998; 161:6510-7.
7. + T cells into high IL-4-producing effectors. Blood 1998; 92:3338-45.
8. Maxwell JR, Weinberg A, Prell RA, Vella AT. Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion. J Immunol 2000; 164:107-12.
9. Ohshima Y, Tanaka Y, Tozawa H, Takahashi Y, Maliszewski C, Delespesse G. Expression and function of OX40 ligand on human dendritic cells. J Immunol 1997; 159:3838-48.
10. Chen AI, McAdam AJ, Buhlmann JE et al. Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions. Immunity 1999; 11:689-98.
11. Murata K, Ishii N, Takano H, Miura S, Ndhlovu LC, Nose M, Noda T, Sugamura K. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J Exp Med 2000; 191:365-74.
12. Wu T, Hering B, Kirchof N, Sutherland D, Yagita H, Guo Z. The effect of OX40/OX40L and CD27/CD70 pathways on allogeneic islet graft rejection. Transplant Proc 2001; 33:217-8.
13. Tittle TV, Weinberg AD, Stenkeler CN, Maziarz RT. Expression of the T-cell activation antigen, OX40, identifies alloreactive T cells in acute graft-versus-host disease. Blood 1997; 89:4652-8.
14. Tsukada N, Akiba H, Kobata T, Aizawa Y, Yagita H, Okumura K. Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in murine model of allogeneic bone marrow transplantation. Blood 2000; 95:2434-9.
15. Stuber E, Freier AV, Marinescu D, Folsch UR. Involvement of OX40-OX40L interactions in the intestinal manifestations of the murine acute graft-versus-host disease. Gastroenterology 1998; 115:1205-15.
16. Imura A, Hori T, Imada K, Ishikawa T, Tanaka Y, Maeda M, Imamura S, Uchiyama T. The human OX40/OX40L system directly mediates adhesion of activated T cells to vascular endothelial cells. J Exp Meal 1996; 183:2185-95.
17. Kunitomi A, Hori T, Imura A, Uchiyama T. Vascular endothelial cells provide T cells with costimulatory signals via the OX40/gp34 system. J Leukoc Biol 2000; 68:111-8.
18. Walker LSK, Gulbranson-Judge A, Flynn S et al. Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J Exp Meal 1999; 190:1115-22.
19. Rogers PR, Song J, Gramaglia I, Killeen N, Croft M. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 2001; 15:445-55.
20. Lamb LS Jr, Abhyankar SA, Hazlett L et al. Expression of CD134 (OX-40) on T cells during the first 100 days following allogeneic bone marrow transplantation as a marker for lymphocyte activation and therapy-resistant graft-versus-host disease. Cytometry 1999; 38:238-43.
21. Gadisseur AP, Gratama JW, Lamers C, van Esser JW, Bolhuis RL, Cornelissen JJ. Expression of T cell activation antigen CD134 (OX40) has no predictive value for the occurrence or response to therapy of acute graft-versus-host disease in partial T cell-depleted bone marrow transplantation. Bone Marrow Transplant 1999; 23:1013-7.
22. +) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation. Blood 2001; 98:3162-4.