Increased interleukin-10 expression is not responsible for failure of T helper 1 immunity to resolve airborne Mycobacterium tuberculosis infection in mice

Immunology

Volumn 109, Issue 2, 2003, Pages 295-299

  Jung, Yu Jin ^a   Ryan, Lynn ^a   Lacourse, Ronald ^a   North, Robert J ^a  

^a TRUDEAU INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; MESSENGER RNA; NITRIC OXIDE SYNTHASE; PROTEIN P40;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GENE DELETION; GENE FUNCTION; HOST RESISTANCE; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOREGULATION; INFECTION CONTROL; LUNG TUBERCULOSIS; MALE; MESSENGER RNA SYNTHESIS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TH1 CELL; TUBERCULOSIS; WILD TYPE;

ANIMALS; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TH1 CELLS; TUBERCULOSIS, PULMONARY;

EID: 0037505421     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2003.01645.x     Document Type: Article

References (31)

1. Boom WH. The role of T cell subsets in Mycobacterium tuberculosis infection. Infect Agents Dis 1996; 5:73-81.
2. Cooper AM, Saunders BM, D'Souza CD, Frank AA, Orme IM. Mycobacterium tuberculosis-driven processes in gene-disrupted mice. Bull Inst Pasteur 1997; 95:85-95.
3. Mogues T, Goodrich ME, Ryan L, LaCourse R, North RJ. The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice. J Exp Med 2001; 193:271-80.
4. Shiloh MU, Nathan DF. Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria. Curr Opin Microbiol 2000; 3:35-42.
5. Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM. Disseminated tuberculosis in IFN-γ gene disrupted mice. J Exp Med 1993; 178:2243-7.
6. Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 1993; 178:2249-54.
7. MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK, Nathan CF. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci USA 1997; 94:5243-8.
8. Power CA, Wei G, Bretscher PA. Mycobacterial dose defines the Th1/Th2 nature of the immune response independently of whether immunization is administered by intravenous, subcutaneous, or intradermal route. Infect Immun 1998; 66:5743-50.
9. Hernandez-Pando R, Orozcoe H, Sampieri A, Pavon L, Velasquillo C, Larriva-Sahd J, Alcocer JM, Madrid MV. Correlation between the kinetics of Th1, Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis. Immunology 1996; 89:26-33.
10. Reiner SL, Locksley RM. The regulation of immunity to Leishmania major. Annu Rev Immunol 1995; 13:151-77.
11. Jung Y-J, LaCourse R, Ryan L, North RJ. Evidence inconsistent with a negative influence of T helper 2 cells on protection afforded by a dominant T helper I response against Mycobacterium tuberculosis lung infection in mice. Infect Immun 2002; 70:6436-43.
12. Moore KW, deWaal Malefyt R, Coffman RL, O'Garra A. Interleukin-10. Annu Rev Immunol 1993; 11:165-90.
13. Redpath S, Ghazal P, Gascoigne NR. Hijacking and exploitation of IL-10 by intracellular pathogens. Trends Microbiol 2001; 9:86-92.
14. Belkaid Y, Hoffmann KF, Mendez S, Kamhawi S, Udey MC, Wynn TA, Sacks DL. The role of (IL)-I0 in persistence of Leishmania major infection in the skin after healing and the therapeutic potential of any IL-10 receptor antibody for sterile cure. J Exp Med 2001; 194:1497-506.
15. Lang R, Patel D, Morris JJ, Rutschman RL, Young PJ. Shaping gene expression in activated and resting primary macrophages by IL-10. J Immunol 2002; 169:2253-63.
16. Flesch IE, Hess JH, Oswald IP, Kaufmann SH. Growth inhibition of Mycobacterium bovis by IFN-γ-stimulated macrophages: regulation by endogenous tumor necrosis factor and by IL-10. Int Immunol 1993; 6:693-700.
17. Murray PJ, Young RA. Increased antimycobacterial immunity in interleukin-10-deficient mice. Infect Immun 1999; 67:3087-305.
18. Jacobs M, Brown N, Allie N, Gulert R, Ryffel B. Increased resistance to mycobacterial infection in the absence of interleukin-10. Immunology 2000; 100:494-501.
19. Murray PJ, Wang L, Onufryk C, Tepper RI, Young RA. T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection. J Immunol 1997; 158:315-21.
20. Lang R, Rutschman RL, Greives DR, Murray PJ. Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the CD68 promoter. J Immunol 2002; 168:3402-11.
21. Bermudez LE, Champsi J. Infection with Mycobacterium avium induces production of interleukin-10 (IL-10), and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice. Infect Immun 1992; 61:3093-7.
22. Denis M, Ghadirian E. IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infection. J Immunol 1993; 151:5425-30.
23. Roach DR, Martin E, Bean AG, Renick DM, Briscoe H, Britton WJ, Endogenous inhibition of antimycobacterial immunity by IL-10 varies between mycobacterial species. Scand J Immunol 2001; 54:163-70.
24. Turner J, Gonzalez-Juarrero M, Ellis DL, Basaraba RJ, Kipnis A, Orme IM, Cooper AM. In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. J Immunol 2002; 169:6343-51.
25. North RJ, Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis. Clin Exp Immunol 1998; 113:55-8.
26. + T cell clones producing both interferon-gamma and interleukin-10 predominate in bronchiolar lavages of active pulmonary tuberculosis patients. Clin Immunol 1999; 92:224-34.
27. Gong JH, Zhang M, Modlin RL, Linsley PS, Iyer D, Lin Y, Barnes PF. Interleukin-10 downregulates Mycobacterium tuberculosis-induced responses and CTLA-4 expression. Infect Immun 1996; 64:913-8.
28. Boussiotis VA, Tsai EY, Yunis EJ et al. IL-10-producing T cells suppress response in anergic tuberculosis patients. J Clin Invest 2000; 105:1317-25.
29. Cooper AM, Magram J, Ferrante J, Orme IM. Interleukin-12 (IL-12) is crucial for the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J Exp Med 1997; 186:39-45.
30. Park AY, Hondowicz BD, Scott P. IL-12 is required to maintain a Th1 response during Leishmania major infection. J Immunol 2000; 165:896-902.
31. Stobie L, Gurunathan S, Prussin C, Sacks DL, Glaichenhaus N, Wu CY, Seder RA. The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasitic challenge. Proc Natl Acad Sci USA 2000; 97:8427-32.